Allergologia et immunopathologia最新文献

{"title":"Regional patterns of molecular sensitization to dust mites and pollens in a Portuguese pediatric population: a multicentric study.","authors":"João Nogueira Oliveira, Mafalda Moreira, Manuel Lima Ferreira, Sandra Teixeira, Marta Santalha, Teresa São Simão, Armandina Silva, Filipa Almeida, Hernani Brito, Fernanda Carvalho, Estefânia Maia, Carla Chaves Loureiro, Catarina Leuzinguer, Sara Machado, Cláudia Pedrosa, Patricia Silva Veríssimo, Sofia Guedes, Carla Rosa, Georgeta Oliveira, Ana Paula Aguiar, Catarina Freitas, Lara Torres, Maria Alexandra Rodrigues, Pedro Guerra, Helena Ramalho, Beatriz Sousa, Mariana Branco, Ana Sofia Nunes, Mariana Oliveira Pereira, Margarida Reis Morais, José Fraga, Inês Falcão, Maria José Dinis, Conceição Silva, Raquel Santos, Rita Silva Pereira, Márcia Quaresma, Diana Pinto, Ana Rita Araújo","doi":"10.15586/aei.v54i2.1582","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1582","url":null,"abstract":"<p><p>Molecular tools enable detailed analysis of molecular allergens. Understanding their regional variability, considering environmental factors, improves diagnostic accuracy and allows individualized approaches in pediatric allergy management. This multicenter retrospective study analyzed the results of ImmunoCAP ISAC^® test (n = 1010) performed in pediatric patients from 14 Portuguese hospitals. Sensitization to dust mite (DM) molecular allergens was found in 64% of patients, mainly to major allergens Der p 1, Der p 2, and Der p 23. There were 96 patients (10%) monosensitized to one DM molecular allergen with almost half of them being sensitized to Der p 23 (48%), followed by Der p 1 (26%). Urbanization and coastal residence were associated with a higher risk of DM sensitization, particularly to <i>Dermatophagoides</i> species. Pollen sensitization affected 57% of patients, with grass pollens-mainly Phl p 1 and Cyn d 1-being the most prevalent pollens. Interior regions, characterized by greater vegetation, showed a significantly higher prevalence of pollen sensitization. Regional trends that reflected the native flora were noted, such as elevated sensitivity to olive pollen allergen Ole e 1 in Trás-os-Montes region and Arizona cypress pollen allergen Cup a 1 in Coimbra region. Sensitization to birch pollen allergen Bet v 1 and proteins of the pathogenesis-related class 10 plant protein family (PR-10) was associated with food allergy. The findings of this research emphasized the need for incorporating these regional variations into clinical practice and draw attention to notable regional variations in allergy sensitivity patterns among Portuguese children.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"109-116"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline serum double-mite (D1+D2) sIgE/tIgE ratio as a predictor of early-phase response to dual-mite subcutaneous immunotherapy in allergic rhinitis.","authors":"Chengzhi Huang, Zhiyuan Tang","doi":"10.15586/aei.v54i2.1514","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1514","url":null,"abstract":"<p><strong>Background: </strong>Subcutaneous immunotherapy (SCIT) for allergic rhinitis (AR) requires long-term treatment, and its phased efficacy often influences patient adherence. Identifying early biomarkers, such as serum-specific IgE to total IgE (sIgE/tIgE) ratio, may support individualized management.</p><p><strong>Objective: </strong>To determine the predictive value of baseline double-mite (D1+D2) sIgE/tIgE ratio for phased dual-mite SCIT response in AR patients.</p><p><strong>Methods: </strong>We prospectively enrolled 194 AR patients sensitized to <i>Dermatophagoides pteronyssinus</i> (D1) and <i>Dermatophagoides farinae</i> (D2) who received dual-mite SCIT between September 2022 and January 2023. Baseline serum tIgE and sIgE (D1+D2) were measured, and the combined sIgE/tIgE ratio was calculated. Treatment response was evaluated by reduction in visual analogue scale (VAS) scores at months 6 and 12, with the efficacy distribution compared between the two time points using the Chi-square test. Univariable and multivariable logistic regression identified predictors of achieving at least an effective response, and receiver operating characteristic (ROC) analysis was applied for sIgE/tIgE ratio when indicated.</p><p><strong>Results: </strong>SCIT efficacy improved over time, with a significant shift in response distribution between 6 and 12 months (<i>χ</i> ² = 10.084, P = 0.006). At 6 months, multivariable analysis showed that both higher baseline VAS score (OR = 0.954, 95% CI: 0.929-0.980, P < 0.001) and higher sIgE/tIgE ratio (OR = 0.985, 95% CI: 0.972-0.999, P = 0.036) were independently associated with lower likelihood of achieving at least effective response. ROC analysis indicated a cutoff sIgE/tIgE ratio of 26.62% for predicting poor short-term response. At month 12, only baseline VAS score remained a significant predictor (OR = 1.038, 95% CI: 1.005-1.072, P = 0.025).</p><p><strong>Conclusion: </strong>SCIT efficacy progressively improves over the first year. A higher baseline sIgE (D1+D2)/tIgE ratio (>26.62%) predicts poorer short-term response, highlighting the value of objective biomarkers for early response assessment and individualized management.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"164-169"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of reporting, statistical methodology, and interpretation in a preclinical intranasal curcumin model of allergic rhinitis.","authors":"Kazim Okan Dolu","doi":"10.15586/aei.v54i2.1708","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1708","url":null,"abstract":"","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"178-179"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering Type 2 inflammatory profiles in severe eosinophilic asthma with nasal polyps: the role of transcript-protein ratios and <i>Staphylococcus aureus</i> enterotoxin B-specific IgE.","authors":"İnsu Yılmaz, Serpil Taheri, Bahar Arslan, Şerife Erdem, Ahmet Eken, Gülden Paçacı Çetin, Murat Türk, Zeynep Yılmaz, Zuhal Hamurcu, Nuri Tutar","doi":"10.15586/aei.v54i2.1486","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1486","url":null,"abstract":"<p><strong>Background: </strong>Severe eosinophilic asthma with nasal polyps (SEAwNP) is a clinical phenotype characterized by elevated peripheral eosinophil counts and heightened type 2 (T2) inflammation.</p><p><strong>Objective: </strong>In this study, we aimed to compare the transcript/protein expression ratios of factor XIII-A (F13A), B-cell activating factor (BAFF), interleukin-5 (IL-5), and thymus- and activation-regulated chemokine (TARC), as well as serum Staphylococcus aureus Enterotoxin B-Specific IgE (SEB-IgE) levels, among patients with SEAwNP, SEA without nasal polyps (NP), NP without asthma, and healthy controls groups.</p><p><strong>Material and methods: </strong>A total of 73 participants were enrolled and stratified into four groups: SEAwNP (n=20), SEA without NP (n=18), NP without asthma (n=15), and healthy controls (n=20). Peripheral blood samples were analyzed using real-time quantitative PCR and protein levels using ELISA for periostin, F13A, BAFF, IL-5, and TARC. Serum SEB-IgE levels were also assessed.</p><p><strong>Results: </strong>SEAwNP patients exhibited significantly elevated transcript/protein expression ratios of periostin, F13A, BAFF, and IL-5 compared to SEA without NP (p=0.007, p=0.001, p=0.019, and p=0.017, respectively). Furthermore, periostin, F13A, BAFF, IL-5, and TARC transcript/protein ratios were significantly higher in SEAwNP patients compared to healthy controls (p=0.0001, p=0.001, p=0.003, p=0.014, and p=0.02, respectively). SEB-IgE positivity rates were 45% in SEAwNP, 38% in SEA without NP, 13% in NP without asthma, and 0% in healthy controls.</p><p><strong>Conclusion: </strong>SEAwNP is associated with elevated transcript/protein expression ratio of key T2 inflammatory mediators and increased SEB-IgE positivity, supporting their potential role in the immunopathogenesis of this phenotype. These findings underscore the importance of biomarker profiling in distinguishing endotypes within the spectrum of eosinophilic airway diseases.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"35-44"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers and immune cells in allergen-specific immunotherapy: toward objective evaluation.","authors":"Chengzhi Huang, Zhiyuan Tang","doi":"10.15586/aei.v54i2.1533","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1533","url":null,"abstract":"<p><strong>Background: </strong>Allergen-specific immunotherapy (AIT) is the only intervention capable of modifying the natural course of allergic diseases by inducing long-term immune tolerance. Its clinical efficacy depends on complex regulations of humoral and cellular immunity, yet objective assessment remains hindered by the absence of standardized biomarkers.</p><p><strong>Summary: </strong>This review summarizes recent advances in the immunological mechanisms of AIT and highlights emerging biomarkers-including allergen-specific immunoglobulin G4, regulatory T and B cells, and innate lymphoid cells-that may provide objective measures of efficacy and support individualized treatment strategies.</p><p><strong>Key messages: </strong>(1) AIT uniquely modifies the natural history of allergic diseases; (2) current evaluation relies on subjective measures, highlighting the urgent need for standardized and clinically applicable biomarkers; (3) molecular markers and immune cell subsets offer promising tools for bridging mechanistic insights with clinical endpoints, supporting real-time monitoring and precision-guided optimization of AIT.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"156-163"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can food allergy trigger acute pancreatitis? Exploring an unusual etiology.","authors":"Yasemin Akgul Balaban, Mustafa Ilker Inan, Fikriye Kalkan, Ezgi Sonmez, Galip Buyukturan, Fevzi Demirel, Ali Selcuk, Sait Yesillik, Yusuf Serdar Sakin, Ozgur Kartal","doi":"10.15586/aei.v54i2.1544","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1544","url":null,"abstract":"<p><strong>Backgrounds: </strong>Food allergy (FA) is an immune-mediated hypersensitivity reaction to specific dietary antigens. While FA typically manifests with skin, respiratory, or gastrointestinal symptoms, its role in acute pancreatitis remains unclear. Acute pancreatitis is a potentially life-threatening inflammatory condition with well-known etiologies; however, in up to 30% of cases, no identifiable cause is found, resulting in a diagnosis of idiopathic acute pancreatitis (IAP).</p><p><strong>Objective: </strong>This prospective study aimed to investigate the potential association between FA and IAP in adult patients.</p><p><strong>Material and methods: </strong>Forty-nine adult patients diagnosed with IAP were evaluated. During the acute episode, serum tryptase, total immunoglobulin E (IgE), and eosinophil levels were measured. Eight weeks post-recovery, skin prick tests (SPT) and serum-specific IgE (sIgE) tests were performed for common and suspected food allergens. Patients with positive results underwent further testing, including prick-to-prick testing.</p><p><strong>Results: </strong>Among 49 patients, eight (16.3%) demonstrated sensitization to food allergens, such as cow's milk, wheat, red meat, banana, plum, and tomatoes. These patients had significantly higher total IgE levels (P = 0.001). No significant differences were found in attack severity or tryptase levels between FA and non-FA groups. One patient experienced recurrence after re-exposure to the identified allergen. SPT alone failed to detect sensitization in several cases, whereas sIgE and prick-to-prick tests improved diagnostic accuracy.</p><p><strong>Conclusion: </strong>This is the first prospective study to suggest a potential link between FA and IAP. In cases of unexplained pancreatitis, FA should be considered in the differential diagnosis. Multidisciplinary collaboration between gastroenterologists and allergists is recommended for accurate diagnosis and management.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"45-50"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing drug allergy diagnosis in Tunisia using flow cytometry: a promising first step.","authors":"Rania Mzoughi, Baraa Ben Houria, Aymen Tazeghdanti, Mouna Ben Azaiz, Radhia Kochkar, Ezzedine Ghazouani","doi":"10.15586/aei.v54i2.1512","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1512","url":null,"abstract":"<p><strong>Background: </strong>Hypersensitivity reactions to drugs represent a significant and growing health concern worldwide, with the potential to cause severe and life-threatening outcomes. Accurate diagnosis of drug allergies is essential for effective patient management, particularly in differentiating true allergic reactions from other adverse drug reactions.</p><p><strong>Objective: </strong>This study aimed to evaluate for the first time the Basophil Activation Test (BAT) using flow cytometry as a reliable diagnostic tool for immediate-type drug allergies in Tunisia.</p><p><strong>Methods: </strong>This study included 35 BATs, conducted between November 2022 and December 2024. Only one patient underwent two separate BATs on different drugs. From each patient, venous blood was drawn and BAT was assessed using flow cytometry. Serial dilutions of suspected drugs, including antibiotics (e.g., amoxicillin and cefixime), non-steroidal anti-inflammatory drugs (e.g., mefenamic acid), and others, were tested. For each sample, basophils were incubated with the drug dilutions stained with antibodies marked with different fluorescents, such as CRTH2-FITC, CD3-PC7, CD203c-PE, and then analyzed on a Navios Ex flow cytometry.</p><p><strong>Results: </strong>Of all the performed BATs, antibiotics represented the majority of tested drugs accounting for 56%. However, only three tests were positive, in favor of a type I hypersensitivity drug reaction.</p><p><strong>Conclusion: </strong>By applying BAT in the Immunology Department of the Military Hospital of Tunisia, this study seeks to enhance diagnostic accuracy and contribute to personalized patient care.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"99-108"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of starting very-low-dose wheat intake in children with severe allergy: a retrospective study.","authors":"Kosei Yamashita, Takanori Imai, Midori Takahashi, Sawa Seki, Toshiyuki Takagi, Megumi Okawa, Aiko Honda, Chihiro Kunigami, Yuki Okada, Mayu Maeda, Taro Kamiya","doi":"10.15586/aei.v54i2.1451","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1451","url":null,"abstract":"<p><strong>Background: </strong>In order to prevent total elimination of wheat from their diet, we introduced a very-low-dose (VLD) oral food challenge (OFC) in patients with severe wheat allergy in 2019.</p><p><strong>Objective: </strong>This study investigated the efficacy of starting VLD wheat intake for achieving full-dose OFC.</p><p><strong>Material and methods: </strong>Patients with a history of overt allergic reactions to low-dose (LD; 80-mg wheat protein) wheat or lesser within 6 months and those with complete wheat elimination were included in the study. We retrospectively compared the proportion of passing a full-dose OFC (2650-mg wheat protein) between patients who underwent an LD OFC prior to 2019 (LD group) and those who underwent a VLD OFC (26.5-mg wheat protein) after 2019 (VLD group). The period for passing the full-dose OFC was evaluated using Kaplan-Meier survival analyses.</p><p><strong>Results: </strong>We enrolled 200 and 58 patients in LD group and VLD group, respectively. The median age at OFC initiation was 2.1 (1.6-4.2) and 1.9 (1.4-3.6) years in LD group and VLD group, respectively. Wheat- and ω-5 gliadin-specific immunoglobulin E (IgE) levels were 25.2 (7.7-59.8) kUA/L and 2.5 (0.8-12.6) kUA/L, respectively, in the LD group and 21.9 (7.4-94.9) kUA/L and 3.3 (1.2-9.4) kUA/L, respectively, in the VLD group. Over 4 years, the LD group and VLD group passed the full-dose OFC at proportions of 50% and 75%, respectively, with a significant difference (Log-rank test, P < 0.01).</p><p><strong>Conclusion: </strong>Starting VLD wheat intake may contribute to achieving a full-dose OFC in patients with severe wheat allergies.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"76-84"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic characteristics and allergen sensitization profiles in patients with allergic rhinitis in Shenzhen, China.","authors":"Chengzhi Huang, Zhiyuan Tang","doi":"10.15586/aei.v54i2.1515","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1515","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) is increasingly prevalent in China, yet allergen sensitization data in coastal subtropical cities such as Shenzhen remain scarce.</p><p><strong>Objective: </strong>To investigate allergen distribution and demographic characteristics among AR patients in Shenzhen, China.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 3351 AR patients from January to December 2022. Serum-specific immunoglobulin E (sIgE) levels were measured; values ≥0.35 kU/L were considered positive and graded into six levels. Allergen patterns were compared by gender, age (<14 vs. ≥14 years), and sIgE level.</p><p><strong>Results: </strong>Clinic visits peaked in August. The most prevalent allergens were <i>Blomia tropicalis</i> (<i>Bt</i>), <i>Dermatophagoides pteronyssinus</i> (<i>Dp</i>), and <i>Dermatophagoides farinae</i> (<i>Df</i>). Other important indoor allergens included cockroach, dog dander, and cat dander. Leading outdoor allergens were <i>Ambrosia artemisiifolia</i> (ragweed), <i>Chenopodium album</i>/<i>Amaranthus retroflexus</i>, and <i>Platanus</i>/<i>Fraxinus</i>. Male patients showed higher sensitization to <i>Dp</i> and <i>Df</i> (P < 0.05). The sensitization proportions for leading allergens (<i>Bt, Dp</i>, and <i>Df</i>) declined with increasing age: compared with adolescents and adults (≥14 years), pediatric patients (<14 years) had significantly higher sensitization to indoor allergens, whereas the adolescent/adult group showed significantly higher sensitization to pollens and molds (P < 0.05). <i>Dp</i> and <i>Df</i> responses peaked at class 3, <i>Bt</i> and cat dander at class 2, and cockroach/dog dander/pollens/molds at class 1, with significant differences in sIgE levels among allergens (P < 0.05).</p><p><strong>Conclusion: </strong>Dust mites, especially <i>Bt</i>, are the primary source of allergens affecting AR patients in Shenzhen. Sensitization patterns differ by age, gender, and sIgE levels, highlighting the importance of region-specific allergen surveillance and personalized AR management.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"170-177"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of sexual life and sleep quality in patients with hereditary angioedema.","authors":"Filiz Sadi Aykan, Hasan Bakay, Fatih Çölkesen, Şakir Gıca, Mehmet Kılınç, Evcen Recep, Tuğba Önalan, Selim Kahraman, Eray Yıldız, Şevket Arslan","doi":"10.15586/aei.v54i2.1546","DOIUrl":"https://doi.org/10.15586/aei.v54i2.1546","url":null,"abstract":"<p><strong>Background: </strong>Hereditary angioedema (HAE) is a genetic disorder characterized by recurrent, spontaneous, and sometimes life-threatening episodes of swelling. Attacks of angioedema that negatively impact quality of life can occur anywhere in the body. The chronic and unpredictable course of the disease can also affect mental health, sleep quality, and sexual life.</p><p><strong>Objective: </strong>This study aimed to investigate sexual function, sleep quality, and related factors in HAE patients.</p><p><strong>Material and methods: </strong>In all, 40 patients diagnosed with type 1 and type 2 HAE were followed up in the Immunology and Allergy Clinic, and 40 healthy controls were included in the study. Participants completed the Arizona Sexual Experience Scale (ASEX), Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depression Scale (HADS).</p><p><strong>Results: </strong>The patient group had significantly higher ASEX and PSQI scores compared to the healthy control group. In the patient group, ASEX scores showed a significant positive correlation with HADS-Depression (HADS-D) and HADS-Anxiety (HADS-A) scores. It was shown that as frequency of monthly attacks in patients increased, both HADS-D and HADS-A scores increased, and with increase in HADS-D scores, sleep efficiency decreased. Furthermore, a strong positive correlation was shown between HADS-A scores and PSQI scores. Longer disease duration, history of genital attacks, and decreased sleep quality were found to be significantly correlated with sexual dysfunction.</p><p><strong>Conclusion: </strong>The results supported our hypothesis that sexual life and sleep quality are more affected in this patient group than known previously. It is expected that evaluating sexual life, sleep quality, and general well-being in the routine follow-up of these patients may contribute to disease control.</p>","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"54 2","pages":"10-21"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}