Kelly R. Reveles PharmD, PhD , Kelsey A. Strey PharmD , Esther L. Albuquerque , Damaris Jacota , Xavier Jones BS , Joseph J. Carreno PharmD, MPH
{"title":"Retrospective, propensity score--matched study examining the relationship between frailty and Clostridioides difficile infection in a national cohort of US veterans","authors":"Kelly R. Reveles PharmD, PhD , Kelsey A. Strey PharmD , Esther L. Albuquerque , Damaris Jacota , Xavier Jones BS , Joseph J. Carreno PharmD, MPH","doi":"10.1016/j.ajic.2024.08.020","DOIUrl":"10.1016/j.ajic.2024.08.020","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is often more predictive of disease and mortality compared with chronological age. This study determined the impact of frailty on <em>Clostridioides difficile</em> infection (CDI) risk and outcomes in a national veteran population.</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study of CDI and control veteran inpatients and outpatients from fiscal year 2003 to 2018. Baseline frailty was presented as the Veterans Affairs (VA) Frailty Index. Propensity score--matched analyses were conducted to compare CDI risk, CDI health outcomes, and 1-year new-onset frailty-associated conditions.</div></div><div><h3>Results</h3><div>A total of 11,451 CDI and 11,451 matched control patients were included. Baseline frailty conditions were more common among CDI patients, especially involuntary weight loss (6.0% vs 3.4%, <em>P</em> < .001) and anemia (24.6% vs 18.7%, <em>P</em> < .001). VA Frailty Index was significantly higher for CDI patients (0.13 vs 0.11, <em>P</em> = .019). Frail CDI patients were more likely to experience 30-day mortality (11.3% vs 1.1%, <em>P</em> < .001) and 60-day CDI recurrence (20.4% vs 16.3%, <em>P</em> < .001) compared with non-/prefrail CDI patients. At 1<!--> <!-->year, CDI patients were significantly more likely to be categorized as frail (19.6% vs 17.0%, <em>P</em> < .001).</div></div><div><h3>Conclusions</h3><div>This study demonstrated the potential association between frailty and CDI risk and health outcomes, as well as new-onset frailty diagnoses in patients who develop CDI.</div></div>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"52 12","pages":"Pages 1412-1418"},"PeriodicalIF":3.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily J Haas, Mihili Edirisooriya, Rohan Fernando, Caitlin McClain, Margaret Sietsema, Adam Hornbeck, Paul Thurman, Sara Angelilli, Hope Waltenbaugh, Sricharan Chalikonda, Stella E Hines
{"title":"Experiences when using different EHMR models: Implications for different designs and meeting user expectations.","authors":"Emily J Haas, Mihili Edirisooriya, Rohan Fernando, Caitlin McClain, Margaret Sietsema, Adam Hornbeck, Paul Thurman, Sara Angelilli, Hope Waltenbaugh, Sricharan Chalikonda, Stella E Hines","doi":"10.1016/j.ajic.2024.08.019","DOIUrl":"10.1016/j.ajic.2024.08.019","url":null,"abstract":"<p><strong>Background: </strong>New elastomeric half-mask respirator (EHMR) models without exhalation valves (EVs) or with exhalation valve filters (EVFs) are facilitating expanded use in health settings to reduce workers' exposure to airborne hazards while acting as source control to prevent pathogen spread. The physical comfort of new models has not been assessed in comparison to previously used EHMRs with EVs.</p><p><strong>Methods: </strong>Researchers assessed 1,962 health care and emergency medical service personnels' self-reported adverse experiences from 2 cohorts while wearing EHMR models with EVs (cohort 1, n = 1,080) and without EVs or with EVFs (cohort 2, n = 882). Fisher exact test identified differences between the cohorts accounting for organizational factors when possible.</p><p><strong>Results: </strong>Cohort 1 respondents experienced communication challenges and discomfort when wearing the EHMR > 1 hour statistically significantly more often than cohort 2. Cohort 2 respondents reported statistically significantly more instances of difficulty breathing, moisture buildup, being uncomfortable to wear < 1 hour, and being uncomfortably warm.</p><p><strong>Conclusions: </strong>Discomfort is prevalent among end users and more often among those wearing EHMRs without an EV/with an EVF. As EHMR research and development advances, prevalence in use may increase for emergency and routine situations. Organizations may not only need guidance about respirator selection but also model-specific selection.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142078888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Grupel, Abraham Borer, Riki Yosipovich, Ronit Nativ, Orli Sagi, Lisa Saidel-Odes
{"title":"A multilayered infection control intervention on carbapenem-resistant Acinetobacter baumannii acquisition: An interrupted time series.","authors":"Daniel Grupel, Abraham Borer, Riki Yosipovich, Ronit Nativ, Orli Sagi, Lisa Saidel-Odes","doi":"10.1016/j.ajic.2024.08.018","DOIUrl":"10.1016/j.ajic.2024.08.018","url":null,"abstract":"<p><strong>Background: </strong>Carbapenem-resistant Acinetobacter baumannii (CRAB) causes life-threating hospital-acquired. Due to a limited number of Intensive-Care-Unit (ICU) beds, these patients are often treated in high-dependency (HD) non-ICUs within internal-medicine wards (IMW) in Israel. We aimed to assess the effectiveness of a multilayered infection-control intervention on CRAB infection rate in IMWs, especially in its HD non-ICUs with ongoing CRAB transmission.</p><p><strong>Methods: </strong>A quasi-experimental, before-and-after, interrupted time-series study with control outcomes. We conducted a multilayered intervention over 3.5years, which included 4 phases: (1) Pre intervention; (2) Intervention introduction: introduced enhanced environment cleaning; (3) Intervention phase 1: introduced active surveillance; (4) Intervention phase 2: introduced CRAB-positive patient cohorting, in addition to previous ongoing measures taken.</p><p><strong>Results: </strong>CRAB was isolated from 204 patients aged 69.8y/o ± 15.86y, 59.8% male, 34.3% had CRAB-positive clinical samples. Mean hospital length-of-stay was 30.5days, with a 30-day postdischarge mortality rate of 55.9%. Mean CRAB clinical cases decreased from 0.89 in preintervention to 0.11 at the end of phase 2, with a change in slope and level after the intervention of P = .02 (CI: -0.204 to -0.040) and P = .004 (CI: -0.013 to -0.003), respectively.</p><p><strong>Conclusions: </strong>This intervention, including enhanced environment cleaning, active surveillance, and patient cohorting, successfully reduced CRAB acquisition in IMWs and their HD non-ICUs.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maximillian S Wu, Wesley Kufel, Scott Riddell, Jeff Steele, Elizabeth Asiago-Reddy
{"title":"Persistent methicillin-resistant Staphylococcus aureus (MRSA) nares test positivity during initial days of systemic antistaphylococcal antimicrobial therapy.","authors":"Maximillian S Wu, Wesley Kufel, Scott Riddell, Jeff Steele, Elizabeth Asiago-Reddy","doi":"10.1016/j.ajic.2024.08.014","DOIUrl":"10.1016/j.ajic.2024.08.014","url":null,"abstract":"<p><p>The typical duration of positive nucleic acid tests for methicillin-resistant Staphylococcus aureus (MRSA) in the nares of patients receiving systemic anti-MRSA antimicrobials is unknown. In this study, hospitalized adult patients with an initial positive MRSA nares nucleic acid test prescribed systemic anti-MRSA antimicrobials had follow-up testing done 48 to 96 hours later. A positive follow-up test was detected in 100/113 (88.5%), indicating that MRSA nares DNA tests still have utility for screening after patients have initiated anti-MRSA therapy.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Terri Rebmann, Charlesnika Evans, Ashley M Hughes, Rachel L Mazzara, Kaeli A Lugo, Jessica Waechter, Shay Drummond, Amanda Carnes, Abigail L Carlson, Janet Glowicz
{"title":"Infection preventionists' current and preferred training strategies and tools.","authors":"Terri Rebmann, Charlesnika Evans, Ashley M Hughes, Rachel L Mazzara, Kaeli A Lugo, Jessica Waechter, Shay Drummond, Amanda Carnes, Abigail L Carlson, Janet Glowicz","doi":"10.1016/j.ajic.2024.08.015","DOIUrl":"10.1016/j.ajic.2024.08.015","url":null,"abstract":"<p><strong>Background: </strong>Educating health care staff on infection prevention and control (IPC) is an essential role of infection preventionists (IPs), but the COVID-19 pandemic diverted resources away from IPC education.</p><p><strong>Methods: </strong>Association for Professionals in Infection Control and Epidemiology members were invited to complete an online survey from spring 2023 to assess current and preferred approaches and tools for training health care personnel on IPC. Vendors, retirees, APIC staff, or those not working in health care or public health were excluded.</p><p><strong>Results: </strong>In all, 2,432 IPs participated. IPs were more likely to report engaging in impromptu health care worker training (ie, just-in-time teaching and team huddles) versus planned educational activities (ie, learning modules, formal presentations, train-the-trainer, or simulation; Kruskal-Wallis = 288, P < .001). IPs' top preferred teaching methodologies included simulation or interactive activity, and their lowest preferred approach was independent learning modules. IPC training apps were frequently requested technology.</p><p><strong>Discussion: </strong>IPs ranked simulation as their top preferred teaching method; however, simulation was one of the least frequently used approaches. IP education should include strategies for delivering effective impromptu training and how to develop and implement interactive simulation-based education.</p><p><strong>Conclusions: </strong>The expressed needs and preferences of IPs should be considered when developing IPC-related teaching and training tools.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to “Alcohol flush does not aid in endoscope channel drying but may serve as an adjunctive microbiocidal measure: A new take on an old assumption” [Am J Infect Control, 51/7 (2023) 772–778, 6367]","authors":"Michelle Nerandzic BS, Kathleen Antloga MS, Nancy Robinson PhD","doi":"10.1016/j.ajic.2024.08.002","DOIUrl":"10.1016/j.ajic.2024.08.002","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"52 11","pages":"Page 1342"},"PeriodicalIF":3.8,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to “The effects of a novel, continuous disinfectant technology on methicillin-resistant Staphylococcus aureus (MRSA), fungi, and aerobic bacteria in 2 separate intensive care units in 2 different states: An experimental design with observed impact” [Am J Infect Control 52 (2024) 884–892]","authors":"Kimberly Trosch RN, BSN , Patricia Lawrence MS, RN, CIC , Amy Carenza BBA , Katherine Baumgarten MD , Beth Ann Lambert MS, CIC , Nattie Leger RN, MSN, LSSBB , Lori Berthelot RN, BSN, CIC , Melissa Woosley RN, CIC , Deborah Birx MD","doi":"10.1016/j.ajic.2024.08.006","DOIUrl":"10.1016/j.ajic.2024.08.006","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"52 11","pages":"Pages 1343-1344"},"PeriodicalIF":3.8,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Information for Readers","authors":"","doi":"10.1016/S0196-6553(24)00618-7","DOIUrl":"10.1016/S0196-6553(24)00618-7","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"52 9","pages":"Page A8"},"PeriodicalIF":3.8,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}