Science China Materials最新文献

{"title":"Laminated self-healing thermochromic gel for visualizing thermal management","authors":"Siying Wang \u0000 (,&nbsp;),&nbsp;Yu Yu \u0000 (,&nbsp;),&nbsp;Qian Wang \u0000 (,&nbsp;),&nbsp;Hanjun Sun \u0000 (,&nbsp;),&nbsp;Yuxin Guo \u0000 (,&nbsp;),&nbsp;Lulu Qu \u0000 (,&nbsp;),&nbsp;Xiaochen Dong \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3747-3","DOIUrl":"10.1007/s40843-025-3747-3","url":null,"abstract":"<div><p>Thermochromic soft materials are flexible functional materials that adaptively tune optical properties (transmittance, reflectance, or scattering) with temperature for thermal modulation. Herein, a laminated thermochromic gel (DEE-DA) is synthesized by encapsulating a thermochromic hydrogel (DA) between two hydrophobic ionogels (DEE) in a stacked configuration. The synergy of multiple dynamic bonds endows the DEE-DA gel with exceptional mechanical properties and remarkable self-healing capability (98.8% at 30 °C). More importantly, attributed to the temperature-responsive reversible cleavage and recombination of hydrogen bonds and borate ester bonds, DEE-DA gel demonstrates tunable transmittance with a light modulation efficiency of 85.45%. In response to the various external conditions, the gel can auto-adjust the optical properties to avoid sun irradiation or heat loss. Accordingly, the gel enables efficient dual-mode thermal modulation across a broad temperature range to realize thermal management. The research proposes gel thermochromism and laminated durability enhancement for adaptive materials in smart buildings and wearables.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 3","pages":"1654 - 1664"},"PeriodicalIF":7.4,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147352870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cation and vacancy engineering in high-entropy layered double hydroxides for water oxidation","authors":"Yin Liu \u0000 (,&nbsp;),&nbsp;Xiaorong Jiao \u0000 (,&nbsp;),&nbsp;Yujie Li \u0000 (,&nbsp;),&nbsp;Changwei Shi \u0000 (,&nbsp;),&nbsp;Xingmao Jiang \u0000 (,&nbsp;),&nbsp;Xueqiang Qi \u0000 (,&nbsp;),&nbsp;Congcong Xing \u0000 (,&nbsp;),&nbsp;Xiang Wang \u0000 (,&nbsp;),&nbsp;Andreu Cabot","doi":"10.1007/s40843-025-3713-y","DOIUrl":"10.1007/s40843-025-3713-y","url":null,"abstract":"<div><p>Layered double hydroxides (LDHs) are promising electrocatalysts for the oxygen evolution reaction (OER), yet their practical application remains limited by poor electrical conductivity and sluggish reaction kinetics. In this work, we synthesize three high-entropy LDHs (HELDHs) featuring a hierarchical architecture of microspheres assembled from ultrathin nanosheets, via a simple hydrothermal method using a combination of low-cost, catalytically active transition metals (Fe, Co, Ni, Mn, Zn, Cu, and Cr). Among them, the FeCoNiMnZn HELDH exhibits outstanding OER performance, requiring an overpotential of only 306 mV to reach a current density of 100 mA cm⁻². Notably, during 200 h of continuous operation, the device exhibits a stable and, in some cases, increasing current output. This exceptional activity is attributed to the formation of abundant cation vacancies, induced by Zn leaching, which enhance the intrinsic catalytic properties by optimizing the adsorption energies of key OER intermediates. Density functional theory calculations further validate that these vacancies modulate the electronic structure and lower reaction barriers, underscoring the effectiveness of cation-vacancy engineering in high-entropy systems for efficient and durable water oxidation catalysis. The optimized catalyst was further evaluated as the air cathode in a zinc-air battery, demonstrating practical electrochemical performance.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 3","pages":"1529 - 1537"},"PeriodicalIF":7.4,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147352869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional flexible thermoelectric devices for next-generation wearable and integrated systems","authors":"Sihui Li \u0000 (,&nbsp;),&nbsp;Wantian Zhang \u0000 (,&nbsp;),&nbsp;Li-Dong Zhao \u0000 (,&nbsp;),&nbsp;Yao Lu \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3888-9","DOIUrl":"10.1007/s40843-025-3888-9","url":null,"abstract":"<div><p>Flexible thermoelectrics (f-TEs) are being developed rapidly due to their unique advantages, such as direct conversion between electricity and thermal energy, compatibility with curved heat sources, and ease of integration. Over the past decade, significant progress has been made in enhancing the overall performance of f-TE materials and devices, particularly in terms of output power, mechanical flexibility, and durability. Recent research efforts are increasingly focused on translating these advancements into practical applications across diverse fields. For example, f-TE-based multimodal sensors are capable of simultaneously detecting temperature, pressure and strain. In biomedicine, f-TE generators are being explored for wound healing, antibacterial therapy, and neural modulation. Furthermore, f-TE devices show promise in personalized thermal management and hybrid energy harvesting systems. This review moves beyond material preparation and device optimization to focus on the expanding multifunctional applications of f-TEs. We provide a broad perspective by comprehensively exploring the latest progress of f-TEs in intelligent sensing, biomedicine, personalized thermal management, and multifunctional hybrid systems. Key challenges are also discussed, including the development of high-performance flexible devices, robust biointerfaces, ensuring long-term stability, and achieving intelligent integration with data-driven algorithms and multimodal platforms. Finally, we offer insights into future directions for f-TEs, pointing toward next-generation intelligent and bio-integrated flexible electronics.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 2","pages":"636 - 650"},"PeriodicalIF":7.4,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147338790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From bench to buoy: challenges in seawater uranium extraction","authors":"Zhenli Sun \u0000 (,&nbsp;),&nbsp;Hanyang Wang \u0000 (,&nbsp;),&nbsp;Zhongshan Chen \u0000 (,&nbsp;),&nbsp;Xishi Tai \u0000 (,&nbsp;),&nbsp;Jiehong Lei \u0000 (,&nbsp;),&nbsp;Baowei Hu \u0000 (,&nbsp;),&nbsp;Suhua Wang \u0000 (,&nbsp;),&nbsp;Xiangke Wang \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3919-0","DOIUrl":"10.1007/s40843-025-3919-0","url":null,"abstract":"<p>作为低碳能源体系的重要组成部分, 核能的可持续发展依赖于铀资源的长期稳定供给. 鉴于陆地铀资源储量有限且分布不均, 海水提铀被认为是具有重要战略意义的补充途径. 近年来, 围绕化学配位、 吸附过程调控、 光/电催化等机制, 多种新型材料体系不断涌现, 包括多孔有机框架、 碳基材料、 金属氧化物及功能化纤维和膜材料等, 并在实验室研究中取得了显著进展, 在提升铀酰离子选择性识别、 还原转化能力及循环稳定性方面展现出良好的应用前景. 然而, 海水中铀浓度极低且体系高度复杂, 多种高浓度竞争离子、 有机质、 微生物以及复杂多变的海洋环境条件共存, 在实现高选择性、 高稳定性和低成本的铀提取中面临重大挑战. 本文总结了海水铀提取领域的代表性研究成果, 分析了实验室研究向真实海洋环境过程中材料稳定性、 生物污染、 环境安全性、 成本控制及测试标准等方面所面临的关键问题, 并对未来发展方向进行了展望, 以及发展人工智能驱动的材料设计策略在推动海水铀资源可持续利用中的关键作用.</p>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 3","pages":"1416 - 1419"},"PeriodicalIF":7.4,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147352822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionogel sensor for reproducible detection of trace methamphetamine analogues","authors":"Gonghai Yang \u0000 (,&nbsp;),&nbsp;Chonghao Xiong \u0000 (,&nbsp;),&nbsp;Ziyi Guo \u0000 (,&nbsp;),&nbsp;Junyao Zhang \u0000 (,&nbsp;),&nbsp;Chenshuang Pan \u0000 (,&nbsp;),&nbsp;Chenghao Wang \u0000 (,&nbsp;),&nbsp;Liqiong Zhang \u0000 (,&nbsp;),&nbsp;Jiaying Yun \u0000 (,&nbsp;),&nbsp;Lize Xiong \u0000 (,&nbsp;),&nbsp;Shiqi Zhang \u0000 (,&nbsp;),&nbsp;Yidong Zou \u0000 (,&nbsp;),&nbsp;Jie Yang \u0000 (,&nbsp;),&nbsp;Yanyan Fu \u0000 (,&nbsp;),&nbsp;Jia Huang \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3860-0","DOIUrl":"10.1007/s40843-025-3860-0","url":null,"abstract":"<div><p>Drug detection is highly important, yet reversible and highly sensitive sensing materials are still scarce. A novel ionogel sensor material, poly(ethylene glycol) diacrylate (PEGDA)/1-butyl-3-methylimidazole tetrafluoroborate, was developed for reproducible <i>N</i>-methylphenylethylamine (MPEA) detection. It was fabricated by immobilizing a flowable ionic liquid within a PEGDA network via UV curing. The immobilized ions retain mobility, enabling efficient ionic conduction. Integrated on a flexible poly(ethylene naphthalate) substrate, the sensor is fully transparent and flexible, showing over 72.6% transmittance in the visible spectrum. This allows it to be discreetly attached to surfaces for concealed detection. Using non-covalent interactions, the sensor achieves reproducible MPEA detection at sub ppb levels at room temperature, with a theoretical detection limit of 317 ppt. It also exhibits high selectivity and consistency. Ionic conductivity was confirmed through current voltage tests and impedance spectroscopy, and the sensing mechanism was clarified. The device performs reliably under bending, proving suitable for dynamic environments. With a Bluetooth module for wireless transmission, the sensor shows strong potential for practical and discreet drug monitoring in real world applications.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 2","pages":"1077 - 1087"},"PeriodicalIF":7.4,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147338458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the scalability and monolithic shaping barriers with a solid-state hot-pressing strategy for COFs","authors":"Xia Li,&nbsp;Zhenjie Zhang","doi":"10.1007/s40843-025-3736-8","DOIUrl":"10.1007/s40843-025-3736-8","url":null,"abstract":"","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 3","pages":"1808 - 1809"},"PeriodicalIF":7.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147352728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly composite supercritical purification enables simultaneous lightweighting and strengthening of reed membranes for bioelectronics","authors":"Boyi Cheng \u0000 (,&nbsp;),&nbsp;Yu Jiang \u0000 (,&nbsp;),&nbsp;Lei Li \u0000 (,&nbsp;),&nbsp;Mingge Wang \u0000 (,&nbsp;),&nbsp;Jie Wang \u0000 (,&nbsp;),&nbsp;Kuan-Chang Chang \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3678-1","DOIUrl":"10.1007/s40843-025-3678-1","url":null,"abstract":"<div><p>Reed membrane, a natural cellulosic material traditionally used in musical instruments, holds promise in flexible electronics due to its abundance, low cost, and excellent biocompatibility. However, its native form contains water-soluble ions and lipid-soluble waxes that hinder performance in acoustic and electronics by compromising electrical insulation and mechanical stability. Here, supercritical fluid superposition purification (SCSP-WA) is introduced, which utilizes supercritical CO₂ with water and acetone as bipolar co-solvents to selectively remove these impurities. Post-SCSP-WA treatment, the reed membrane exhibits significant enhancements in mechanical strength and electrical insulation, achieving a 4-fold increase in elongation at break, improved tensile strength and Young’s modulus, and a 98.5% reduction in leakage current, all while maintaining low and stable capacitance. These improvements stem from the restructuring of the fibrous network into a porous, interconnected microstructure. Material characterization (X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM)) confirmed the effective removal of magnesium and waxy functional groups, along with enhanced fiber cross-linking. Cytotoxicity tests further validated the biocompatibility of the SCSP-WA-treated membranes. This environmentally sustainable approach expands the potential of reed membranes in flexible bioelectronics and bio-integrated acoustic systems.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 3","pages":"1741 - 1750"},"PeriodicalIF":7.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147352693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteria outer membrane-based oxygen gels alleviate tumor hypoxia for enhanced systemic immune response to radiotherapy","authors":"Deyuan Zheng \u0000 (,&nbsp;),&nbsp;Junhong Yao \u0000 (,&nbsp;),&nbsp;Haiheng Xu \u0000 (,&nbsp;),&nbsp;Shuqin Xiong \u0000 (,&nbsp;),&nbsp;Qingsong Ye \u0000 (,&nbsp;),&nbsp;Yiyun Chen \u0000 (,&nbsp;),&nbsp;Chuan Zhao \u0000 (,&nbsp;),&nbsp;Min Zhang \u0000 (,&nbsp;),&nbsp;Xuehui Rui \u0000 (,&nbsp;),&nbsp;Jinhui Wu \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3581-2","DOIUrl":"10.1007/s40843-025-3581-2","url":null,"abstract":"<div><p>Radiotherapy (RT) is considered a standard cancer treatment that directly kills tumor cells and promotes a systemic immune response. However, RT may also lead to tumor hypoxia, which further inhibits the antigen-presenting function of dendritic cells (DCs) and thereby weakens the systemic anti-tumor immune response induced by radiotherapy. In this study, the oxygen-loaded <i>in situ</i> gels carrying bacterial outer membrane (MOGel) were synthesized. As the gels slowly degraded, oxygen was gradually released to alleviate tumor hypoxia. The released bacterial outer membrane (OM) continuously activated DCs, enhancing their antigen-presenting capability. The results demonstrated that MOGel combined with RT induced the strongest tumor cell apoptosis <i>in vitro</i> and achieved a 80% tumor suppression rate in a colon cancer orthotopic model. Importantly, MOGel+RT induced an enhanced abscopal effect, and hypoxia and enhanced DCs activation contributed to the systemic immune response. Thus, OM-based oxygen gels may offer a novel strategy for enhancing the systemic immune response to RT.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 3","pages":"1729 - 1740"},"PeriodicalIF":7.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147352682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural material-based biodegradable flexible pressure sensor for fall detection and rehabilitation monitoring in elderly care","authors":"Shengyu Xie \u0000 (,&nbsp;),&nbsp;Zihe Li \u0000 (,&nbsp;),&nbsp;Chenhao Li \u0000 (,&nbsp;),&nbsp;Qihui Zhou \u0000 (,&nbsp;),&nbsp;Ho-Kun Sung \u0000 (,&nbsp;),&nbsp;Leonid Chernogor \u0000 (,&nbsp;),&nbsp;Zhao Yao \u0000 (,&nbsp;),&nbsp;Yang Li \u0000 (,&nbsp;),&nbsp;Yuanyue Li \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3716-x","DOIUrl":"10.1007/s40843-025-3716-x","url":null,"abstract":"<div><p>Flexible pressure sensors (FPSs) offer unique benefits for fall detection and rehabilitation training, but conventional FPSs made from synthetic materials have drawbacks, including resource-heavy manufacturing, high costs, and environmental pollution. To address these limitations, this study proposes an innovative fabrication strategy for FPS based on natural materials. The upper and lower electrodes were made by treating a natural wood strip with a flame retardant, converting it into high-quality graphene via a cost-effective infrared laser, and transferring it onto starch-based substrates. The dielectric layer was created by electrospinning a composite nanofiber membrane with cyclodextrin and carbon nanotubes. The resulting capacitive FPS shows high sensitivity (2.15 kPa⁻¹ within 0–10 kPa), a low detection limit (∼6.5 Pa), fast response and recovery times (29 and 39 ms), and excellent long-term stability (over 5000 cycles). It also demonstrates excellent biocompatibility (cell viability &gt;98%) and fully degrades within 6 h. By integrating this sensor with wireless technology, a fall detection and rehabilitation monitoring system was developed. Data processing was handled by a Tiny Machine Learning module on a mobile platform, which transmitted relevant data to a cloud-based platform. The system accurately identified five common fall postures and assisted clinicians in guiding rehabilitation exercises, achieving recognition accuracies of 99% and 100%, respectively, offering a sustainable healthcare solution for the elderly.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 3","pages":"1772 - 1785"},"PeriodicalIF":7.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147352685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PANoptosis driven immunogenic cell death by a single NIR laser triggered nanoplatform for cancer phototherapy","authors":"Yi Jin \u0000 (,&nbsp;),&nbsp;Chang Liu \u0000 (,&nbsp;),&nbsp;Zhanwang Wang \u0000 (,&nbsp;),&nbsp;Yuanyu Tang \u0000 (,&nbsp;),&nbsp;Pan Zhu \u0000 (,&nbsp;),&nbsp;E. Pang \u0000 (,&nbsp;),&nbsp;Wenjie Gao \u0000 (,&nbsp;),&nbsp;Qingxu Diao \u0000 (,&nbsp;),&nbsp;Jie Zeng \u0000 (,&nbsp;),&nbsp;Minhuan Lan \u0000 (,&nbsp;),&nbsp;Jianing Yi \u0000 (,&nbsp;)","doi":"10.1007/s40843-025-3665-2","DOIUrl":"10.1007/s40843-025-3665-2","url":null,"abstract":"<div><p>It remains a major challenge in phototherapeutics to achieve a high quantum yield of singlet oxygen generation and efficient photothermal conversion using a single near-infrared laser for immuno-phototherapy. To bridge this gap, we utilized an acceptor-donor-acceptor (A-D-A) structured molecule, 3,9-bis(2-methylene-((3-(1,1-dicyanomethylene)-6/7-methyl)-indanone))-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-<i>d</i>:2′,3′-<i>d</i>′]-<i>s</i>-indaceno[1,2-<i>b</i>:5,6-<i>b</i>′]-dithiophene (<i>m</i>-ITIC), and formulated it into nanoparticles (NPs) by assembling with distearoylphosphatidylethanolamine-polyethylene glycol-amino (DSPE-PEG-NH₂). At 688 and 768 nm, these NPs present significant near-infrared absorption and fluorescence. They simultaneously generate heat, O₂^−·, and ¹O₂, with the ¹O₂ generation quantum yield of 56.8% and photothermal conversion efficiency (PCE) of 27.4%, enabling them excellent near-infrared (NIR) fluorescence imaging guided synergic photodynamic therapy (PDT) and photothermal therapy (PTT) capabilities. Importantly, this nanoplatform induces PANoptosis, a coordinated cell death program integrating pyroptosis, apoptosis, and necroptosis, in tumor cells, thereby amplifying immunogenic cell death (ICD) and enhancing antitumor immune responses. The combined effects lead to robust dendritic cell activation, macrophage polarization toward the M1 phenotype, elevated CD8⁺ T cell infiltration, and suppression of immunosuppressive Treg cells, resulting in significant tumor growth inhibition and prevention of lung metastasis <i>in vivo</i>. Furthermore, the therapeutic efficacy was validated in patient-derived tumor organoids, demonstrating translational potential. This study presents a novel strategy for NIR light-guided cancer phototherapy, wherein a single laser-activated nanoplatform simultaneously mediates efficient photothermal and photodynamic effects and induces PANoptosis driven ICD for synergistic cancer immunotherapy.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"69 3","pages":"1751 - 1761"},"PeriodicalIF":7.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147352683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}