Nature reviews bioengineering最新文献

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Catalyzing change in the women’s health innovation ecosystem 推动妇女健康创新生态系统的变革
Nature reviews bioengineering Pub Date : 2024-07-11 DOI: 10.1038/s44222-024-00222-0
Ru-fong Joanne Cheng, Mark A. Barone
{"title":"Catalyzing change in the women’s health innovation ecosystem","authors":"Ru-fong Joanne Cheng, Mark A. Barone","doi":"10.1038/s44222-024-00222-0","DOIUrl":"10.1038/s44222-024-00222-0","url":null,"abstract":"At the Gates Foundation, the newly established Women’s Health Innovations team supports the research, development and increased access to innovative products, devices and platforms aimed at improving women’s health. Importantly, women should have a central role in the women’s health innovation ecosystem, leading research, shaping strategies and making funding decisions.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 10","pages":"799-800"},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141586211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ethical landscape of human brain organoids and a mindful innovation framework 人脑器官组织的伦理前景与心灵创新框架
Nature reviews bioengineering Pub Date : 2024-07-11 DOI: 10.1038/s44222-024-00211-3
Nathan A. Shlobin, Julian Savulescu, Matthew L. Baum
{"title":"The ethical landscape of human brain organoids and a mindful innovation framework","authors":"Nathan A. Shlobin, Julian Savulescu, Matthew L. Baum","doi":"10.1038/s44222-024-00211-3","DOIUrl":"10.1038/s44222-024-00211-3","url":null,"abstract":"Human brain organoids can partly mimic the structure and function of human brains in vitro, thereby providing a platform for investigating health and disease in the human brain. However, human brain organoids require complex ethical considerations that pose challenges for standard ethical approaches owing to their increasing complexity, human mimicry and implementation in chimera models. In this Perspective, we outline the ethical landscape of human brain organoids, including sample procurement and informed consent, translational animal research, personalized medicine and transplantation, commercialization, moral status, regulatory policy, scarcity and prioritization, uncertainty, and responsible innovation. We then propose to view brain organoid research through a new lens of ‘mindful innovation’, that is, societally responsible and responsive innovation with respect to the scientific landscape and social, political and economic conditions. We introduce five core principles of this framework: exploration, contemplation, involvement, adaptation and demarcation, and we illustrate how a framework of mindful innovation may handle ethical challenges and chart an ethical pathway for brain organoid research. Human brain organoids can partly mimic features of the human brain. This Perspective discusses key ethical considerations in human brain organoid research and introduces an ethical framework of mindful innovation to conceptualize and guide ethical considerations of human brain organoid research.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 9","pages":"785-796"},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141586212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioengineered insect proteins and fats as high-quality and sustainable food constituents 生物工程昆虫蛋白质和脂肪作为高质量和可持续的食品成分
Nature reviews bioengineering Pub Date : 2024-07-09 DOI: 10.1038/s44222-024-00221-1
Seyed Mohammad Taghi Gharibzahedi, Zeynep Altintas
{"title":"Bioengineered insect proteins and fats as high-quality and sustainable food constituents","authors":"Seyed Mohammad Taghi Gharibzahedi, Zeynep Altintas","doi":"10.1038/s44222-024-00221-1","DOIUrl":"10.1038/s44222-024-00221-1","url":null,"abstract":"Insect-derived proteins and fats present viable food constituents. They can be bioengineered and fermented to improve their nutritional value and functionality to promote food security and the development of new superfoods. Nonetheless, scale-up production and translation of insect-derived proteins and fats remain difficult.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 10","pages":"804-805"},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141573041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered nanoparticles for clinical assays 用于临床检测的工程纳米颗粒
Nature reviews bioengineering Pub Date : 2024-07-08 DOI: 10.1038/s44222-024-00208-y
Jiyong Cheong, Ala Jo, Jangwon Lee, Sujin Lee, Jung-uk Lee, Jae-Hyun Lee, Hakho Lee, Jinwoo Cheon
{"title":"Engineered nanoparticles for clinical assays","authors":"Jiyong Cheong, Ala Jo, Jangwon Lee, Sujin Lee, Jung-uk Lee, Jae-Hyun Lee, Hakho Lee, Jinwoo Cheon","doi":"10.1038/s44222-024-00208-y","DOIUrl":"10.1038/s44222-024-00208-y","url":null,"abstract":"Nanoparticles exhibit distinctive physical and chemical properties that make them effective mediators for optical, magnetic or electric signal transduction. Consequently, nanoparticles are increasingly used in the development of biosensing systems that can detect diseases rapidly and accurately, with potential applications extending to point-of-care settings. In this Review, we discuss key aspects of translating nanoparticles into clinical diagnostics, including particle optimization, device construction and biosensing applications. We focus on two representative particle types; gold nanoparticles and magnetic ferrite nanoparticles, which are widely used in biosensing. We explain the characteristics of these particles and illustrate how they can be tailored to detect various analytical targets such as nucleic acids, proteins and small molecules. Finally, we discuss emerging research directions to advance the clinical integration of nanoparticle assays. Nanoparticles, such as gold nanoparticles and magnetic ferrite nanoparticles, can be applied in biosensors for disease detection. This Review discusses the design of nanoparticles for clinical diagnostics, focusing on their optimization and device construction for the detection of nucleic acids, proteins and small molecules.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 10","pages":"887-905"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141573043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Microneedle-based biosensing 出版商更正:基于微针的生物传感
Nature reviews bioengineering Pub Date : 2024-07-05 DOI: 10.1038/s44222-024-00223-z
Lalitkumar K. Vora, Akmal H. Sabri, Peter E. McKenna, Achmad Himawan, Aaron R. J. Hutton, Usanee Detamornrat, Alejandro J. Paredes, Eneko Larrañeta, Ryan F. Donnelly
{"title":"Publisher Correction: Microneedle-based biosensing","authors":"Lalitkumar K. Vora, Akmal H. Sabri, Peter E. McKenna, Achmad Himawan, Aaron R. J. Hutton, Usanee Detamornrat, Alejandro J. Paredes, Eneko Larrañeta, Ryan F. Donnelly","doi":"10.1038/s44222-024-00223-z","DOIUrl":"10.1038/s44222-024-00223-z","url":null,"abstract":"","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 8","pages":"710-710"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00223-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141973750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial nanowires for sustainable electronics 用于可持续电子器件的微生物纳米线
Nature reviews bioengineering Pub Date : 2024-07-04 DOI: 10.1038/s44222-024-00204-2
Matthew J. Guberman-Pfeffer, Noémie-Manuelle Dorval Courchesne, Derek R. Lovley
{"title":"Microbial nanowires for sustainable electronics","authors":"Matthew J. Guberman-Pfeffer, Noémie-Manuelle Dorval Courchesne, Derek R. Lovley","doi":"10.1038/s44222-024-00204-2","DOIUrl":"10.1038/s44222-024-00204-2","url":null,"abstract":"Microbial protein nanowires are emerging as an alternative to abiotic nanowires for electronics applications. Microbial nanowires are sustainably produced, robust, non-toxic, biodegradable and uniquely malleable to precision genetic tailoring, which can confer specific functionalities. At present, the microbial nanowires that seem most adaptable to electronics applications are curli fibres, electrically conductive pili (e-pili) and c-type cytochrome filaments. These nanowires are all highly resistant to conditions that denature most proteins. Editing of the genes encoding curli fibre and e-pili monomers has yielded nanowires with enhanced functions, including increased conductivity, improved sensor selectivity and sensitivity, metal-binding properties, increased surface attachment, and improved nanowire alignment. Such microbial nanowires are highly processable in the organic solvents required for some device fabrication methods and readily incorporated into polymers without loss of function. This Review describes promising electronic devices for sensing, electricity generation and neuromorphic memory that depend on microbial nanowire components and discusses preliminary evidence of the feasibility of other microbial nanowire applications such as transistors, optoelectronics and supercapacitors. Factors that affect the commercialization of microbial nanowire-based electronics are also considered. Microbial nanowires are attractive materials for the fabrication of electronic devices because they are sustainably produced and can be genetically reengineered for a broad range of functionalities. Guberman-Pfeffer and colleagues describe novel devices and mass production strategies that have been demonstrated and outline the optimization strategies required for their commercialization.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 10","pages":"869-886"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding resource competition to achieve predictable synthetic gene expression in eukaryotes 了解资源竞争,在真核生物中实现可预测的合成基因表达
Nature reviews bioengineering Pub Date : 2024-07-04 DOI: 10.1038/s44222-024-00206-0
Roberto Di Blasi, Jacopo Gabrielli, Kiyan Shabestary, Ioanna Ziarti, Tom Ellis, Cleo Kontoravdi, Rodrigo Ledesma-Amaro, Francesca Ceroni
{"title":"Understanding resource competition to achieve predictable synthetic gene expression in eukaryotes","authors":"Roberto Di Blasi, Jacopo Gabrielli, Kiyan Shabestary, Ioanna Ziarti, Tom Ellis, Cleo Kontoravdi, Rodrigo Ledesma-Amaro, Francesca Ceroni","doi":"10.1038/s44222-024-00206-0","DOIUrl":"10.1038/s44222-024-00206-0","url":null,"abstract":"Synthetic gene expression in engineered cells typically depends on the host cell’s limited pool of intracellular resources, which can lead to resource competition between native and engineered functions and may cause unanticipated effects in the host and synthetic gene circuit. For example, competition for shared resources may lead to cellular overload affecting physiological functions (that is, cellular burden) and negatively affect synthetic construct performance to the point of unreliability. This fundamental problem has implications for the use of synthetic genetic constructs in cell engineering for foundational research, therapy and bioprocessing. Resource competition has mainly been investigated in model bacteria systems, but also considerably affects eukaryotic systems, including mammalian cells. In this Review, we discuss resource competition beyond bacteria, outlining how it can lead to gene expression coupling, gene expression and metabolic burden. We also examine ways to quantify cellular burden in mammalian cells, and investigate circuit-centric and host-centric mitigation strategies, highlighting important implications of resource competition for cell engineering in therapeutic and bioproduction applications as well as in fundamental biology studies. Cell engineering by synthetic biology typically relies on synthetic gene constructs that compete with the host cell for intracellular resources. This Review discusses how such resource competition can impact mammalian cell engineering and outlines strategies for how to mitigate cellular burden using circuit-centric and host-centric approaches.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 9","pages":"721-732"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating organoids and organ-on-a-chip devices 集成器官组织和片上器官设备
Nature reviews bioengineering Pub Date : 2024-07-02 DOI: 10.1038/s44222-024-00207-z
Yimu Zhao, Shira Landau, Sargol Okhovatian, Chuan Liu, Rick Xing Ze Lu, Benjamin Fook Lun Lai, Qinghua Wu, Jennifer Kieda, Krisco Cheung, Shravanthi Rajasekar, Kimia Jozani, Boyang Zhang, Milica Radisic
{"title":"Integrating organoids and organ-on-a-chip devices","authors":"Yimu Zhao, Shira Landau, Sargol Okhovatian, Chuan Liu, Rick Xing Ze Lu, Benjamin Fook Lun Lai, Qinghua Wu, Jennifer Kieda, Krisco Cheung, Shravanthi Rajasekar, Kimia Jozani, Boyang Zhang, Milica Radisic","doi":"10.1038/s44222-024-00207-z","DOIUrl":"10.1038/s44222-024-00207-z","url":null,"abstract":"Organoids and organs-on-chips are two rapidly emerging 3D cell culture techniques that aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically relevant drug discovery and model human diseases. Despite their similar goals, they use different approaches and exhibit varying requirements for implementation. Integrative approaches promise to provide improved cellular fidelity in the format of a device that can control the geometry of the organoid and provide flow, mechanical and electrical stimuli. In this Review, we discuss recent integrative approaches in the areas of intestine, kidney, lung, liver, pancreas, brain, retina, heart and tumour. We start by defining the two fields and describe how they emerged from the fields of tissue engineering, regenerative medicine and stem cells. We compare the scales at which the two methods operate and briefly describe their achievements, followed by studies integrating organoids and organ-on-a-chip devices. Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the differentiation stage at which an organoid should be placed into an organ-on-a-chip device, providing perfusable vasculature within the organoid and overcoming limitations of cell line and batch-to-batch variability. Organoids and organs-on-chips aim to improve drug testing and disease modelling, but each has limitations. This Review discusses the integration of these systems to improve cellular hierarchy, structural fidelity, reproducibility, throughput, scale-up and efficiency to improve translational outcomes.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 7","pages":"588-608"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141508939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical translation of 3D printed pharmaceuticals 3D 打印药品的临床转化
Nature reviews bioengineering Pub Date : 2024-07-01 DOI: 10.1038/s44222-024-00217-x
Liam Krueger, Atheer Awad, Abdul W. Basit, Alvaro Goyanes, Jared A. Miles, Amirali Popat
{"title":"Clinical translation of 3D printed pharmaceuticals","authors":"Liam Krueger, Atheer Awad, Abdul W. Basit, Alvaro Goyanes, Jared A. Miles, Amirali Popat","doi":"10.1038/s44222-024-00217-x","DOIUrl":"10.1038/s44222-024-00217-x","url":null,"abstract":"The versatility of three-dimensional printed pharmaceuticals, relative to traditionally manufactured ones, could be leveraged for personalized treatment at the point of care, as well as being integrated into mass-manufacturing pipelines. Improvements in quality control and collaboration with regulatory bodies will pave the way to large-scale clinical translation.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 10","pages":"801-803"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141508936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digitalizing health trials by the Clinical Trials Transformation Initiative 临床试验转型倡议实现医疗试验数字化
Nature reviews bioengineering Pub Date : 2024-06-20 DOI: 10.1038/s44222-024-00212-2
Joerg Goldhahn, Noé Brasier, Lindsay Kehoe
{"title":"Digitalizing health trials by the Clinical Trials Transformation Initiative","authors":"Joerg Goldhahn, Noé Brasier, Lindsay Kehoe","doi":"10.1038/s44222-024-00212-2","DOIUrl":"10.1038/s44222-024-00212-2","url":null,"abstract":"The Clinical Trials Transformation Initiative (CTTI) provides recommendations to unlock the full potential of digital health trials, including tools to develop digital biomarkers or endpoints, apply remote technology and interact with health authorities.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 9","pages":"717-718"},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141529842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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