{"title":"Sex differences in Acinetobacter baumannii infections: A comprehensive analysis of antibiotic resistance patterns in Hebei Province, China.","authors":"Xiaoxuan Liu, Pu Qin, Hainan Wen, Weigang Wang, Qiuyue Huo, Qianqing Li, Jianhong Zhao","doi":"10.1016/j.ajic.2025.07.011","DOIUrl":"10.1016/j.ajic.2025.07.011","url":null,"abstract":"<p><strong>Background: </strong>To investigate the clinical distribution and antimicrobial resistance patterns of Acinetobacter baumannii in Hebei Province, with a focus on sex-based differences.</p><p><strong>Methods: </strong>Surveillance data from 45 hospitals across Hebei Province were retrospectively analyzed from January 2020 to December 2022. Isolates were stratified by patient sex, age group, and specimen type. Data were processed using WHONET 5.6 and GraphPad Prism 8.4.0.</p><p><strong>Results: </strong>A total of 27,754 A baumannii strains were collected, with 84.0% isolated from respiratory specimens. Male patients accounted for 65.9% of cases, nearly double that of females. Isolates from males showed higher resistance rates to β-lactamase inhibitor combinations, fluoroquinolones, cephalosporins, aminoglycosides, and carbapenems, particularly in the 15 to 50-year age group. Sex-related differences in resistance were also influenced by infection site.</p><p><strong>Conclusions: </strong>Marked sex differences exist in A baumannii infection and antibiotic resistance patterns in Hebei Province, especially among males of reproductive age. These findings highlight the potential role of sex-specific factors in antimicrobial resistance and may inform targeted prevention and treatment strategies.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zongke Long, Shengjia Xu, Jian Liu, Bingyan Zhang, Peiyun Zhou, Fang Xue, Lan Gao, Siya Meng, Xiaorong Luan
{"title":"Evaluation of the economic burden of carbapenem-resistant Enterobacteriaceae nosocomial infection in intensive care unit patients: A propensity score--adjusted analysis.","authors":"Zongke Long, Shengjia Xu, Jian Liu, Bingyan Zhang, Peiyun Zhou, Fang Xue, Lan Gao, Siya Meng, Xiaorong Luan","doi":"10.1016/j.ajic.2025.07.007","DOIUrl":"10.1016/j.ajic.2025.07.007","url":null,"abstract":"<p><strong>Background: </strong>This study examines the impact of carbapenem-resistant Enterobacteriaceae (CRE) infections relative to carbapenem-sensitive Enterobacteriaceae (CSE) on the length of stay and hospitalization costs of patients in the intensive care unit (ICU).</p><p><strong>Methods: </strong>We retrospectively analyzed patients who developed nosocomial infections with Enterobacteriaceae bacteria while admitted to the ICU of a university-affiliated general hospital in China between January 2022 and December 2024. Using propensity score matching (PSM), matched 1:1 to analyze their length of stay and hospitalization costs. A generalized linear model (GLM) was used to calculate the odds ratio (OR) of matching them.</p><p><strong>Results: </strong>Of the 346 patients, 90 had CRE infections, and 256 had CSE infections. After PSM, patients in the CRE group had an extended hospital stay (8 days longer, P < .001) and higher hospital costs (26,842.44 Yuan more, P = .039). The GLM analysis showed that CRE-infected patients had significantly higher hospital stays (OR: 1.456, 95% CI: 1.176-1.806) and hospital costs (OR: 1.303, 95% CI: 1.107-1.536).</p><p><strong>Conclusions: </strong>CRE infections in ICU patients are associated with longer hospital stays and increased hospitalization costs. Clinicians should strengthen infection prevention and control measures to reduce the incidence of CRE infections and conserve medical resources.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing infection prevention and control practices among nurses: The mediating role of resilience and the moderating effect of training participation.","authors":"Yeongmi Kim, Jihea Choi","doi":"10.1016/j.ajic.2025.07.009","DOIUrl":"10.1016/j.ajic.2025.07.009","url":null,"abstract":"<p><strong>Background: </strong>Infection prevention and control (IPC) practices are essential for pandemic preparedness. This study examined the individual-level cognitive and psychological factors influencing IPC practices among nurses during the coronavirus disease 2019 pandemic.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted with 120 nurses in Korea from July 7 to August 31, 2022. Partial least squares-based path analysis was performed to assess the relationships among knowledge, nursing attitude, resilience, IPC practices, and training participation, as well as the mediation and moderation effects.</p><p><strong>Results: </strong>Knowledge (β = 0.216, P = .007) and resilience (β = 0.211, P = .014) significantly influenced IPC practices. Resilience significantly mediated the relationship between nursing attitude and IPC practices. Training participation significantly moderated the effects of knowledge on resilience (β = 0.184, P = .004) and nursing attitude on IPC practices (β = 0.158, P = .025). The adjusted R<sup>2</sup> value of resilience was 13.3%, whereas that of IPC practice was 18.6%.</p><p><strong>Conclusions: </strong>Nurses' knowledge and attitude enhance IPC practices through the mediating effect of resilience and the moderating role of training participation. Prioritizing practical reinforcement training and resilience-building programs can strengthen IPC compliance and improve infection prevention in future outbreaks.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinli Shen, Jin Zhao, Songjun Ji, Lulu Jin, Xinling Pan
{"title":"Influencing factors and benefits of repeated sampling for mycobacterial culture: A real-world study.","authors":"Xinli Shen, Jin Zhao, Songjun Ji, Lulu Jin, Xinling Pan","doi":"10.1016/j.ajic.2025.07.006","DOIUrl":"10.1016/j.ajic.2025.07.006","url":null,"abstract":"<p><strong>Background: </strong>Bacterial culture plays a crucial role in diagnosing Mycobacterium-induced infections, and repeated sampling significantly improves positive rates in both culture and microscopy tests. However, the factors influencing repeated sampling and the benefits across different patient subpopulations remain unclear.</p><p><strong>Methods: </strong>This retrospective study included patients suspected of respiratory-tract infections at a tertiary hospital between January 2010 and December 2023. Data on sampling frequency for mycobacterial culture, culture results, clinical features, radiological examinations, and laboratory tests were extracted from the clinical records database.</p><p><strong>Results: </strong>Of the 16,930 cases, 6.2% (1,047/16,930) had repeated specimens, which yielded a higher positivity rate in culture results (23.6%) than single samples (14.8%, P < .001). Repeated sampling was more common among patients with positive acid-fast bacilli, or T. spot assay results, or pulmonary cavities than those with negative results or without pulmonary cavities. However, repeated sampling did not significantly increase culture positivity in patients with positive acid-fast bacilli (P = .436), Gene Xpert (P = .688), or T. spot (P = .841) assay results, or chronic obstructive pulmonary disease (P = .269).</p><p><strong>Conclusions: </strong>Repeated sampling is influenced by clinical features and laboratory findings. Although repeated sampling may enhance mycobacterial culture detection rates, its benefit appears limited in certain patient groups.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel Yoken BA , Caroline A. O’Neil MA, MPH , Kate Peacock MPH , Candice Cass BS , Meghan A. Wallace BS , Kelly Alvarado BS , Mostafa Amor BS , Emily Struttmann BA , Daniel Park BS , David McDonald BA , Karl Hock BA , Hilary Babcock MD, MPH , Carey-Ann D. Burnham PhD , Christopher W. Farnsworth PhD , Jennie H. Kwon DO, MSCI
{"title":"SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021","authors":"Rachel Yoken BA , Caroline A. O’Neil MA, MPH , Kate Peacock MPH , Candice Cass BS , Meghan A. Wallace BS , Kelly Alvarado BS , Mostafa Amor BS , Emily Struttmann BA , Daniel Park BS , David McDonald BA , Karl Hock BA , Hilary Babcock MD, MPH , Carey-Ann D. Burnham PhD , Christopher W. Farnsworth PhD , Jennie H. Kwon DO, MSCI","doi":"10.1016/j.ajic.2025.07.005","DOIUrl":"10.1016/j.ajic.2025.07.005","url":null,"abstract":"<div><div>In this prospective cohort study, 30 health care personnel with a known SARS-CoV-2 exposure provided oropharyngeal swabs for polymerase chain reaction (PCR) testing and blood specimens for serologic testing at 2 time points postexposure. At a median 7<!--> <!-->days postexposure (range, 1-13<!--> <!-->days), none had a positive PCR and 1 (3%) had a reactive antibody test. No additional participants were PCR or antibody-positive at a median 25<!--> <!-->days postexposure (range, 14-36<!--> <!-->days).</div></div>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"53 10","pages":"Pages 1124-1126"},"PeriodicalIF":2.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huiwen Xu, John R Bowblis, Shuang Li, Yong-Fang Kuo, James S Goodwin
{"title":"Nursing home visitor policy and COVID-19 infection rates.","authors":"Huiwen Xu, John R Bowblis, Shuang Li, Yong-Fang Kuo, James S Goodwin","doi":"10.1016/j.ajic.2025.07.003","DOIUrl":"10.1016/j.ajic.2025.07.003","url":null,"abstract":"<p><strong>Background: </strong>During the Coronavirus disease 2019 (COVID-19) pandemic, Ohio was the only state that collected facility-level visitation data after rescinding its ban on visitors. This study examines the association of allowing outside visitors with COVID-19 infection rates among nursing home residents.</p><p><strong>Methods: </strong>We assembled a cohort of Ohio nursing homes over 9 weeks (November 1, 2020-January 3, 2021). For each week, we obtained whether a facility allowed visitors, any COVID-19 infections among residents, community infection rates, and other facility characteristics. Marginal structural models examined the association of allowing visitors with resident infections, weighted by the inverse of the probability of allowing visitors.</p><p><strong>Results: </strong>Of the 677 nursing homes with visitation data, the number of facilities allowing visitors during any week from October 29, 2020 to January 3, 2021 ranged from 226 to 327. Marginal models substantially improved the balance in covariates. In the marginal models, allowing visitors was not associated with the unadjusted rates or adjusted odds of new infection among residents (odds ratio = 0.92, 95% confidence interval: 0.78, 1.08). The result was similar in sensitivity analyses on the lagged effect of allowing visitors.</p><p><strong>Conclusions: </strong>Allowing visitors in the context of adequate preventive measures was safe, even during a period of high community transmission and before vaccine rollouts.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geneva M Wilson, Ravyn Jackson, Sara Abdelrahim, Taissa Bej, Robin L P Jump, Charlesnika T Evans
{"title":"Determining appropriateness of treatment by evaluating providers' documentation of UTI symptoms.","authors":"Geneva M Wilson, Ravyn Jackson, Sara Abdelrahim, Taissa Bej, Robin L P Jump, Charlesnika T Evans","doi":"10.1016/j.ajic.2025.07.004","DOIUrl":"10.1016/j.ajic.2025.07.004","url":null,"abstract":"<p><strong>Background: </strong>Asymptomatic bacteriuria (ASB) is a positive urine culture (UCX) without urinary symptoms. ASB treatment is discouraged due to clinical ineffectiveness and increased risk of antimicrobial resistance. This retrospective cohort determined the prevalence of inappropriate ASB prescribing.</p><p><strong>Methods: </strong>Eligible patients included those seen at any Department of Veterans Affairs outpatient clinic with a positive UCX from January 1, 2019, to December 31, 2022. Visits were placed into 3 categories based on documentation of urinary tract infection (UTI)-specific symptoms: UTI-present, UTI-unlikely, and UTI-absent. Provider reasoning for antibiotic prescriptions was assessed for UTI-unlikely and UTI-absent visits. The time between the visit and prescription dates was also evaluated.</p><p><strong>Results: </strong>A total of 484 visits were analyzed. There were 258 (53%) UTI-present visits, 113 (23%) UTI-unlikely visits, and 113 (23%) UTI-absent. Two-thirds of the UTI-absent visits and 58% of the UTI-unlikely visits resulted in antibiotic prescriptions. Over one-third (37.6%) of the prescriptions in UTI-absent visits and 27% in UTI-unlikely visits were in response to the urinalysis or UCX results. Most prescriptions given before the visit or more than 9 days after were inappropriate.</p><p><strong>Conclusions: </strong>In outpatient clinics, most inappropriate antibiotics resulted from providers reacting to laboratory test results. This emphasizes the need for increased ASB diagnostic and antimicrobial stewardship.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author response: Impact of antibiotic treatment and predictors for subsequent infections in multidrug-resistant Pseudomonas Aeruginosa catheter-associated asymptomatic bacteriuria","authors":"Chisook Moon MD, PhD , Yu Mi Wi MD, PhD","doi":"10.1016/j.ajic.2025.05.009","DOIUrl":"10.1016/j.ajic.2025.05.009","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"53 8","pages":"Pages 913-914"},"PeriodicalIF":3.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}