Allergologia et immunopathologia最新文献

{"title":"Poppy seed anaphylaxis: clinical and allergic features.","authors":"Elio Novembre, Carla Mastrorilli, Luca Pecoraro, Stefania Arasi, Simona Barni, Lucia Caminiti, Riccardo Castagnoli, Mariannita Gelsomino, Angela Klain, Mattia Giovannini, Lucia Liotti, Francesca Mori, Francesca Saretta, Michele Miraglia Del Giudice","doi":"10.15586/aei.v54i2.1404","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1404","url":null,"abstract":"<p><p>Poppy seeds are increasingly used for flavoring, for example, in cakes, bread, and fruit salads, and it is gaining popularity globally. Most case reports of poppy seed allergy are in children. Ingestion of cake, in which ground poppy seed is used, is mostly associated with anaphylactic reactions. Reactions may occur even with minimal amounts or traces. In sera of patients allergic to poppy seeds, four IgE-reactive poppy seed proteins were identified. Cross allergy with sesame and buckwheat are reported. Cross-reaction is described with nuts (cashew and walnut), wheat, rye flour, buckwheat, rice, and kiwi. Although rare, allergy to poppy seed is often rapid, generalized, and potentially life-threatening and, therefore, should be considered in allergic work-up. Therapy of poppy seed allergy/anaphylaxis is based on an elimination diet. However, oral desensitization could be hypothesized in some high-risk allergic patients, according to other reports of oral desensitization in seed anaphylaxis.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"151-155"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cow's milk protein allergy damages not only the baby's health but also the mother's health.","authors":"Ayça Demir, Hülya Tan, İdil Akay Hacı, Mehmet Şirin Kaya, Figen Çelebi Çelik, Özgen Soyöz, İlke Taşkırdı, Semiha Bahçeci Erdem, Canan Şule Ünsal Karkıner, Özlem Sancaklı, Demet Can","doi":"10.15586/aei.v54i2.1361","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1361","url":null,"abstract":"<p><p>The aim of this study was to evaluate the nutritional status, especially calcium deficiency, of breastfeeding mothers of infants diagnosed with cow's milk food protein-induced allergic proctocolitis (FPIAP) on an elimination diet and to investigate the relationship between daily calcium intake and body composition of these mothers. Our prospective cohort study included 86 patients with cow's milk protein allergy (CMPA) and their mothers on an elimination diet. The mother's body fat, muscle, and water percentages were measured with the Bioelectrical Impedance Method (Tanita MC-580). All mothers were administered a diet containing an average of 2000 kcal (kilocalorie), 1000 mg of calcium, and 400 units per day of vitamin D. The final measurements were repeated 1 month later and the results of the first and second assessments were compared. The mean age of the patients included in the study was 3.8 ± 1.8 months, and the M/F (male to female) ratio was 18/17. In all, 54.3% of the patients had only CMPA, while 45.7% had multiple food allergies, including milk. A comparison of the mother's body measurements before and after the diet showed a significant decrease in fat but with an increase in calcium levels. In contrast, muscle and water ratios did not change (p < 0.001, p = 0.332, p = 0.189). Despite the recommendation of a 2000 kcal per day diet, the second evaluation found that calorie, fat, and protein ratios were significantly reduced (p = < 0.001, p = 0.011, p = 0.009, p < 0.05, respectively). The metabolic health of breastfeeding mothers who follow an elimination diet for CMPA is affected even with dietician support.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"22-27"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and differential diagnosis values of indirect markers of inflammation in atopic children.","authors":"Selçuk Yazıcı, Fatma Damla Kurt, Yağmur Güvendik, Aslıhan İzol","doi":"10.15586/aei.v54i2.1522","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1522","url":null,"abstract":"<p><p>Atopic diseases are characterized by intense inflammation. There are increasing studies examining the relationship between atopic diseases and hematological parameters and indirect markers of inflammation, such as neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), and platelet-to-lymphocyte ratio (PLR). The aim of this study was to investigate these parameters in patients with asthma, allergic rhinitis, and atopic dermatitis. The study was conducted retrospectively and cross-sectionally. The study group consisted of 172 patients (53 with asthma, 93 with allergic rhinitis, and 26 with atopic dermatitis) and 105 controls. There were no age or gender differences between patients and controls. When all atopic patients were compared to controls, ELR (P < 0.001), eosinophil count (P < 0.0019), and WBC (P < 0.05) were significantly higher in the patient group. When patient groups were compared independently, ELR (P < 0.001), eosinophil count (P < 0.001), and WBC (P < 0.05) were higher in asthmatic patients than in controls. In allergic rhinitis patients, ELR (P < 0.001) and eosinophil count (P < 0.001) were higher than in controls. In patients with atopic dermatitis, ELR (P < 0.001), eosinophil count (P > 0.001), WBC (P = 0.0019), and, additionally, NLR (P < 0.001) and PLR (P < 0.05) were higher than in controls. NLR and PLR were significantly higher in patients with atopic dermatitis than in controls, in patients with asthma and in patients with allergic rhinitis. Among all hemogram parameters, only ELR and eosinophil count stand out as markers that may be useful in the diagnosis of atopic diseases. NLR and PLR may be useful in the differential diagnosis of AD among atopic patients.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stepwise, precision-based management of allergic Bronchopulmonary Aspergillosis/Mycosis: A real-life multicenter study.","authors":"Şeyma Özden, Fatma Merve Tepetam, Umut İlhan, Tuğba Üstüner, Ramazan Eren, Barış Demirkol, Özge Atik, Elif Tanrıverdi, Erdoğan Çetinkaya","doi":"10.15586/aei.v54i2.1623","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1623","url":null,"abstract":"<p><strong>Background: </strong>Allergic bronchopulmonary aspergillosis (ABPA) and allergic bronchopulmonary mycosis (ABPM) are hypersensitivity disorders characterized by fungal colonization of the airways and exaggerated Th2-mediated immune responses. Despite corticosteroids being the cornerstone of treatment, adverse effects, relapses, and steroid dependence necessitate adjunctive antifungal and biologic therapies. This study aimed to evaluate clinical, functional, and immunologic responses to different treatment combinations in patients with ABPA or ABPM.</p><p><strong>Methods: </strong>This retrospective, multicenter, cross-sectional study included 70 patients diagnosed with ABPA (n = 54) or ABPM (n = 16) at two tertiary chest disease centers between 2016 and 2023. Patients were grouped according to systemic corticosteroid (SS) use (SS-using vs non-SS) and further subdivided based on treatment composition (antifungal ± biologic therapy vs antifungal alone). Changes in FEV₁ (Forced Expiratory Volume in 1 second), Asthma Control Test (ACT) scores, total serum IgE, and peripheral blood eosinophil count (PBEC) before and after treatment were analyzed.</p><p><strong>Results: </strong>In the SS-using group, combination therapy with antifungal ± biologic agents produced significant improvements in FEV₁ (mL and %) and ACT scores, along with substantial reductions in total IgE and PBEC levels (all P < 0.05). Antifungal monotherapy yielded significant reductions in immunologic parameters but no functional improvement. In the non-SS group, changes were minimal across most parameters, except for a modest reduction in total IgE within the antifungal ± biologic subgroup. The most comprehensive clinical and immunologic responses were observed in patients treated with corticosteroids combined with antifungal and biologic therapy.</p><p><strong>Conclusion: </strong>SS remain the primary therapeutic modality for ABPA, but the addition of antifungal and biologic agents enhances both immunologic and functional recovery. A precision-based, stepwise treatment model-initiating with corticosteroids, followed by antifungal therapy, and incorporating targeted biologics-may optimize long-term outcomes, minimize steroid exposure, and promote sustained remission in ABPA and ABPM.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"117-124"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: effectiveness of topical intranasal curcumin in the experimentally induced allergic rhinitis model in rats.","authors":"Erbay Demir, Muhsin Koten, Fatma Elif Usturalı Keskin, Canan Eryıldız, Selis Gülseven Güven","doi":"10.15586/aei.v54i2.1718","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1718","url":null,"abstract":"","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"180"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the seasonal effects of bee sting allergies on anxiety, somatization, and quality of life in children.","authors":"Mehmet Özkaya, Zehra Bayazıt, Emre Özdamar, Burcu Özge Erdoğan, Melike Kevser Gül, Fulya Tahan","doi":"10.15586/aei.v54i2.1482","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1482","url":null,"abstract":"<p><strong>Objective: </strong>Bee stings, a prevalent issue globally, trigger severe allergic reactions and significantly impact physical health. However, their effects on psychologic well-being and quality of life, especially across seasons, are less understood. This study evaluates the impact of bee sting allergies on anxiety, somatization, and quality of life in children, with a focus on seasonal differences.</p><p><strong>Methods: </strong>Conducted at the Medical Faculty of Erciyes University, this prospective study involved 106 children aged 6-18 years-53 with bee sting allergies and 53 healthy controls. Assessments using the Screen for Child Anxiety-Related Disorders (SCARED), Children's Somatization Inventory-24 (CSI-24), and Pediatric Quality of Life Inventory (PedsQL) were performed in winter and spring.</p><p><strong>Results: </strong>Children with bee sting allergies exhibited significantly higher anxiety and somatization compared to controls, with lower quality of life scores in physical, emotional, and academic domains. Seasonal variations showed increased anxiety in spring, with fluctuating somatization and quality of life indicators, although these changes were not statistically significant.</p><p><strong>Conclusion: </strong>Bee sting allergies significantly affect children's anxiety, somatization, and quality of life, with seasonal changes exacerbating these impacts. Targeted interventions are needed to address these challenges, particularly during peak allergen periods.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"93-98"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effectiveness and safety of dupilumab in children with atopic dermatitis: a Latin American single-center study.","authors":"Victor Gonzalez-Uribe, Hector Rodrigo Pastrana-Ayala, Luis Angel Hernandez-Zarate, Carlos Andres Gomez-Nuñez, Maria Julia Rendon-Salazar, Tamara Hernandez-Hernandez, Ricardo Martinez-Tenopala, Zaira Selene Mojica-Gonzalez","doi":"10.15586/aei.v54i2.1402","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1402","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is common in children (affecting ~20% of children globally) and imposes a substantial burden. Many children in Latin America have moderate-to-severe AD with limited access to advanced therapies, highlighting an unmet need for safe and effective treatment options. Dupilumab, a targeted anti-interleukin-4 (IL-4)-IL-13 biologic, has demonstrated efficacy in pediatric AD, but real-world data in Latin American children are scarce.</p><p><strong>Methods: </strong>We conducted a single-center retrospective observational study in Mexico City with children (aged 4-18 years) with moderate-to-severe AD treated with dupilumab from 2018 to 2024. Clinical outcomes (Eczema Area and Severity Index; Scoring Atopic Dermatitis [SCORAD], and pruritus Numerical Rating Scale [NRS]) and quality-of-life (Dermatology Life Quality Index) were assessed at baseline and ~3, ~6, and ~12 months. Changes over time were analyzed using nonparametric tests, and adverse events were documented.</p><p><strong>Results: </strong>In all, 23 children (~50% female) with severe, treatment-refractory AD were included. Dupilumab led to rapid and significant improvement in all endpoints (P < 0.001). In 12 months, most patients achieved clear or almost clear skin with no pruritus (median SCORAD and itch NRS = 0), and quality-of-life scores improved from a median of 19 to 3. No serious adverse events occurred; mild conjunctivitis was reported in 13% patients (with one discontinuation).</p><p><strong>Conclusion: </strong>In this Latin American pediatric cohort, dupilumab achieved marked and sustained improvements in disease severity and quality of life, with a favorable safety profile. This real-world study addresses a regional evidence gap and supports dupilumab as an effective and well-tolerated treatment for moderate-to-severe pediatric AD.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"28-34"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy to cabazitaxel: Cross-reactivity between taxanes.","authors":"Paola C Fernández-Paredes, Mariola Navarro Guerrero, Elisa Peñalver de la Puente, J Damian Lopez-Sanchez","doi":"10.15586/aei.v54i2.1458","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1458","url":null,"abstract":"<p><p>A 46-year-old man, with HIV infection A2 stage and chronic C hepatitis was diagnosed with stage 4 prostate cancer with bone metastases in September 2019. His treatment was started with docetaxel, receiving five cycles with good tolerance, after which he received hormonal treatment. Currently, he presents progression of the disease and docetaxel is reintroduced. After infusing the first 5 mL, he showed respiratory distress with thoracic pain and low oxygen saturation (88%) together with lumbar pain. Both tryptase and interleukin 6 (IL-6) levels in blood were measured at the time of the reaction, and were elevated. The case was discussed in an oncology clinical round, and it was decided a change to cabazitaxel. Allergy tests were performed, including skin prick and intradermal tests, with docetaxel and cabazitaxel. A positive result to intradermal test with docetaxel, 10 mg/mL, was obtained 24 h later. Then 48 h later, another positive intradermal test reaction with 1-mg/mL docetaxel as skin ulceration was reported. However, skin prick and intradermal tests with cabazitaxel were negative.Drug provocation test with cabazitaxel was subsequently performed. After the infusion of 11 mL, the patient presented pharyngeal obstruction with dyspnoea, facial erythema, genital pruritus, and cervical pain that required treatment with intramuscular epinephrine. The results of the allergy study were not concordant with clinical presentation and confirmed the poor predictive value of taxane skin tests.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"148-150"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypersensitivity reactions with proton pump inhibitors: five years of clinical experience.","authors":"Melis Yağdıran, Kurtuluş Aksu, Özgür Akkale, Hatice Çelik Tuğlu, Onur Telli, Fatma Dindar Çelik, Gürgün Tuğçe Vural Solak","doi":"10.15586/aei.v54i2.1537","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1537","url":null,"abstract":"<p><strong>Introduction: </strong>Proton pump inhibitors (PPIs) are generally well tolerated and are frequently prescribed drugs because their risk of adverse effects is 1-3%. Although PPIs have a good safety profile, allergic reactions to these molecules can occur. We aimed to investigate hypersensitivity reactions in patients who underwent oral provocation tests with PPIs in our clinic.</p><p><strong>Methods: </strong>In all, 58 subjects who applied to allergy clinic between January 2018 and December 2023 with a history of early allergic reactions with PPIs and subsequently underwent oral provocation testing to find a diagnostic or safe alternative PPI were included in our study. Information on the subjects' demographic and clinical data and the results of provocation tests was recorded by reviewing patient records.</p><p><strong>Results: </strong>Of the 58 subjects included in the study, 44 (75.9%) were females. The mean age of the patients was 54.4 ± 13.8 years. Fifty-three (91.4%) subjects had a history of allergic reactions to a single PPI and 5 (8.6%) subjects had a history of allergic reactions to two different PPIs, such as lansoprazole, pantoprazole, rabeprazole, esomeprazole, and omeprazole. Intradermal skin testing was performed in 51 (87.9%) of the subjects and all were found to be negative. After the provocation test, only two patients (3.4%) developed early-onset hypersensitivity reactions, one with lansoprazole and the other with esomeprazole.</p><p><strong>Conclusion: </strong>Skin testing is a valuable tool in predicting hypersensitivity reactions associated with PPIs. Although rare, hypersensitivity reactions may occur in patients with negative skin tests.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"70-75"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal tobacco smoke exposure in 12,405 mother-infant pairs: findings from the EISL Phase 3 in South America.","authors":"Javier Mallol, Dirceu Solé, Viviana Aguirre, Carolina S Aranda, Luis Garcia-Marcos, Herberto Chong-Neto, Nelson Rosario, Marilyn Urrutia-Pereira, Gabriela Szulman, Jurg Niederbacher, Erika Arruda-Chavez, Eliana Toledo, Lillian Sánchez, Catalina Pinchak","doi":"10.15586/aei.v54i2.1647","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1647","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence, risk factors for perinatal tobacco smoking, and the effects on infants' respiratory health in 12,450 mother-infant pairs from South America.</p><p><strong>Methods: </strong>Cross-sectional population-based study in eleven centres from six countries, using a standardised questionnaire completed by parents.</p><p><strong>Results: </strong>The prevalence of smoking during pregnancy was 8.4%, ranging from 1.4% in Lima to 15.3% in Montevideo; current maternal smoking was 15.3%, from 5.4% in Lima to 34.4% in Santiago; and second-hand tobacco smoke (SHS) at home was 29.8%, from 13.7% in Lima to 50.7% in Santiago. SHS and current maternal smoking were strong and independent risk factors for smoking during pregnancy (p < 0.0001). Low maternal education and monthly household income were significant risk factors for perinatal tobacco exposure. The prevalence and severity of wheezing, admissions for wheezing, pneumonia diagnosis, and admissions for pneumonia were significantly higher (p < 0.0001) in infants exposed to tobacco smoke.</p><p><strong>Conclusions: </strong>The prevalence of smoking during pregnancy, current maternal tobacco smoking, and SHS remain high in South America. Perinatal tobacco smoke exposure is strongly related to greater wheezing severity and a higher prevalence of admissions for wheezing and pneumonia during the first year of life. Low socioeconomic status and low maternal education were the most significant risk factors for smoking during pregnancy, as well as for current maternal smoking and the presence of SHS at home. Our results point to the urgent need to improve the quantity and quality of education against tobacco smoking in girls and families, starting very early in life.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"125-134"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}