ige介导的鸡蛋蛋白过敏。

IF 2.1 4区 医学 Q3 ALLERGY
Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i4.1447
Laura Valdesoiro-Navarrete, Monica Piquer Gibert, Natalia Molini Menchon, Celia Pinto-Fernández, Carlos García-Magán, Ángela Claver-Monzón, Felipe Thorndike-Piedra, Cristina Blasco Valero, Sara Pereiro Fernández, Ana Prieto-Del-Prado, Gloria Ortega-Bernal, Antonio Martorell Aragonés
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引用次数: 0

摘要

鸡蛋过敏是儿科人群中最常见的食物过敏之一。它显著影响患者及其家属的生活质量。鸡蛋过敏是一种由免疫机制介导的不良反应。这涉及到不同的机制。本文综述了免疫球蛋白E (IgE)介导的鸡蛋过敏。鸡蛋致敏和过敏的患病率在牛奶过敏儿童和特应性皮炎儿童中较高。幼儿对鸡蛋过敏的预后通常是好的,尽管在某些情况下,它往往持续到成年。蛋清中的主要过敏原是卵黏液和卵清蛋白。诊断是基于提示的临床病史和特定的阳性鸡蛋过敏的研究。口腔食物激发试验是确诊的金标准试验。鸡蛋过敏,像其他食物过敏一样,主要是通过避免饮食和对症治疗来应对过敏反应。目前的方法强调尽可能减少限制性饮食。因此,通过成分解析诊断获得准确诊断至关重要,必要时通过口腔激发试验确认耐受性。食物免疫疗法具有潜在的疗效,可被视为ige介导的鸡蛋过敏的治疗选择。它增加了食物的耐受性,降低了危及生命的过敏反应的风险。有不同的途径:口服、舌下、皮下或经表皮。其中,口服免疫治疗是临床研究最广泛、应用最广泛的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
IgE-mediated allergy to egg protein.

Egg allergy is one of the most common food allergies in the pediatric population. It significantly impacts the quality of life of patients and their families. Egg allergy is an adverse reaction mediated by an immune mechanism. There are different mechanisms involved. This review refers to immunoglobulin E (IgE)-mediated egg allergy. The prevalence of egg sensitization and allergy is higher in children with cow's milk allergy and in those with atopic dermatitis. The prognosis for egg allergy in young children is generally good, although in some cases it tends to persist at adult age. The main allergens in egg white are ovomucoid and ovalbumin. Diagnosis is based on the suggestive clinical history and the study of specific positive egg allergy. Oral food challenge test is the gold standard test to confirm diagnosis. Egg allergy, like other food allergies, is primarily managed with the avoidance diet and symptomatic treatment in case of an allergic reaction. The current approach emphasizes minimizing restrictive diets, if possible. Therefore, obtaining an accurate diagnosis through component-resolved diagnostics is essential, and whenever necessary, confirming tolerance through oral challenge tests. Food immunotherapy can be potentially curative and can be regarded as a therapeutic option for IgE-mediated egg allergy. It increases the amount of food tolerated and reduces the risk of a life-threatening anaphylactic reaction. There are different approaches: orally, sublingually, subcutaneous, or via epicutaneous. Among these, oral immunotherapy is the most extensively studied and widely used approach in clinical practice.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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