成分解析诊断在儿童小麦依赖运动诱发的过敏反应:一个病例报告。

IF 2.1 4区 医学 Q3 ALLERGY
Allergologia et immunopathologia Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i4.1316
Manabu Miyamoto, Nobuyuki Maruyama, Shigemi Yoshihara
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引用次数: 0

摘要

小麦依赖性运动诱导过敏反应(WDEIA)是免疫球蛋白E (IgE)介导的小麦过敏的一种亚型,其特征是小麦摄入后进行体育锻炼。虽然omega-5麦胶蛋白特异性IgE (sIgE)被广泛用于诊断WDEIA,但其在儿童中的敏感性低于成人。本报告描述了一名13岁男性疑似小麦过敏,他在摄入小麦和运动后出现了过敏反应。免疫cap结果显示小麦和面筋sIgE阳性,但ω -5麦胶蛋白sIgE阴性。开放标签口服食物挑战结合运动证实了WDEIA的诊断。值得注意的是,使用酶联免疫吸附法检测患者血清中的α / β麦胶蛋白sIgE,这表明α / β麦胶蛋白可以作为无法检测到ω -5麦胶蛋白sIgE的儿科病例的替代标记物。这表明单独使用omega-5麦胶蛋白sIgE可能不适合诊断儿童WDEIA。相反,利用其他小麦蛋白成分的组合可以提高诊断的敏感性和特异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Component-resolved diagnostics in pediatric wheat-dependent exercise-induced anaphylaxis: A case report.

Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a subtype of immunoglobulin E (IgE)-mediated wheat allergy characterized by symptoms from wheat intake followed by physical exercise. Although omega-5 gliadin-specific IgE (sIgE) is widely used for diagnosing WDEIA, its sensitivity is lower in children than in adults. This report describes a 13-year-old male with suspected wheat allergy who experienced anaphylaxis following wheat ingestion and exercise. ImmunoCAP results revealed positive sIgE for wheat and gluten but negative results for omega-5 gliadin. An open-label oral food challenge combined with exercise confirmed the diagnosis of WDEIA. Notably, alpha/beta gliadin sIgE was detected using an enzyme-linked immunosorbent assay with the patient's serum, suggesting that alpha/beta gliadin can serve as an alternative marker in pediatric cases where omega-5 gliadin sIgE is undetectable. This suggests that omega-5 gliadin sIgE alone may not be appropriate for diagnosing WDEIA in children. Instead, utilizing a combination of other wheat protein components may enhance both sensitivity and specificity in diagnosis.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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