American journal of infection control最新文献

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Relationship between COVID-19 vaccination coverage in residents and staff and COVID-19 outcomes in long-term care facilities in Hawai'i, June 2022 to May 2024. 2022年6月至2024年5月,夏威夷居民和工作人员COVID-19疫苗接种覆盖率与长期护理机构COVID-19结局的关系
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-30 DOI: 10.1016/j.ajic.2026.07.011
Karina Ruiz Lopez, Nicole A Mintz, Vila Chanthasouvanh, Isami A Freeman, Hua He, David I Johnston, Garret Hino, Sarah K Kemble
{"title":"Relationship between COVID-19 vaccination coverage in residents and staff and COVID-19 outcomes in long-term care facilities in Hawai'i, June 2022 to May 2024.","authors":"Karina Ruiz Lopez, Nicole A Mintz, Vila Chanthasouvanh, Isami A Freeman, Hua He, David I Johnston, Garret Hino, Sarah K Kemble","doi":"10.1016/j.ajic.2026.07.011","DOIUrl":"10.1016/j.ajic.2026.07.011","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 mortality rates among long-term care facility (LTCF) residents remain high post-pandemic, signifying this population remains highly vulnerable.</p><p><strong>Methods: </strong>We conducted a retrospective facility-level multivariate regression analysis of 38 LTCFs in Hawai'i to examine the relationship between COVID-19 vaccination coverage and COVID-19 outcomes. COVID-19 infections and deaths among LTCF residents were derived from Hawai'i State Department of Health case data. Facility-level COVID-19 vaccination coverage among residents and staff, number of occupied beds, and county were obtained from the Centers for Medicare and Medicaid Services public datasets (June 1, 2022, to May 31, 2024). Relative change was defined as the difference in the median vaccination coverage between Year 2 and Year 1, divided by the median coverage in Year 1.</p><p><strong>Results: </strong>The median relative change in vaccination coverage was -15% for residents and -53% for staff. Among staff, 27% of small and 12% of medium facilities achieved a positive relative change. A 10% relative increase in staff vaccination coverage was associated with 2.7 fewer resident infections per 100 beds.</p><p><strong>Conclusions: </strong>Increasing staff COVID-19 vaccination coverage remains an important infection control priority post-pandemic.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A replicable colectomy surgical site infection prevention bundle: Implementation and electronic health record--enabled compliance monitoring. 可复制结肠切除术手术部位感染预防捆绑:实施和启用电子健康记录的依从性监测。
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-30 DOI: 10.1016/j.ajic.2026.07.016
Rodovaldo Rodriguez, Andrea Lynn Cromer, Courtney Jones, Emily Porupski
{"title":"A replicable colectomy surgical site infection prevention bundle: Implementation and electronic health record--enabled compliance monitoring.","authors":"Rodovaldo Rodriguez, Andrea Lynn Cromer, Courtney Jones, Emily Porupski","doi":"10.1016/j.ajic.2026.07.016","DOIUrl":"10.1016/j.ajic.2026.07.016","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infections (SSIs) after colectomy are a major source of morbidity, mortality, and cost. Despite evidence supporting prevention bundles, reliable implementation remains challenging. We describe the implementation of a colectomy SSI bundle guided by the Translating Research into Practice (TRIP) model, featuring novel electronic health record (EHR)-enabled compliance monitoring.</p><p><strong>Methods: </strong>A pre/post quasi-experimental study compared baseline (n = 227) and post-implementation (n = 164) colectomies at a community teaching hospital. An Epic (Epic Systems Corporation, Verona, WI) EHR dashboard monitore compliance. The primary outcome was the National Healthcare Safety Network (NHSN) Standardized Infection Ratio (SIR).</p><p><strong>Results: </strong>SSI rates decreased from 10.6% to 4.9% (relative risk 0.46, 95% CI: 0.21-0.99, P = .051). The SIR decreased from 2.04 to 0.895 (relative risk 0.44, 95% CI: 0.19-0.95, P = .037), indicating fewer SSIs than expected. Compliance was high across most elements.</p><p><strong>Discussion: </strong>The TRIP model provided a replicable implementation framework. The EHR dashboard enabled actionable compliance monitoring without requiring capital investment.</p><p><strong>Conclusions: </strong>A colectomy SSI prevention bundle, guided by the TRIP model and supported by an EHR dashboard, achieved a statistically significant reduction in SIR and a clinically meaningful decrease in SSI rates.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Agile Science to implement alternatives to indwelling urinary catheters. 运用敏捷科学实现留置导尿管的替代方案。
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-28 DOI: 10.1016/j.ajic.2026.07.012
Bethany Gregg, Edmond Ramly, Diveena Davis, Mildred Patrick, Mary Grove
{"title":"Using Agile Science to implement alternatives to indwelling urinary catheters.","authors":"Bethany Gregg, Edmond Ramly, Diveena Davis, Mildred Patrick, Mary Grove","doi":"10.1016/j.ajic.2026.07.012","DOIUrl":"10.1016/j.ajic.2026.07.012","url":null,"abstract":"<p><strong>Background: </strong>Alternatives to indwelling urinary catheters can reduce catheter-associated urinary tract infections (CAUTIs), but adoption is often inconsistent. We used an Agile Science framework to implement external urinary devices across a large hospital network.</p><p><strong>Methods: </strong>Using an Agile Implementation process, a multidisciplinary team co-designed iterative \"sprints\" targeting electronic medical record changes, standardized auditing, education, and workflow integration. Process measures included learning-module completion and audit compliance. Outcome measures were CAUTI Standardized Infection Ratio (SIR) and indwelling catheter Standardized Utilization Ratio (SUR).</p><p><strong>Results: </strong>An initial daily auditing plan proved infeasible, leading to risk-based audits that achieved 99% to 100% compliance. Completion of a learning module, introduced in quarter 1 (Q1) 2024, increased from 34% (February 2024) to 99% by Q3 2025. Network CAUTI SIR decreased to 0.52 by Q3 2025, a 36% reduction from the pre-intervention period (Q4 2023). The network SUR has been sustained below the 2023 National Healthcare Safety Network (NHSN) national median.</p><p><strong>Discussion: </strong>Agile Implementation's emphasis on iteration and feedback proved critical for adapting interventions to ensure their success and sustainability.</p><p><strong>Conclusions: </strong>Agile Implementation enabled rapid adoption and optimization of indwelling urinary catheter alternatives, associated with reductions in CAUTI SIR.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148597619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: "Beyond catheter presence: Risk factors for progression to bloodstream infection during the COVID-19 era---A matched case-control study". 评论:“超越导管存在:COVID-19时代进展为血液感染的危险因素:一项匹配病例-对照研究”。
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-20 DOI: 10.1016/j.ajic.2026.07.010
Zainab Arfan, Abdul Moeed Sarfraz
{"title":"Comment on: \"Beyond catheter presence: Risk factors for progression to bloodstream infection during the COVID-19 era---A matched case-control study\".","authors":"Zainab Arfan, Abdul Moeed Sarfraz","doi":"10.1016/j.ajic.2026.07.010","DOIUrl":"10.1016/j.ajic.2026.07.010","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-effectiveness of a practical approach to prevent respiratory infection outbreaks in long-term care settings: The CARES strategy. 在长期护理环境中预防呼吸道感染爆发的实用方法的成本效益:护理战略。
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-17 DOI: 10.1016/j.ajic.2026.06.029
Naoki Takayama, Mayumi Aminaka, Haruyo Sakaki, Eiko Endo, Masahiro Shirai, Atsushi Toyoda, Midori Nishioka
{"title":"Cost-effectiveness of a practical approach to prevent respiratory infection outbreaks in long-term care settings: The CARES strategy.","authors":"Naoki Takayama, Mayumi Aminaka, Haruyo Sakaki, Eiko Endo, Masahiro Shirai, Atsushi Toyoda, Midori Nishioka","doi":"10.1016/j.ajic.2026.06.029","DOIUrl":"10.1016/j.ajic.2026.06.029","url":null,"abstract":"<p><strong>Background: </strong>Respiratory infection outbreaks often occur in long-term care (LTC) settings and can disrupt health care delivery, including admissions and visitation.</p><p><strong>Methods: </strong>This study evaluated the cost-effectiveness of the Concurrent Approach for Respiratory Epidemiological Surveillance and Symptom Screening (CARES), which integrates patient syndromic surveillance with staff and visitor symptom screening. We compared two 6-month periods in 2 wards of a single LTC hospital, including 202 patients (98 non-CARES; 104 CARES). Staff time was assessed using time-motion observations. Incremental effectiveness was measured as reductions in ward-level calendar days under facility-mandated admission suspension, defined as the temporary suspension of new admissions, and visitation restriction, defined as the temporary restriction of family and visitor access.</p><p><strong>Results: </strong>Admission suspension decreased from 16 days in the non-CARES period to 0 days in the CARES period, and visitation restriction decreased from 23 days to 0 days. Incremental cost-effectiveness ratios were US $115.48 per day of admission suspension avoided and US $80.34 per day of visitation restriction avoided.</p><p><strong>Discussion: </strong>CARES demonstrated operational efficiency and measurable benefits in maintaining health care access and patient-family interaction.</p><p><strong>Conclusions: </strong>CARES may be an economically feasible and practical strategy that helps preserve quality of life and supports sustainable infection prevention in LTC settings.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprocessing practice gaps associated with low-temperature hydrogen peroxide gas plasma sterilizers in public hospitals in Sichuan, China: A cross-sectional survey. 四川省公立医院与低温过氧化氢等离子灭菌器相关的后处理实践差距:一项横断面调查
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-13 DOI: 10.1016/j.ajic.2026.07.009
Rui Mao, Lei Gao, Qing Zhao, Jin Li, Ruixue Qin, Lin Wen
{"title":"Reprocessing practice gaps associated with low-temperature hydrogen peroxide gas plasma sterilizers in public hospitals in Sichuan, China: A cross-sectional survey.","authors":"Rui Mao, Lei Gao, Qing Zhao, Jin Li, Ruixue Qin, Lin Wen","doi":"10.1016/j.ajic.2026.07.009","DOIUrl":"10.1016/j.ajic.2026.07.009","url":null,"abstract":"<p><strong>Background: </strong>Low-temperature hydrogen peroxide gas plasma (LTHPGP) sterilizers are increasingly used in public hospitals, but whether deployment is matched by infection prevention and control capacity remains unclear. This study assessed LTHPGP reprocessing practices and infection prevention and control gaps in Sichuan, China.</p><p><strong>Methods: </strong>From January to February 2025, Central Sterile Supply Department (CSSD) nurse managers from 165 secondary and tertiary public hospitals completed an online questionnaire covering device configuration, environmental protection, loading, monitoring, residue and leak events, and information system connectivity. Descriptive statistics, χ² tests, and exploratory logistic regression were performed.</p><p><strong>Results: </strong>The survey covered 360 LTHPGP sterilizers, with a mean of 2.2 devices per hospital and service life of 6.0 years. Hazardous gas alarms were present in 69.1% of hospitals; H₂O₂ leaks were reported by 8.5%; and signs of H₂O₂ residue by 82.4%. Routine loading ratios exceeded 80% in 7.9%, and information system connectivity was 44.8%. More devices were associated with H₂O₂ leak reporting (OR, 2.09; 95% CI, 1.01-4.33).</p><p><strong>Discussion: </strong>Device expansion was not fully matched by process-control capacity, particularly in environmental protection and traceability.</p><p><strong>Conclusions: </strong>Tiered improvements in environmental safety, loading control, monitoring completeness, and electronic traceability are needed to support safer LTHPGP reprocessing.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond admission diagnosis: Integrating dynamic clinical risk factors to improve hospital-acquired infection risk stratification. 超越住院诊断:整合动态临床危险因素改善医院获得性感染风险分层。
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-12 DOI: 10.1016/j.ajic.2026.07.007
Hrithika Jeswani
{"title":"Beyond admission diagnosis: Integrating dynamic clinical risk factors to improve hospital-acquired infection risk stratification.","authors":"Hrithika Jeswani","doi":"10.1016/j.ajic.2026.07.007","DOIUrl":"10.1016/j.ajic.2026.07.007","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Staff contact frequency as a novel digital biomarker for late onset neonatal sepsis in the NICU. 工作人员接触频率作为新生儿重症监护室晚发性新生儿败血症的新型数字生物标志物。
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-12 DOI: 10.1016/j.ajic.2026.07.006
Nayab Magsi, Fasih Mehmood, Abdul Samad
{"title":"Staff contact frequency as a novel digital biomarker for late onset neonatal sepsis in the NICU.","authors":"Nayab Magsi, Fasih Mehmood, Abdul Samad","doi":"10.1016/j.ajic.2026.07.006","DOIUrl":"10.1016/j.ajic.2026.07.006","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective multicenter multinational cohort study: Time-to-central line-associated bloodstream infection with plain vs chlorhexidine/silver sulfadiazine impregnated central venous catheters. 前瞻性多中心多国队列研究:平与氯己定/磺胺嘧啶银浸渍中心静脉导管的时间到中心线相关血流感染
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-11 DOI: 10.1016/j.ajic.2026.07.005
Victor Daniel Rosenthal, Zhilin Jin, Ruijie Yin, Mat Nor Mohd Basri, Lai Yin Hoong, Fatimah Mohamad, Mohit Kharbanda, Bikas Nag, Arpita Bhakta, Subhash Kumar Todi, Mahuya Bhattacharyya, Ertugrul Guclu, Esra Olmez Gazioglu, Aziz Ogutlu, Oguz Karabay, Sunita Gupta, Nellie Tumu, Valentina Perez
{"title":"Prospective multicenter multinational cohort study: Time-to-central line-associated bloodstream infection with plain vs chlorhexidine/silver sulfadiazine impregnated central venous catheters.","authors":"Victor Daniel Rosenthal, Zhilin Jin, Ruijie Yin, Mat Nor Mohd Basri, Lai Yin Hoong, Fatimah Mohamad, Mohit Kharbanda, Bikas Nag, Arpita Bhakta, Subhash Kumar Todi, Mahuya Bhattacharyya, Ertugrul Guclu, Esra Olmez Gazioglu, Aziz Ogutlu, Oguz Karabay, Sunita Gupta, Nellie Tumu, Valentina Perez","doi":"10.1016/j.ajic.2026.07.005","DOIUrl":"10.1016/j.ajic.2026.07.005","url":null,"abstract":"<p><strong>Background: </strong>Central line-associated bloodstream infections (CLABSIs) cause preventable harm. We evaluated whether Chlorhexidine/Silver Sulfadiazine (CH/SSD)-impregnated CVCs reduce the CLABSI hazard compared with plain CVCs using time-to-event methodology.</p><p><strong>Methods: </strong>A prospective cohort study was conducted in 6 hospitals in India, Malaysia, Papua New Guinea, and Turkey from 03/01/2023-10/31/2025. We included 1,294 plain-CVC patients and 456 CH/SSD-CVC patients. The primary endpoint was time to first CLABSI, estimated by Kaplan-Meier modeled with Cox proportional hazards regression. A prespecified landmark analysis assessed early risk at days 0-5.</p><p><strong>Results: </strong>Within 30 days, 51 CLABSIs occurred in the plain-CVC group and 12 in the CH/SSD group. Kaplan-Meier cumulative incidence at 30 CVC-days showed statistically significant separation (log-rank X<sup>2</sup> = 5.309; P = .021). In the primary Cox proportional hazards model, CH/SSD-CVCs were associated with a significantly lower hazard of CLABSI than plain-CVCs (hazard ratio = 0.297; 95%CI = 0.134-0.658; P = .003). In the prespecified early 0-5-day period, 13 CLABSIs occurred in the plain-CVC group and 0 in the CH/SSD-CVC group (log-rank X<sup>2</sup> = 4.923; P = .026). ICU mortality was higher in the plain-CVC group (28.3% vs 18.4%; P < .001).</p><p><strong>Conclusions: </strong>CH/SSD-CVCs were associated with a significant reduction in the CLABSI hazard, supporting further study of their use as tools to prevent CLABSI.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The safety and effectiveness of hypochlorous acid used as surgical irrigation solution to reduce postoperative complications: A systematic review and network meta-analysis. 次氯酸作为外科冲洗液减少术后并发症的安全性和有效性:一项系统综述和网络荟萃分析。
IF 2.6 3区 医学
American journal of infection control Pub Date : 2026-07-10 DOI: 10.1016/j.ajic.2026.07.001
Donald B Ayers, Paul J Niklewski, Evelyn J Rizzo, Robert Bilkovski
{"title":"The safety and effectiveness of hypochlorous acid used as surgical irrigation solution to reduce postoperative complications: A systematic review and network meta-analysis.","authors":"Donald B Ayers, Paul J Niklewski, Evelyn J Rizzo, Robert Bilkovski","doi":"10.1016/j.ajic.2026.07.001","DOIUrl":"10.1016/j.ajic.2026.07.001","url":null,"abstract":"<p><p>The safety and effectiveness of hypochlorous acid used as surgical irrigation solution to reduce postoperative complications: A systematic review and network meta-analysis (NMA).</p><p><strong>Objective: </strong>The objective of this systematic literature review was to determine the safety and effectiveness of hypochlorous acid (HOCl) surgical irrigation solution compared to alternative treatments.</p><p><strong>Methods: </strong>PubMed and EMBASE databases were searched between 2009 and 2024. Quantitative synthesis technology was utilized for summary statistics and NMA. Meta-analytical regression analyses were performed using R, with 2-sided P values < .05 considered statistically significant.</p><p><strong>Results: </strong>Eighty-one studies, 13 of which reported HOCl as the primary intervention, were included for the final NMA, and 46 studies for subgroup analysis in abdominal surgery. Surgical site infection (SSI) was reported, and the NMA showed that the odds of SSI were nearly twice as likely (OR 1.97, (95% CI [1.13, 3.44]) for basic irrigation than that of HOCl. A pairwise, study-level, meta-analytical regression of abdominal subgroup studies, directly comparing HOCl irrigation with other agents, demonstrated a statistically significant reduction (P= .010) in SSI risk. Across eleven contrasts, HOCl reduced odds of SSI approximately 50% relative to basic irrigation.</p><p><strong>Conclusions: </strong>These findings indicate that HOCl irrigation provides a safe, statistically and clinically meaningful reduction in SSI risk compared with basic irrigation. Additional studies are warranted as the magnitude of benefit may vary by intervention type and surgical context.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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