{"title":"Defining the clinical niche for photoacoustic imaging","authors":"","doi":"10.1038/s44222-025-00284-8","DOIUrl":"10.1038/s44222-025-00284-8","url":null,"abstract":"Biomedical imaging continues to advance, providing ever more refined methods to diagnose and monitor diseases. Photoacoustic imaging, a hybrid modality that combines optical and acoustic technologies, stands out for its ability to deliver high-resolution images at a greater depth than optical microscopy. However, as with any imaging technology, its success will hinge on identifying specific clinical applications for which it offers clear advantages over established methods.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 3","pages":"181-181"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-025-00284-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar S. Mahshid, Sripadh Guptha Yedire, Roozbeh S. Moakhar, Tamer AbdElFatah, Sara Mahshid
{"title":"A nucleic acid detection device for rapid multiplexed molecular disease diagnostics","authors":"Sahar S. Mahshid, Sripadh Guptha Yedire, Roozbeh S. Moakhar, Tamer AbdElFatah, Sara Mahshid","doi":"10.1038/s44222-025-00288-4","DOIUrl":"10.1038/s44222-025-00288-4","url":null,"abstract":"A user-friendly nucleic acid detection device, called QolorEX, uses plasmonic nanostructures to provide colorimetric readouts with gold-standard-test accuracy for fully automated, deployable multiplex disease diagnostics. Here, we explore its journey towards commercialization, highlighting its underlying approach and the challenges faced in bringing this technology to the market.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 3","pages":"187-189"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pushing the boundaries of biofabrication","authors":"","doi":"10.1038/s44222-025-00278-6","DOIUrl":"10.1038/s44222-025-00278-6","url":null,"abstract":"Biofabrication technologies have advanced from proof-of-concept demonstrations to sophisticated and scalable methods. This month’s Focus issue explores this progress and highlights how biofabrication is revolutionizing our ability to create complex biological structures with unprecedented precision and control.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 2","pages":"103-103"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-025-00278-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cryogenic printing of hydrogel machines","authors":"Caroline Beyer","doi":"10.1038/s44222-025-00282-w","DOIUrl":"10.1038/s44222-025-00282-w","url":null,"abstract":"An article in Nature Communications presents a new biofabrication technique called multimaterial cryogenic printing, which leverages cryogenic solvent phase transitions to develop free-standing hydrogel constructs and hydrogel-based machines.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 2","pages":"107-107"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-025-00282-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-invasive hormone monitoring with a wearable sweat biosensor","authors":"Yerim Lee, Wei Gao","doi":"10.1038/s44222-025-00276-8","DOIUrl":"10.1038/s44222-025-00276-8","url":null,"abstract":"Wearable sweat biosensors enable the non-invasive, real-time monitoring of hormones. Here, we highlight the development and commercialization of a wearable technology that can measure hormone levels in sweat for women’s health applications, including fertility tracking and menopause management.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 3","pages":"190-191"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Terahertz brain–computer interfaces","authors":"Aarthy Nagarajan, Ranjan Singh","doi":"10.1038/s44222-025-00275-9","DOIUrl":"10.1038/s44222-025-00275-9","url":null,"abstract":"Brain–computer interfaces (BCIs) face data and transmission limitations. Terahertz (THz) waves offer high-resolution brain imaging and terabit-per-second wireless data transfer, addressing these challenges. The convergence of THz and neurotechnology promises to accelerate clinical adoption of BCIs, transforming neurorehabilitation and neural control.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 3","pages":"185-186"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3D-printed intravaginal ring for infertility treatment","authors":"Soumya Rahima Benhabbour","doi":"10.1038/s44222-025-00272-y","DOIUrl":"10.1038/s44222-025-00272-y","url":null,"abstract":"Intravaginal rings provide a patient-friendly method for delivering progesterone in assisted reproductive technology. AnelleO has leveraged 3D printing technology to reengineer customizable intravaginal rings that enable self-administered and sustained progesterone delivery for over 28 days.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 2","pages":"104-105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-025-00272-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From research to business","authors":"","doi":"10.1038/s44222-024-00270-6","DOIUrl":"10.1038/s44222-024-00270-6","url":null,"abstract":"Engineering is about transforming innovative solutions from the lab into real-world impact. In our Down to Business articles, we highlight inspiring stories of spin-off companies that have navigated the challenges of translation. These stories, shared by the inventors themselves, reveal the triumphs and hurdles of bringing ideas to life.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00270-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michelle S. Huang, Fotis Christakopoulos, Julien G. Roth, Sarah C. Heilshorn
{"title":"Organoid bioprinting: from cells to functional tissues","authors":"Michelle S. Huang, Fotis Christakopoulos, Julien G. Roth, Sarah C. Heilshorn","doi":"10.1038/s44222-024-00268-0","DOIUrl":"10.1038/s44222-024-00268-0","url":null,"abstract":"The biofabrication of complex human tissues to recapitulate organ-specific architecture and function requires a combination of engineering control and intrinsic self-assembly. Organoid bioprinting encompasses additive manufacturing approaches that can impart spatial control over the placement of organoids or organoid-forming cells to fabricate multicellular, 3D structures. In particular, bioprinting can be leveraged to control the spatial positioning of printed cells or tissues while maintaining the architecture and physiology of the constituent building blocks. In this Review, we discuss the emerging integration of bioprinting methods and tissue engineering. As bioprinting conventionally involves the patterning of a ‘material’ ink, we characterize cells and organoids as a living material and discuss how such a living material can be manipulated through biofabrication techniques. We focus on continuous and pick-and-place bioprinting methods in which spheroids, organoids or organoid-forming cells comprise the bioink. Additionally, we discuss organoid support baths into which inks are printed. Finally, we highlight how the combination of bioprinting approaches and organoid technology has the potential to improve engineered tissue models of development and disease. Integrating bioprinting with organoid technology can enhance tissue engineering by improving complexity, reproducibility and scalability. This Review discusses living materials in bioprinting, current organoid bioprinting methods, support baths and future innovations that could advance complex tissue development and applications.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 2","pages":"126-142"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00268-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}