微生理系统的培养基应该是营养生理的吗?

IF 37.6
Alastair G. Stewart, Avanka Gunatilaka, Bryan Gao
{"title":"微生理系统的培养基应该是营养生理的吗?","authors":"Alastair G. Stewart, Avanka Gunatilaka, Bryan Gao","doi":"10.1038/s44222-025-00290-w","DOIUrl":null,"url":null,"abstract":"The incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of drug efficacy, safety and toxicology, compared with other novel alternative methods (NAMs) or animal studies. Current MPS practice is not deploying available physiological culture media solutions. Will the clinical translational reliability of MPSs be potentially compromised by the use of hyper-nutritional media?","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 5","pages":"357-358"},"PeriodicalIF":37.6000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Should culture media for microphysiological systems be nutritionally physiological?\",\"authors\":\"Alastair G. Stewart, Avanka Gunatilaka, Bryan Gao\",\"doi\":\"10.1038/s44222-025-00290-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of drug efficacy, safety and toxicology, compared with other novel alternative methods (NAMs) or animal studies. Current MPS practice is not deploying available physiological culture media solutions. Will the clinical translational reliability of MPSs be potentially compromised by the use of hyper-nutritional media?\",\"PeriodicalId\":74248,\"journal\":{\"name\":\"Nature reviews bioengineering\",\"volume\":\"3 5\",\"pages\":\"357-358\"},\"PeriodicalIF\":37.6000,\"publicationDate\":\"2025-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature reviews bioengineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44222-025-00290-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44222-025-00290-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

与其他新颖替代方法(NAMs)或动物研究相比,微生理系统(mps)在药物监管途径中的初步应用在药物疗效、安全性和毒理学评估方面具有同等或更高的预测价值。目前的MPS实践没有部署可用的生理培养基解决方案。使用高营养培养基是否会降低mps的临床转化可靠性?
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Should culture media for microphysiological systems be nutritionally physiological?
The incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of drug efficacy, safety and toxicology, compared with other novel alternative methods (NAMs) or animal studies. Current MPS practice is not deploying available physiological culture media solutions. Will the clinical translational reliability of MPSs be potentially compromised by the use of hyper-nutritional media?
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信