Allergologia et immunopathologia最新文献

{"title":"Enhancing the diagnostic accuracy of the IgE crosslinking-induced luciferase expression (EXiLE) method for walnut allergy.","authors":"Hikaru Sugita, Yuji Mori, Tetsushi Yoshikawa, Yasuto Kondo","doi":"10.15586/aei.v53i2.1267","DOIUrl":"https://doi.org/10.15586/aei.v53i2.1267","url":null,"abstract":"<p><strong>Background: </strong>Walnut (<i>Juglans regia</i>) frequently triggers nut allergies in the United Kingdom and in the United States, with increasing cases in Japan. While oral food challenges (OFCs) are the definitive method for diagnosing these allergies, they pose the risk of symptom provocation, necessitating safer alternative tests. Our aim here was to evaluate the diagnostic utility of IgE (immunoglobulin E) crosslinking-induced luciferase expression (EXiLE) for walnut allergy compared with the walnut-specific IgE (sIgE) test, Jug r 1-sIgE test, and skin prick test (SPT).</p><p><strong>Methods: </strong>This retrospective study analyzed 55 patients tested for walnut allergy (WA) at Fujita Health University Bantane Hospital from January 2021 to December 2023. Among them, 38 had allergic reactions to walnuts based on history or OFCs and 17 did not. We evaluated the sensitivity, specificity, positive predictive value, negative predictive value, and the area under the curve (AUC) of the receiver operating characteristic curve.</p><p><strong>Results: </strong>The EXiLE method (AUC = 0.938) exhibited superior diagnostic accuracy compared to the walnut-sIgE and comparable performance to Jug r 1-sIgE and SPT. The optimal cutoff value of 1.26-fold change demonstrated high sensitivity (0.92), specificity (0.88), positive predictive value (0.92), and negative predictive value (0.82). The EXiLE method yielded positive results in all three cases with negative Jug r 1-sIgE (< 0.35 U_A/mL).</p><p><strong>Conclusion: </strong>The EXiLE method showed high sensitivity and specificity for diagnosing WA, indicating its potential clinical utility. Furthermore, the combination of Jug r 1-sIgE and EXiLE may enhance diagnostic accuracy. Future large-scale studies are warranted to confirm these findings and establish comprehensive diagnostic protocols.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"89-99"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change of administration route of allergen immunotherapy: Rates and causes.","authors":"Cristina Rivas-Juesas, Ana Delgado Vicente","doi":"10.15586/aei.v53i2.1196","DOIUrl":"https://doi.org/10.15586/aei.v53i2.1196","url":null,"abstract":"<p><p>Allergen immunotherapy (AIT) has shown efficacy in the short and the long term in the management of allergic respiratory diseases, and it's administered subcutaneously (subcutaneous immunotherapy, or SCIT) or sublingually (sublingual immunotherapy, or SLIT), being both effective and safe options.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 2","pages":"10-12"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced enterocolitis, a new condition under consideration.","authors":"Lucía Hernando Marín, Ana María Segura Machado, Marta Castro Ramos, Javier Torres-Borrego","doi":"10.15586/aei.v53i1.1202","DOIUrl":"10.15586/aei.v53i1.1202","url":null,"abstract":"<p><p>Drug-induced enterocolitis syndrome (DIES), little known due to its recent description, is analogous to food protein-induced enterocolitis syndrome (FPIES). Both processes are more frequent in pediatric age and share diagnostic criteria, the main one being the appearance of persistent vomiting 1-4 hours after ingestion of the drug or food, in the absence of IgE-mediated allergy symptoms.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"123-125"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis due to green beans (<i>Phaseolus vulgaris</i>): a new phenotype?","authors":"Estela Menéndez Rivero, Manuel Prados Castaño, Isabel María Domínguez Romero, María José Martínez Martínez, Fernando Pineda De La Losa","doi":"10.15586/aei.v53i1.1176","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1176","url":null,"abstract":"<p><strong>Background: </strong>Anaphylaxis is a severe allergic reaction with increasing incidence in Europe. It is often caused by food, insect venom, and drugs. White, red, and green beans (<i>Phaseolus vulgaris</i>) are legumes of the <i>Fabaceae</i> family consumed worldwide. In Spain, beans are the third most consumed legume species after chickpeas and lentils. Allergy to different legumes is very frequent in children and represents the fifth cause of food allergy.</p><p><strong>Objective: </strong>Demonstrate a new phenotype in patients with green bean anaphylaxis.</p><p><strong>Material and methods: </strong>We report a 20-year-old woman who experienced anaphylaxis after consuming cooked green beans and required emergency treatment. There were no associated cofactors such as medications, alcohol, or physical exercise. After the episode, she tolerated well nuts, garlic, chickpeas, peas, and soy. Prick-prick with raw and cooked green bean, ISAC, SDS-PAGE and IgE-Western blot were performed.</p><p><strong>Results: </strong>The prick+prick test with raw and cooked green beans was positive. The sodium dodecyl sulfate-polyacrylamide gel electrophoresis-immunoglobulin E (SDS-PAGE/IgE)-western blot analysis with white and red beans as well as cooked and raw green beans showed identification of several proteins with a molecular weight of 25-75 kDa in the extract of raw beans. Only one protein with a molecular weight of approximately 10 kDa was recognized in cooked beans.</p><p><strong>Conclusion: </strong>We present a case of anaphylaxis induced by green beans (<i>Phaseolus vulgaris</i>) because of a 10-kDa protein and tolerance to other legumes, which suggests a new phenotype.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"8-11"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a predictive model for allergic rhinitis complicating children with bronchial asthma.","authors":"Qi Zhang, Fengqin Xu, Fuzhe Chen","doi":"10.15586/aei.v53i1.1242","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1242","url":null,"abstract":"<p><p>This study aimed to investigate the factors influencing the complication of allergic rhinitis in children with bronchial asthma and to construct a nomogram model to predict the occurrence of allergic rhinitis. A total of 190 children with bronchial asthma admitted to our hospital from August 2020 to August 2024 were retrospectively analyzed. The children were randomly divided into the training cohort (133 cases) and validation cohort (57 cases) in a ratio of 7:3. The children in the modeling set were divided into an allergic rhinitis group (n=44) and a nonallergic rhinitis group (n=89) depending on the presence or absence of concomitant allergic rhinitis. A total of 62 cases in 190 children with bronchial asthma had complications with allergic rhinitis, with an incidence of 32.63%. In the training cohort, compared with the children in the nonallergic rhinitis group, percentage of smokers in the household, C-reactive protein (CRP), white blood cell count (WBC), and neutrophils/lymphocytes (NLR) were significantly higher in the allergic rhinitis group (P < 0.05). Multivariable logistic regression analysis showed that smokers in the household; IgE; early use of antibiotics; and elevated CRP, WBC, and NLR were all risk factors for the complication of allergic rhinitis in children with bronchial asthma (P < 0.05). A nomogram prediction model was constructed based on the above risk factors. The C-index of the nomogram was 0.919 (95% CI: 0.742-0.934) and 0.841 (95% CI: 0.773-0.902) for the training cohort and validation cohort, respectively. The Hosmer-Lemeshow test results of the training and validation cohorts were both P > 0.05, suggesting a good model fit. The results of DCA showed that the training and validation cohorts had good threshold probability and clinical net benefit. Smokers in the household, IgE, CRP, WBC, and NLR levels were all risk factors for the complication of allergic rhinitis in children with bronchial asthma. A nomogram model based on these risk factors may be a valuable clinical tool for predicting allergic rhinitis in children with bronchial asthma.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"131-138"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cell-derived exosomes improved septic lung injury by reducing excessive NETs formation and alleviating inflammatory response.","authors":"Ting Zou, Jianshuang Lu, Yanke Zhu, Yue Xu, Yuanyuan Sun","doi":"10.15586/aei.v53i1.1238","DOIUrl":"10.15586/aei.v53i1.1238","url":null,"abstract":"<p><p>To illustrate the potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in mitigating septic lung injury by reducing the excessive formation of neutrophil extracellular traps (NETs), a mouse model of septic lung injury was induced through cecal ligation and puncture (CLP). The mice received intraperitoneal injections of MSC-Exos. Post injection, pathological alterations of the lung tissue were evaluated through HE staining, and the levels of inflammatory markers in each mouse group at various time points were assessed using ELISA kits. The presence of NETs markers in lung tissue (colocalization of CitH3 and MPO) was determined via immunofluorescence, and the levels of dsDNA in mouse serum were measured using a dsDNA kit. The findings indicated noticeable damage in the sepsis group postsurgically, whereas the severity of lung tissue damage was significantly diminished in mice of the MSC-Exos group. By the 72-h mark after the CLP procedure, there was an elevation in TNF-α, IL-6, IL-1β, and IL-10. Compared to the CLP group, the inflammatory factors in the serum of mice from the CLP + MSC-Exo group were higher at 12 and 24 h but decreased at the 72-h point. Furthermore, the fluorescence intensity of CitH3 and MPO and the dsDNA content increased in the CLP group mice over different time intervals, with MSC-Exos reversing these changes. In summary, MSC-Exos effectively suppressed sepsis-induced NETs formation and ameliorated lung injury.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"63-68"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis in infancy: An area that needs to be highlighted.","authors":"Evanthia Chiampou, Konstantinos Douros, Anastasios Serbis, Fani Ladomenou, Alexandros Makis, Ekaterini Siomou, Sophia Tsabouri","doi":"10.15586/aei.v53i1.1212","DOIUrl":"10.15586/aei.v53i1.1212","url":null,"abstract":"<p><p>Anaphylaxis, the most severe end of the spectrum of allergic reactions, has shown increasing incidence globally over recent years. This hypersensitivity reaction can occur at any age, including infancy. Recent data, although scarce, show that anaphylaxis is increasingly reported in infancy, with food identified as the leading cause of anaphylaxis cases in this age group. Infants constitute a unique subgroup with specific challenges regarding diagnosis of anaphylaxis due to a variety of factors, such as lack of age-specific diagnostic criteria, inability of infants to describe their symptoms, and the broad spectrum of clinical manifestations that may be mistaken as normal findings. Additionally, there are special issues in reference to the treatment of anaphylaxis during infancy, such as the limited availability of weight-appropriate epinephrine autoinjectors for infants weighing <15 kg. In this study, we review the current literature regarding specific characteristics of anaphylaxis in infants as well as unique challenges in terms of diagnosis, acute treatment, and long-term management of this medical emergency in this vulnerable age group.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"139-145"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of Sinomenium in the treatment of rheumatoid arthritis and suggestions for future research.","authors":"Guanghui Zhou, Zhuoxu Gu, Xianquan Zhang, Lingfeng Zeng, Jun Liu","doi":"10.15586/aei.v53iSP1.1204","DOIUrl":"https://doi.org/10.15586/aei.v53iSP1.1204","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic autoimmune joint disease. Its main pathological manifestations are joint cartilage, bone tissue injury, synovial hyperplasia, and chronic inflammation. At present, the pathogenesis of the disease has not been fully defined, and delaying the disease to improve joint function is the existing treatment. Sinomenium (SIN) is an effective ingredient in <i>Sinomenium acutum</i> (Thunb.) Rehd. et Wils., with anti-inflammatory, analgesic, immunosuppressive, anti-tumor, and other pharmacological activities, which is quite effective in the treatment of RA. There are many SIN compound preparations in the market, such as Zhengqing Fengtongning capsule, Zhubi Huoluo prescription, and Qinxitong tablet. They all exhibit good anti-RA effect with less adverse reactions. This study summarized the mechanism of action of SIN in the treatment of RA and further explored the possibility of SIN in the treatment of RA combined with other diseases for future research.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 S Pt 1","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in serum periostin levels in uncontrolled asthma in children (DADO phase 2 study).","authors":"Alicia Habernau Mena, Maria Angela Gonzalo Garijo, Victoria Del Pozo Abejón, Francisco Félix Rodríguez Vidigal","doi":"10.15586/aei.v53i1.1134","DOIUrl":"https://doi.org/10.15586/aei.v53i1.1134","url":null,"abstract":"<p><strong>Objective: </strong>Asthma is an inflammatory airway condition and the most common chronic disease in children. However, there is a lack of biological markers for asthma, especially in children. This study aimed to analyze the changes in periostin levels in children with uncontrolled asthma after 12 months of optimized management. The secondary objectives were to evaluate the changes in symptoms, exacerbations, and other biomarkers after 12 months of follow-up.</p><p><strong>Methods: </strong>This was an observational, prospective study of children aged 5 to 14 with uncontrolled asthma who visited the Hospital Materno Infantil of Badajoz's Allergy Unit between September 2015 and June 2016. At the first visit and after a 12-month follow-up, lung function, asthma control test (ACT/cACT), quality of life by PAQLQ (Paediatric Asthma Quality of Life Questionnaire), blood eosinophils, total and specific IgE, and serum periostin levels were assessed. Periostin levels were also analyzed in a control group.</p><p><strong>Results: </strong>After the 12-month follow-up, the percentage of symptoms, the proportion of patients with FEV1 <80%, and the levels of blood eosinophils decreased, whereas ACT and PAQLQ increased. Children with uncontrolled asthma showed high serum periostin concentrations on their first visit (901.48 ng/ml), which decreased after 12 months (67.93 ng/ml) (p<0.001). In the control group, periostin levels were 56.12 ng/ml. The sensitivity and specificity of periostin were 77.8% and 54.8%, respectively, for the diagnosis of controlled and uncontrolled asthma.</p><p><strong>Conclusion: </strong>Our study showed that periostin levels in children with uncontrolled asthma decreased with the correct treatment after asthma control.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"1-7"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with asthma symptoms in Colombian subpopulations aged 1 to 17 and 18 to 59: Secondary analysis of the study \"Prevalence of asthma and other allergic diseases in Colombia 2009-2010\".","authors":"Elizabeth Garcia, María X Rojas, Maria C Ardila, Martín A Rondón, Augusto Peñaranda, Ana M Barragán, Adriana Pérez, Sergio Moreno, Lina Sotaquirá, Luis Caraballo, Rodolfo J Dennis","doi":"10.15586/aei.v53i1.1122","DOIUrl":"10.15586/aei.v53i1.1122","url":null,"abstract":"<p><strong>Background: </strong>Asthma, a chronic inflammatory lung disease, is one of the leading causes of disability, demands on health resources, and poor quality of life. It is necessary to identify asthma-related risk factors to reduce the presence and development of symptoms.</p><p><strong>Objective: </strong>This study aimed to explore the association of multiple possible factors with asthma symptoms in two subpopulations, children, adolescents, and adults, in six cities in Colombia.</p><p><strong>Materials and methods: </strong>This was an observational analytical case-control study based on a cross-sectional study conducted as a secondary analysis of the prevalence of asthma and other allergic diseases in Colombia during 2009 and 2010. Weighted logistic regressions were conducted for each population.</p><p><strong>Results: </strong>Out of the 5978 subjects in the cross-sectional survey, 747 were identified as cases, and 3109 were identified as controls. The prevalence of asthma was 30.8% in the child and adolescent population and 14.7% in the adult population. Among the various factors studied, those associated with asthma symptoms in children/adolescents were: a family history of asthma (OR 2.4; 95% CI 1.3-4.7) and rhinitis (OR 2.0; 95% CI 1.1-3.6); acetaminophen consumption at least once a month (OR 3.6; 95% CI 2.1-6.2); and the presence of birds at home (OR 2.0; 95% CI 1.1-3.8). Regarding food consumption: fruit consumption (OR 3.8; 95% CI 1.1-12.7). In adults, the factors that showed significant association were: a family history of allergic diseases (rhinitis OR 3.3; 95% CI 2.3-4.6), atopic eczema (OR 4.4; 95% CI 2.8-7.0), or asthma (OR 1.8;95% CI 1.3-2.6); acetaminophen consumption at least once a month (OR 2.0; 1.5-2.8); the presence of dogs at home (OR 1.4;95% CI 1.03-1.8), exposure to second-hand smoke (OR 1.7; 95% CI 1.2-2.2), and exposure to exhaust fumes during the day (OR 1.7; 95% CI 1.04-2.7).</p><p><strong>Conclusions: </strong>Our findings suggest that different cultural, environmental, and family factors are associated with asthma symptoms in children and adolescents, and these associations are evident in both males and females.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 1","pages":"69-85"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}