{"title":"Turning smartphones into medical devices","authors":"","doi":"10.1038/s44222-025-00368-5","DOIUrl":"10.1038/s44222-025-00368-5","url":null,"abstract":"Although medical devices remain out of reach for many, smartphones are now in the hands of most of the world’s population. Turning these everyday tools into diagnostic devices could thus be a game-changer for global healthcare access, but only if trust is earned and privacy protected.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"805-805"},"PeriodicalIF":37.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44222-025-00368-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Magnetobacterial microrobots","authors":"Lan Vi Nguyen","doi":"10.1038/s44222-025-00373-8","DOIUrl":"10.1038/s44222-025-00373-8","url":null,"abstract":"An article in Nature Communications reports a magnetically guided biohybrid microrobot system for active and efficient pneumonia therapy in vivo.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"815-815"},"PeriodicalIF":37.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The untapped potential of mRNA–lipid nanoparticles","authors":"","doi":"10.1038/s44222-025-00362-x","DOIUrl":"10.1038/s44222-025-00362-x","url":null,"abstract":"mRNA–lipid nanoparticles have transformed vaccines and are beginning to have an effect in cancer therapy, yet remain absent in therapies for acute critical illnesses, such as stroke, infarction or other traumatic injuries. Economic disincentives and historical reputation might be behind this gap.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 9","pages":"715-715"},"PeriodicalIF":37.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44222-025-00362-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Floss-based vaccination","authors":"Caroline Beyer","doi":"10.1038/s44222-025-00365-8","DOIUrl":"10.1038/s44222-025-00365-8","url":null,"abstract":"An article in Nature Biomedical Engineering demonstrates a needle-free floss-based vaccination platform that can be self-administered and triggers systemic and mucosal immune responses.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 9","pages":"726-726"},"PeriodicalIF":37.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lalitkumar K. Vora, Akmal H. Sabri, Peter E. McKenna, Achmad Himawan, Aaron R. J. Hutton, Usanee Detamornrat, Alejandro J. Paredes, Eneko Larrañeta, Ryan F. Donnelly
{"title":"Author Correction: Microneedle-based biosensing","authors":"Lalitkumar K. Vora, Akmal H. Sabri, Peter E. McKenna, Achmad Himawan, Aaron R. J. Hutton, Usanee Detamornrat, Alejandro J. Paredes, Eneko Larrañeta, Ryan F. Donnelly","doi":"10.1038/s44222-025-00357-8","DOIUrl":"10.1038/s44222-025-00357-8","url":null,"abstract":"","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 9","pages":"804-804"},"PeriodicalIF":37.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44222-025-00357-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lin Yang, Lianyong Han, Otmar Schmid, Chunying Chen
{"title":"Precision dosimetry in pulmonary drug delivery","authors":"Lin Yang, Lianyong Han, Otmar Schmid, Chunying Chen","doi":"10.1038/s44222-025-00356-9","DOIUrl":"10.1038/s44222-025-00356-9","url":null,"abstract":"Nanotechnology-based platforms are being explored for the delivery of therapeutics directly to the lungs through inhalation. However, to ensure translational relevance between preclinical animal models and human applications, it is essential to accurately quantify and report the lung-deposited dose, rather than relying solely on the nominally administered dose.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"810-812"},"PeriodicalIF":37.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient-powered innovation","authors":"","doi":"10.1038/s44222-025-00341-2","DOIUrl":"10.1038/s44222-025-00341-2","url":null,"abstract":"Healthcare technology should not only be functional and safe but also responsive to patient needs. Therefore, patients should be proactively involved from the earliest stages of the design process.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 8","pages":"613-613"},"PeriodicalIF":37.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44222-025-00341-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Label-free optical surgical guidance during endocrine surgery","authors":"Alexandria G. Cousart, Anita Mahadevan-Jansen","doi":"10.1038/s44222-025-00353-y","DOIUrl":"10.1038/s44222-025-00353-y","url":null,"abstract":"The PTeye is a label-free, intraoperative optical device that uses near-infrared autofluorescence to confirm the real-time identification of parathyroid glands during surgery. Developed without venture capital, it exemplifies how academic–industry collaboration can bring light-based technologies to the clinic.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"813-814"},"PeriodicalIF":37.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pere Dosta, Alexander M. Cryer, Michaela Prado, Natalie Artzi
{"title":"Bioengineering strategies to optimize STING agonist therapy","authors":"Pere Dosta, Alexander M. Cryer, Michaela Prado, Natalie Artzi","doi":"10.1038/s44222-025-00337-y","DOIUrl":"10.1038/s44222-025-00337-y","url":null,"abstract":"The stimulator of interferon genes (STING) pathway is a key target in cancer immunotherapy. Although STING agonists have shown promise in preclinical models, this has not been translated into the clinic. There is an incomplete understanding, particularly in non-murine models, of dose–toxicity and dose–efficacy relationships. Moreover, the ideal dose and delivery kinetics to achieve an optimal response and to avoid overt or chronic inflammation, as well as the appropriate combination therapy, remains unclear. These challenges are compounded by the delivery barriers, including short circulatory half-life, poor cell internalization and non-specific tissue uptake — all of which hinder their clinical application. Biomaterial-based delivery systems offer a powerful means to overcome these hurdles, expanding the therapeutic window of STING agonists and providing mechanistic insights into immune cell interactions that dictate therapeutic outcomes. In this Review, we discuss the current landscape of STING agonists in cancer and how biomaterial platforms can be leveraged to enhance their therapeutic benefits while minimizing toxicity. We also explore biomaterials that can improve combinatorial therapies and regimens that overcome the immunosuppressive tumour microenvironments. Additionally, we investigate biomaterial strategies used to understand the biological mechanisms and long-term effects of STING-based therapies. The stimulator of interferon genes (STING) pathway can be targeted to promote antitumour immunity. This Review discusses the clinical translation of STING agonists and explores the use of biomaterials to investigate STING pathways, enhance STING agonist delivery and facilitate development of cancer immunotherapies.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 8","pages":"660-680"},"PeriodicalIF":37.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dylan Mostert, Cas van der Putten, Cecilia M. Sahlgren, Nicholas A. Kurniawan, Carlijn V. C. Bouten
{"title":"Bioengineering structural anisotropy in living tissues","authors":"Dylan Mostert, Cas van der Putten, Cecilia M. Sahlgren, Nicholas A. Kurniawan, Carlijn V. C. Bouten","doi":"10.1038/s44222-025-00338-x","DOIUrl":"10.1038/s44222-025-00338-x","url":null,"abstract":"Structural anisotropy is a hallmark of many tissues in humans. The spatially aligned organization of cells and extracellular matrix (ECM) is crucial to physiological functions such as contraction (muscle, myocardium), locomotion (tendon, muscle) and sight (cornea). Restoration of tissue anisotropy lost due to injury or disease is thus a fundamental — yet overlooked — aspect of functional tissue regeneration. In vivo, tissue anisotropy develops from cell patterning and subsequent ECM synthesis and organization and is influenced by ECM remodelling. By contrast, regenerative bioengineering strategies often dictate tissue anisotropy by providing cues that direct cells and ECM during neo-tissue formation, for example, by implanting resorbable scaffolds that present such cues. However, in vivo regeneration, development and remodelling of the new tissue might influence the intended tissue layout, rendering the engineered tissues dysfunctional. Thus, strategies for restoring tissue anisotropy could benefit from improved understanding of tissue structural evolution and the manipulation thereof using external cues. Here, we summarize the development of structural anisotropy in native tissues, followed by in vitro reductionist approaches to understand and gear the driving forces of cell and tissue anisotropy. Translating these insights to in vivo contexts, we discuss knowledge gaps and propose new research directions for the bioengineering of structural anisotropy in damaged tissues. Structural anisotropy is crucial for the function of various human tissues such as myocardial and locomotion muscles and cornea. In this Review, the authors summarize the development of structural anisotropy in native tissues and discuss in vitro reductionist approaches to understand and direct anisotropy for tissue regeneration applications.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 9","pages":"727-741"},"PeriodicalIF":37.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
求助内容：
应助结果提醒方式：