Science China Materials最新文献

{"title":"High-performance deep ultraviolet light detectors composed of MXene/GaN heterostructures enabled by p-type doping of MXenes","authors":"Liangpan Yang \u0000 (,&nbsp;),&nbsp;Yu Cheng \u0000 (,&nbsp;),&nbsp;Deng Ke \u0000 (,&nbsp;),&nbsp;Shijie Xu \u0000 (,&nbsp;),&nbsp;Chao Xie \u0000 (,&nbsp;),&nbsp;Wenhua Yang \u0000 (,&nbsp;),&nbsp;Pengbin Gui \u0000 (,&nbsp;),&nbsp;Zhixiang Huang \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3253-3","DOIUrl":"10.1007/s40843-024-3253-3","url":null,"abstract":"<div><p>The performance enhancement of MXene/semiconductor heterostructure-based light detectors is greatly restricted by the relatively small junction barrier due to the limited work function of MXenes. The work function of MXenes can be largely adjusted to approach 600 meV through simple incorporation of V₂O₅ via a charge transfer doping mechanism. Exploiting this strategy, the performance of MXene/GaN heterostructure-based deep ultraviolet (DUV) photodetectors has been greatly improved. Specifically, the photocurrent is enhanced by nearly 3 times, and the dark current is suppressed at the lowest order of magnitude, resulting in improved responsivity and specific detectivity of 121.6 mA/W and 2.23×10¹³ Jones, respectively, at 265 nm. The device also displays an ultralow dark current of 10⁻¹⁴ A, a fast response speed of 0.4 ms/15.1 ms, a large linear dynamic range exceeding 150 dB, and a high DUV/near ultraviolet rejection ratio of 2.41×10⁵. Owing to its good device performance, the detector is capable of sensing weak photon signals produced by a fire flame and functions as an optical receiver to transmit a text signal in a DUV light communication system. The proposed MXene doping method is expected to help develop MXene-based electronic/optoelectronic devices, and the present DUV photodetectors will find potential applications in DUV optoelectronic systems.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1012 - 1021"},"PeriodicalIF":6.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color-tunable supramolecular luminescent materials for information anticounterfeiting","authors":"Zhen Qi \u0000 (,&nbsp;),&nbsp;Qian Wang \u0000 (,&nbsp;),&nbsp;Da-Hui Qu \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3265-2","DOIUrl":"10.1007/s40843-024-3265-2","url":null,"abstract":"<div><p>Counterfeiting-related crimes pose a serious threat to the economic interests, security, and health of governments, businesses, and consumers. The urgent need for advanced anticounterfeiting materials with multilevel security for information encryption and decryption has driven significant research in this area. Supramolecular luminescent materials are potential for anticounterfeiting owing to their dynamic and controllable optical properties. In this review, the strategies adopted for fabricating supramolecular fluorescent materials and their corresponding anticounterfeiting technologies have been discussed. Especially, the time-dependent luminescent materials, which were created by non-equilibrium supramolecular assemblies and exhibited significant changes in fluorescence intensity and wavelength over time, were highlighted for their unique dynamic feature. This feature endowed materials programmable properties on time dimension, allowing for automatic and spontaneous behavior. Consequently, a series of information encryption materials have been developed, including self-erasing fluorescence hydrogels and 4D codes, demonstrating an enhanced level of security.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"962 - 978"},"PeriodicalIF":6.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pillararene based supramolecular nanoplatform for endoplasmic reticulum-targeting type I photodynamic and NO gas therapy","authors":"Shaoqi Xie \u0000 (,&nbsp;),&nbsp;Chang Liu \u0000 (,&nbsp;),&nbsp;Yue Cao \u0000 (,&nbsp;),&nbsp;Jiachen Xia \u0000 (,&nbsp;),&nbsp;Bing Lu \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3268-6","DOIUrl":"10.1007/s40843-024-3268-6","url":null,"abstract":"<div><p>The development of tumor-targeted multimodality therapy is an important strategy to improve the curative effects of cancer treatment. It is critical to construct such a platform that can perfectly integrate these functional entities into one. Herein, we designed a phenyl sulfonamide-modified pillararene WP5-PEG-BSA. WP5-PEG-BSA can be used to construct endoplasmic reticulum (ER)-targeting nanocarriers. Then NO donor <i>S</i>-nitroso-<i>N</i>-acetyl-<i>D</i>-penicillamine (SNAP) and the newly designed photosensitizer DPP-DMATPE were loaded into the nanocarriers via different paths. Under laser irradiation, DPP-DMATPE exhibited excellent type I photodynamic activity, while SNAP can release NO under the action of glutathione. The formed nanodrugs BSA-DPP/SNAP exhibited outstanding ER-targeting and high lethality towards tumor cells as well as biocompability. What’s even more worth saying is that BSA-DPP/SNAP performed well even in hypoxic tumor cells. The final experimental results <i>in vivo</i> again confirmed the good therapeutic effects of BSA-DPP/SNAP. As a result, a supramolecular nanoplatform that realizes highly efficient ER-targeting type I photodynamic and NO gas cancer therapy was constructed.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1285 - 1291"},"PeriodicalIF":6.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible polyvinylidene fluoride/multiwall carbon nanotube-based thermoelectric composite films with excellent environmental stability and enhanced power factor from ferroelectric polarization","authors":"Qinghui Jiang \u0000 (,&nbsp;),&nbsp;Zhenxiang Yu \u0000 (,&nbsp;),&nbsp;Xinyue Zhang \u0000 (,&nbsp;),&nbsp;Shanliang Chen \u0000 (,&nbsp;),&nbsp;Jitao Yi \u0000 (,&nbsp;),&nbsp;Yong Liu \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3240-9","DOIUrl":"10.1007/s40843-024-3240-9","url":null,"abstract":"<div><p>Flexible thermoelectric (TE) films and devices have potential applications in wearable technology and the Internet of Things. One of the main challenges is how to simultaneously achieve good TE performance and high chemical/thermal stability in air with low cost and large-scale production. To address this, we utilized tape casting to fabricate composite films of polyvinylidene fluoride (PVDF) and multi-walled carbon nanotubes (MWCNTs). In the composite, polar β-PVDF introduced by hot pressing can decouple the electrical conductivity and Seebeck coefficient and significantly lead to enhanced power factor of MWCNTs/PVDF composite film. As a result, the MWCNTs (60 wt%)/PVDF film has a power factor of 1.1–1.4 µW m⁻¹ K⁻² near room temperature. The film also has excellent flexibility and stability in the air. Its power factor is decreased by only 9% after 1000 bends and can keep stable in air for above 6 months, which is much longer than that (15 days) of Bi₂Te₃/PEDOT: PSS film. A demo TE device with 10 p-type legs has an output voltage of 11.5 mV and output power of 47.53 nW at a temperature difference of 60°C. The above descriptions make the MWCNTs/PVDF films have a significant advantage in the commercial application of flexible TE devices.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1240 - 1248"},"PeriodicalIF":6.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystal-phase engineering of ε-Ga2O3 for high-performance deep UV photodetectors via MOCVD","authors":"Zhiwei Wang \u0000 (,&nbsp;),&nbsp;Hong Huang \u0000 (,&nbsp;),&nbsp;Xiaohu Hou \u0000 (,&nbsp;),&nbsp;Keju Han \u0000 (,&nbsp;),&nbsp;Weiheng Zhong \u0000 (,&nbsp;),&nbsp;Xiao Feng \u0000 (,&nbsp;),&nbsp;Haoyan Zhan \u0000 (,&nbsp;),&nbsp;Weizhen Liu \u0000 (,&nbsp;),&nbsp;Xiaolong Zhao \u0000 (,&nbsp;),&nbsp;Nan Gao \u0000 (,&nbsp;),&nbsp;Shibing Long \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3245-6","DOIUrl":"10.1007/s40843-024-3245-6","url":null,"abstract":"<div><p>Gallium oxide (Ga₂O₃), with an ultrawide bandgap corresponding to the deep ultraviolet (DUV) spectra range, provides a potential subversive scheme for the filter-free DUV photodetection. Meanwhile, the various crystal phases of Ga₂O₃ provide more substrate options for achieving heteroepitaxy, with the coupling of Ga₂O₃ to SiC substrates conducive to developing integrated Ga₂O₃ DUV photodetectors. Phase engineering of <i>β</i>-Ga₂O₃ and <i>ε</i>-Ga₂O₃ was achieved on the commercial 4H-SiC substrate via metal-organic chemical vapor deposition. According to the in-depth analysis of different Ga₂O₃ growth stages, it was found that <i>β</i>-Ga₂O₃ is easy to form under high-pressure growth conditions, while low-pressure conditions promote the formation of <i>ε</i>-Ga₂O₃ at 500°C. Furthermore, the developed <i>ε</i>-phase dominated Ga₂O₃ DUV photodetector exhibits obvious advantages in high responsivity (∼639 A/W), photo-to-dark current ratio (∼2.4×10⁷), external quantum efficiency (∼3.15×10⁵%), and specific detectivity (∼9.62×10¹³ Jones) under 254 nm illumination. This work not only reveals the growth mechanism of Ga₂O₃ films under various pressures but also ensures the great potential of <i>ε</i>-Ga₂O₃ for highly sensitive DUV detection on the heterogeneous substrate, which is expected to expand the application of Ga₂O₃ optoelectronic devices.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1174 - 1183"},"PeriodicalIF":6.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating Li2S agglomeration in lithium-sulfur batteries with hierarchically structured CNT/Ni-Ni0.85Se sulfur hosts","authors":"Yonghui Xie \u0000 (,&nbsp;),&nbsp;Fan Wu \u0000 (,&nbsp;),&nbsp;Wenrui Zheng \u0000 (,&nbsp;),&nbsp;Hong Zhang \u0000 (,&nbsp;),&nbsp;Xinghui Wang \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3259-x","DOIUrl":"10.1007/s40843-024-3259-x","url":null,"abstract":"<div><p>The development of sulfur host materials with high catalytic activity to tackle the shuttling effect of polysulfides and their slow conversion kinetics is a prospective strategy for improving the performance of lithium-sulfur batteries. However, it may result in excessively thick Li₂S films that cover the entire electrode structure, consequently weakening the functionalization effect of the sulfur host. Herein, we developed a hierarchical structured sulfur host material composed of a three-dimensional composite conductive network of carbon nanotubes and Ni nanoparticles, along with Ni_0.85Se nanosheets grown on its surface. The synergistic effects of hierarchical structure and conductive network accelerate the electron and ion transport, mitigate the volume expansion during lithiation, enhance the conversion kinetics of polysulfides, and importantly prevent the agglomeration of thick Li₂S films, which results in a significant improvement in the electrochemical performance of the sulfur cathode. The developed CC@CNT/Ni-Ni_0.85Se-S exhibits excellent rate performance and long-term stability, achieving a discharge-specific capacity of 965 mA h g⁻¹ at 3 C and maintaining a discharge-specific capacity of 789 mA h g⁻¹ even after 300 cycles at 1 C. Notably, the capacity retention rate is as high as 92.9% for 100 cycles at 0.1 C, even with a high sulfur loading of 4.0 mg mg⁻². This work not only effectively mitigates the agglomeration of Li₂S film but also offers a novel design approach for the practical application of high-energy-density lithium-sulfur batteries.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1100 - 1108"},"PeriodicalIF":6.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing MXene quantum dots decorated covalent organic frameworks as oil-based lubricant additive","authors":"Yichen Wang \u0000 (,&nbsp;),&nbsp;Fei Zhao \u0000 (,&nbsp;),&nbsp;Haoyuan Yang \u0000 (,&nbsp;),&nbsp;Ke Yang \u0000 (,&nbsp;),&nbsp;Tianyi Zhang \u0000 (,&nbsp;),&nbsp;Qian Ye \u0000 (,&nbsp;),&nbsp;Yibo He \u0000 (,&nbsp;),&nbsp;Xuqing Liu \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3250-x","DOIUrl":"10.1007/s40843-024-3250-x","url":null,"abstract":"<div><p>Nanoadditives offer a promising way to reduce friction and wear. In this study, an organic–inorganic hybrid material composed of MXene quantum dots (MQDs) and cetyl trimethylammonium bromide decorated covalent organic frameworks (CNUS-2) is successfully constructed via an electrostatic self-assembly strategy. The combination of MQDs and CNUS-2 not only increases the interlayer spacing of NUS-2 but also mitigates the self-aggregation of MQDs, maximizing the advantages of their intrinsic characteristics. Owing to the synergistic lubrication effect of zero-dimensional MQDs and two-dimensional NUS-2, improved lubricity and interfacial bonding ability are realized. In addition, the relative slip between the CNUS-2@MQDs sheets can reduce friction and anti-wear. As expected, different levels of CNUS-2@MQDs effectively boost the tribological properties. The friction coefficient (0.097) and wear volume (1.48×10⁵ µm³) of PAO-10 oil are reduced by 46.7% and 92.6% respectively, after the introduction of the 3.0 wt% CNUS-2@MQDs nanocomposite. Furthermore, the abundant oxygen-containing functional groups in CNUS-2 can accelerate the formation of adsorption and tribochemical reaction films, whereas the MQDs can repair worn surfaces, resulting in superior lubrication performance under variable load, temperature, and frequency conditions. This work not only effectively improves lubrication performance by developing a unique CNUS-2@MQDs nanocomposite, but also provides a reference for the design of novel lubricant additives.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1220 - 1229"},"PeriodicalIF":6.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photomechanical macroscopic movements driven by photoinduced topochemical [2 + 2] cycloaddition reaction in tridentate cyanostilbene","authors":"Hui Yu \u0000 (,&nbsp;),&nbsp;Shuyu Li \u0000 (,&nbsp;),&nbsp;Wenbo Wu \u0000 (,&nbsp;),&nbsp;Yutong Yao \u0000 (,&nbsp;),&nbsp;Jiaxuan Zhu \u0000 (,&nbsp;),&nbsp;Haoqiang Qi \u0000 (,&nbsp;),&nbsp;Ting Wang \u0000 (,&nbsp;),&nbsp;Xin Huang \u0000 (,&nbsp;),&nbsp;Na Wang \u0000 (,&nbsp;),&nbsp;Hongxun Hao \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3249-x","DOIUrl":"10.1007/s40843-024-3249-x","url":null,"abstract":"<div><p>Photomechanical crystals are capable of converting light energy into mechanical energy, making them as potential candidates for a wide range of applications in areas such as actuators, artificial muscles, and optical switches. In this work, we successfully synthesized a tridentate cyano styrene derivative molecule, (2<i>Z</i>,2′<i>Z</i>,2′<i>Z</i>)-3,3′,3′-(benzene-1,3,5-triyl)tris-(2-(4-(trifluoromethoxyl)ph-enyl)acrylonitrile) (C3-CF₃), along with its three different polymorphs. Both blocky Form I and sheet-like Form II, exhibit photosalient effects (ballistic splitting, moving, and jumping) under both ultraviolet and visible lasers. More importantly, they could even respond to sunlight and light-emitting diode white light with a subdued photomechanical response. ¹H nuclear magnetic resonance indicates that Form I and Form II undergo photo-induced [2 + 2] cycloaddition reactions under various light sources. The kinetic analysis of the photoreactions reveals that both polymorphs demonstrate rapid reaction kinetics and high photodimerization conversion when exposed to 420 nm visible laser, with conversions reaching 97.6% and 95.26% after 300 s of irradiation, respectively. Additionally, although the needle-shaped Form III of C3-CF₃ lacks photomechanical activity, it possesses notable mechanical flexibility. Finally, films composed of powders from Form I or Form II with poly(vinyl alcohol) were created, which were capable of controllable photo-induced bending.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1038 - 1046"},"PeriodicalIF":6.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel broadband near-infrared phosphor NaBaScSi2O7: Fe3+ and its application in pc-LED and night vision","authors":"Changshuai Gong \u0000 (,&nbsp;),&nbsp;Ziying Wang \u0000 (,&nbsp;),&nbsp;Jiantong Wang \u0000 (,&nbsp;),&nbsp;Xuyan Xue \u0000 (,&nbsp;),&nbsp;Xuejiao Wang \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3234-0","DOIUrl":"10.1007/s40843-024-3234-0","url":null,"abstract":"<div><p>In recent years, Fe³⁺-doped near-infrared (NIR) phosphors have garnered significant attention, primarily due to their non-toxic nature, long emission wavelength, and excellent thermal stability. In this work, a series of NaBaScSi₂O₇: <i>x</i>Fe³⁺ (<i>x</i> = 0.01–0.07) phosphors were synthesized by the conventional solid-state reaction method. The impact of Fe³⁺ doping on the bandgap of NaBaScSi₂O₇ was analyzed by diffuse reflectance spectroscopy (DRS) and first-principles calculations. Under excitation at 301 nm, the series of phosphors emitted broadband NIR luminescence at 815 nm with full width at half maximum (FWHM) of 116 nm. Varying-temperature testing of the NaBaScSi₂O₇: 0.03Fe³⁺ phosphor indicated that it can retain 46% of its room temperature luminescence intensity at 423 K. This excellent thermal stability is attributed to the small Huang-Rhys factor (<i>S</i>), which results in weak electron-phonon coupling. In addition, the NIR phosphor-converted light-emitting diode (NIR pc-LED) integrated from the NaBaScSi₂O₇: 0.03Fe³⁺ optimal phosphor and a 310 nm ultraviolet (UV) chip showed a superior night vision capability.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1074 - 1081"},"PeriodicalIF":6.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposome of a synergistic combination of HDP-mimicking polymer and rifampicin for treating bacterial infections in aquaculture via oral administration","authors":"Haowen Yu \u0000 (,&nbsp;),&nbsp;Luhang Chen \u0000 (,&nbsp;),&nbsp;Yueming Wu \u0000 (,&nbsp;),&nbsp;Wenhui Dai \u0000 (,&nbsp;),&nbsp;Minzhang Chen \u0000 (,&nbsp;),&nbsp;Yuan Chen \u0000 (,&nbsp;),&nbsp;Longqiang Liu \u0000 (,&nbsp;),&nbsp;Jiangzhou Wang \u0000 (,&nbsp;),&nbsp;Xinqi Huang \u0000 (,&nbsp;),&nbsp;Kang Chen \u0000 (,&nbsp;),&nbsp;Runhui Liu \u0000 (,&nbsp;)","doi":"10.1007/s40843-024-3254-y","DOIUrl":"10.1007/s40843-024-3254-y","url":null,"abstract":"<div><p>The extensive use of antibiotics in high-density aquaculture has accelerated the emergence of antibiotic-resistant bacteria. The presence of antibiotics in water and soil, and their transmission through the food chain exacerbate the pressures associated with antibiotic resistance, posing a significant threat to human health. Despite this challenge and serious issue, effective alternatives to antibiotics remain lacking. In this study, we report a potent synergistic effect between an HDP-mimicking polymer, ^DLLys₉₀-BLG₁₀, and rifampicin against <i>Vibrio</i> species. This synergistic combination substantially reduces the required dosage of rifampicin, thereby mitigating the risk of antibiotic resistance development and the release of rifampicin into water and soil. Furthermore, we developed a cell-penetrating peptide-modified liposome system that can co-encapsulate ^DLLys₉₀-BLG₁₀ and rifampicin, which exerts potent antibacterial activity against <i>Vibrio</i> both <i>in vitro</i> and <i>in vivo</i>, while maintaining bio-compatibility. Additionally, oral administration of CPP-Lip@Syn showed effective control of <i>Vibrio</i> infections. This strategy opens new avenues in exploring antibiotic alternatives in aquaculture and implies potential applications in aquaculture.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1259 - 1270"},"PeriodicalIF":6.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}