Allergologia et immunopathologia最新文献

Efficacy of tezepelumab in patients with severe allergic asthma in clinical practice. tezepelumab治疗重度变应性哮喘的临床疗效观察。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-16 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1448

Juan Carlos Miralles-López, Yulia Petryk Petryk, Juan José Cortés Collado, Francisco-Javier Bravo-Gutierrez, Rubén Andújar-Espinosa, Manuel Castilla-Martínez, Cayetano Díaz-Chantar, Sheila Cabrejos-Perotti, José Valverde-Molina, Virginia Pérez-Fernández, Re-Asgramur Group

{"title":"Efficacy of tezepelumab in patients with severe allergic asthma in clinical practice.","authors":"Juan Carlos Miralles-López, Yulia Petryk Petryk, Juan José Cortés Collado, Francisco-Javier Bravo-Gutierrez, Rubén Andújar-Espinosa, Manuel Castilla-Martínez, Cayetano Díaz-Chantar, Sheila Cabrejos-Perotti, José Valverde-Molina, Virginia Pérez-Fernández, Re-Asgramur Group","doi":"10.15586/aei.v53i5.1448","DOIUrl":"10.15586/aei.v53i5.1448","url":null,"abstract":"Introduction: Tezepelumab is a human monoclonal immunoglobulin G2λ antibody that targets the cytokine thymic stromal lymphopoietin (TSLP). In clinical trials, tezepelumab has been shown to reduce the annualized asthma exacerbation rate in patients with both high and low levels of T2 inflammation biomarkers.Methods: This is a prospective, multicenter study of RE-ASGRAMUR (Register of Severe Asthma of the Region of Murcia) conducted under routine clinical practice conditions. We analyzed exacerbations, changes in lung function (pre-bronchodilator FEV1), asthma control (ACT), and quality of life (mini AQLQ). In addition, T2 biomarkers, including blood eosinophils and exhaled nitric oxide (FeNO), were analyzed.Results: We present a series of 38 patients with severe allergic asthma who received treatment with tezepelumab. More than half of these patients had previously shown inadequate responses to other biologic therapies. Following treatment, the annualized rate of exacerbations decreased markedly from a baseline mean of 2.2 to 0.28, representing an 86.8% reduction. The Asthma Control Test (ACT) score improved by an average of 5.2 points, while the mini Asthma Quality of Life Questionnaire (miniAQLQ) score increased by 1 point. Pulmonary function also improved significantly, with a mean increase of 170 mL in FEV1. Furthermore, type 2 inflammatory biomarkers, including blood eosinophil counts and fractional exhaled nitric oxide (FeNO), showed a significant reduction.Conclusions: Tezepelumab is an effective treatment for severe allergic asthma, improving exacerbations, disease control, quality of life, and lung function.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"193-196"},"PeriodicalIF":2.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and production of conjugated neurotensin-silver nanoparticles and evaluation of its effect on pathophysiology of allergic asthma. 共轭神经紧张素-银纳米颗粒的制备及其对过敏性哮喘病理生理的影响。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1391

Yu Yang, Entezar Mehrabi Nasab, Seyyed Shamsadin Athari

引用次数: 0

Studying the relationship between allergo-inflammation and left atrium and pulmonary vein pathological changes in allergic asthma. 变应性哮喘患者变应性炎症与左心房、肺静脉病变的关系研究。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1419

Deng Zou, Hualing Xiao, Seyyed Shamsadin Athari, Xiujuan Hu

{"title":"Studying the relationship between allergo-inflammation and left atrium and pulmonary vein pathological changes in allergic asthma.","authors":"Deng Zou, Hualing Xiao, Seyyed Shamsadin Athari, Xiujuan Hu","doi":"10.15586/aei.v53i5.1419","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1419","url":null,"abstract":"Allergic asthma is an inflammatory airway disease influenced by genetic and environmental factors and orchestrated by imbalance between T helper 1 cell (Th1) and two immune responses. Inflammation contributes to pathological changes and remodeling in tissues such as the vascular, lung, heart, and beds. The purpose for this study was to evaluate the effects of allergic asthma on heart pathology and remodeling. In methodology, mice were allocated into two healthy and asthma groups, followed by the assessment of airway hyperresponsiveness (AHR), cell enumeration in bronchoalveolar lavage fluid (BALF), measurement of interleukin (IL)-4, IL-33, IL-5, interferon gamma (IFN-γ), and IL-13, total immunoglobulin E (IgE) levels, and analysis of remodeling factors. Also, gene expression analysis was performed for troponin, suppressor of mothers against decapentaplegic (SMAD)2, myocyte enhancer factor 2 (MEF-2), and SMAD3. Finally, histopathological study was conducted. The result revealed that asthma induction augmented AHR and elevated eosinophil percentage, elevated the levels of IL-13, IL-33, IL-5, IL-4, IgE, Helicobacter pylori (HP), and transforming growth factor beta (TGF-β), and the gene expression of SMAD3. Also, eosinophilic inflammation, goblet cell meta/hyperplasia, and mucus secretion were increased in asthmatic versus healthy mice. The level of IFN-γ was lower in the asthma compared to the control group; however, the expressions of troponin, SMAD2, and MEF-2 genes showed no significant differences. It was concluded that allergic asthma changed the balance between type 1 and 2 cytokines, which could possibly lead to profound effects on the cardiovascular system's structure and/or function.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"100-107"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergy to Alternaria alternata: Comprehensive review from the origin to the therapeutic approach. 互花莲子过敏：从起源到治疗方法的综合综述。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1454

Javier Torres-Borrego, Javier Suárez-Pérez, Yolanda Aliaga-Mazas, Ana Martínez-Cañavate Burgos, Santiago Nevot-Falcó

{"title":"Allergy to Alternaria alternata: Comprehensive review from the origin to the therapeutic approach.","authors":"Javier Torres-Borrego, Javier Suárez-Pérez, Yolanda Aliaga-Mazas, Ana Martínez-Cañavate Burgos, Santiago Nevot-Falcó","doi":"10.15586/aei.v53i5.1454","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1454","url":null,"abstract":"Alternaria alternata is an ubiquitous mold commonly found in both outdoor and indoor environments. It is a common airborne mold recognized as a significant aeroallergen linked to pediatric allergic rhinitis and asthma. Although sensitization rates in children vary regionally, evidence suggests that A. alternata allergy significantly impacts pediatric respiratory health and as its exposure worsens, respiratory outcomes in susceptible pediatric populations Alternaria. Children are especially vulnerable due to their developing immune and respiratory systems and greater exposure to environmental allergens. This narrative review aims to summarize current knowledge on A. alternata as an allergenic source in children, including its biology, allergenic components (especially Alt a 1), interactions with immune system, airway epithelium interacting with other allergens, and clinical relevance. We also discuss the allergen-specific immunotherapy strategies with standardized extracts that are effective and safe in pediatric patients. Understanding the role of Alternaria in allergic disease is essential for early and accurate diagnosis (including component-resolved methods), effective intervention, and improving long-term outcomes in affected children. Future research should focus on novel vaccine technologies and standardized pediatric-specific treatment protocols.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"179-188"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A practical and applicable desensitization scheme for ciprofloxacin with a glass of water. 一种实用、适用的一杯水环丙沙星脱敏方案。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1413

Zeynep Yegin Katran, İsmet Bulut, Feyza Yegin, Mustafa Katran

引用次数: 0

Efficacy of hypertonic saline nasal irrigation in allergic rhinitis: A systematic review and meta-analysis. 高渗盐水鼻冲洗治疗变应性鼻炎的疗效：一项系统综述和荟萃分析。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1409

Nishtha Singh, Sheetu Singh, Arvind Kumar Sharma, Udaiveer Singh, Vaibhav Bhatnagar, Virendra Singh

{"title":"Efficacy of hypertonic saline nasal irrigation in allergic rhinitis: A systematic review and meta-analysis.","authors":"Nishtha Singh, Sheetu Singh, Arvind Kumar Sharma, Udaiveer Singh, Vaibhav Bhatnagar, Virendra Singh","doi":"10.15586/aei.v53i5.1409","DOIUrl":"10.15586/aei.v53i5.1409","url":null,"abstract":"Saline nasal irrigation provides symptom relief in allergic rhinitis (AR), but the optimal saline concentration remains uncertain. The comparative efficacy of 3% hypertonic saline nasal irrigation (HSNI) versus 0.9% isotonic saline is still debated. We conducted a meta-analysis to evaluate nasal symptom scores from studies comparing HSNI with control (isotonic saline or no saline) in patients with AR. Systematic search of PubMed, Scopus, and Cochrane Central was performed for randomized controlled trials (RCTs) comparing 3% HSNI with control from inception to May 8, 2024. Primary outcomes were total nasal symptom scores and antihistamine use. We pooled mean differences and odds ratios (OR) with 95% confidence intervals (CI) using a random effects model and assessed heterogeneity with I2. Nine RCTs involving 645 patients met the inclusion criteria. Follow-up ranged from 4 weeks to 2 months. The mean age was 35.49 years in adults and 9.3 years in children. HSNI significantly reduced nasal symptom scores compared with control in adults (MD = -2.09; 95% CI: -3.86 to -0.33; P = 0.02; I2 = 97%) and children (MD = -0.97; 95% CI: -1.51 to -0.44; P = 0.0004; I2 = 42%). Antihistamine use was also lower with HSNI than control (OR = 0.39; 95% CI: 0.21-0.70; P = 0.002; I2 = 14%), but no significant difference was found between HSNI and isotonic saline alone (OR = 0.69; 95% CI: 0.41-1.16; P = 0.16; I2 = 0%). HSNI appears effective in reducing symptoms and medication use in allergic rhinitis across age groups.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"164-178"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antituberculosis drug-induced hypersensitivity: clinical characteristics and risk factors. 抗结核药物致超敏反应：临床特点及危险因素。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1427

Zeynep Yegin Katran, İsmet Bulut, Aylin Babalık, Metin Keren, Fatma Merve Tepetam

{"title":"Antituberculosis drug-induced hypersensitivity: clinical characteristics and risk factors.","authors":"Zeynep Yegin Katran, İsmet Bulut, Aylin Babalık, Metin Keren, Fatma Merve Tepetam","doi":"10.15586/aei.v53i5.1427","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1427","url":null,"abstract":"Background: Antituberculosis drugs can cause hypersensitivity reactions that interrupt treatment and increase morbidity. Early identification and management are essential to prevent complications and drug resistance.Objective: To evaluate the clinical characteristics, risk factors, and outcomes of antituberculosis drug-induced hypersensitivity reactions over a 10-year period in a tertiary referral center.Methods: We retrospectively analyzed 449 patients hospitalized for antituberculosis drug-induced hypersensitivity between 2015 and 2024. A control group of 478 tuberculosis patients without hypersensitivity was included. Demographic features, comorbidities, hypersensitivity types, causative drugs, and treatment outcomes were compared.Results: The prevalence of hypersensitivity was 12.1%. Female gender, older age, Turkish nationality, and history of other drug allergies were significant risk factors. Type 1 reactions (77.7%) were more common and associated with shorter treatment interruption and higher cure rates. Pyrazinamide was the most frequently implicated drug. Desensitization was successful in the majority of patients.Conclusion: This large cohort study highlights key risk factors and clinical outcomes in tuberculosis drug hypersensitivity. Close monitoring of high-risk patients in the early treatment phase may reduce delays and improve outcomes.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"69-77"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective IgA deficiency and allergic diseases: Clinical and immunological evaluation. 选择性IgA缺乏与过敏性疾病：临床和免疫学评价。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1374

Selami Ulaş, Serdar Al, Sezin Naiboğlu, Işılay Turan, Gülşah Kalay, Nermin Kapçı, Özge Türkyılmaz Uçar, Sibel Kaplan, Erkan Çakmak, Kübra Yırgın, Ahmet Sert, Meryem Özçelik, Burcu Çil, Şeyda Köse, Ilke Yıldırım, Simge Kılıçoğlu, Pınar Gökmirza Özdemir, Mehmet Halil Çeliksoy, Çiğdem Aydoğmuş

{"title":"Selective IgA deficiency and allergic diseases: Clinical and immunological evaluation.","authors":"Selami Ulaş, Serdar Al, Sezin Naiboğlu, Işılay Turan, Gülşah Kalay, Nermin Kapçı, Özge Türkyılmaz Uçar, Sibel Kaplan, Erkan Çakmak, Kübra Yırgın, Ahmet Sert, Meryem Özçelik, Burcu Çil, Şeyda Köse, Ilke Yıldırım, Simge Kılıçoğlu, Pınar Gökmirza Özdemir, Mehmet Halil Çeliksoy, Çiğdem Aydoğmuş","doi":"10.15586/aei.v53i5.1374","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1374","url":null,"abstract":"Purpose: We aimed to investigate allergic sensitization and associated factors in pediatric patients with selective immunoglobulin A deficiency (SIgAD) and to evaluate differences between allergic and nonallergic groups.Methods: We analyzed 110 patients (aged 4-18 years) diagnosed with SIgAD at Çam and Sakura City Hospitals, Istanbul, between 2021 and 2024. Their demographic, clinical, and laboratory data were assessed.Results: Allergic sensitization was detected in 62.7% of patients. Patients with allergic sensitization, family history of allergic diseases, eosinophilia, and elevated total immunoglobulin E (IgE) levels were significantly higher (P < 0.05). Immunglobulin M (IgM) levels were higher in the allergic group (P = 0.01), and they had lower neutrophil counts (P = 0.03). Allergic sensitization was lower in patients with autoimmune diseases (P = 0.03). In 60% of the patients, the main reason for presentation was recurrent infection.Conclusion: Allergic sensitization with SIgAD is associated with genetic and immunological factors. A family history of allergic disease, eosinophilia, and elevated total IgE levels are important markers for the development of allergy. These findings highlight the need to closely monitor allergies in people with SIgAD.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"78-86"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between serum copper and childhood asthma: A systematic review and meta-analysis. 血清铜与儿童哮喘的关系：一项系统回顾和荟萃分析。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1394

Beilei Wang, Xingyue Su, Xiang Ma

{"title":"Association between serum copper and childhood asthma: A systematic review and meta-analysis.","authors":"Beilei Wang, Xingyue Su, Xiang Ma","doi":"10.15586/aei.v53i5.1394","DOIUrl":"10.15586/aei.v53i5.1394","url":null,"abstract":"Background: Asthma is a chronic respiratory disease with complex pathogenesis. Some studies suggest that certain trace metals may be associated with asthma. However, the relationship between serum copper (Cu) and childhood asthma remains unclear. This meta-analysis evaluates the association between Cu and childhood asthma.Methods: Studies of multiple databases were searched from inception to 2024. We recorded the standardized mean difference (SMD), 95% confidence intervals (CIs), and other data. The analysis was performed using Stata 18.0 software. Two independent reviewers appraised methodological quality using the Newcastle-Ottawa Scale. Sensitivity analysis was used to test robustness. To evaluate publication bias, we used Begg's funnel plots and Egger's regression test.Results: A total of 11 studies with a combined 1006 participants were included. There was no significant difference in the level of serum Cu between children with asthma cases and controls (SMD = -0.032, 95% CI: -0.291-0.228, P = 0.811). There was significant heterogeneity among the studies (I2 = 73.5%, P < 0.0001). Subgroup analysis demonstrated that heterogeneity was not caused by the continent of origin, publication year, sample size, detection methods, and the mean age of participants. No publication bias was found.Conclusion: There is no statistically significant association between serum Cu levels and childhood asthma. Further research, particularly large-scale prospective cohort studies, is needed to clarify this relationship.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"154-164"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wiskott-Aldrich syndrome complicated with IgG4-related Sclerosing disease: A case report and literature review. Wiskott-Aldrich综合征合并igg4相关硬化疾病1例报告及文献复习

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1437

Seda Altiner, Makbule Seda Bayrak Durmaz

{"title":"Wiskott-Aldrich syndrome complicated with IgG4-related Sclerosing disease: A case report and literature review.","authors":"Seda Altiner, Makbule Seda Bayrak Durmaz","doi":"10.15586/aei.v53i5.1437","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1437","url":null,"abstract":"Wiskott-Aldrich Syndrome (WAS) is an X-linked immunodeficiency characterized by eczema, microthrombocytopenia, and recurrent infections. Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory disorder involving various organs. We present a 34-year-old male with WAS who developed cervical lymphadenopathy and parotid gland swelling. Initial biopsies were inconclusive and imaging suggested pleomorphic adenoma. Given the persistent cervical lymphadenopathy and the underlying immunodeficiency, lymphoma was also considered in the differential diagnosis. However, histopathological examination of excised salivary gland and lymph nodes revealed lymphoplasmacytic and eosinophilic infiltrates, numerous IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis, consistent with IgG4-RD. The patient responded well to prednisone therapy. This case emphasizes the importance of considering IgG4-RD in the differential diagnosis of lymphoproliferative lesions in immunodeficient individuals and highlights the diagnostic value of histopathological evaluation in excisional tissue specimens. To our knowledge, this represents a rare coexistence of WAS and IgG4-RD not previously reported in the literature.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"138-142"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0