Alejandra Guarnizo-Lozano, Daniela Saa González, Cándida Díaz-Brochero, Laura Cristina Nocua-Báez, Javier Mora Arteaga, Óscar Orlando Sanabria Rodríguez, Sandra Liliana Valderrama-Beltrán
{"title":"Infection prevention strategies for carbapenem-resistant and ESBL-producing gram-negative bacteria in intensive care units: A systematic review with exploratory component network meta-analysis.","authors":"Alejandra Guarnizo-Lozano, Daniela Saa González, Cándida Díaz-Brochero, Laura Cristina Nocua-Báez, Javier Mora Arteaga, Óscar Orlando Sanabria Rodríguez, Sandra Liliana Valderrama-Beltrán","doi":"10.1016/j.ajic.2026.06.030","DOIUrl":"10.1016/j.ajic.2026.06.030","url":null,"abstract":"<p><strong>Background: </strong>Health care-associated infections caused by multidrug-resistant gram-negative bacteria remain a major challenge in intensive care units (ICUs). Although infection prevention and control (IPC) bundles are widely used, the contribution of individual components remains uncertain.</p><p><strong>Methods: </strong>We performed a systematic review of interventional studies evaluating IPC strategies in adult ICUs and an exploratory component network meta-analysis (CNMA). The primary outcome was acquisition of carbapenem-resistant gram-negative bacilli or extended-spectrum β-lactamase-producing Enterobacterales during ICU stay. Standard precautions (SP) were the reference, and certainty of evidence was assessed using GRADE.</p><p><strong>Results: </strong>Seventeen studies met the inclusion criteria, and 12 contributed to the CNMA (36,264 patients; 2,542 acquisition events). Compared with SP, two multimodal strategies reduced acquisition: active surveillance, chlorhexidine bathing, contact precautions, and enhanced environmental cleaning (RR 0.34, 95% CI 0.14-0.82), and chlorhexidine bathing plus decolonization (RR 0.39, 95% CI 0.18-0.84). No individual IPC component showed a significant independent effect. Certainty of evidence was low because of heterogeneity, indirectness, and imprecision.</p><p><strong>Conclusions: </strong>Multimodal IPC strategies may reduce acquisition of multidrug-resistant gram-negative organisms in ICUs, whereas isolated interventions beyond SP provide uncertain benefit. Findings should be interpreted cautiously because of substantial clinical heterogeneity and low-certainty evidence.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simulation-based outbreak training and large language models in infection prevention and control education.","authors":"Jiao Shan, Fang Wang, Xiaoyuan Bao, Meng Jin, Yicheng Jin, Yixi Jin, Zhining Zhang, Yulong Cao","doi":"10.1016/j.ajic.2026.06.028","DOIUrl":"10.1016/j.ajic.2026.06.028","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuewei Du, Huiqing Guo, Yun Chen, Qinglan Meng, Min Liu, Xinru Lu, Xinfang Shi, Chang Liu, Li Li
{"title":"Quantitative assessment of environmental blood contamination in interventional radiology operating rooms: A cross-sectional study.","authors":"Xuewei Du, Huiqing Guo, Yun Chen, Qinglan Meng, Min Liu, Xinru Lu, Xinfang Shi, Chang Liu, Li Li","doi":"10.1016/j.ajic.2026.06.022","DOIUrl":"10.1016/j.ajic.2026.06.022","url":null,"abstract":"<p><strong>Background: </strong>Health care-associated infections remain a global threat to patient safety, with contaminated environmental surfaces serving as important pathogen transmission vectors. Interventional radiology operating rooms are high-frequency blood exposure settings, yet quantitative contamination data remain scarce. This study applied a quantitative occult blood detection method to assess environmental blood contamination in interventional operating rooms.</p><p><strong>Methods: </strong>A quantitative occult blood detection method (HGBTEST WIPES with AI-based image analysis) measured hemoglobin residues at 142 sampling sites (44 operating tables, 37C-arms, 61 other surfaces) across 4 operating rooms at a tertiary hospital. Contamination levels were graded using quartile-based thresholds.</p><p><strong>Results: </strong>Environmental blood contamination was widespread (median: 62.21 μg/cm², interquartile range [IQR]: 41.37-96.94; mean ± SD: 142.75 ± 337.77; range: 1.23-3026.98 μg/cm²). Operating tables showed the highest contamination (median: 71.19 μg/cm², IQR: 38.47-120.25), followed by other surfaces (median: 66.60 μg/cm², IQR: 46.09-101.02) and C-arms (median: 57.99 μg/cm², IQR: 39.42-67.54).</p><p><strong>Conclusions: </strong>This study reveals distribution patterns of environmental blood contamination in interventional radiology operating rooms and proposes 3 hypothetical contamination pathways. The Pareto distribution pattern suggests optimized resource allocation through targeted cleaning, while the proposed pathways indicate the necessity of differentiated prevention strategies for improving environmental quality.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hospitalization reasons as risk factors for hospital-acquired infections and hospital-acquired resistant infections in adults.","authors":"Hila Ben-Amram, Maya Azrad, Yaron Michael, Shimon Edelstein, Avi Peretz, Keren Agay-Shay","doi":"10.1016/j.ajic.2026.06.018","DOIUrl":"10.1016/j.ajic.2026.06.018","url":null,"abstract":"<p><strong>Background: </strong>Hospitalization reasons may reflect vulnerability and influence risks of hospital-acquired infections (HAI) and resistant infections (HARI).</p><p><strong>Aim: </strong>To evaluate the association between hospitalization reasons and the risk of HAI and HARI.</p><p><strong>Methods: </strong>We analyzed 17,240 adult admissions (2020-2022). Reasons were coded using ICD-9 diagnostic categories. HAI/HARI were identified by antibiotic susceptibility testing. Generalized linear models assessed crude and adjusted associations.</p><p><strong>Results: </strong>Infections occurred in 322 patients (1.9%). Compared with tissue, skeleton and nervous system disorders, adjusted HAI risk was higher for endocrine, metabolic and immunity disorders (OR = 3.1; 95.0% CI: 1.8-5.3; P< .001), neoplasms (OR = 2.3; 95.0% CI: 1.3-4.0, P = .002), genitourinary disorders (OR = 2.4; 95.0% CI: 1.0-3.8, P = .020), circulatory and blood disorders (OR = 1.9; 95.0% CI: 1.2-3.0, P = .002) and digestive disorders (OR = 1.7; 95.0% CI: 1.1-2.4, P = .004). Circulatory and blood disorders also increased HARI risk (OR = 3.0; 95.0% CI: 1.5-6.1, P = .002). Respiratory disorders showed the strongest associations for both outcomes (HAI: OR = 5.0; 95.0% CI: 3.4-7.4, P < .001, HARI: OR = 6.5; 95.0% CI: 3.4-12.2, P < .001).</p><p><strong>Conclusions: </strong>Identifying high-risk groups may guide tailored infection control and reduce burden.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sibel Altunışık Toplu, Elif Seren Tanrıverdi, Funda Memişoğlu, Yusuf Yakupoğulları, Tülay Çelik, Ramazan Özdemir
{"title":"Investigation of environmental bacterial contamination associated with distilled water in a neonatal formula preparation unit.","authors":"Sibel Altunışık Toplu, Elif Seren Tanrıverdi, Funda Memişoğlu, Yusuf Yakupoğulları, Tülay Çelik, Ramazan Özdemir","doi":"10.1016/j.ajic.2026.06.007","DOIUrl":"10.1016/j.ajic.2026.06.007","url":null,"abstract":"<p><strong>Background: </strong>Environmental microorganisms detected in neonatal feeding preparation areas may raise concern for healthcare-associated outbreaks and warrant investigation to identify potential environmental sources of contamination.</p><p><strong>Methods: </strong>Between July 2025 and February 2026, repeated bacterial growth was detected during routine microbiological surveillance of formula prepared for neonates. An investigation was conducted, including sampling of powdered formula, prepared formula, and distilled water. Bacterial identification was performed using routine methods, and genetic relatedness among selected Herbaspirillum isolates was evaluated using arbitrarily primed polymerase chain reaction.</p><p><strong>Results: </strong>Environmental microorganisms were isolated from prepared formula and distilled water, while powdered formula showed no growth. Repeated isolation of Herbaspirillum species demonstrated clonal relatedness, suggesting a common environmental source. No clinical infections associated with these microorganisms were identified among neonates during the study period.</p><p><strong>Conclusions: </strong>This study identified environmental bacterial contamination associated with distilled water used during formula preparation. Molecular typing was valuable in confirming a common environmental source and guiding corrective interventions. Monitoring water sources is critical in neonatal care.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pediatric central line-associated bloodstream infections management: A retrospective study","authors":"Roberta Pellegrino MD , Carlotta Montagnani PhD, MD , Edoardo Timitilli MD , Annalisa Tondo MD , Elisabetta Venturini PhD, MD , Elena Chiappini PhD, MD , Luisa Galli MD","doi":"10.1016/j.ajic.2025.10.018","DOIUrl":"10.1016/j.ajic.2025.10.018","url":null,"abstract":"<div><h3>Background</h3><div>Managing central-line-associated bloodstream infections (CLABSI) in children with long-term central venous catheters (CVC) is challenging. Catheter salvage strategy (CSS) can be attempted when intravenous therapy is essential.</div></div><div><h3>Methods</h3><div>A retrospective cohort study at a tertiary-care paediatric hospital evaluated CLABSI management and compared outcomes between CSS and CVC removal, including all children with CLABSI from January 2021 to June 2024. CSS was defined as CVC retention for ≥ 72 hours after starting empiric antibiotic therapy. Outcomes assessed included fever and bacteraemia persistence at 72 hours, hospital stay, complications, recurrence within 60 days, and treatment failure.</div></div><div><h3>Results</h3><div>Among 111 CLABSI episodes (23 short-term, 88 long-term CVCs) early CVC removal was applied in 18.9%. CSS occurred in 88.6% of long-term CLABSIs. Early removal was associated with non-tunnelled CVCs, multi-lumen CVCs, and <em>Candida</em> spp. or <em>Staphylococcus aureus</em> CLABSI. CSS was associated with oncological patients and/or stem-cell transplant recipients. CSS achieved a 61.4% success rate without significant differences in treatment success between CSS and early CVC removal groups, nor across different pathogens.</div></div><div><h3>Conclusions</h3><div>CSS was widely used with a success rate of 61.4% without differences across pathogens. Further studies are needed to define CSS's role in children according to the aetiology and patient characteristics.</div></div>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"54 4","pages":"Pages 376-381"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manuel Rodríguez-Matesanz MSc , Virginia González-Díez BSc , Gema Nieto Gómez BSc , Cristina Diaz-Agero Pérez PhD , Diego Moreno-Blanco PhD , Ezequiel Hidalgo-Galache MSc , Enrique J. Gómez PhD , Jorge Vicente-Guijarro PhD , Patricia Sánchez-González PhD
{"title":"Enhancing surgical instrument assembly training through virtual reality: A case study on laparoscopic forceps","authors":"Manuel Rodríguez-Matesanz MSc , Virginia González-Díez BSc , Gema Nieto Gómez BSc , Cristina Diaz-Agero Pérez PhD , Diego Moreno-Blanco PhD , Ezequiel Hidalgo-Galache MSc , Enrique J. Gómez PhD , Jorge Vicente-Guijarro PhD , Patricia Sánchez-González PhD","doi":"10.1016/j.ajic.2025.09.018","DOIUrl":"10.1016/j.ajic.2025.09.018","url":null,"abstract":"<div><h3>Background</h3><div>Proper reprocessing of surgical instruments is essential for patient safety and infection prevention. Inadequate assembly can compromise sterilization, delay procedures, and increase the risk of health care-associated infections. Existing training methods for sterilization staff are often informal and lack standardization. The aim is to design and validate a virtual reality (VR) training system to improve the assembly and disassembly skills of laparoscopic forceps among health care professionals.</div></div><div><h3>Methods</h3><div>We codeveloped a VR training tool with clinical staff at Hospital Universitario Ramón y Cajal. The system simulates the assembly of laparoscopic instruments and provides real-time performance feedback. Thirty health care professionals tested the tool and completed a System Usability Scale questionnaire to evaluate its realism, usability, and training utility.</div></div><div><h3>Results</h3><div>Participants rated the system highly for realism (mean 4.73/5), immersion, and ease of use. Most reported improved understanding of the instrument assembly process. Performance metrics, including errors and completion time, were collected and visualized using a desktop application. Only one participant experienced mild discomfort.</div></div><div><h3>Conclusions</h3><div>This VR-based simulation provides a safe, engaging, and effective training environment for surgical instrument reprocessing. It addresses existing gaps in education and may contribute to improved procedural accuracy and infection prevention.</div></div>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"54 4","pages":"Pages 407-414"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of bacterial contamination on antimicrobial disposable curtains compared to fabric curtains in intensive care unit patients at a university hospital setting","authors":"Sumawadee Skuntaniyom MSc , Chonnamet Techasaensiri MD , Pitak Santanirand PhD , Tharntip Siriratpaiboon BSc , Thanomvong Muntajit MSc , Phaniphak Kariyapol MBA , Thitirat Dilokkunanant MNS , Ratikon Yuttharak BSc","doi":"10.1016/j.ajic.2025.10.031","DOIUrl":"10.1016/j.ajic.2025.10.031","url":null,"abstract":"<div><h3>Background</h3><div>Hospital privacy curtains represent high-touch surfaces frequently implicated in the transmission of health care-associated pathogens. This study aimed to evaluate the microbiological efficacy and cost-effectiveness of antimicrobial disposable curtains compared to conventional polyester fabric curtains in an intensive care unit setting.</div></div><div><h3>Methods</h3><div>A quasi-experimental study was conducted from July to October 2024. In the experimental group, antimicrobial disposable curtains were sampled on days 0, 15, 30, 60, 90, and 120 post-installation. In the control group, composed of standard 100% polyester fabric curtains, sampling occurred on days 0, 15, and then at 30-day intervals. For both groups, additional sampling was performed following patient discharge under contact precautions to assess in-use contamination levels.</div></div><div><h3>Results</h3><div>Curtains in the experimental group demonstrated significantly lower bacterial contamination than controls at all time points (<em>P</em> < .001). Peak contamination in the control group reached 2.1 CFU/cm² at day 30, whereas experimental curtains maintained contamination below 0.2 CFU/cm² throughout. Cost analysis revealed a 59.42% reduction in cumulative curtain-related expenditures in the experimental group.</div></div><div><h3>Conclusions</h3><div>Antimicrobial disposable curtains offer superior microbial control and substantial cost savings. Integration of such curtains into infection prevention protocols may enhance environmental hygiene and resource optimization in critical care settings.</div></div>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"54 4","pages":"Pages 382-388"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of using full personal protective equipment in reducing the transmission of SARS-CoV-2 in health care workers: A systematic review","authors":"Juliette Gagnon MD , Myriam Naïmi MD , Frederic Bergeron MSI , Yves Longtin MD , Judith Villeneuve BSc , Katia Boudaoud MD , Daphnée Jolicoeur-Ouellette MD , Hong Hao Xu MD , Émile Cormier MD , Jason R. Guertin PhD , Tania Marx MD, PhD , Judicaël Adadja MD, MSc , Ariane Bluteau MSc , Simon Berthelot MD, MSc","doi":"10.1016/j.ajic.2025.11.013","DOIUrl":"10.1016/j.ajic.2025.11.013","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review aimed to assess the effectiveness of full personal protective equipment (PPE) in preventing COVID-19 transmission among health care workers.</div></div><div><h3>Methods</h3><div>Studies published from December 2019 to August 2024 were searched in MEDLINE, Embase, Cochrane Library, CINAHL, Epistemonikos, ClinicalTrials.gov, MedRxiv, and Web of Science. Full PPE was defined as the combination of respiratory protection (surgical mask, N95, or equivalents), eye protection (visor or goggles), gown, and gloves, as recommended by the World Health Organization (WHO). The comparator was partial PPE or no PPE. Two reviewers independently performed screening, data extraction, and risk of bias assessment. The review was registered on PROSPERO (CRD4202230259).</div></div><div><h3>Results</h3><div>Eight observational studies were included; 4 showed a significant reduction in transmission with full PPE. Seven studies compared full to partial PPE, and 1 compared full PPE to no protection. Among studies with significant results, odds ratios ranged from 0.03 to 0.6. Risk of bias was critical in 6 studies and serious in 2. No meta-analysis was performed due to study quality.</div></div><div><h3>Conclusion</h3><div>Full PPE appears protective for health care workers. The small number and low quality of studies limit the certainty of this conclusion. Further analyses are required to establish clear guideline for its use.</div></div>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"54 4","pages":"Pages 443-450"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salma Abbas MBBS, MPH , Faisal Jamil MS , Ahsan Shaikh MS , Sehrish Ilyas BS , Abdullah Bin Masood BS , Muhammad Usman Afzal MS , Awais Touseef BS , Ali Noor BS , Mirza Wasim-ud-Din MCS , Muhammad Tayyib Akbar MCS , Sajid Ali MS , Muhammad Abid Nazir MCS , Amir Mukhtar MS , Faisal Sultan MBBS
{"title":"Leveraging artificial intelligence for surgical site infection surveillance: A comparison of 5 large language models","authors":"Salma Abbas MBBS, MPH , Faisal Jamil MS , Ahsan Shaikh MS , Sehrish Ilyas BS , Abdullah Bin Masood BS , Muhammad Usman Afzal MS , Awais Touseef BS , Ali Noor BS , Mirza Wasim-ud-Din MCS , Muhammad Tayyib Akbar MCS , Sajid Ali MS , Muhammad Abid Nazir MCS , Amir Mukhtar MS , Faisal Sultan MBBS","doi":"10.1016/j.ajic.2025.12.004","DOIUrl":"10.1016/j.ajic.2025.12.004","url":null,"abstract":"<div><div>We conducted a retrospective study to evaluate the performance of 5 large language models in detecting surgical site infections (SSIs), compared with manual surveillance by an infection preventionist nurse. Forty abdominal surgery patients were included. Manual review achieved 100% diagnostic accuracy. All large language models demonstrated high accuracy (90%-95%) and strong agreement with manual review (κ = 0.80-0.90), with no statistically significant differences in performance (<em>P</em> > .05). AI-based tools may enhance the efficiency of surgical site infection surveillance.</div></div>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"54 4","pages":"Pages 451-453"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}