Critical appraisal of the effects of the COVID-19 pandemic on allergen sensitivity of individuals.

This letter offers constructive feedback of the study by Sağun et al. on changing allergen sensitivity in the COVID-19 pandemic. The data presented were very interesting concerning the changing rates of sensitization, but the authors neglected some important areas requiring further consideration. The study does not take into account whether or not enhanced sensitization had translated into more clinical allergic disease, thus putting restrictions on considering actual real-world implications. Lifestyle disruption and COVID-19 infection status have not been directly measured and analyzed as potential confounds. Also, the allergy clinic's patient focus raises concerns about selection bias. Stating these issues may help shape future inquiries in building a more comprehensive picture of how the pandemic has affected allergy risks and outcomes.