American journal of infection control最新文献

Preparing for the next pandemic: Efficacy of 2 commercial glycol vapor and aerosol products against aerosolized surrogate viruses and microbes on surfaces. 为下一次大流行做准备：2种商业乙二醇蒸汽和气溶胶产品对表面雾化替代病毒和微生物的功效

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-05-06 DOI: 10.1016/j.ajic.2026.05.001

Jennifer L Cadnum, Maria M Torres-Teran, Samir Memic, Amelia L Milner, Claire E Kaple, Curtis J Donskey

{"title":"Preparing for the next pandemic: Efficacy of 2 commercial glycol vapor and aerosol products against aerosolized surrogate viruses and microbes on surfaces.","authors":"Jennifer L Cadnum, Maria M Torres-Teran, Samir Memic, Amelia L Milner, Claire E Kaple, Curtis J Donskey","doi":"10.1016/j.ajic.2026.05.001","DOIUrl":"https://doi.org/10.1016/j.ajic.2026.05.001","url":null,"abstract":"Background: Aerosolized or vaporized glycols have been proposed as a safe and low-cost measure for air sanitization, but limited information is available on their efficacy in real-world conditions.Methods: We evaluated 2 commercial glycol products, including a dipropylene glycol aerosol spray air sanitizer containing 30% to 60% ethanol and a triethylene glycol product released as a vapor over up to 48 hours. In a simulated patient room with 8 air changes per hour, we tested the efficacy of both products in reducing aerosolized bacteriophages Phi6 and MS2 in air and settling on disks, and the triethylene glycol vapor in reducing the viruses and bacterial pathogens and Candidozyma auris on steel disks.Results: Both products significantly reduced recovery of the bacteriophages in air and significantly reduced recovery of bacteriophage Phi6, but not bacteriophage MS2, on settle disks. After 16 or 48 hours, the triethylene glycol vapor reduced recovery of Phi6, Acinetobacter baumanii, and C. auris by >1 log10, and reduced methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and Klebsiella pneumoniae by ~0.5 log10.Conclusion: The glycol products could be an effective adjunctive method to reduce airborne viruses, and with prolonged exposure might have a modest impact on surface contamination with bacteria and fungi.","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Chlorhexidine Gluconate and Alternative Cleansers in Pediatric Skin Cells In Vitro: Are There Less Toxic Alternatives? 葡萄糖酸氯己定和其他洗面奶对体外儿童皮肤细胞的影响：是否有毒性更小的替代品？

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-05-04 DOI: 10.1016/j.ajic.2026.04.022

Daniel R Streetman, Adam Hutchinson, Jennifer M Hahn, Felicia Scaggs Huang, Dorothy M Supp

{"title":"Effects of Chlorhexidine Gluconate and Alternative Cleansers in Pediatric Skin Cells In Vitro: Are There Less Toxic Alternatives?","authors":"Daniel R Streetman, Adam Hutchinson, Jennifer M Hahn, Felicia Scaggs Huang, Dorothy M Supp","doi":"10.1016/j.ajic.2026.04.022","DOIUrl":"https://doi.org/10.1016/j.ajic.2026.04.022","url":null,"abstract":"Background: Chlorhexidine Gluconate (CHG) is a commonly used antimicrobial cleanser, but its safety in children and neonates is not fully understood. This study analyzed the cytotoxicity of CHG and two alternatives in pediatric epidermal keratinocytes and dermal fibroblasts in vitro.Methods: Keratinocytes and fibroblasts were cultured from skin of three pediatric donors. CHG, a baby wash, and a colloidal silver foam were diluted and analyzed in cells versus untreated controls. Proliferation, migration, and expression of genes involved in proliferation, apoptosis, and inflammation were analyzed in vitro.Results: CHG inhibited keratinocyte and fibroblast proliferation the most; colloidal silver foam had the least effect. CHG and baby shampoo significantly inhibited keratinocyte migration, whereas no cleanser significantly affected fibroblast migration. Gene expression suggested CHG decreased keratinocyte proliferation, increased fibroblast inflammatory signaling, and increased apoptosis in both cell types.Conclusions: The results suggest CHG damages pediatric skin cells but less cytotoxic alternatives exist. Although keratinized epidermal layers in skin provide a barrier to protect deeper proliferative cells, this barrier is thinner in pediatric vs. adult skin, potentially exposing these cells to cytotoxic CHG levels. Further studies including antimicrobial assays are required to fully define the optimal cleanser to combat infection without damaging pediatric skin.","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Multidisciplinary Triad Model for Modern Infection Prevention and Control Departments: Moving Beyond Manual Surveillance to Data Driven-Action. 现代感染预防和控制部门的多学科三元模型：超越人工监测到数据驱动的行动。

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-05-01 DOI: 10.1016/j.ajic.2026.04.021

Corinne Thompson, Mary Elizabeth Guyton, Sarah Hochman, Hemangi Modi, Ilseung Cho, Samuel Levine, Debra Albert, Ranekka Dean, Michael Phillips

引用次数: 0

First Report of Lodderomyces elongisporus in France: Tracing from Accidental Skin Contact to Mobile Device Contamination. 法国首次报告长孢loderomyces elongisporus：从意外皮肤接触到移动设备污染的追踪。

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-04-29 DOI: 10.1016/j.ajic.2026.04.019

Andres Ceballos-Garzon, Saliha Desitter, Erwin Sentausa, Marion Holzapfel, Jeremy Welsch, Derry Mercer

引用次数: 0

"Candida auris in the Acute Care Environment: Identifying and Controlling Transmission Through a Systematic Investigation in an Academic Hospital". “急性护理环境中的耳念珠菌：通过一所学术医院的系统调查来识别和控制传播”。

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-04-27 DOI: 10.1016/j.ajic.2026.04.017

Maria L Vacca, Randy R Persaud, Jack S Evans, Mary Ehly, Phyllis R Flomenberg, Marissa Leahy, Brianna Schriver, Scott Cowan, Mark R Sterner

引用次数: 0

Quantifying the Impact of Visitors with Upper Respiratory Tract Infections (URTIs) During Respiratory Virus Season. 在呼吸道病毒季节，量化上呼吸道感染（URTIs）游客的影响。

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-04-23 DOI: 10.1016/j.ajic.2026.04.014

Jayvee Guerrero, Senthuri Paramalingam, Satyajeet Bhoite, Reena Lovinsky, Abdel Belhaj

{"title":"Quantifying the Impact of Visitors with Upper Respiratory Tract Infections (URTIs) During Respiratory Virus Season.","authors":"Jayvee Guerrero, Senthuri Paramalingam, Satyajeet Bhoite, Reena Lovinsky, Abdel Belhaj","doi":"10.1016/j.ajic.2026.04.014","DOIUrl":"https://doi.org/10.1016/j.ajic.2026.04.014","url":null,"abstract":"Background: Transmission of viral respiratory tract infections (vRTIs) from sick visitors with symptoms of upper respiratory tract infections (URTIs) to patients is a concern. This study aimed to quantify the impact of sick visitors with URTI in an acute care hospital.Methods: Retrospective chart review was conducted to identify patients exposed to symptomatic visitors with URTI. Patients who tested positive for a vRTI and their secondary contacts were identified. Attack rate and isolation days were calculated.Results: Twenty-three patients were identified as primary contacts of sick visitors and were isolated for 192 days; 17 of the 23 patients tested positive for SARS-CoV-2, Respiratory syncytial virus, or Adenovirus. Twenty-five secondary contacts were identified, with 8 positive for SARS-CoV-2 and a total of 129 isolation days with secondary attack rate of 35%.Discussion: Sick visitors with URTI may contribute to the transmission of healthcare-associated vRTIs. Limitations include reliance on visitor self-reporting and the assumption that symptomatic visitors were the source of the infection.Conclusions: Visitors are essential to patient care but those with URTIs pose a risk to patients. Visitors should avoid visiting when sick and adhere to hospital protocols including hand hygiene, personal protective equipment usage and compliance with masking policies.","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is there a correlation between airborne bacterial load measured by volumetric air sampling and fluorescent particle counting? 体积空气取样和荧光粒子计数测量的空气细菌负荷之间是否存在相关性？

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-04-23 DOI: 10.1016/j.ajic.2026.04.016

S Widesköld, J Nordenadler, E Tano, B Reinmüller, B Ljungqvist, D Gustafsson, N P Hailer, S Lazarinis

{"title":"Is there a correlation between airborne bacterial load measured by volumetric air sampling and fluorescent particle counting?","authors":"S Widesköld, J Nordenadler, E Tano, B Reinmüller, B Ljungqvist, D Gustafsson, N P Hailer, S Lazarinis","doi":"10.1016/j.ajic.2026.04.016","DOIUrl":"https://doi.org/10.1016/j.ajic.2026.04.016","url":null,"abstract":"Background: Microbiological air sampling in operating rooms, based on colony-forming unit (CFU) counts, is time-consuming and costly. Novel technologies, such as particle counters that detect fluorescent bioparticles (FBPs), may offer a simpler method for estimating airborne bacterial loads. This study aimed to assess the correlation between CFU and FBP counts under realistic operating room conditions.Methods: During 22 primary hip arthroplasty procedures at a tertiary university hospital, CFUs were measured using a Sartorius MD8 air sampler placed adjacent to the surgical field. Simultaneously, the Bio Aerosol Measuring System (BAMS), recorded FBPs sized 0.5-25 µm. FBP counts were analyzed during CFU sampling periods and using each CFU sampling interval as an individual data point, yielding 115 paired comparisons. Correlations were assessed using Spearman's rank correlation coefficient.Results: No significant correlation was observed between FBP and CFU counts. Comparing FBP with CFU counts during Sartorius sampling intervals, rho was -0.31 (p = 0.23). Using individual CFU sampling intervals, the correlation for particles ≥3 µm rho was = -0.10 (p = 0.35).Conclusions: Analyses revealed no correlation between FBP and CFU counts in operation room air quality assessments, suggesting that BAMS-based FBP measurement is not a suitable alternative to established microbiological methods.","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of a Pseudo-outbreak of Myroides odoratimimus in High-Dependency Units Reveals an Environmental Reservoir. 一次高依赖单位伪爆发的调查揭示了一个环境水库。

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-04-23 DOI: 10.1016/j.ajic.2026.04.015

Serpil Genç, Emine Türkoğlu, Tuba İça, Furkan Demirkaya, Duygu Perçin Renders

{"title":"Investigation of a Pseudo-outbreak of Myroides odoratimimus in High-Dependency Units Reveals an Environmental Reservoir.","authors":"Serpil Genç, Emine Türkoğlu, Tuba İça, Furkan Demirkaya, Duygu Perçin Renders","doi":"10.1016/j.ajic.2026.04.015","DOIUrl":"https://doi.org/10.1016/j.ajic.2026.04.015","url":null,"abstract":"Background: Unusual clustering of opportunistic pathogens in high-dependency units (HDUs) may raise concern for healthcare-associated outbreaks and requires careful investigation to distinguish true transmission from pseudo-outbreaks. In mid-2025, a sudden increase in urinary isolates of Myroides spp., intrinsically multidrug-resistant non-fermentative Gram-negative bacilli, was observed in HDUs of a tertiary-care hospital. This study aimed to determine whether the clustering represented sustained transmission or a pseudo-outbreak linked to a common source.Methods: A combined retrospective-prospective investigation was conducted in HDUs comprising eight intensive care units and one palliative care unit (total capacity:89 beds). Seventy-five unique patients with Myroides spp. isolated from urine cultures between July 2024-August 2025 were included. Prospective isolates underwent species identification, antimicrobial susceptibility testing, biofilm production assessment, rep-PCR genotyping, selected 16S rRNA gene sequencing. Targeted environmental sampling was performed in units with case clustering.Results: A temporal peak occurred in June 2025 (n:16). All prospectively analysed isolates were identified as Myroides odoratimimus. Environmental sampling recovered the organism from urine collection containers. rep-PCR analysis of 33 isolates demonstrated a dominant molecular profile shared by 32 isolates, including 29 of 30 clinical isolates and all 3 environmental isolates. Most isolates showed strong biofilm production. After the introduction of single-use urine collection bags, no further isolates were detected.Conclusions: These findings indicate a healthcare-associated pseudo-outbreak linked to an environmental source rather than sustained patient-to-patient transmission.","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Six-year trends in health care-associated infections in Chilean hospitals: A national surveillance analysis (2017-2022). 智利医院医疗相关感染的六年趋势：一项国家监测分析（2017-2022）。

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-04-21 DOI: 10.1016/j.ajic.2026.04.002

C Lara, M Kappes, P Chandia, K Osorio, A Ferreira-Umpiérrez, P Brotons de Los Reyes

{"title":"Six-year trends in health care-associated infections in Chilean hospitals: A national surveillance analysis (2017-2022).","authors":"C Lara, M Kappes, P Chandia, K Osorio, A Ferreira-Umpiérrez, P Brotons de Los Reyes","doi":"10.1016/j.ajic.2026.04.002","DOIUrl":"10.1016/j.ajic.2026.04.002","url":null,"abstract":"Background: Health care-associated infections (HAIs) remain a major patient safety challenge in hospital settings. Surveillance systems provide monitoring, but few studies integrate long-term trends in infection risk and outcomes with measures of system capacity and emergency investment.Methods: We conducted a descriptive analysis of national HAI surveillance data from Chilean public hospitals spanning 2017 to 2022, reported in accordance with STROBE guidelines. Indicators included HAI prevalence, device utilization ratios, incidence densities for ventilator-associated pneumonia (VAP), central-line-associated bloodstream infection, catheter-associated urinary tract infection, VAP case fatality rates, and outbreak reports. Emergency health investment data were integrated to explore temporal patterns before, during, and after the COVID-19 pandemic.Results: HAI prevalence remained stable over 6 years. However, device utilization increased during 2020 to 2021, with corresponding rises in device-associated infection rates, particularly VAP. VAP case fatality rates increased in 2020 to 2021, reversing pre-pandemic declines. Periods of rapid expansion in critical care capacity coincided with higher outbreak reports.Conclusions: During the COVID-19 pandemic, device-associated infections and infection-related severity increased despite stable HAI prevalence. By linking surveillance data with indicators of system capacity and emergency investment, this study helps explain how large-scale system disruptions affect infection risk and patient outcomes. Strengthening infection prevention alongside surge planning remains essential.","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The competency challenge: A quest for accurate health care-acquired infection event classification among infection preventionists. 能力挑战：对感染预防医师中医疗保健获得性感染事件准确分类的探索。

IF 2.4 3区医学

American journal of infection control Pub Date : 2026-04-21 DOI: 10.1016/j.ajic.2026.04.001

Emily Grohs, Kenneth M Short, Andrea L Ankrum

引用次数: 0