Science China Materials最新文献_第2页

A pro-healing short-chain antimicrobial peptide that inhibits sepsis 一种能抑制败血症的促愈合短链抗菌肽

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-28 DOI: 10.1007/s40843-024-3002-0

Zekai Ren, Xin Ding, Yumei Wang, Han Wu, Xin Liu, Yang Cao, Hailin Cong, Youqing Shen, Bing Yu

{"title":"A pro-healing short-chain antimicrobial peptide that inhibits sepsis","authors":"Zekai Ren, Xin Ding, Yumei Wang, Han Wu, Xin Liu, Yang Cao, Hailin Cong, Youqing Shen, Bing Yu","doi":"10.1007/s40843-024-3002-0","DOIUrl":"https://doi.org/10.1007/s40843-024-3002-0","url":null,"abstract":"Chronic wounds experiencing infections with multidrug-resistant bacteria can be fatal, and in severe cases can lead to sepsis. Antimicrobial peptides are widely used in the field of wound care for their broad-spectrum antibacterial properties and good anti-drug resistance. We prepared bacterial cell membrane chromatography (BCMC) by extracting cell membranes of bacteria using SiO2 microspheres as stationary phase. A library of antimicrobial peptides was synthesized in solid phase and screened by BCMC to identify the antimicrobial peptide LKAHR (later named LS5), which is characterized by biosafety, broad-spectrum antibacterial activity, and drug resistance, and a gelatin-based antimicrobial hydrogel (LS5-gel) was prepared to be better applied to wounds. LS5-gel was found to have good in vivo bactericidal properties as well as the ability to promote wound healing in a wound healing model. In the sepsis model, LS5 was found to have a significant inhibitory effect on sepsis infection. It is important for the selection of next-generation antimicrobial drugs and the treatment of chronic wound healing.\u0000","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design principle of single-atom catalysts for sulfur reduction reaction–interplay between coordination patterns and transition metals 单原子硫还原反应催化剂的设计原理--配位模式与过渡金属之间的相互作用

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-28 DOI: 10.1007/s40843-024-3068-5

Wentao Zhang, Gaoshang Zhang, Zhaotian Xie, Xinming Zhang, Jiabin Ma, Ziyao Gao, Kuang Yu, Lele Peng

{"title":"Design principle of single-atom catalysts for sulfur reduction reaction–interplay between coordination patterns and transition metals","authors":"Wentao Zhang, Gaoshang Zhang, Zhaotian Xie, Xinming Zhang, Jiabin Ma, Ziyao Gao, Kuang Yu, Lele Peng","doi":"10.1007/s40843-024-3068-5","DOIUrl":"https://doi.org/10.1007/s40843-024-3068-5","url":null,"abstract":"The polysulfide shuttling effect is the primary bottleneck restricting the industrial application of Li-S batteries, and the electrocatalytic sulfur reduction reaction (SRR) has emerged as an effective solution. Carbon-based single-atom catalysts (SACs), which promotes SRR, show great potential in inhibiting the shuttling effect of polysulfides. Meanwhile, the optimization and rational design of such catalysts requires a deep understanding to the fundamental SRR mechanism and remains highly nontrivial. In this work, we construct a comprehensive database of carbon-based SACs, covering different coordination patterns, heteroatoms, and transition metals. The SRR activities are determined using density functional theory calculations, revealing a synergistic effect between the p orbital of the heteroatom and the d orbital of the transition metal. This interplay underscores the critical importance of the coordination environment for SRR under the ortho-P2C2 structure. Regardless of the transition metal type, the ortho-P2C2 coordination pattern significantly enhances the SRR performance of SACs, surpassing the widely reported N3C1 and N4 coordinated graphene-based SACs. Furthermore, heteroatoms with ortho-P2C2 may exhibit SRR activity. In a word, by using this comprehensive dataset and data-driven framework, we propose a promising novel class of coordination structure (ortho-P2C2 structure) and neglected design principle.\u0000","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memristor-based artificial tactile perception systems with integrated functions of sensing, storage and computing 基于 Memristor 的人工触觉感知系统，集传感、存储和计算功能于一体

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-28 DOI: 10.1007/s40843-024-3072-4

Yulong Xie, Subhas C. Kundu, Suna Fan, Yaopeng Zhang

引用次数: 0

Multifunctional endogenous small molecule-derived polymer composite nanoparticles for the treatment of acute sepsis therapy 用于急性败血症治疗的多功能内源性小分子聚合物复合纳米粒子

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-27 DOI: 10.1007/s40843-024-3051-y

Jiahui Gao, Huixin Li, Penghan Yue, Dayang Xie, Hao Li, Kai Hao, Yanhui Li, Huayu Tian

{"title":"Multifunctional endogenous small molecule-derived polymer composite nanoparticles for the treatment of acute sepsis therapy","authors":"Jiahui Gao, Huixin Li, Penghan Yue, Dayang Xie, Hao Li, Kai Hao, Yanhui Li, Huayu Tian","doi":"10.1007/s40843-024-3051-y","DOIUrl":"https://doi.org/10.1007/s40843-024-3051-y","url":null,"abstract":"The complex and rapidly progressing nature of sepsis calls for the development of multifunctional and rapid-acting therapeutic agents, instead of single-modal treatments. To address this challenge, a biodegradable, easily synthesized, and antibiotic-free multifunctional nanoparticle has been created for sepsis therapy. The nanoparticle was formed by the electrostatic interaction between two endogenous small molecule-derived polymers, poly(lipoic acid) and poly-lysine, and possessed various functions such as antibacterial activity, adsorption of cell-free DNA, scavenging of reactive oxygen and nitrogen species, providing a comprehensive approach to combating sepsis. Treatment using the cecal ligation and puncture (CLP) model confirmed the therapeutic benefits of the nanoparticles, demonstrating reduced levels of reactive oxygen across multiple organs, diminished levels of M1 proinflammatory macrophages, and elevated levels of M2 anti-inflammatory macrophages post-treatment. These findings emphasized the effectiveness of the nanoparticles in sepsis therapy, and properties of degradation, easy preparation, and swift therapeutic response made them promising for the future clinical applications.","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable thermosensitive microsphere-hydrogel composite system: combined therapy of hepatocellular carcinoma by remodeling tumor immune microenvironment 可注射热敏微球-水凝胶复合系统：通过重塑肿瘤免疫微环境联合治疗肝细胞癌

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-26 DOI: 10.1007/s40843-024-3001-3

Jinghan Liao, Zhihua Wu, Yijie Qiu, Fangqin Xue, Ke Gong, Yi Duan, Chao Xu, Bin Liu, Jiangtao Lin, Yi Dong, Ying Sun, Yourong Duan

{"title":"Injectable thermosensitive microsphere-hydrogel composite system: combined therapy of hepatocellular carcinoma by remodeling tumor immune microenvironment","authors":"Jinghan Liao, Zhihua Wu, Yijie Qiu, Fangqin Xue, Ke Gong, Yi Duan, Chao Xu, Bin Liu, Jiangtao Lin, Yi Dong, Ying Sun, Yourong Duan","doi":"10.1007/s40843-024-3001-3","DOIUrl":"https://doi.org/10.1007/s40843-024-3001-3","url":null,"abstract":"Advanced hepatocellular carcinoma (HCC) is one of the most prevalent malignancies, and the clinical treatment outcomes are not satisfactory. Due to the complexity, heterogeneity, and immunosuppressive microenvironment of HCC, monotherapies have limited effects. Therefore, combined therapy may effectively enhance antitumor treatment by remodeling the tumor immune microenvironment. This study reports an injectable thermosensitive microsphere-hydrogel composite system for local co-delivery of the targeted drug sorafenib (SOR) and immunomodulatory cytokines for the combined therapy of HCC. The delivery system exhibited superior properties such as dual-drug delivery, sustained and slow release, local injectability, thermosensitivity, and low side effects. Moreover, it successfully remodeled the immune microenvironment of HCC by increasing the infiltration of CD8+ T cells and natural killer cells while decreasing the infiltration of immunosuppressive Treg cells, thereby achieving a potent synergistic effect with SOR. This safe composite delivery system can remodel the tumor microenvironment and enhance anti-tumor treatment, providing a valuable option for the treatment of HCC.","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneously improving efficiency and stability of organic solar cells by enhancing molecular crystallinity and intermolecular interactions 通过增强分子结晶度和分子间相互作用，同时提高有机太阳能电池的效率和稳定性

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-23 DOI: 10.1007/s40843-024-3074-6

Jiangtong Zhao, Xinrong Yang, Yiming Shao, Rui Sun, Jie Min

{"title":"Simultaneously improving efficiency and stability of organic solar cells by enhancing molecular crystallinity and intermolecular interactions","authors":"Jiangtong Zhao, Xinrong Yang, Yiming Shao, Rui Sun, Jie Min","doi":"10.1007/s40843-024-3074-6","DOIUrl":"https://doi.org/10.1007/s40843-024-3074-6","url":null,"abstract":"Precisely controlling bulk heterojunction (BHJ) morphology through molecular design is one of the main longstanding challenges in developing high-performance organic solar cells (OSCs). Herein, three small molecule acceptors (SMAs) with different side chains (methyl, 2-ethylhexyl, and 2-decyl tetradecyl on benzotriazole unit), namely R-M, R-EH, R-DTD, were designed and synthesized. Such side-chain engineering can effectively modulate the intermolecular interactions between acceptor/acceptor (A/A) and donor/A (D/A) molecules, thereby fine-tuning the bulk microstructures of BHJ active layer systems. Compared with R-M and R-DTD, R-EH shows stronger A/A and D/A interactions with donor PM6, which delivers improved BHJ networks with better molecular ordering, enhancing charge transport and extraction properties. Consequently, PM6:R-EH not only performs a competitive device efficiency of over 18% but also exhibits excellent operation stability without obvious degradation behaviors among the three systems. This study deepens the synergistic effects of A/A and D/A interactions on BHJ morphology to achieve industrially viable OSCs with high device efficiency and stability.","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crystal structure graph neural networks for high-performance superconducting critical temperature prediction 用于高性能超导临界温度预测的晶体结构图神经网络

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-23 DOI: 10.1007/s40843-024-3026-8

Jingzi Zhang, Chengquan Zhong, Xiaoting Lu, Jiakai Liu, Kailong Hu, Xi Lin

{"title":"Crystal structure graph neural networks for high-performance superconducting critical temperature prediction","authors":"Jingzi Zhang, Chengquan Zhong, Xiaoting Lu, Jiakai Liu, Kailong Hu, Xi Lin","doi":"10.1007/s40843-024-3026-8","DOIUrl":"https://doi.org/10.1007/s40843-024-3026-8","url":null,"abstract":"The utilization of machine learning methods to predict the superconducting critical temperature (Tc) traditionally necessitates manually constructing elemental features, which challenges both the provision of meaningful chemical insights and the accuracy of predictions. In this work, we introduced crystal structure graph neural networks to extract structure-based features for Tc prediction. Our results indicated that these structure-based models outperformed all previously reported models, achieving an impressive coefficient of determination (R2) of 0.962 and a root mean square error (RMSE) of 6.192 K. From the existing Inorganic Crystal Structure Database (ICSD), our model successfully identified 76 potential high-temperature superconducting compounds with Tc ⩾ 77 K. Among these, Tl5Ba6Ca6Cu9O29 and TlYBa2Cu2O7 exhibit remarkably high Tc values of 108.4 and 101.8 K, respectively. This work provides a perspective on the structure-property relationship for reliable Tc prediction.\u0000","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microgroove-structured liquid-like surface for liquid discrimination 用于辨别液体的微凹槽结构类液体表面

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-23 DOI: 10.1007/s40843-024-3054-9

Shouzheng Jiao, Peng Cheng, Hua Lai, Zhongjun Cheng, Yuyan Liu, Lei Jiang

{"title":"Microgroove-structured liquid-like surface for liquid discrimination","authors":"Shouzheng Jiao, Peng Cheng, Hua Lai, Zhongjun Cheng, Yuyan Liu, Lei Jiang","doi":"10.1007/s40843-024-3054-9","DOIUrl":"https://doi.org/10.1007/s40843-024-3054-9","url":null,"abstract":"Discriminating between different liquids using surfaces with special wettability holds significant implications for both fundamental research and practical applications. However, current differentiation surfaces still struggle with challenges such as complex microstructure design, a limited detection range, and poor stability. In this study, we present a new platform for droplet discrimination achieved through a combination of groove structures and a liquid-like polydimethylsiloxane (PDMS) brushes coating. The PDMS brushes coating exhibits excellent stability and low adhesion across a wide range of liquids with surface tensions ranging from 27.5 to 72.8 mN/m, while the groove structure provides distinct energy barriers for droplet sliding. Consequently, liquids with varying surface tensions can be effectively discriminated, as evidenced by the increased sliding angles (SAs) observed as liquids with lower surface tension moving across the groove. Furthermore, we utilized a three dimensional (3D) model of the droplet developed using Surface Evolver, and conducted energy variation calculations during droplet sliding across the groove to analyze the SA differences among liquids with different surface tensions. Additionally, we proposed two simple differentiation platforms that successfully demonstrated effective droplet discrimination. This work introduces a novel strategy for droplet discrimination, offering innovative ideas for the design of functional surfaces. These findings may potentially be applied in other fields involving droplet manipulation, such as droplet-based microchemical reactions and bio-detection.","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Na4Fe3(PO4)2(P2O7)/C composite with porous structure enabling all-climate and long-life sodium-ion batteries 具有多孔结构的 Na4Fe3(PO4)2(P2O7)/C 复合材料可制成全天候长寿命钠离子电池

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-23 DOI: 10.1007/s40843-024-3082-x

Xiaoyan Shi, Zhiqiang Hao, Wenqing Zhu, Xunzhu Zhou, Xiaomin Chen, Chenchen Wang, Lin Li, A. Robert Armstrong, Shu-Lei Chou

{"title":"Na4Fe3(PO4)2(P2O7)/C composite with porous structure enabling all-climate and long-life sodium-ion batteries","authors":"Xiaoyan Shi, Zhiqiang Hao, Wenqing Zhu, Xunzhu Zhou, Xiaomin Chen, Chenchen Wang, Lin Li, A. Robert Armstrong, Shu-Lei Chou","doi":"10.1007/s40843-024-3082-x","DOIUrl":"https://doi.org/10.1007/s40843-024-3082-x","url":null,"abstract":"Na4Fe3(PO4)2(P2O7) (NFPP) with the advantages of low cost and stable crystal structure has been considered a highly promising cathode candidate for sodium-ion batteries. However, limited by its undesirable intrinsic conductivity, it still suffers from unsatisfactory electrochemical performance. Herein, we synthesized NFPP/C composites with porous structure (p-NFPP) by a facile self-assembly strategy. Its well-developed pore structure can effectively reduce the ion diffusion path, accelerate electrolyte infiltration and accommodate volume expansion during the charge/discharge process. In addition, in-situ X-ray diffraction revealed the superior structural stability of p-NFPP. They enable a high reversible capacity (104.8 mAh g−1), and good rate performance (75.0 mAh g−1 at 10 A g−1), and excellent cycling stability (a reversible capacity of 85.1 mAh g−1 after 2000 cycles). More importantly, the p-NFPP realizes a stable operation in a wide temperature range of 55°C to −10°C. This work highlights morphology engineering as a powerful strategy to boost the all-climate sodium storage performance of electrode materials.","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular carbon monoxide release unveils selective antibacterial effects 细胞内一氧化碳释放揭示了选择性抗菌效果

IF 8.1 2区材料科学

Science China Materials Pub Date : 2024-08-23 DOI: 10.1007/s40843-024-2989-0

Tengfei Ma, Shaoqiu Zheng, Jian Cheng, Guoying Zhang, Jinming Hu

{"title":"Intracellular carbon monoxide release unveils selective antibacterial effects","authors":"Tengfei Ma, Shaoqiu Zheng, Jian Cheng, Guoying Zhang, Jinming Hu","doi":"10.1007/s40843-024-2989-0","DOIUrl":"https://doi.org/10.1007/s40843-024-2989-0","url":null,"abstract":"Carbon monoxide (CO) is recognized as a diffusible and biologically membrane-permeable gasotransmitter. However, the question of whether extracellular and intracellular CO delivery would yield similar or distinct biological functions remains unresolved. In this study, utilizing nonmetallic CO-releasing micelles as a platform for localized CO delivery, we present evidence suggesting that selective antibacterial effects against Staphylococcus aureus (S. aureus) are exclusively evident upon intracellular CO release, even in cases of extracellular release with higher CO concentrations showing no comparable effect. To substantiate this assertion, we systematically design micellar nanoparticles with varying sizes, monomer sequences, and shell compositions. Among these variants, only the micelles taken up by S. aureus and capable of intracellular CO release exhibit efficient bacteria-killing properties. We further demonstrate that the selective bactericidal effect is closely linked to the production of hydroxyl radicals after intracellular CO release. Additionally, intracellular CO release proves to be an efficient treatment for S. aureus-induced skin abscesses without the need for additional antibiotics, showcasing synergistic antibacterial and anti-inflammatory effects. These findings underscore the pivotal role of the spatial location of CO release, significantly enhancing our understanding of the pathophysiological functions of gasotransmitters.","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0