Neural Control of Naturalistic Behavior Choices.

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI:10.1146/annurev-neuro-111020-094019
Samuel K Asinof, Gwyneth M Card
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引用次数: 0

Abstract

In the natural world, animals make decisions on an ongoing basis, continuously selecting which action to undertake next. In the lab, however, the neural bases of decision processes have mostly been studied using artificial trial structures. New experimental tools based on the genetic toolkit of model organisms now make it experimentally feasible to monitor and manipulate neural activity in small subsets of neurons during naturalistic behaviors. We thus propose a new approach to investigating decision processes, termed reverse neuroethology. In this approach, experimenters select animal models based on experimental accessibility and then utilize cutting-edge tools such as connectomes and genetically encoded reagents to analyze the flow of information through an animal's nervous system during naturalistic choice behaviors. We describe how the reverse neuroethology strategy has been applied to understand the neural underpinnings of innate, rapid decision making, with a focus on defensive behavioral choices in the vinegar fly Drosophila melanogaster.

自然行为选择的神经控制
在自然界中,动物不断做出决策,不断选择下一步要采取的行动。然而,在实验室中,决策过程的神经基础大多是通过人工试验结构来研究的。现在,基于模式生物基因工具包的新实验工具使得在实验中监测和操纵自然行为过程中小神经元子集的神经活动变得可行。因此,我们提出了一种研究决策过程的新方法,即反向神经伦理学。在这种方法中,实验人员根据实验的可及性选择动物模型,然后利用连接组和基因编码试剂等尖端工具分析动物在自然选择行为中神经系统的信息流。我们将介绍如何应用反向神经伦理学策略来了解先天快速决策的神经基础,重点是醋蝇黑腹果蝇的防御行为选择。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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