{"title":"微生理系统的培养基应该是营养生理的吗?","authors":"Alastair G. Stewart, Avanka Gunatilaka, Bryan Gao","doi":"10.1038/s44222-025-00290-w","DOIUrl":null,"url":null,"abstract":"The incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of drug efficacy, safety and toxicology, compared with other novel alternative methods (NAMs) or animal studies. Current MPS practice is not deploying available physiological culture media solutions. Will the clinical translational reliability of MPSs be potentially compromised by the use of hyper-nutritional media?","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 5","pages":"357-358"},"PeriodicalIF":37.6000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Should culture media for microphysiological systems be nutritionally physiological?\",\"authors\":\"Alastair G. Stewart, Avanka Gunatilaka, Bryan Gao\",\"doi\":\"10.1038/s44222-025-00290-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of drug efficacy, safety and toxicology, compared with other novel alternative methods (NAMs) or animal studies. Current MPS practice is not deploying available physiological culture media solutions. Will the clinical translational reliability of MPSs be potentially compromised by the use of hyper-nutritional media?\",\"PeriodicalId\":74248,\"journal\":{\"name\":\"Nature reviews bioengineering\",\"volume\":\"3 5\",\"pages\":\"357-358\"},\"PeriodicalIF\":37.6000,\"publicationDate\":\"2025-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature reviews bioengineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44222-025-00290-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44222-025-00290-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Should culture media for microphysiological systems be nutritionally physiological?
The incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of drug efficacy, safety and toxicology, compared with other novel alternative methods (NAMs) or animal studies. Current MPS practice is not deploying available physiological culture media solutions. Will the clinical translational reliability of MPSs be potentially compromised by the use of hyper-nutritional media?