Russian Journal of Coordination Chemistry最新文献_第5页

Synthesis, Spectroscopic Characterization, Computational Studies and In Vitro Anticancer Investigations of a Novel Platinum(II)–Hypoxanthine Complex: Targeting ERα and Inducing Apoptosis in MCF-7 Cells 新型铂(II) -次黄嘌呤复合物的合成、光谱表征、计算研究及体外抗癌研究：靶向ERα并诱导MCF-7细胞凋亡

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-05-26 DOI: 10.1134/S1070328425601311

Ç. Bilkan

{"title":"Synthesis, Spectroscopic Characterization, Computational Studies and In Vitro Anticancer Investigations of a Novel Platinum(II)–Hypoxanthine Complex: Targeting ERα and Inducing Apoptosis in MCF-7 Cells","authors":"Ç. Bilkan","doi":"10.1134/S1070328425601311","DOIUrl":"10.1134/S1070328425601311","url":null,"abstract":"In this study, a novel platinum(II) coordination complex, Pt(HX)2Cl2, incorporating hypoxanthine ligands, was synthesized and fully characterized using Fourier-transform infrared (FTIR), 1H/13C nuclear magnetic resonance (NMR) spectroscopy, and density functional theory (DFT) calculations. Spectroscopic data confirmed that coordination occurs via the N7 nitrogen atoms of the ligand in a distorted square-planar geometry. The anticancer potential of the complex was evaluated against ERα-positive MCF‑7 breast cancer cells and compared with cisplatin and tamoxifen. The complex exhibited a dose-dependent antiproliferative activity with an IC50 value of 56.67 µg/mL. Although less aggressive than cisplatin (IC50 = 20.0 µg/mL) at lower doses, Pt(HX)2Cl2 achieved comparable efficacy at therapeutic concentrations (reducing viability to 28% at 75 µg/mL). Crucially, flow cytometric analysis revealed that the compound induces cell death primarily via apoptosis (34.9%) rather than necrosis, matching the apoptotic efficacy of cisplatin (36.9%) and tamoxifen (39.2%). Molecular docking simulations indicated that the complex acts as a high-affinity dual-targeting agent, exhibiting a superior binding score (–107.06) against the estrogen receptor alpha (ERα) compared to the reference drugs. Furthermore, in silico ADMET and toxicity assessments predicted a significantly improved safety profile, characterized by lower systemic toxicity (Class 4), reduced risks of hepatotoxicity and neurotoxicity, and minimal blood-brain barrier penetration. Collectively, these findings highlight Pt(HX)2Cl2 as a promising, safer alternative to classical platinum-based chemotherapeutics with a distinct apoptosis-inducing mechanism.","PeriodicalId":759,"journal":{"name":"Russian Journal of Coordination Chemistry","volume":"52 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148012002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial and Cytotoxic Properties of Zinc and Copper(II) Coordination Compounds with Bis((pyridin-2-yl)-1,2,4-triazolyl)alkanes 锌和铜（II）双（（吡啶-2-基）-1,2,4-三唑基）烷配位化合物的抗菌和细胞毒性

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-05-26 DOI: 10.1134/S1070328425601517

A. B. Kiyaev, S. L. Safronyuk, I. M. Samokhvalov, K. S. Zakharov, A. N. Gusev, A. M. Katsev, M. A. Kiskin

引用次数: 0

Copper(I) Thiocyanate Complexes with tert-Butylpyridylphosphine Ligands: Synthesis and Photophysical Properties 叔丁基吡啶膦配体硫氰酸铜配合物的合成及其光物理性质

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-04-01 DOI: 10.1134/S1070328425601426

A. Yu. Baranov, I. Yu. Bagryanskaya, A. V. Artem’ev

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Spin Crossover–Few-Layer Graphene Nanocomposites: Synthesis and Magnetic Properties of Fe(NH2trz)3A2@FLG (A = Cl–, Br–) 自旋交叉-少层石墨烯纳米复合材料Fe(NH2trz)3A2@FLG （A = Cl -, Br -）的合成与磁性能

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-04-01 DOI: 10.1134/S1070328425601244

L. G. Lavrenova, V. G. Makotchenko, E. V. Korotaev, E. Yu. Gerasimov, A. I. Bulavchenko, O. G. Shakirova

{"title":"Spin Crossover–Few-Layer Graphene Nanocomposites: Synthesis and Magnetic Properties of Fe(NH2trz)3A2@FLG (A = Cl–, Br–)","authors":"L. G. Lavrenova, V. G. Makotchenko, E. V. Korotaev, E. Yu. Gerasimov, A. I. Bulavchenko, O. G. Shakirova","doi":"10.1134/S1070328425601244","DOIUrl":"10.1134/S1070328425601244","url":null,"abstract":"Stable nanoparticles capable of experiencing spin crossover with hysteresis on curves of the µeff(T) dependence near ambient temperature have been synthesized. The earlier synthesized complexes [Fe(NH2trz)3]Cl2·H2O and [Fe(NH2trz)3]Br2·H2O exhibiting sharp spin crossover with hysteresis are used for the preparation of the nanocomposites. Few-layer graphene (FLG) formed by the microwave heating of the intercalated polydicarbonfluoride compound with acetone served as the basis. Nanoparticles Fe(NH2trz)3Cl2@FLG (SCO1-n) and Fe(NH2trz)3Br2@FLG (SCO2-n) (n = 1–3) have been prepared (n indicates time (h) of the treatment of the initial particles with ultrasound). The effective hydrodynamic diameter of particles of the complexes in ethanol is determined by photon correlation spectroscopy. The structures and microstructures of the samples are studied by high resolution transmission electron microscopy. The study of the µeff(T) dependence shows that all synthesized composites exhibit crossover with hysteresis on the µeff(T) curves. The temperature and character of the transition depend substantially on the particle size. The variation of the ultrasonication time during the preparation of the composites makes it possible to purposefully modify their magnetic properties.","PeriodicalId":759,"journal":{"name":"Russian Journal of Coordination Chemistry","volume":"51 12","pages":"1172 - 1186"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Photochromic Zinc(II) Complexes with 1,2,4-Triazole-Containing Schiff Bases 新型含1,2,4-三唑希夫碱光致变色锌（II）配合物

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-04-01 DOI: 10.1134/S1070328425601529

A. A. Bovkunova, A. A. Anisimov, V. E. Gontcharenko, E. S. Bazhina, I. V. Taydakov, I. L. Eremenko, I. V. Ananyev

{"title":"New Photochromic Zinc(II) Complexes with 1,2,4-Triazole-Containing Schiff Bases","authors":"A. A. Bovkunova, A. A. Anisimov, V. E. Gontcharenko, E. S. Bazhina, I. V. Taydakov, I. L. Eremenko, I. V. Ananyev","doi":"10.1134/S1070328425601529","DOIUrl":"10.1134/S1070328425601529","url":null,"abstract":"The reactions of zinc(II) bromide with Schiff bases, 4-(2-hydroxyphenyl)methyleneamino-1,2,4-triazole (HL1) and 4-(2-hydroxy-3-methoxyphenyl)methyleneamino-1,2,4-triazole (HL2), yielded the complexes [Zn(HL1)2Br2] (I) and [Zn(HL2)2Br2] (II). It was shown that I and II are also formed upon the addition of hydrobromic acid to a suspension of zinc(II) coordination compounds containing anionic [L1]– and [L2]– ligands in MeOH. The crystal structures of compounds I and II were determined by single-crystal X-ray diffraction (CIF files CCDC no. 2502710 (I), no. 2502711 (II)). It was found that upon complexation with Zn2+ ions, conformational changes occur in the HL1 and HL2 molecules. This facilitates intramolecular proton transfer, causing compounds I and II to exhibit a photochromic effect, which is confirmed by diffuse reflectance spectroscopy data.","PeriodicalId":759,"journal":{"name":"Russian Journal of Coordination Chemistry","volume":"51 12","pages":"1082 - 1094"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination Chemistry: Part 1. Electronic Structure, Stability, Reaction Mechanisms, Nonaqueous Solvents 配位化学：第1部分电子结构，稳定性，反应机理，非水溶剂

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-04-01 DOI: 10.1134/S1070328425601438

M. N. Sokolov, A. L. Gushchin, D. G. Samsonenko

引用次数: 0

Synthesis, Study of the Structure, and Molecular Docking of Cu(II) Coordination Compounds with 3-Benzylidene-1-pyrrolines 铜（II）配位化合物与3-苄基吡咯啉的合成、结构及分子对接研究

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-04-01 DOI: 10.1134/S1070328425601268

O. V. Zvereva, M. A. Shmelev, E. S. Bazhina, Yu. K. Voronina, I. L. Eremenko

{"title":"Synthesis, Study of the Structure, and Molecular Docking of Cu(II) Coordination Compounds with 3-Benzylidene-1-pyrrolines","authors":"O. V. Zvereva, M. A. Shmelev, E. S. Bazhina, Yu. K. Voronina, I. L. Eremenko","doi":"10.1134/S1070328425601268","DOIUrl":"10.1134/S1070328425601268","url":null,"abstract":"A series of copper nitrate complexes with 3-benzylidene-1-pyrroline (LH) and its derivatives [3-(4-chlorobenzylidene)-1-pyrroline (LCl), 3-(4-bromobenzylidene)-1-pyrroline (LBr), and 3-(4-methoxybenzylidene)-1-pyrroline (LOMe)] was synthesized: [Cu(H2O)2(LH)2(NO3)2] (IH), [Cu(LCl)2(NO3)2] (IICl), [Cu(LBr)2(NO3)2] (IIBr), and [Cu(LOMe)2(NO3)2] (IIOMe). The obtained coordination compounds were characterized by X-ray diffraction, IR spectroscopy, and CHN analysis. UV/Vis spectra of the complexes in solutions were studied. The structure and crystal packing of the complexes were analyzed in detail, and the main structuring non-covalent interactions in the crystals were identified. The interaction of synthesized coordination compounds with the HER2 (human epidermal growth factor receptor) was investigated using molecular docking.","PeriodicalId":759,"journal":{"name":"Russian Journal of Coordination Chemistry","volume":"51 12","pages":"1125 - 1139"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Copper(II) Indole Carboxylate Complexes: Features of Synthesis, Structural Organization, and Biological Activity 铜（II）吲哚羧酸盐配合物：合成、结构组织和生物活性的特点

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-04-01 DOI: 10.1134/S1070328425601463

K. A. Koshenskova, L. S. Razvorotneva, A. D. Filippova, F. M. Dolgushin, N. V. Gogoleva, O. B. Bekker, V. O. Shender, I. L. Eremenko, I. A. Lutsenko

{"title":"First Copper(II) Indole Carboxylate Complexes: Features of Synthesis, Structural Organization, and Biological Activity","authors":"K. A. Koshenskova, L. S. Razvorotneva, A. D. Filippova, F. M. Dolgushin, N. V. Gogoleva, O. B. Bekker, V. O. Shender, I. L. Eremenko, I. A. Lutsenko","doi":"10.1134/S1070328425601463","DOIUrl":"10.1134/S1070328425601463","url":null,"abstract":"Complexes [Cu2(ind)4(EtOH)2] (I), [Cu(ind)2bpy]·1.15MeCN·0.85MeOH (II), and [Cu(ind)(phen)2]+ ·ind–·0.5Hind·1.5H2O (III) were synthesized using slow diffusion of the starting solutions of copper(II) acetate, indole-2-carboxylic acid (Hind), and oligopyridines (2,2'-bipyridine (bpy)/1,10-phenanthroline (phen)). The structures of the complexes were established by single crystal X-ray diffraction and the phase purity was confirmed by powder X-ray diffraction. According to single-crystal X-ray diffraction data, I and II are molecular complexes, while III is an ionic complex comprising the cationic mononuclear [Cu(ind)(phen)2]+ moiety in the independent part of the unit cell and the ind– anion in the outer sphere. The coordination environment of copper(II) cation (C.N.Cu 5) is described by a square pyramid (I, III) or a planar square with C.N.Cu 4 (II). The supramolecular level involves both hydrogen bonds and non-covalent interactions, mainly of the π…π and C–H…π type. The stability of salt solutions of I–III was studied by spectrophotometry in comparison with the free ligands and over a period of 2 days. Complexes I–III were investigated for biological activity: the antimycobacterial activity was evaluated against the non-pathogenic Mycolicibacterium smegmatis strain and the cytotoxicity of III was assessed against the test human ovarian adenocarcinoma cells (SKOV3).","PeriodicalId":759,"journal":{"name":"Russian Journal of Coordination Chemistry","volume":"51 12","pages":"1159 - 1171"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Template Synthesis of Functionalized o-Iminosemiquinones and o-Iminoquinones in the Coordination Sphere of Nickel(II) and Zinc(II) Ions 镍（II）和锌（II）离子配位球中功能化邻亚胺半醌和邻亚胺醌的模板合成

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-04-01 DOI: 10.1134/S1070328425601475

N. O. Druzhkov, T. N. Kocherova, I. N. Meshcheryakova, A. V. Cherkasov, I. A. Yakushev, S. V. Baryshnikova, P. V. Dorovatovskii, A. V. Piskunov

{"title":"Template Synthesis of Functionalized o-Iminosemiquinones and o-Iminoquinones in the Coordination Sphere of Nickel(II) and Zinc(II) Ions","authors":"N. O. Druzhkov, T. N. Kocherova, I. N. Meshcheryakova, A. V. Cherkasov, I. A. Yakushev, S. V. Baryshnikova, P. V. Dorovatovskii, A. V. Piskunov","doi":"10.1134/S1070328425601475","DOIUrl":"10.1134/S1070328425601475","url":null,"abstract":"New nickel(II) bis-o-iminobenzosemiquinolate complexes (L1)2Ni (I) and (L2)2Ni (II) were prepared by template synthesis using o- and m-phenylenediamine compounds with NiCl2 ((o-PDA)2NiCl2 and (m-PDA)2NiCl2) as precursors in the reaction with thallium(I) 3,5-di-tert-butyl-o-benzosemiquinolate. The o-phenylenediamine complex with ZnI2 ((o-PDA)ZnI2) was allowed to react with 4-(tert-butyl)-5-methoxy-o-benzoquinone to give L3ZnI2 (III) containing a neutrally coordinated molecule of new o-iminobenzoquinone. It was shown that the condensation of o(m)-phenylenediamine with o-benzosemiquinone/o-benzoquinone takes place in the coordination sphere of nickel(II) and zinc(II) ions, giving rise to new o-iminobenzosemiquinolate/o-iminobenzoquinone ligands functionalized with an amino group. The structure of complexes I and III was confirmed by X-ray diffraction.","PeriodicalId":759,"journal":{"name":"Russian Journal of Coordination Chemistry","volume":"51 12","pages":"1051 - 1059"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination Complexes of Arylimine Derivatives of Aceanthrylene-1,2-dione 乙炔-1,2-二酮芳胺衍生物的配位配合物

IF 1.1 3区化学

Russian Journal of Coordination Chemistry Pub Date : 2026-04-01 DOI: 10.1134/S107032842560130X

G. V. Markin, R. V. Rumyantsev, G. Yu. Zhigulin, A. A. Belikov, G. K. Fukin, S. Yu. Ketkov

引用次数: 0