Madysen Schreiber, Valerie L S Ocampo, Alexia Zhang, Angela Dusko, Eric W Hall
{"title":"Effectiveness of a mRNA vaccine booster dose against COVID-19 among Oregon health care personnel, January 2021 to June 2023.","authors":"Madysen Schreiber, Valerie L S Ocampo, Alexia Zhang, Angela Dusko, Eric W Hall","doi":"10.1016/j.ajic.2025.08.022","DOIUrl":"10.1016/j.ajic.2025.08.022","url":null,"abstract":"<p><strong>Background: </strong>The prioritization of US health care personnel (HCP) for early receipt of messenger RNA (mRNA) vaccines against SARS-CoV-2 allowed for the evaluation of the effectiveness of these vaccines in a real-world setting among a high-risk population. This study aimed to summarize the sociodemographic characteristics of eligible HCP in Oregon and estimate vaccine effectiveness (VE) of a mRNA COVID-19 vaccine booster dose.</p><p><strong>Methods: </strong>Using a case-control design, we compared HCP with positive antigen or nucleic acid amplification test SARS-CoV-2 test results (cases) to those with negative results (controls) and matched by site and test date. Using conditional logistic regression adjusted for age, sex, race and ethnicity, educational level, underlying conditions, and exposure to COVID-19, we estimated VE for a third COVID-19 vaccine booster dose using the screening method as 1-odds ratio × 100%.</p><p><strong>Results: </strong>VE of a mRNA booster dose was 62.6% (95% CI: 37.6%, 77.6%), compared with 2-dose primary mRNA vaccination. Additionally, HCP with a college degree (vs no degree), private insurance (vs government), and an income level $200K+ (vs < $50K) were more likely to have received the booster vaccine.</p><p><strong>Conclusions: </strong>The mRNA COVID-19 booster vaccine conferred approximately 63% protection against COVID-19 among Oregon HCP. These findings encourage remaining up-to-date with subsequent COVID-19 vaccines.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Egenia Dorsan, Frank A Drews, Lindsay D Visnovsky, Molly Leecaster, Styn M Jamu, Kristina Stratford, Tavis Huber, Hannah Higgs, Matthew H Samore
{"title":"A qualitative study of health care professionals' attitudes and practices of mobile equipment cleaning.","authors":"Egenia Dorsan, Frank A Drews, Lindsay D Visnovsky, Molly Leecaster, Styn M Jamu, Kristina Stratford, Tavis Huber, Hannah Higgs, Matthew H Samore","doi":"10.1016/j.ajic.2025.08.024","DOIUrl":"10.1016/j.ajic.2025.08.024","url":null,"abstract":"<p><strong>Background: </strong>Skilled nursing facilities report a high prevalence of multidrug-resistant organisms (MDROs) among their vulnerable patient population. While research has identified fomite-mediated transmission such as surfaces and health care professional (HCP) hands and clothing, emerging work on outbreaks has focused on the role of mobile medical equipment and associated cleaning procedures. This study sought to better characterize HCP attitudes toward cleaning and MDRO transmission, as well as describe cleaning practices for mobile equipment.</p><p><strong>Methods: </strong>Fifteen focus groups were conducted at 3 skilled nursing facilities (n ≥ 4 focus groups per site) with HCP likely to be tasked with cleaning mobile equipment (ie, nurses, certified nursing assistants, and environmental service workers). Focus groups were recorded and transcribed, reviewed for accuracy, and analyzed by 2 independent reviewers using thematic analysis.</p><p><strong>Results: </strong>Participants at all 3 sites described suboptimal cleaning practices of mobile equipment. Barriers to MDRO infection prevention and control practices included time pressure, knowledge gaps, and cost (material and staff).</p><p><strong>Conclusions: </strong>Many of these challenges can be addressed through role-specific education campaigns, substituting dedicated equipment (eg, vital signs carts) for mobile equipment where possible, and human factors-based interventions to support cleaning efforts within existing clinical workflow.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gargee Anand, Rijhul Lahariya, Asim Sarfraz, Jutang Babat Ain Tiewsoh
{"title":"Early screening of central line-associated bloodstream infections: A novel comparative analysis of AISI, SII, and SIRI as predictive biomarkers.","authors":"Gargee Anand, Rijhul Lahariya, Asim Sarfraz, Jutang Babat Ain Tiewsoh","doi":"10.1016/j.ajic.2025.08.020","DOIUrl":"10.1016/j.ajic.2025.08.020","url":null,"abstract":"<p><strong>Background: </strong>Central line-associated bloodstream infections (CLABSIs) are a significant cause of morbidity and early detection remains a challenge. This study aimed to evaluate the predictive value of inflammatory indices, Aggregate Index of Systemic Inflammation (AISI), Systemic Inflammatory Index (SII), and Systemic Inflammatory Response Index (SIRI), within 2 calendar days of central line insertion.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of patients who underwent central line insertion. Indices were calculated with the parameters collected within 2 calendar days post-insertion. Logistic regression analysis was used to assess the predictive performance.</p><p><strong>Results: </strong>Among 234 patients, 39 were CLABSI-positive. We found all 3 indices significantly elevated in the CLABSI-positive group and logistic regression confirmed each index as an independent predictor of CLABSI. AISI demonstrated the strongest overall performance, with an optimal cutoff of 3,257.4 yielding the highest area under the receiver operating characteristic curve (AUROC = 0.75) and a sensitivity of 87.2%. These indices may serve as the effective early screening marker for CLABSI in this cohort.</p><p><strong>Conclusions: </strong>AISI, SII, and SIRI offer promising, accessible and low-cost early warning tools for CLABSI prediction with AISI emerging as the most reliable marker within 2 calendar days of central line insertion, enabling timely decisions.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Corey H Basch, Erela Datuowei, Apeksha Mewani, Vincent Jones, Grace C Hillyer
{"title":"Analysis of Google News coverage during the 2025 US measles outbreak.","authors":"Corey H Basch, Erela Datuowei, Apeksha Mewani, Vincent Jones, Grace C Hillyer","doi":"10.1016/j.ajic.2025.08.018","DOIUrl":"10.1016/j.ajic.2025.08.018","url":null,"abstract":"<p><p>In 2025, US measles cases reached the highest levels since 2000, coinciding with persistent vaccine hesitancy and mixed media messaging. This study analyzed 100 Google News reports from June 2025. Nonmainstream outlets published more credentialed content (31.6% vs 11.6%, P = .02), yet fewer than 25% cited research. Most reports were informational (94%) and pro-vaccination (72%), though 28% presented mixed messaging. Findings highlight gaps in evidence-based reporting and opportunities for improved health communication.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felicia Scaggs Huang, Qing Duan, Abraham Araya, Anna Sheets, Joshua K Schaffzin
{"title":"Effectiveness of COVID-19 vaccination to prevent health care personnel absences: A single site experience.","authors":"Felicia Scaggs Huang, Qing Duan, Abraham Araya, Anna Sheets, Joshua K Schaffzin","doi":"10.1016/j.ajic.2025.08.016","DOIUrl":"10.1016/j.ajic.2025.08.016","url":null,"abstract":"<p><p>Absenteeism from infections has a significant impact on the health care workforce. We found that COVID-19 vaccination as a condition of employment reduced absenteeism in health care personnel until February 2022 when absences became higher in vaccinated than unvaccinated health care personnel. Maintaining a COVID-19 vaccine mandate is challenging given changing epidemiology.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to editor: Influencing factors and benefits of repeated sampling for mycobacterial culture: A real-world study.","authors":"Ruihang Luo, Hanlin Jin, Zhehao Wu, Maosen Liu","doi":"10.1016/j.ajic.2025.08.019","DOIUrl":"10.1016/j.ajic.2025.08.019","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blood cultures processing after death: Best practice, cost-effective, or HAI reduction measure.","authors":"Dixon Heather, Schafer Mathea, Amelia Cardiff, Kenneth Smith, Yassin Mohamed","doi":"10.1016/j.ajic.2025.08.014","DOIUrl":"10.1016/j.ajic.2025.08.014","url":null,"abstract":"<p><strong>Background: </strong>Blood cultures (BC) are essential for the diagnosis of bloodstream infections (BSI). BSI can be inaccurately attributed due to BC contamination or bacterial translocation. Reporting BCs after patient death (PD) can be inaccurate and potentially increase BSI incidence.</p><p><strong>Methods: </strong>The study was performed in two phases, a retrospective review of positive BCs that resulted after PD and a prospective phase of discontinuing BC after PD. A cost-benefit analysis was conducted of the program considering the cost of HAIs.</p><p><strong>Results: </strong>Retrospectively, there were 4,868 positive BC (10%) and 407 (8%) were finalized after PD. The BCs that resulted after PD and were identified as HAI included 8 CLABSI (Central Line Associated Blood Stream Infections), 11 primary and 25 secondary BSIs. During the prospective phase, the infection preventionists reviewed 795 patients and identified 285 with pending BC at the time of PD. 90.5% of these cultures were cancelled, reducing the number of potential HAI events related to BCs after PD to seven.</p><p><strong>Conclusions: </strong>HAI rates could be falsely increased as NHSN (National Healthcare Safety Network) definitions do not address positive BC after PD. Implementing a stewardship protocol to discontinue BCs after PD is appropriate clinical practice and likely cost beneficial.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathleen McMullen, Shelley Bujnak, Steve Kovak, Jennifer Jaffe
{"title":"Flexible endoscope sterilizer usability study in an endoscopy center.","authors":"Kathleen McMullen, Shelley Bujnak, Steve Kovak, Jennifer Jaffe","doi":"10.1016/j.ajic.2025.08.013","DOIUrl":"10.1016/j.ajic.2025.08.013","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel Gee, Kathleen Haurin, Arjun Saxena, Katherine I DiSantis
{"title":"The impact of nutritional status on surgical site infection rates among total joint arthroplasty patients: A systematic review.","authors":"Rachel Gee, Kathleen Haurin, Arjun Saxena, Katherine I DiSantis","doi":"10.1016/j.ajic.2025.08.015","DOIUrl":"10.1016/j.ajic.2025.08.015","url":null,"abstract":"<p><strong>Background: </strong>The increasing prevalence of total joint arthroplasty (TJA) procedures, driven by an aging population, highlights the importance of identifying modifiable risk factors for surgical complications. Malnutrition has been associated with adverse outcomes, including higher rates of surgical site infections (SSIs). Food insecurity, affecting approximately 9% of U.S. adults aged 65 and older, may contribute to malnutrition and influence postoperative recovery. This systematic review examines the relationship between food security, nutritional status, and SSIs in patients undergoing TJA.</p><p><strong>Methods: </strong>A systematic search of PubMed and CINAHL was conducted between January and October 2024 for studies published before December 2023, following PRISMA guidelines. Eligible studies assessed the impact of food access and/or nutritional status on SSI incidence among TJA patients. Data on study characteristics, nutritional indicators, SSI rates, and postoperative outcomes were extracted and analyzed.</p><p><strong>Results: </strong>Of 2,766 articles identified, 20 met inclusion criteria. Malnutrition, particularly low serum albumin, was significantly associated with increased SSIs, longer hospital stays, higher complication rates, and increased readmissions. However, no studies directly evaluated the impact of food insecurity on SSIs.</p><p><strong>Conclusions: </strong>These findings support the implementation of preoperative nutritional and food security screening to identify at-risk patients and guide interventions that may improve postoperative outcomes.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Prascius, Alex Wells, Anne Marie Collier, Amanda Renard, Deanna Hooper, Tricia Stein
{"title":"Reduction of hospital-onset methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with the use of twice daily alcohol-based nasal antiseptic in intensive care units.","authors":"Sarah Prascius, Alex Wells, Anne Marie Collier, Amanda Renard, Deanna Hooper, Tricia Stein","doi":"10.1016/j.ajic.2025.08.006","DOIUrl":"10.1016/j.ajic.2025.08.006","url":null,"abstract":"<p><strong>Background: </strong>A 191-bed hospital within a Midwest health care system experienced an increase in hospital acquired Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. In response, the hospital sought a targeted intervention for MRSA prevention within 2 intensive care units using an alcohol based nasal antiseptic.</p><p><strong>Methods: </strong>In August 2021, Infection Prevention and Control (IPC) partnered with Nursing and the alcohol-based nasal antiseptic product vendor to implement the product in the 2 units. Nasal antiseptic was administered twice daily. To measure process adherence, a report was created within the electronic medical record to track compliance. Patient tracking and communication of data reports to nurse leadership by IPC began shortly afterward.</p><p><strong>Results: </strong>MRSA standardized infection ratios (SIR) declined with an SIR of 1.18 in 2021 to an SIR of 0.90 in 2023. The total number of MRSA cases decreased from 2021 to 2022 with 4 cases and 1 case, respectively.</p><p><strong>Discussion: </strong>Barriers were identified, including personnel permitted to administer alcohol-based antiseptic, product location, and administration documentation. As these were addressed, compliance in administration began to increase. Manually tracking compliance was later replaced with an automated report for sustainability purposes. Options available to analyze the data were limited due to lack of control data.</p><p><strong>Conclusion: </strong>Implementation of universal decolonization using twice daily alcohol based nasal antiseptic can be accomplished and assessed with the development of an electronic data tracking process.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}