{"title":"Funding research on women’s health","authors":"","doi":"10.1038/s44222-024-00253-7","DOIUrl":"10.1038/s44222-024-00253-7","url":null,"abstract":"Women’s health research has long been underfunded, in part owing to stigmas associated with conditions that primarily affect women. Equitable health research funding requires transparency from funding agencies, investment in women-centred innovations, support for women in science and a cultural shift in how health issues are viewed.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00253-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Donor kidney assessment by robotic optical coherence tomography","authors":"Sadra Bakhshandeh","doi":"10.1038/s44222-024-00254-6","DOIUrl":"10.1038/s44222-024-00254-6","url":null,"abstract":"An article in Communications Engineering presents a robotic optical coherence tomography system that offers robust, flexible and automatic scanning of the surface of a full kidney for quality assessment prior to transplantation.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-cost, high-performance light-sheet microscopy","authors":"Christine-Maria Horejs","doi":"10.1038/s44222-024-00249-3","DOIUrl":"10.1038/s44222-024-00249-3","url":null,"abstract":"An article in Nature Biomedical Engineering reports a low-cost and scalable light-sheet microscopy framework that benefits from high imaging performance as well as small device and computational footprints.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthetic macromolecular switches for precision control of therapeutic cell functions","authors":"Ana Palma Teixeira, Martin Fussenegger","doi":"10.1038/s44222-024-00235-9","DOIUrl":"https://doi.org/10.1038/s44222-024-00235-9","url":null,"abstract":"<p>Cells rely on complex molecular networks to perceive and process external and internal signals into tailored responses. These cellular abilities can be augmented and modified by integrating artificial gene circuitry for the engineering of cell-based therapeutics. In this Review, we outline the engineering principles that govern the design of synthetic gene networks, highlighting how the sensitivity, detection range and specificity of synthetic gene networks can be optimized for in vivo functionality. In particular, we examine synthetic molecular modules, including transcriptionally regulated, translationally regulated and post-translationally regulated circuits, that enable tailored adjustments in therapeutic cell functions based on dynamic disease-state cues, or that can be remotely controlled using clinically compatible external molecular or physical signals. Furthermore, we explore the potential of multi-input regulatable logic-gated programs to enhance the efficacy and safety of engineered cell immunotherapies for cancer treatment, and highlight the application of synthetic gene circuits for gene therapy and the design of therapeutic microbes. Finally, we examine how synthetic-biology-inspired therapies may benefit from evolving genome engineering technologies and synergy with artificial intelligence.</p>","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pedagogy in bioengineering: pipettes, practice and patience","authors":"Ritu Raman","doi":"10.1038/s44222-024-00248-4","DOIUrl":"https://doi.org/10.1038/s44222-024-00248-4","url":null,"abstract":"Strategies for hands-on and hands-off teaching, coupled with dynamic adaptation to students and science, enable effective pedagogy in bioengineering.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deana Mohr-Haralampieva, Steve Kappenthuler, Marcus Droege
{"title":"Treating stress urinary incontinence by tissue engineering","authors":"Deana Mohr-Haralampieva, Steve Kappenthuler, Marcus Droege","doi":"10.1038/s44222-024-00246-6","DOIUrl":"https://doi.org/10.1038/s44222-024-00246-6","url":null,"abstract":"Stress urinary incontinence (SUI), a frequently underdiagnosed condition that mainly affects women, lacks effective and long-term treatment options. MUVON Therapeutics has developed a tissue-engineered advanced therapy medicinal product for the treatment of SUI, based on autologous cells, which is being tested in a phase II clinical study — a challenging development effort.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ethics need to keep up with human brain organoid research","authors":"","doi":"10.1038/s44222-024-00236-8","DOIUrl":"10.1038/s44222-024-00236-8","url":null,"abstract":"Research on human brain organoids is progressing at speed. Therefore, an ethical and legal framework needs to be put in place to ensure their responsible use, while not constraining innovation.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00236-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siliang Li, Xinyuan Zuo, Matthew D. Carpenter, Rafael Verduzco, Caroline M. Ajo-Franklin
{"title":"Microbial bioelectronic sensors for environmental monitoring","authors":"Siliang Li, Xinyuan Zuo, Matthew D. Carpenter, Rafael Verduzco, Caroline M. Ajo-Franklin","doi":"10.1038/s44222-024-00233-x","DOIUrl":"https://doi.org/10.1038/s44222-024-00233-x","url":null,"abstract":"<p>In a world confronting pollution across diverse environments, fast, sensitive and cost-efficient methods are required to monitor complex chemicals. In particular, microbial bioelectronic sensors can report on the presence of chemicals through electrical signals enabled by biological processes. For example, microbial bioelectronic sensors have been developed for the rapid detection of riverine toxins within minutes of contact, for selective sensing of redox-active pharmaceuticals, and for monitoring of pesticide degradation. However, transferring these laboratory-tested technologies into field-deployable products poses several challenges: sensor sensitivity, specificity, longevity and robustness need to be improved. In this Review, we discuss the design of field-deployable microbial bioelectronic sensors, including chassis selection, approaches for rewiring electron transfer, strategies to establish the cell–electrode interface and fabrication methods. Importantly, we outline key challenges and possible solutions for the application of such sensors in the real world.</p>","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cells as active crosslinkers in living materials","authors":"Sadra Bakhshandeh","doi":"10.1038/s44222-024-00244-8","DOIUrl":"10.1038/s44222-024-00244-8","url":null,"abstract":"An article in Nature Materials reports a new method for generating macroscale living materials by using cells as active crosslinkers.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A biodegradable tent electrode","authors":"Caroline Beyer","doi":"10.1038/s44222-024-00243-9","DOIUrl":"10.1038/s44222-024-00243-9","url":null,"abstract":"An article in Nature Electronics reports the development of a biodegradable, minimally invasive tent electrode for large-area cortex monitoring.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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