Allergologia et immunopathologia最新文献_第10页

Characteristics of childhood anaphylaxis in different age groups. 不同年龄组儿童过敏性休克的特征。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1131

Mehmet Halil Celiksoy, Selami Ulas, Isılay Turan, Ilke Yıldırım, Ozge Turkyilmaz Ucar, Serdar Al

{"title":"Characteristics of childhood anaphylaxis in different age groups.","authors":"Mehmet Halil Celiksoy, Selami Ulas, Isılay Turan, Ilke Yıldırım, Ozge Turkyilmaz Ucar, Serdar Al","doi":"10.15586/aei.v52i5.1131","DOIUrl":"https://doi.org/10.15586/aei.v52i5.1131","url":null,"abstract":"Background: Anaphylaxis is a severe systemic hypersensitivity reaction that usually has a rapid onset and can be fatal. Presentations of childhood anaphylaxis vary widely in accordance with the triggers and the patient's age, geographical region and dietary and lifestyle habits.Methods: The medical records of 177 paediatric patients diagnosed with anaphylaxis between January 2021 and January 2024, whose disease progression was monitored at a single tertiary care centre, were reviewed retrospectively.Results: The study included 177 patients diagnosed with anaphylaxis (107 males and 70 females with a median age of 48 months). The most common allergen responsible was food (53.7%). Egg allergy was the most common source of anaphylaxis, afflicting 35 patients (19.3%), while beta-lactam provoked the most common drug allergy, affecting 24 patients (13.6%). The most common organ involved was the skin (92.7%). When the patients were analysed by age group, there were more males in the infancy, preschool and school age groups, while there were more females in the adolescent group (p = 0.44). Food-induced anaphylaxis became less common with increasing age, whereas the rate of drug-induced anaphylaxis increased (p = 0.01 and p = 0.01, respectively). Cardiovascular system findings were observed more frequently in adolescents compared to other age groups (p = 0.003). Most cases stemming from a food allergy were mild, whereas most drug-induced cases were moderate or severe (p < 0.05). When severity was analysed by age group, mild cases in infants were more common than moderate to severe cases.Conclusion: The aetiological and clinical manifestations of childhood anaphylaxis vary among different age groups.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"52 5","pages":"1-5"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shengmai Powder regulates alveolar macrophage PPAR-γ and improves the chronic inflammatory state of chronic obstructive pulmonary disease. 升麻粉调节肺泡巨噬细胞 PPAR-γ 并改善慢性阻塞性肺病的慢性炎症状态

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1135

Dongmei Liu, Zongwei Liu, Xunxun Ma, Shengjie Wang, Jie Lin, Xiuyan Shi, Xiaoyong Xu

{"title":"Shengmai Powder regulates alveolar macrophage PPAR-γ and improves the chronic inflammatory state of chronic obstructive pulmonary disease.","authors":"Dongmei Liu, Zongwei Liu, Xunxun Ma, Shengjie Wang, Jie Lin, Xiuyan Shi, Xiaoyong Xu","doi":"10.15586/aei.v52i5.1135","DOIUrl":"https://doi.org/10.15586/aei.v52i5.1135","url":null,"abstract":"This study examines the therapeutic effects of Shengmai Powder (SMP) on both in vitro and in vivo models of chronic obstructive pulmonary disease (COPD) and the underlying mechanisms. Cigarette smoke and cigarette extracts were used to create in vitro and in vivo models of COPD. ELISA was used to measure the levels of pro-inflammatory factors (IL-6, TNF-α, and IL-1β) in mouse lung tissue and alveolar macrophages. Flow cytometry assessed the phagocytic capacity of alveolar macrophage. Western blotting was used to analyze the expression of RhoA, PPARγ, IκBα, p-IκBα, P65, and p-P65 in alveolar. The results show that SMP reversed the increased levels of pro-inflammatory factors (IL-6, TNF-α, and IL-1β) in mouse lung tissue and alveolar macrophages induced by cigarette smoke and cigarette extract. SMP also restored the decreased fluorescence intensity and RhoA levels in alveolar macrophages caused by cigarette extract. Additionally, SMP increased PPARγ expression and decreased IκBα and P65 phosphorylation in alveolar macrophages exposed to cigarette extract. Also, the effects of SMP were reversed by PPARγ inhibitors. The study concluded that SMP regulates alveolar macrophage phagocytic function through the PPAR-γ/NF-κB pathway, thereby improving the chronic inflammatory state of COPD.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"52 5","pages":"73-79"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling wasp sensitization in a patient with systemic mastocytosis by CAP-inhibition assay. 通过 CAP 抑制试验揭示系统性肥大细胞增多症患者对黄蜂过敏的原因。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1142

Helena Valero, Olga Luengo, Victoria Cardona, Javier Pereira, Moises Labrador-Horrillo

{"title":"Unraveling wasp sensitization in a patient with systemic mastocytosis by CAP-inhibition assay.","authors":"Helena Valero, Olga Luengo, Victoria Cardona, Javier Pereira, Moises Labrador-Horrillo","doi":"10.15586/aei.v52i5.1142","DOIUrl":"https://doi.org/10.15586/aei.v52i5.1142","url":null,"abstract":"Systemic mastocytosis (SM) is a clonal mast cell disorder that can lead to potentially severe anaphylactic reactions. Hymenoptera sting is one of the most frequent triggers of anaphylaxis in these patients, and diagnosis of indolent SM (ISM) without skin involvement (ISMs) is not rare. In this subgroup of patients, venom immunotherapy (VIT) is an effective treatment decreasing subsequent systemic reactions, and lifelong administration is recommended. An individualized diagnosis is necessary to offer the most adequate VIT, and molecular diagnosis (MD) may be useful to discriminate between primary sensitization and cross-reactivity. Nevertheless, other techniques such as ImmunoCAP inhibition assays may be necessary to identify the genuine sensitization to offer the most suitable VIT. We present a male patient with an anaphylactic reaction following several wasp stings. The patient was diagnosed with ISM, and allergy to both Polistes dominula and Vespula sp venom was confirmed. In this scenario, MD did not discriminate between a genuine double sensitization and venom cross-reactivity between both vespids. Thus, CAP-inhibition assay was performed. This case indicated the importance of an accurate diagnosis of hymenoptera venom allergy (HVA). It also highlights the usefulness of CAP-inhibition assays when MD fails to distinguish between genuine double Polistes-Vespula sensitization and cross-reactivity.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"52 5","pages":"85-88"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the diagnostic value of coagulation markers and coagulation function indices on the occurrence of DIC in sepsis and its prognosis. 分析凝血标志物和凝血功能指数对败血症 DIC 发生及其预后的诊断价值。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1119

Xiaowei Fang, Wei Fu, Luyang Xu, Yichao Qiu

{"title":"Analysis of the diagnostic value of coagulation markers and coagulation function indices on the occurrence of DIC in sepsis and its prognosis.","authors":"Xiaowei Fang, Wei Fu, Luyang Xu, Yichao Qiu","doi":"10.15586/aei.v52i5.1119","DOIUrl":"https://doi.org/10.15586/aei.v52i5.1119","url":null,"abstract":"Sepsis is a life-threatening condition that has the potential to multiple organ dysfunction and mortality. One of its frequent complications is disseminated intravascular coagulation (DIC), characterized by hyperactive clotting mechanisms that cause widespread clot formation and tissue damage. This study aimed to investigate early diagnostic markers of sepsis-associated DIC by comparing inflammatory factor levels, 28-day survival rates, coagulation function, and markers between patients with sepsis (non-DIC group) and those with sepsis-induced DIC (DIC group). The study analyzed the diagnostic efficacy of coagulation function and markers in predicting the occurrence and prognosis of sepsis-associated DIC, presenting survival curves. Results indicated significantly increased levels of APTT, TAT, tPAIC, PIC, and sTM in the DIC group compared to the non-DIC group. Sequential Organ Failure Assessment (SOFA) scores on days 1, 3, and 7 were notably lower in the non-DIC group. Correlation analysis revealed positive associations between PT, APTT, TAT, tPAIC, PIC, sTM levels, and SOFA scores, as well as negative associations with Fib and SOFA scores. Survival curves showed substantially lower mortality rates in the non-DIC group, highlighting significant survival disparities between groups. Combining all four coagulation indicators (TAT+ tPAIC + PIC + sTM) showed promising diagnostic value in evaluating disease severity, early DIC diagnosis, and sepsis prognosis.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"52 5","pages":"65-72"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From triggers to treatment: An epidemiological exploration of anaphylaxis in a lower middle-income area in Colombia. 从诱因到治疗：哥伦比亚中低收入地区过敏性休克的流行病学调查。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1120

Yorlady Muñoz, Tomas Rosero, Sofia Martínez Betancur, Jacobo Triviño Arias, Oriana Arias-Valderrama, Jessica Largo Ocampo, Carlos Daniel Serrano, Manuela Olaya

{"title":"From triggers to treatment: An epidemiological exploration of anaphylaxis in a lower middle-income area in Colombia.","authors":"Yorlady Muñoz, Tomas Rosero, Sofia Martínez Betancur, Jacobo Triviño Arias, Oriana Arias-Valderrama, Jessica Largo Ocampo, Carlos Daniel Serrano, Manuela Olaya","doi":"10.15586/aei.v52i5.1120","DOIUrl":"https://doi.org/10.15586/aei.v52i5.1120","url":null,"abstract":"In this cross-sectional, descriptive, and observational study conducted at Fundación Valle del Lili in Colombia, the clinical and sociodemographic characteristics of anaphylaxis were investigated in a cohort of 80 patients who sought medical care between January 2021 and December 2022. With a median age of 16 years and a notable prevalence among individuals aged below 18 years, the study revealed that 63.8% of patients had concomitant allergic diseases. Medications emerged as the primary triggers for anaphylaxis, followed by food. The mucocutaneous system was predominantly affected in 55% of cases, with respiratory involvement observed in 37.5%. Alarmingly, anaphylactic shock occurred in 17.5%, and 7.5% experienced biphasic anaphylaxis. Intramuscular adrenaline was administered in 88.8% of cases, with 75% of patients not receiving an allergy consultation upon discharge, and 52.5% lacking follow-up for allergy care. Considering that in Colombia epidemiological data on the clinical and sociodemographic aspects of anaphylaxis remain largely unknown, this study documents the features of anaphylaxis in both adult and pediatric populations and highlights the urgent need for improved awareness, timely evaluation by allergists, and comprehensive follow-up care for individuals experiencing anaphylaxis.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"52 5","pages":"89-93"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoorientin alleviates ovalbumin-stimulated allergic rhinitis in mice by restoring Th1/Th2 balance. 异连翘素通过恢复Th1/Th2平衡缓解小鼠卵清蛋白刺激性过敏性鼻炎

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1154

Jianyi Huang, Ran Ji, Xueshen Qian, Yuli Shen

{"title":"Isoorientin alleviates ovalbumin-stimulated allergic rhinitis in mice by restoring Th1/Th2 balance.","authors":"Jianyi Huang, Ran Ji, Xueshen Qian, Yuli Shen","doi":"10.15586/aei.v52i5.1154","DOIUrl":"https://doi.org/10.15586/aei.v52i5.1154","url":null,"abstract":"Allergic rhinitis (AR) is a chronic, non-infectious inflammatory condition of the nasal mucosa mediated by IgE. There is a need for the development of novel medications to treat this ailment. Isoorientin is a naturally occurring flavonoid that possesses antioxidant, anti--inflammatory, and various other advantageous characteristics. However, its potential effects on AR remain unclear. This study evaluates the therapeutic effects of isoorientin on ovalbumin (OVA)-induced allergic rhinitis (AR) in mice and explores the underlying mechanism. Our study revealed that isoorientin administration effectively decreased the frequency of nose rubbing and sneezing in AR mice. The groups treated with isoorientin showed a significant decrease in serum levels of IgE and histamine, with reductions of 40% and 30%, respectively. Isoorientin ameliorated inflammation of the nasal mucosa and restored the Th1/Th2 balance. In addition, isoorientin inhibited the activation of the NF-κB pathway in nasal tissues. In summary, Isoorientin alleviates OVA-stimulated AR in mice by restoring Th1/Th2 balance and blocking the NF-κB pathway. Thus, isoorientin exhibits promise as a natural therapeutic agent for allergic rhinitis.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"52 5","pages":"29-35"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Study of Ragweed Sublingual Immunotherapy in Hungary. 匈牙利豚草舌下免疫疗法真实世界研究

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1150

Adrienne Nagy, Katalin Balogh, Csilla Csáki, Beáta Fábos, Edit Mohácsi, Gábor Papp

{"title":"Real-World Study of Ragweed Sublingual Immunotherapy in Hungary.","authors":"Adrienne Nagy, Katalin Balogh, Csilla Csáki, Beáta Fábos, Edit Mohácsi, Gábor Papp","doi":"10.15586/aei.v52i5.1150","DOIUrl":"https://doi.org/10.15586/aei.v52i5.1150","url":null,"abstract":"Background: Ragweed (Ambrosia elatior) has become invasive in Europe, causing significant respiratory issues. Subcutaneous allergen immunotherapy (SCIT) has long been used to manage pollen allergies, but sublingual immunotherapy (SLIT) has gained interest.Objective: This study aimed to evaluate the clinical benefits of ragweed SLIT under real-world in a cohort of Hungarian patients allergic to ragweed pollen.Methods: We retrospectively reviewed the clinical records of 57 patients during the 2015 and 2016 ragweed pollen seasons. Patients were divided into two groups: Group 1 (n = 29), who had not received immunotherapy, and Group 2 (n = 28), who had previously undergone immunotherapy with another sublingual preparation. All patients were treated with Oraltek® ragweed for 4-6 months, initiating 2-4 months before the pollen season and rest of the period was 2 months of the 2016 pollen season. Symptom score (SS), medication score (MS), and combined symptom and medication score (CSMS) were evaluated intra- and intergroup.Results: Pollen counts were consistent between 2015 and 2016. All patients showed significant improvement in SS, MS, and CSMS, with a large effect size (>0.8). Group 2 had significantly lower SS and CSMS in 2015 because of prior immunotherapy. By 2016, both groups exhibited marked improvements, with Group 1 showing a 75% improvement in CSMS. No local or systemic reactions were recorded, indicating a high safety profile.Conclusions: Ragweed SLIT significantly improved symptoms and reduced use of medication in patients allergic to ragweed pollen. The treatment was effective even in patients with previous immunotherapy, with a high benefit-risk ratio demonstrated by the absence of adverse reactions. These findings support the use of Oraltek SLIT for managing ragweed pollen allergy.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"52 5","pages":"80-84"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of direct oral provocation in beta-lactam allergy. 直接口服激惹法治疗β-内酰胺过敏的安全性。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1169

Öner Özdemir

引用次数: 0

Simvastatin alleviates experimental autoimmune encephalomyelitis through regulating the balance of Th17 and Treg in mice. 辛伐他汀通过调节小鼠Th17和Treg的平衡缓解实验性自身免疫性脑脊髓炎

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1100

Dongsheng Xu, Manxia Wang, Lijuan Wang

{"title":"Simvastatin alleviates experimental autoimmune encephalomyelitis through regulating the balance of Th17 and Treg in mice.","authors":"Dongsheng Xu, Manxia Wang, Lijuan Wang","doi":"10.15586/aei.v52i5.1100","DOIUrl":"https://doi.org/10.15586/aei.v52i5.1100","url":null,"abstract":"The aim of this study was to elucidate the therapeutic effect of simvastatin on experimental autoimmune encephalomyelitis (EAE) by regulating the balance between Th17 and Treg cells in mice. C57BL/6 mice were randomly divided into four groups: normal group, EAE group, simvastatin (2 and 10 mg/kg) group, and AG490 group (with AG490 serving as the positive control). Neurological function scores of mice were assessed daily. The four groups received treatments of normal saline, normal saline, and simvastatin (2 and 10 mg/kg), respectively. In the AG490 group, mice were injected intraperitoneally with AG490 (1 mg) every other day, and treatment was halted after 3 weeks. The spinal cord was stained with hematoxylin and eosin (H&E), and immunohistochemical staining for retinoic acid receptor-related orphan receptor γ(RORγ) and Foxp3 (Foxp3) was performed. Spleen samples were taken for Th17 and Treg analysis using flow cytometry. The levels of interleukin-17 and transforming growth factor-β (TGF-β) were detected using enzyme-linked immunosorbent assay (ELISA). In the simvastatin and AG490 groups, recovery from neurological impairment was earlier compared to the EAE group, and the symptoms were notably improved. Both simvastatin and AG490 reduced focal inflammation, decreased RORγ-positive cell infiltration, and significantly increased the number of FOXP3-positive cells. The number of Th17 cells and the level of IL-17 in the spleen were decreased in the simvastatin and AG490 treatment groups, while the number of Treg cells and TGF-β levels were significantly increased across all treatment groups. Simvastatin exhibits anti-inflammatory and immunomodulatory effects, potentially alleviating symptoms of neurological dysfunction of EAE. Regulating the balance between Th17 and Treg may represent a therapeutic mechanism for simvastatin in treating EAE.","PeriodicalId":7536,"journal":{"name":"Allergologia et immunopathologia","volume":"52 5","pages":"36-43"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold-induced urticaria and development of anaphylaxis. 寒冷诱发的荨麻疹和过敏性休克的发展。

IF 2.5 4区医学

Allergologia et immunopathologia Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.15586/aei.v52i5.1167

Öner Özdemir

引用次数: 0