Nature reviews bioengineering最新文献_第7页

Inclusion and diversity in organoid research 类器官研究的包容性和多样性

IF 37.6

Nature reviews bioengineering Pub Date : 2025-03-18 DOI: 10.1038/s44222-025-00296-4

Amy Hinterberger

引用次数: 0

Genetic tools for investigating the life cycle of extracellular vesicles 研究细胞外囊泡生命周期的遗传工具

IF 37.6

Nature reviews bioengineering Pub Date : 2025-03-17 DOI: 10.1038/s44222-025-00286-6

Wenyi Zheng, Samantha Roudi, Houze Zhou, Maribel Lara Corona, Guillaume van Niel, Joel Z. Nordin, Samir EL Andaloussi

{"title":"Genetic tools for investigating the life cycle of extracellular vesicles","authors":"Wenyi Zheng, Samantha Roudi, Houze Zhou, Maribel Lara Corona, Guillaume van Niel, Joel Z. Nordin, Samir EL Andaloussi","doi":"10.1038/s44222-025-00286-6","DOIUrl":"10.1038/s44222-025-00286-6","url":null,"abstract":"Mammalian cells ubiquitously release membrane-enclosed vesicles, known as extracellular vesicles. These particles carry a variety of molecules that reflect the status of their cells of origin, making them valuable sources for biomarker discovery. Furthermore, extracellular vesicles deliver their cargo locally and systemically to regulate biological processes, piquing interest in modulating extracellular vesicle biogenesis and developing extracellular vesicle-based therapies. Therefore, a thorough understanding of the extracellular vesicle life cycle, from biogenesis and trafficking to degradation, is essential for unlocking their full potential in biomarker identification and for the design of extracellular vesicle-based therapies. In this Review, we start by outlining the key steps in the extracellular vesicle life cycle and highlight remaining open questions. We then discuss the design and application of genetically encoded systems that can be applied to study extracellular vesicle biogenesis and fate. Finally, we highlight technical challenges that remain to be addressed in the engineering and application of genetically encoded systems to extracellular vesicle research. A thorough understanding of the life cycle of extracellular vesicles is essential to unleash their full potential in biomarker identification and therapeutics development. This Review discusses the design and application of genetically encoded systems to study extracellular vesicle biogenesis, trafficking and degradation.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 6","pages":"505-520"},"PeriodicalIF":37.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining the clinical niche for photoacoustic imaging 确定光声成像的临床定位

Nature reviews bioengineering Pub Date : 2025-03-17 DOI: 10.1038/s44222-025-00284-8

引用次数: 0

Wearable multi-sensory haptic devices 可穿戴式多感官触觉设备

IF 37.6

Nature reviews bioengineering Pub Date : 2025-03-06 DOI: 10.1038/s44222-025-00274-w

Joshua J. Fleck, Zane A. Zook, Janelle P. Clark, Daniel J. Preston, Darren J. Lipomi, Claudio Pacchierotti, Marcia K. O’Malley

{"title":"Wearable multi-sensory haptic devices","authors":"Joshua J. Fleck, Zane A. Zook, Janelle P. Clark, Daniel J. Preston, Darren J. Lipomi, Claudio Pacchierotti, Marcia K. O’Malley","doi":"10.1038/s44222-025-00274-w","DOIUrl":"10.1038/s44222-025-00274-w","url":null,"abstract":"Haptic devices enable communication via touch, augmenting visual and auditory displays, or by offering alternative channels of communication when vision and hearing are unavailable. Because of the different types of haptic stimuli that are perceivable by users — vibration, skin stretch, pressure and temperature, among others — devices can be designed to communicate complex information by delivering multiple types of haptic stimuli simultaneously. These multi-sensory haptic devices are often designed to be wearable and have been developed for use in a wide variety of applications, including communication, entertainment and rehabilitation. Multi-sensory haptic devices present unique challenges to designers because human perceptual acuity can vary widely depending on the wearable location on the body and/or the heterogeneity in human perceptual performance, particularly when multiple cues are presented simultaneously. Additionally, packaging haptic systems in a wearable form factor presents its own engineering challenges such as cue masking, device mounting and actuator capabilities, among others. Thus, in this Review, we discuss the state-of-the-art and specific obstacles present in the field to produce multi-sensory devices that enhance the human capacity for haptic interaction and information transmission. Haptic devices enable communication via touch, augmenting visual and auditory displays, or by offering alternative channels of communication when vision and hearing are unavailable. This Review discusses multi-sensory wearable haptics, focusing on body-worn devices that convey multiple types of cutaneous haptic feedback.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 4","pages":"288-302"},"PeriodicalIF":37.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardizing clinical trials for synthetic matrices in rotator cuff tears 规范肩袖撕裂合成基质的临床试验

IF 37.6

Nature reviews bioengineering Pub Date : 2025-03-05 DOI: 10.1038/s44222-025-00292-8

Elnaz S. Mirdamadi, Seyyedmorteza Attari, Cato T. Laurencin

引用次数: 0

Extracellular vesicles for the delivery of gene therapy 用于基因治疗的细胞外囊泡

IF 37.6

Nature reviews bioengineering Pub Date : 2025-03-04 DOI: 10.1038/s44222-025-00277-7

Emilio Di Ianni, Wataru Obuchi, Koen Breyne, Xandra O. Breakefield

{"title":"Extracellular vesicles for the delivery of gene therapy","authors":"Emilio Di Ianni, Wataru Obuchi, Koen Breyne, Xandra O. Breakefield","doi":"10.1038/s44222-025-00277-7","DOIUrl":"10.1038/s44222-025-00277-7","url":null,"abstract":"Gene therapy has brought hope for the treatment of previously incurable diseases, such as genetic disorders, cancers and autoimmune diseases. However, gene therapy requires efficient delivery with cell and tissue specificity, which remains challenging owing to the limited targeting and cargo-loading capacity of viral delivery vehicles, as well as immunogenicity and toxicity concerns. Extracellular vesicles can be designed as non-viral carriers for gene therapy owing to their ability to deliver multiple cargo types, including transgenes, small encoding or non-coding RNA, DNA and functional proteins. Importantly, extracellular vesicles are immunologically neutral and can cross biological barriers. In this Review, we discuss the application of extracellular vesicles in gene therapy. We outline how the inherent content of extracellular vesicles can facilitate different gene-therapy approaches and examine the design of extracellular vesicles for the loading of gene-therapy tools, targeted delivery and cargo release. Finally, we survey clinical applications of extracellular vesicles and highlight important engineering and translational challenges. Extracellular vesicles can be designed to serve as delivery platforms for gene therapy. This Review discusses the application and engineering of extracellular vesicles for different gene-therapy modalities, outlining crucial steps to advance this technology into the clinic.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 5","pages":"360-373"},"PeriodicalIF":37.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling and design of transcriptional enhancers 转录增强子的建模和设计

IF 37.6

Nature reviews bioengineering Pub Date : 2025-02-28 DOI: 10.1038/s44222-025-00280-y

Seppe De Winter, Vasileios Konstantakos, Stein Aerts

{"title":"Modelling and design of transcriptional enhancers","authors":"Seppe De Winter, Vasileios Konstantakos, Stein Aerts","doi":"10.1038/s44222-025-00280-y","DOIUrl":"10.1038/s44222-025-00280-y","url":null,"abstract":"Transcriptional enhancers are the genomic elements that contain critical information for the regulation of gene expression. This information is encoded through precisely arranged transcription factor-binding sites. Genomic sequence-to-function models, computational models that take DNA sequences as input and predict gene regulatory features, have become essential for unravelling the complex combinatorial rules that govern cell-type-specific activities of enhancers. These models function as biological ‘oracles’, capable of accurately predicting the activity of novel DNA sequences. By leveraging these oracles, DNA sequences can be optimized towards designed synthetic enhancers with tailored cell-type-specific or cell-state-specific activities. In parallel, generative artificial intelligence is rapidly advancing in genomics and enhancer design. Synthetic enhancers hold great promise for a wide range of biomedical applications, from facilitating fundamental research to enabling gene therapies. Enhancers are genomic elements critical for regulating gene expression. In this Review, the authors discuss how sequence-to-function models can be used to unravel the rules underlying enhancer activity and function as biological ‘oracles’ aiding the design of synthetic enhancers with tailored cell-type-specific or cell-state-specific activities.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 5","pages":"374-389"},"PeriodicalIF":37.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine–lipoprotein interactions Nanomedicine-lipoprotein交互

IF 37.6

Nature reviews bioengineering Pub Date : 2025-02-26 DOI: 10.1038/s44222-025-00291-9

S. Moein Moghimi, Dmitri Simberg

引用次数: 0

A nucleic acid detection device for rapid multiplexed molecular disease diagnostics 一种用于快速多路分子疾病诊断的核酸检测装置

Nature reviews bioengineering Pub Date : 2025-02-26 DOI: 10.1038/s44222-025-00288-4

Sahar S. Mahshid, Sripadh Guptha Yedire, Roozbeh S. Moakhar, Tamer AbdElFatah, Sara Mahshid

引用次数: 0

Should culture media for microphysiological systems be nutritionally physiological? 微生理系统的培养基应该是营养生理的吗？

IF 37.6

Nature reviews bioengineering Pub Date : 2025-02-25 DOI: 10.1038/s44222-025-00290-w

Alastair G. Stewart, Avanka Gunatilaka, Bryan Gao

引用次数: 0