Allergologia et immunopathologia最新文献_第2页

Fewer injections, less pain: Successful cyanocobalamin desensitization. 更少的注射，更少的疼痛：成功的氰钴胺脱敏。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1320

Zeynep Yegin Katran, İsmet Bulut

引用次数: 0

Diagnostic biomarkers and miRNAs in prognosis of acute respiratory distress syndrome. 诊断性生物标志物和mirna与急性呼吸窘迫综合征预后的关系。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1239

Xian Jin, Mei He

引用次数: 0

Common variable immunodeficiency due to a novel variant in NFKB1 with a neonatal presentation of parechovirus meningitis and sepsis-like illness. 常见的可变免疫缺陷是由于NFKB1的一种新变异，新生儿表现为肺炎病毒脑膜炎和败血症样疾病。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1307

Aleksandra Szczawińska-Popłonyk, Natalia Popłonyk, Katarzyna Bernat-Sitarz, Katarzyna Jończyk-Potoczna, Agnieszka Pollak

{"title":"Common variable immunodeficiency due to a novel variant in NFKB1 with a neonatal presentation of parechovirus meningitis and sepsis-like illness.","authors":"Aleksandra Szczawińska-Popłonyk, Natalia Popłonyk, Katarzyna Bernat-Sitarz, Katarzyna Jończyk-Potoczna, Agnieszka Pollak","doi":"10.15586/aei.v53i3.1307","DOIUrl":"https://doi.org/10.15586/aei.v53i3.1307","url":null,"abstract":"Monoallelic variants in the nuclear factor kappa B 1 (NFKB1) gene reinforce the functional haploinsufficiency causing immunodeficiency with marked individual and intrafamilial variability in genotype-phenotype correlations. The leading clinical manifestations of NF-κB1 deficiency are recurrent infections and immune dysregulation disorders with autoinflammatory and lymphoproliferative disease. The reported patient initially presented with a neonatal sepsis-like illness with meningitis because of a parechovirus infection. The diagnosis of an inborn error of immunity, common variable immunodeficiency (CVID), was established based on hypogammaglobulinemia, impaired antibody response to vaccines, IgG subclass deficiency, and low numbers of switched memory B cells. Molecular genetic testing using trio whole exome sequencing was done to define the background of the presenting phenotype, and it revealed a novel heterozygous variant of NFKB1. Viral meningitis and sepsis-like illness are unusual, previously unreported, infectious complications in NF-κB1 deficiency. The transcriptional NF-κB1 regulatory effect on different target gene repertoires and numerous processes including immune and inflammatory responses may indiacte the vulnerability of deficient patients to severe viral infections. This case report exemplifies the advancement of immunogenetics paving the way for the transition from the initial era of clinical recognition to the era of molecular diagnosis of the pediatric CVID.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 3","pages":"31-40"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 N protein interacts with SLC7A11 to cause ferroptosis in acute lung injury. sars - cov - 2n蛋白与SLC7A11相互作用导致急性肺损伤中的铁下垂。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1340

Yi Liu, Hui Tang, Pan Xu, Xiaoqi Zhou, Shiying Li

{"title":"SARS-CoV-2 N protein interacts with SLC7A11 to cause ferroptosis in acute lung injury.","authors":"Yi Liu, Hui Tang, Pan Xu, Xiaoqi Zhou, Shiying Li","doi":"10.15586/aei.v53i3.1340","DOIUrl":"https://doi.org/10.15586/aei.v53i3.1340","url":null,"abstract":"Background: The nucleocapsid protein (N protein) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is elevated in bodily fluids at the onset of infection and has recently been found to have a direct role in lung damage. However, the exact mode of action of the N protein in acute lung injury is still unknown.Method: Recombinant N protein was used to treat mice and A549 cells in vivo and in vitro. Enzyme-linked immunosorbent assay and hematoxylin and eosin staining were used to detect the levels of inflammatory factors and lung damage in lung tissue. The total iron and Fe2+ contents and the expression of ferroptosis markers in mouse lung tissues and cells were detected. Co-immunoprecipitation detects the binding of N protein and solute carrier family 7 member 11 (SLC7A11). Replenishment experiments were conducted by activating SLC7A11 to study the effect of SLC7A11 on N protein-induced lung injury.Result: Recombinant N protein caused acute lung injury and lung inflammation, increased total iron and Fe2+ contents in vivo and in vitro, promoted the expression of ACSL4, inhibited the expression of GPX4 and FTH1, and triggered ferroptosis. Recombinant N protein can interact with SLC7A11, and activating SLC7A11 can reverse N protein-induced ferroptosis and acute lung injury.Conclusion: SARS-CoV-2 N protein can directly interact with SLC7A11 to cause ferroptosis, which produces a lot of inflammatory factors and results in lung injury in mice.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 3","pages":"23-30"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phaseolus vulgaris anaphylaxis. 菜豆过敏反应。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1341

Hacer Efnan Melek Arsoy, Öner Özdemir

引用次数: 0

Drug or food anaphylaxis? 药物或食物过敏？

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1282

Catalina Gomez-Galán, Bélgica Minaya-Polanco, Jiménez-Freites Martha, Julián Andrés Manrique Niño, Adrianna Machinena-Spera

{"title":"Drug or food anaphylaxis?","authors":"Catalina Gomez-Galán, Bélgica Minaya-Polanco, Jiménez-Freites Martha, Julián Andrés Manrique Niño, Adrianna Machinena-Spera","doi":"10.15586/aei.v53i3.1282","DOIUrl":"10.15586/aei.v53i3.1282","url":null,"abstract":"A 9-month-old infant with a personal history of atopic dermatitis and no family history of atopy presented to the outpatient allergy clinic for evaluation of suspected food and drug allergy. The mother breastfed the infant from birth and had introduced only fruits and vegetables into his diet. After the first dose of Ferplex® (iron protein succinylate), the infant had an immediate moderate systemic reaction that required emergency care and treatment with intramuscular epinephrine. The drug was indicated for the treatment of acute anemia. Skin prick test and specific IgE were done, confirming sensitization to cow's milk and egg proteins. It was determined that the baby was sensitized to cow's milk proteins, without prior ingestion, and experienced an anaphylactic reaction after taking Ferplex®, a pharmaceutical product that contains casein as part of its active ingredients. The presence of succinylated casein was confirmed, without pertinent information on the amount in the technical sheet or package insert. Existing pharmaceutical industry regulations should be modified in order to declare food allergens present in excipients and in active ingredients to avoid potential risks for allergic patients. A detailed food history is important in young children who are gradually being introduced to new foods, and in those that have not yet been introduced, recordings should be made to avoid this type of allergic reaction.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 3","pages":"163-166"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring noninfectious radiological lung findings in adult patients with primary immunodeficiency diseases. 探讨原发性免疫缺陷疾病成人患者肺部非感染性影像学表现。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1302

Filiz Sadi Aykan, Fatih Çölkesen, Recep Evcen, Mehmet Kılınç, Eray Yıldız, Ümmügülsüm Yılmaz Ergün, Tuğba Önalan, Fatma Arzu Akkuş, Selim Kahraman, Mehmet Emin Gerek, Şevket Arslan

{"title":"Exploring noninfectious radiological lung findings in adult patients with primary immunodeficiency diseases.","authors":"Filiz Sadi Aykan, Fatih Çölkesen, Recep Evcen, Mehmet Kılınç, Eray Yıldız, Ümmügülsüm Yılmaz Ergün, Tuğba Önalan, Fatma Arzu Akkuş, Selim Kahraman, Mehmet Emin Gerek, Şevket Arslan","doi":"10.15586/aei.v53i3.1302","DOIUrl":"https://doi.org/10.15586/aei.v53i3.1302","url":null,"abstract":"Primary immunodeficiency diseases (PIDs) show different patterns of airway involvement, particularly bronchiectasis; however, comparative studies of radiologic manifestations in patients with PIDs are scarce. Hence, the aim of this study to investigate radiologic lung findings in adult patients with PIDs and evaluate the possible relationship between clinical and immunologic features and respiratory function in these patients. In this study, the demographic and clinical characteristics, serum immunoglobulins (Ig), lymphocyte subgroups, high-resolution computed tomography (HRCT), and pulmonary function tests (PFTs) of 116 adult patients with PID were evaluated and those with and without abnormal HRCT were compared. The median age was 40 (28-48) years, and there were 51 (44%) females. Abnormal findings were detected in 55.2% of the HRCTs, but the most common findings were bronchiectasis (30.2%), bilateral involvement (73.5%), and lower lobe predominance. The median age and age of diagnosis were higher in those with HRCT findings. The obstructive pattern was the most common found in the PFTs. Forced vital capacity, maximal mid-expiratory flow at 25-75%, immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), cluster of differentiation (CD)4+ T cell, CD4+/CD8+ ratio, and class-switched memory B (cSMB) cell levels were significantly lower, whereas mortality was higher. Noninfectious pulmonary complications are among the important causes of morbidity and mortality in PID that could result in chronic lung disease despite adequate Ig therapy. Considering the extra radiation dose of HRCT, clinical findings and immunological and PFT parameters accompanying radiological features may be helpful in predicting the diagnosis; it may also be useful in determining additional treatment modalities and reducing mortality.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 3","pages":"41-50"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knockdown of THBS1 inhibits inflammatory damage and oxidative stress in in vitro pneumonia model by regulating NF-κB signaling pathway. 敲低THBS1通过调节NF-κB信号通路抑制体外肺炎模型炎症损伤和氧化应激。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1225

Fang Wang, Rixi Xie

引用次数: 0

Mechanisms and implications of histamine-induced reactions and complications. 组胺诱导的反应和并发症的机制和意义。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1272

Ahmed Al-Maamari, Marwa Sultan, Shanshan Ding, Duan Yuxin, Meng-Yao Wang, Suwen Su

{"title":"Mechanisms and implications of histamine-induced reactions and complications.","authors":"Ahmed Al-Maamari, Marwa Sultan, Shanshan Ding, Duan Yuxin, Meng-Yao Wang, Suwen Su","doi":"10.15586/aei.v53i3.1272","DOIUrl":"https://doi.org/10.15586/aei.v53i3.1272","url":null,"abstract":"Histamine, classified as a biogenic amine, plays a crucial role in both pro-inflammatory and immune regulatory processes, thereby establishing itself as a key mediator in allergic diseases and immune responses. This review provides an exhaustive analysis of the structure, function, and regulation of histamine, with particular emphasis on its interaction with four receptor subtypes: histamine H1 receptor (H1R), histamine H2 receptor (H2R), histamine H3 receptor (H3R), and histamine H4 receptor (H4R), all of which are instrumental in mediating a variety of physiological processes, including neurotransmitter release, modulation of immune responses, and gastric acid secretion. The review explores intracellular signaling pathways mediated by the activation of these receptors, highlighting the complex cascades involved in immediate- and delayed-type hypersensitivity reactions. It also examines the broad spectrum of histamine-induced complications, focusing on their effects on the gastrointestinal, cardiovascular, respiratory, and central nervous systems, and emphasizes histamine's potential to cause vascular dysfunction and other pathological changes. Furthermore, the role of histamine in inflammation and immune responses is explored, particularly in the context of allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis. The review also covers pharmacological interventions targeting histamine receptors, including the use of antihistamines and mast cell stabilizers, which are critical for the treatment of symptoms and the inhibition of the progression of histamine-related conditions. Finally, the review addresses emerging research and future directions, identifying potential areas for innovation and improved therapeutic strategies. This comprehensive overview not only deepens understanding of histamine's multifaceted roles in health and disease, but also underscores the importance of developing advanced diagnostic tools and targeted treatments for histamine-associated disorders.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 3","pages":"122-139"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can urticaria images found on the internet be a source of health information? 在互联网上找到的荨麻疹图像能否成为健康信息的来源？

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i3.1351

Merve Erkoç, Makbule Seda Bayrak Durmaz

{"title":"Can urticaria images found on the internet be a source of health information?","authors":"Merve Erkoç, Makbule Seda Bayrak Durmaz","doi":"10.15586/aei.v53i3.1351","DOIUrl":"https://doi.org/10.15586/aei.v53i3.1351","url":null,"abstract":"Background: In parallel with technological developments, patients increasingly benefit from information and communication technologies.Objective: The aim was to evaluate urticaria images that are available on the internet in two different languages.Materials and methods: The terms \"urticaria\" and \"ürtiker\" were used as search terms on Google Images. One hundred images were saved for each term, and each image was opened via its link. Two specialists in immunology and allergy jointly assessed the uploader information, pixel resolution, characteristics of the urticarial lesions, and image quality of the photos.Results: A total of 178 images were included, with 87 from the \"urticaria\" search term and 91 from the \"ürtiker\" search term-71.3% images had isolated urticaria, 1.7% had isolated angioedema, 0.6% had both urticaria and angioedema, and 26.4% had neither urticaria nor angioedema; 131 photographs depicting urticaria and/or angioedema were analyzed. The majority of urticarial plaques were erythematous (84%), with extremities (32.1%) being the most commonly affected area. Images in the preview on Google Images appeared more blurred and of lower resolution than the images after opening the link (n:99 vs. n:26, p < 0.001 and n:55 vs. n:10, p < 0.001, respectively). The quality of the images was found to be better after opening the link compared to the preview (n:34 vs. n:107; p < 0.001).Conclusion: Our study found that approximately one-quarter of urticaria images on Google Images did not match true urticarial lesions and were of suboptimal quality in both Turkish and universally accessible English.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 3","pages":"80-87"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0