Allergologia et immunopathologia最新文献_第10页

Allergy to Alternaria alternata: Comprehensive review from the origin to the therapeutic approach. 互花莲子过敏：从起源到治疗方法的综合综述。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1454

Javier Torres-Borrego, Javier Suárez-Pérez, Yolanda Aliaga-Mazas, Ana Martínez-Cañavate Burgos, Santiago Nevot-Falcó

{"title":"Allergy to Alternaria alternata: Comprehensive review from the origin to the therapeutic approach.","authors":"Javier Torres-Borrego, Javier Suárez-Pérez, Yolanda Aliaga-Mazas, Ana Martínez-Cañavate Burgos, Santiago Nevot-Falcó","doi":"10.15586/aei.v53i5.1454","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1454","url":null,"abstract":"Alternaria alternata is an ubiquitous mold commonly found in both outdoor and indoor environments. It is a common airborne mold recognized as a significant aeroallergen linked to pediatric allergic rhinitis and asthma. Although sensitization rates in children vary regionally, evidence suggests that A. alternata allergy significantly impacts pediatric respiratory health and as its exposure worsens, respiratory outcomes in susceptible pediatric populations Alternaria. Children are especially vulnerable due to their developing immune and respiratory systems and greater exposure to environmental allergens. This narrative review aims to summarize current knowledge on A. alternata as an allergenic source in children, including its biology, allergenic components (especially Alt a 1), interactions with immune system, airway epithelium interacting with other allergens, and clinical relevance. We also discuss the allergen-specific immunotherapy strategies with standardized extracts that are effective and safe in pediatric patients. Understanding the role of Alternaria in allergic disease is essential for early and accurate diagnosis (including component-resolved methods), effective intervention, and improving long-term outcomes in affected children. Future research should focus on novel vaccine technologies and standardized pediatric-specific treatment protocols.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"179-188"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A practical and applicable desensitization scheme for ciprofloxacin with a glass of water. 一种实用、适用的一杯水环丙沙星脱敏方案。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1413

Zeynep Yegin Katran, İsmet Bulut, Feyza Yegin, Mustafa Katran

引用次数: 0

Efficacy of hypertonic saline nasal irrigation in allergic rhinitis: A systematic review and meta-analysis. 高渗盐水鼻冲洗治疗变应性鼻炎的疗效：一项系统综述和荟萃分析。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1409

Nishtha Singh, Sheetu Singh, Arvind Kumar Sharma, Udaiveer Singh, Vaibhav Bhatnagar, Virendra Singh

{"title":"Efficacy of hypertonic saline nasal irrigation in allergic rhinitis: A systematic review and meta-analysis.","authors":"Nishtha Singh, Sheetu Singh, Arvind Kumar Sharma, Udaiveer Singh, Vaibhav Bhatnagar, Virendra Singh","doi":"10.15586/aei.v53i5.1409","DOIUrl":"10.15586/aei.v53i5.1409","url":null,"abstract":"Saline nasal irrigation provides symptom relief in allergic rhinitis (AR), but the optimal saline concentration remains uncertain. The comparative efficacy of 3% hypertonic saline nasal irrigation (HSNI) versus 0.9% isotonic saline is still debated. We conducted a meta-analysis to evaluate nasal symptom scores from studies comparing HSNI with control (isotonic saline or no saline) in patients with AR. Systematic search of PubMed, Scopus, and Cochrane Central was performed for randomized controlled trials (RCTs) comparing 3% HSNI with control from inception to May 8, 2024. Primary outcomes were total nasal symptom scores and antihistamine use. We pooled mean differences and odds ratios (OR) with 95% confidence intervals (CI) using a random effects model and assessed heterogeneity with I2. Nine RCTs involving 645 patients met the inclusion criteria. Follow-up ranged from 4 weeks to 2 months. The mean age was 35.49 years in adults and 9.3 years in children. HSNI significantly reduced nasal symptom scores compared with control in adults (MD = -2.09; 95% CI: -3.86 to -0.33; P = 0.02; I2 = 97%) and children (MD = -0.97; 95% CI: -1.51 to -0.44; P = 0.0004; I2 = 42%). Antihistamine use was also lower with HSNI than control (OR = 0.39; 95% CI: 0.21-0.70; P = 0.002; I2 = 14%), but no significant difference was found between HSNI and isotonic saline alone (OR = 0.69; 95% CI: 0.41-1.16; P = 0.16; I2 = 0%). HSNI appears effective in reducing symptoms and medication use in allergic rhinitis across age groups.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"164-178"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antituberculosis drug-induced hypersensitivity: clinical characteristics and risk factors. 抗结核药物致超敏反应：临床特点及危险因素。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1427

Zeynep Yegin Katran, İsmet Bulut, Aylin Babalık, Metin Keren, Fatma Merve Tepetam

{"title":"Antituberculosis drug-induced hypersensitivity: clinical characteristics and risk factors.","authors":"Zeynep Yegin Katran, İsmet Bulut, Aylin Babalık, Metin Keren, Fatma Merve Tepetam","doi":"10.15586/aei.v53i5.1427","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1427","url":null,"abstract":"Background: Antituberculosis drugs can cause hypersensitivity reactions that interrupt treatment and increase morbidity. Early identification and management are essential to prevent complications and drug resistance.Objective: To evaluate the clinical characteristics, risk factors, and outcomes of antituberculosis drug-induced hypersensitivity reactions over a 10-year period in a tertiary referral center.Methods: We retrospectively analyzed 449 patients hospitalized for antituberculosis drug-induced hypersensitivity between 2015 and 2024. A control group of 478 tuberculosis patients without hypersensitivity was included. Demographic features, comorbidities, hypersensitivity types, causative drugs, and treatment outcomes were compared.Results: The prevalence of hypersensitivity was 12.1%. Female gender, older age, Turkish nationality, and history of other drug allergies were significant risk factors. Type 1 reactions (77.7%) were more common and associated with shorter treatment interruption and higher cure rates. Pyrazinamide was the most frequently implicated drug. Desensitization was successful in the majority of patients.Conclusion: This large cohort study highlights key risk factors and clinical outcomes in tuberculosis drug hypersensitivity. Close monitoring of high-risk patients in the early treatment phase may reduce delays and improve outcomes.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"69-77"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective IgA deficiency and allergic diseases: Clinical and immunological evaluation. 选择性IgA缺乏与过敏性疾病：临床和免疫学评价。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1374

Selami Ulaş, Serdar Al, Sezin Naiboğlu, Işılay Turan, Gülşah Kalay, Nermin Kapçı, Özge Türkyılmaz Uçar, Sibel Kaplan, Erkan Çakmak, Kübra Yırgın, Ahmet Sert, Meryem Özçelik, Burcu Çil, Şeyda Köse, Ilke Yıldırım, Simge Kılıçoğlu, Pınar Gökmirza Özdemir, Mehmet Halil Çeliksoy, Çiğdem Aydoğmuş

{"title":"Selective IgA deficiency and allergic diseases: Clinical and immunological evaluation.","authors":"Selami Ulaş, Serdar Al, Sezin Naiboğlu, Işılay Turan, Gülşah Kalay, Nermin Kapçı, Özge Türkyılmaz Uçar, Sibel Kaplan, Erkan Çakmak, Kübra Yırgın, Ahmet Sert, Meryem Özçelik, Burcu Çil, Şeyda Köse, Ilke Yıldırım, Simge Kılıçoğlu, Pınar Gökmirza Özdemir, Mehmet Halil Çeliksoy, Çiğdem Aydoğmuş","doi":"10.15586/aei.v53i5.1374","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1374","url":null,"abstract":"Purpose: We aimed to investigate allergic sensitization and associated factors in pediatric patients with selective immunoglobulin A deficiency (SIgAD) and to evaluate differences between allergic and nonallergic groups.Methods: We analyzed 110 patients (aged 4-18 years) diagnosed with SIgAD at Çam and Sakura City Hospitals, Istanbul, between 2021 and 2024. Their demographic, clinical, and laboratory data were assessed.Results: Allergic sensitization was detected in 62.7% of patients. Patients with allergic sensitization, family history of allergic diseases, eosinophilia, and elevated total immunoglobulin E (IgE) levels were significantly higher (P < 0.05). Immunglobulin M (IgM) levels were higher in the allergic group (P = 0.01), and they had lower neutrophil counts (P = 0.03). Allergic sensitization was lower in patients with autoimmune diseases (P = 0.03). In 60% of the patients, the main reason for presentation was recurrent infection.Conclusion: Allergic sensitization with SIgAD is associated with genetic and immunological factors. A family history of allergic disease, eosinophilia, and elevated total IgE levels are important markers for the development of allergy. These findings highlight the need to closely monitor allergies in people with SIgAD.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"78-86"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between serum copper and childhood asthma: A systematic review and meta-analysis. 血清铜与儿童哮喘的关系：一项系统回顾和荟萃分析。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1394

Beilei Wang, Xingyue Su, Xiang Ma

{"title":"Association between serum copper and childhood asthma: A systematic review and meta-analysis.","authors":"Beilei Wang, Xingyue Su, Xiang Ma","doi":"10.15586/aei.v53i5.1394","DOIUrl":"10.15586/aei.v53i5.1394","url":null,"abstract":"Background: Asthma is a chronic respiratory disease with complex pathogenesis. Some studies suggest that certain trace metals may be associated with asthma. However, the relationship between serum copper (Cu) and childhood asthma remains unclear. This meta-analysis evaluates the association between Cu and childhood asthma.Methods: Studies of multiple databases were searched from inception to 2024. We recorded the standardized mean difference (SMD), 95% confidence intervals (CIs), and other data. The analysis was performed using Stata 18.0 software. Two independent reviewers appraised methodological quality using the Newcastle-Ottawa Scale. Sensitivity analysis was used to test robustness. To evaluate publication bias, we used Begg's funnel plots and Egger's regression test.Results: A total of 11 studies with a combined 1006 participants were included. There was no significant difference in the level of serum Cu between children with asthma cases and controls (SMD = -0.032, 95% CI: -0.291-0.228, P = 0.811). There was significant heterogeneity among the studies (I2 = 73.5%, P < 0.0001). Subgroup analysis demonstrated that heterogeneity was not caused by the continent of origin, publication year, sample size, detection methods, and the mean age of participants. No publication bias was found.Conclusion: There is no statistically significant association between serum Cu levels and childhood asthma. Further research, particularly large-scale prospective cohort studies, is needed to clarify this relationship.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"154-164"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wiskott-Aldrich syndrome complicated with IgG4-related Sclerosing disease: A case report and literature review. Wiskott-Aldrich综合征合并igg4相关硬化疾病1例报告及文献复习

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1437

Seda Altiner, Makbule Seda Bayrak Durmaz

{"title":"Wiskott-Aldrich syndrome complicated with IgG4-related Sclerosing disease: A case report and literature review.","authors":"Seda Altiner, Makbule Seda Bayrak Durmaz","doi":"10.15586/aei.v53i5.1437","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1437","url":null,"abstract":"Wiskott-Aldrich Syndrome (WAS) is an X-linked immunodeficiency characterized by eczema, microthrombocytopenia, and recurrent infections. Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory disorder involving various organs. We present a 34-year-old male with WAS who developed cervical lymphadenopathy and parotid gland swelling. Initial biopsies were inconclusive and imaging suggested pleomorphic adenoma. Given the persistent cervical lymphadenopathy and the underlying immunodeficiency, lymphoma was also considered in the differential diagnosis. However, histopathological examination of excised salivary gland and lymph nodes revealed lymphoplasmacytic and eosinophilic infiltrates, numerous IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis, consistent with IgG4-RD. The patient responded well to prednisone therapy. This case emphasizes the importance of considering IgG4-RD in the differential diagnosis of lymphoproliferative lesions in immunodeficient individuals and highlights the diagnostic value of histopathological evaluation in excisional tissue specimens. To our knowledge, this represents a rare coexistence of WAS and IgG4-RD not previously reported in the literature.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"138-142"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living at risk: Exploring the psychological effects of childhood food allergy on mothers. 生活在危险之中：探索儿童食物过敏对母亲的心理影响。

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1370

Elif Küçük, Fatih Çiçek

{"title":"Living at risk: Exploring the psychological effects of childhood food allergy on mothers.","authors":"Elif Küçük, Fatih Çiçek","doi":"10.15586/aei.v53i5.1370","DOIUrl":"https://doi.org/10.15586/aei.v53i5.1370","url":null,"abstract":"Objectives: Food allergy (FA) is a growing public health concern, imposing significant psychosocial burdens on families and necessitating strict allergen avoidance. The unpredictability of severe reactions is associated with increased anxiety, dietary restrictions, and reduced quality of life.Methods: We conducted a cross-sectional study including 77 mothers of children (0-12 years) with FA and 71 mothers of healthy children. Participants completed the Spielberger State-Trait Anxiety Inventory (STAI), Zarit Caregiver Burden Scale (ZCBS), and European Health Impact Scale (EUROHIS-QOL). Statistical analyses compared anxiety, caregiver burden, and quality of life between groups and explored sociodemographic factors.Results: Mothers in the FA group had significantly higher state anxiety (STAI-S) (P < 0.001) and ZCBS scores (P < 0.001) compared to controls. However, trait anxiety (STAI-T) did not differ significantly between groups (P = 0.508). Additionally, mothers of children with FA reported lower EUROHIS-QOL scores (P = 0.009). Low maternal educational levels (P = 0.005) and middle-range income levels ($500-1000/month, P = 0.027) were significantly associated with higher anxiety and caregiver burden. Cow's milk protein allergy (CMPA) specifically increased trait anxiety (P = 0.035) and reduced mothers' quality of life (P = 0.003). No significant associations were found between anxiety or caregiver burden and anaphylaxis or other allergenic triggers.Conclusion: Food allergy significantly elevates maternal anxiety and caregiving burden, and reduces quality of life, especially in CMPA cases. Sociodemographic factors exacerbate these effects, highlighting the need for comprehensive, multidimensional interventions. Psychological support and broader public awareness initiatives may help alleviate adverse outcomes and improve caregiver well-being.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"53 5","pages":"53-61"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of the COVID-19 pandemic on allergen sensitivity of individuals. COVID-19大流行对个体过敏原敏感性的影响

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1442

Ferhat Sağun, Fatih Çölkesen, Mehmet Emin Gerek, Seçim Kolak, Emrah Harman, Şevket Arslan

引用次数: 0

Critical appraisal of the effects of the COVID-19 pandemic on allergen sensitivity of individuals. COVID-19大流行对个体过敏原敏感性影响的批判性评估

IF 2.1 4区医学

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.15586/aei.v53i5.1439

Umar Aziz

引用次数: 0