髓母细胞瘤的发育起源和肿瘤发生。

IF 13.2 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2025-07-01 Epub Date: 2025-02-14 DOI:10.1146/annurev-neuro-112723-061540
Karrie M Kiang, Yogesh K H Wong, Soma Sengupta, Martine F Roussel, Q Richard Lu
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引用次数: 0

摘要

髓母细胞瘤是最常见的儿童脑癌,大致分为四个分子亚群。了解成神经管细胞瘤的细胞起源是预防肿瘤形成和复发的关键。最近的单细胞转录组学研究已经确定了髓母细胞瘤中潜在的细胞谱系脆弱性和恶性转化的机制。新出现的证据表明,每个亚群特有的遗传-表观遗传改变导致神经发育程序和随后的肿瘤发生中的谱系特异性停滞。我们讨论了髓母细胞瘤亚群中假定的细胞起源、可塑性和异质性,并深入研究了易使细胞转化的遗传和表观遗传变化。此外,我们回顾了目前关于小脑干/祖细胞和谱系可塑性如何影响成神经管细胞瘤发病机制的见解,并强调了针对这种恶性肿瘤中特定致癌易感性的最新治疗进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Developmental Origins and Oncogenesis in Medulloblastoma.

Medulloblastoma is the most common malignant pediatric brain cancer and is broadly categorized into four molecular subgroups. Understanding the cell origins of medulloblastoma is crucial for preventing tumor formation and relapse. Recent single-cell transcriptomics studies have identified the potential cell lineage vulnerabilities and mechanisms underpinning malignant transformation in medulloblastoma. Emerging evidence suggests that genetic-epigenetic alterations specific to each subgroup lead to a lineage-specific stall in the neural developmental program and subsequent tumorigenesis. We discuss the putative cells of origin, plasticity, and heterogeneity within medulloblastoma subgroups and delve into the genetic and epigenetic changes that predispose cells to transformation. Additionally, we review the current insights into how cerebellar stem/progenitor cells and lineage plasticity impact medulloblastoma pathogenesis and highlight recent therapeutic advances targeting specific oncogenic vulnerabilities in this malignancy.

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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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