{"title":"Effect of Qingchang Yuyang decoction on treatment efficacy and intestinal flora in patients with ulcerative colitis.","authors":"Jing Wang, Linfeng Cao, Yingjie Zhu","doi":"10.15586/aei.v53i3.1332","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the therapeutic effects of Qingchang Yuyang Decoction on ulcerative colitis (UC) and its impact on intestinal flora. Using existing case records, a retrospective analysis was conducted utilizing clinical data from 96 UC patients (damp-heat syndrome of the large intestine) treated at our hospital between June 2022 and June 2024. Based on the different treatment methods recorded, 50 patients were included in the observation group and 46 in the control group. The control group received conventional treatment (oral sustained-release mesalazine tablets), while the observation group received oral Qingchang Yuyang Decoction in addition to conventional treatment. The efficacy and effects on intestinal flora were compared between the two groups. The change in the modified Mayo score before and after treatment in the observation group was significantly greater than that in the control group (p < 0.001). After treatment, scores for abdominal pain and diarrhea, mucus-pus-bloody stools, tenesmus, anal burning, and short and red urine were significantly lower in the observation group compared to the control group (p < 0.05). Post-treatment, the observation group showed significantly higher levels of IL-10 than the control group, while IL-8 and TNF-α levels were lower in the observation group (p < 0.05). After treatment, Enterococcus and Enterobacter counts in the observation group were lower, while the observation group had higher levels of Bifidobacterium, Butyric Clostridium, and Lactobacillus compared to the control group (p < 0.05). The complication rate was lower in the observation group (p < 0.05). The combination of Qingchang Yuyang Decoction with sustained-release mesalazine tablets can improve the clinical efficacy in UC, significantly alleviate clinical symptoms, reduce the inflammatory response, adjust intestinal flora distribution, and promote recovery, making it worthy of clinical application.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 3","pages":"60-71"},"PeriodicalIF":2.5000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergologia et immunopathologia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.15586/aei.v53i3.1332","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigates the therapeutic effects of Qingchang Yuyang Decoction on ulcerative colitis (UC) and its impact on intestinal flora. Using existing case records, a retrospective analysis was conducted utilizing clinical data from 96 UC patients (damp-heat syndrome of the large intestine) treated at our hospital between June 2022 and June 2024. Based on the different treatment methods recorded, 50 patients were included in the observation group and 46 in the control group. The control group received conventional treatment (oral sustained-release mesalazine tablets), while the observation group received oral Qingchang Yuyang Decoction in addition to conventional treatment. The efficacy and effects on intestinal flora were compared between the two groups. The change in the modified Mayo score before and after treatment in the observation group was significantly greater than that in the control group (p < 0.001). After treatment, scores for abdominal pain and diarrhea, mucus-pus-bloody stools, tenesmus, anal burning, and short and red urine were significantly lower in the observation group compared to the control group (p < 0.05). Post-treatment, the observation group showed significantly higher levels of IL-10 than the control group, while IL-8 and TNF-α levels were lower in the observation group (p < 0.05). After treatment, Enterococcus and Enterobacter counts in the observation group were lower, while the observation group had higher levels of Bifidobacterium, Butyric Clostridium, and Lactobacillus compared to the control group (p < 0.05). The complication rate was lower in the observation group (p < 0.05). The combination of Qingchang Yuyang Decoction with sustained-release mesalazine tablets can improve the clinical efficacy in UC, significantly alleviate clinical symptoms, reduce the inflammatory response, adjust intestinal flora distribution, and promote recovery, making it worthy of clinical application.
期刊介绍：
Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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