芍药根提取物抑制特应性皮炎样皮肤症状。

IF 2.1 4区 医学 Q3 ALLERGY
Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i5.1399
Jang Hoon Kim, Kyung-Sook Han, Eun Seo Kang, Ji Hyeon Park, Byoung Ok Cho, Jae Ho Choi
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引用次数: 0

摘要

Peucedanum japonicum Thunberg是一种多年生草本植物Peucedanum属植物,属于蜂科,有效改善炎症,痛风,头晕。然而,芍药根提取物(PJRE)改善皮肤瘙痒的作用及其机制尚未见报道。我们研究了PJRE对化合物48/80 (C48/80)处理小鼠、phorbol 12-肉豆酸酯13-乙酸酯(PMA)/ a23187诱导的人皮肤肥大细胞和lps刺激的小鼠巨噬细胞的瘙痒和炎症反应的调节作用。PJRE显著抑制小鼠抓痒行为、皮肤炎症细胞和肥大细胞浸润增加C48/80。PJRE治疗还通过NF-κB激活HMC-1细胞,减少PMA/ a23187激活的组胺、炎症细胞因子和白细胞介素的分泌。PJRE处理通过磷酸化NF-κB、Akt、ERK1/2和p38 MAPK,降低了lps刺激的炎症细胞因子分泌和iNOS和COX-2的表达。pfjre处理通过NRF2核易位以浓度依赖的方式增加HO-1的表达。这些结果表明,PJRE具有缓解特应性皮炎样皮肤症状的治疗潜力,这可能是由NF-κB作为转录因子和Akt、ERK1/2和p38 MAPK作为上游信号分子介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peucedanum japonicum Thunberg root extract inhibits atopic dermatitis-like skin symptoms.

Peucedanum japonicum Thunberg is a perennial herbaceous plant of the genus Peucedanum that belongs to the Apiaceae family and is effective in improving inflammation, gout, and dizziness. However, the skin pruritus improvement effect and mechanism of action of Peucedanum japonicum Thunberg root extract (PJRE) have not yet been reported. We investigated the effects of PJRE on the regulation of pruritus and inflammatory responses in compound 48/80 (C48/80)-treated mice, phorbol 12-myristate 13-acetate (PMA)/A23187-induced human skin mast cells, and LPS-stimulated mouse macrophages. PJRE administration significantly inhibited scratching behavior, skin inflammatory cells, and mast cell infiltration in mice increased by C48/80. PJRE treatment also reduced the PMA/A23187-activated secretion of histamine, inflammatory cytokines, and interleukins via NF-κB activation in HMC-1 cells. PJRE treatment reduced LPS-stimulated secretion of inflammatory cytokines and expression of iNOS and COX-2 through phosphorylation of NF-κB, Akt, ERK1/2, and p38 MAPK in Raw 264.7 cells. PJRE treatment increases HO-1 expression in a concentration-dependent manner via NRF2 nuclear translocation. These results suggest that PJRE has therapeutic potential for alleviating atopic dermatitis-like skin symptoms, which is likely mediated by NF-κB as a transcription factor and Akt, ERK1/2, and p38 MAPK as upstream signaling molecules.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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