Nature reviews bioengineering最新文献_第10页

Sex-specific nanomedicine- and biomaterials-based therapies of chronic wounds 基于纳米医学和生物材料的慢性伤口性别特异性疗法

Nature reviews bioengineering Pub Date : 2024-04-29 DOI: 10.1038/s44222-024-00191-4

Negar Mahmoudi, David R. Nisbet, Irena Pastar, Lisa Gould, Simon Matoori, Morteza Mahmoudi

引用次数: 0

The convergence of neuromodulation and brain–computer interfaces 神经调控与脑机接口的融合

Nature reviews bioengineering Pub Date : 2024-04-22 DOI: 10.1038/s44222-024-00187-0

Jeffrey Herron, Vaclav Kremen, John D. Simeral, Heather Dawes, Gregory A. Worrell, Philip A. Starr, Timothy Denison, David Borton

引用次数: 0

Innovative dietary fat production 创新性膳食脂肪生产

Nature reviews bioengineering Pub Date : 2024-04-19 DOI: 10.1038/s44222-024-00189-y

Enrico Costanzo, Giorgia Spigno

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Nanoscale anisotropy for biomedical applications 生物医学应用中的纳米级各向异性

Nature reviews bioengineering Pub Date : 2024-04-19 DOI: 10.1038/s44222-024-00169-2

Helena Almeida, Giovanni Traverso, Bruno Sarmento, José das Neves

{"title":"Nanoscale anisotropy for biomedical applications","authors":"Helena Almeida, Giovanni Traverso, Bruno Sarmento, José das Neves","doi":"10.1038/s44222-024-00169-2","DOIUrl":"10.1038/s44222-024-00169-2","url":null,"abstract":"Nanoparticles exhibit anisotropy when distinct features can be identified along different axes. Such disruption in shape and/or composition symmetry can change how nanoparticles behave and interact with the surrounding environment compared with their isotropic counterparts. Anisotropic combinations can be limitless and show potential for tackling biological barriers and developing programmable, targeted, and combined delivery of bioactive molecules, mainly when featuring autonomous motion. In this Review, we summarize the main methods for the generation of anisotropic particles at the nanoscale. We further discuss how geometric cues or the incorporation of propulsive agents (chemically or physically driven) improve transport across biological fluids, promote cellular adhesion and internalization, and/or increase tissue penetration. We finally highlight considerations for the design of anisotropic nanoparticles and the precise control over morphology and properties, in addition to the challenges for clinical translation. Using nanoparticles featuring anisotropic characteristics is a promising approach to developing multifunctional platforms for drug delivery and theranostics. This Review discusses methods to generate anisotropy in nanosystems and strategies to control particle transport, targeting and interaction with cells to overcome biological barriers.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 7","pages":"609-625"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140627915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The multifaceted challenges of bioplastics 生物塑料面临的多方面挑战

Nature reviews bioengineering Pub Date : 2024-04-16 DOI: 10.1038/s44222-024-00181-6

引用次数: 0

Motion artefact management for soft bioelectronics 软生物电子学的运动伪影管理

Nature reviews bioengineering Pub Date : 2024-04-15 DOI: 10.1038/s44222-024-00175-4

Junyi Yin, Shaolei Wang, Trinny Tat, Jun Chen

{"title":"Motion artefact management for soft bioelectronics","authors":"Junyi Yin, Shaolei Wang, Trinny Tat, Jun Chen","doi":"10.1038/s44222-024-00175-4","DOIUrl":"10.1038/s44222-024-00175-4","url":null,"abstract":"Soft bioelectronic devices can be interfaced with anatomically curved organs, such as the heart, brain and skin, to provide continuous analysis of physiological information. However, body movements and physiological activities may induce motion artefacts, which can adversely affect signal accuracy and stability. Importantly, motion artefact management is key to promoting the clinical translation of soft bioelectronics to ensure that soft bioelectronic devices can selectively detect target biological signals with high accuracy. In this Review, we discuss how body activities can affect the soft bioelectronic–tissue interface and result in motion artefact signals, including interface impedance instability motion artefacts, biopotential motion artefacts and mechanical motion artefacts. We then investigate different motion artefact management strategies, including materials engineering, device and circuit design, and algorithmic intervention, to reduce the contribution of motion artefacts to signal acquisition, processing and interpretation. Motion artefacts challenge the translational application of soft bioelectronics by distorting physiological monitoring. This Review introduces fundamental causes of motion artefacts and discusses various management strategies, including materials usage, bioelectronics design and algorithmic intervention.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 7","pages":"541-558"},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic particle imaging scanning at the bedside 床旁磁粉成像扫描

Nature reviews bioengineering Pub Date : 2024-04-15 DOI: 10.1038/s44222-024-00186-1

Sadra Bakhshandeh

引用次数: 0

Microfluidic high-throughput 3D cell culture 微流控高通量三维细胞培养

Nature reviews bioengineering Pub Date : 2024-04-04 DOI: 10.1038/s44222-024-00163-8

Jihoon Ko, Dohyun Park, Jungseub Lee, Sangmin Jung, Kyusuk Baek, Kyung E. Sung, Jeeyun Lee, Noo Li Jeon

{"title":"Microfluidic high-throughput 3D cell culture","authors":"Jihoon Ko, Dohyun Park, Jungseub Lee, Sangmin Jung, Kyusuk Baek, Kyung E. Sung, Jeeyun Lee, Noo Li Jeon","doi":"10.1038/s44222-024-00163-8","DOIUrl":"10.1038/s44222-024-00163-8","url":null,"abstract":"High-throughput 3D microfluidic cell culture systems can be designed to model aspects of human tissues and organs and may thus serve as non-clinical evaluation tools. They benefit from large-scale production, high throughput, compatibility with automated equipment, standardized analysis and the generation of physiologically relevant results. In this Review, we discuss how microfluidic devices can be designed with different biological complexity, cell sources and cell configurations, as well as physiological parameters to mimic human tissues. We examine standardization, scalability and automation strategies, and outline high-throughput data generation and analysis approaches to interpret readouts of microfluidic 3D cell culture models. Finally, we explore the potential of these tools as non-clinical testing systems for drug development and outline key future challenges in device design and application. Microfluidic 3D cell culture platforms may serve as tools for the modelling of human tissues. This Review discusses the design, standardization and automation of such systems for non-clinical drug evaluation and investigation of disease.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 6","pages":"453-469"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploiting gut microbial traits and trade-offs in microbiome-based therapeutics 利用肠道微生物特性和权衡基于微生物组的疗法

Nature reviews bioengineering Pub Date : 2024-04-04 DOI: 10.1038/s44222-024-00178-1

Bin Liu, Daniel Rios Garza, Pallabita Saha, Xingjian Zhou, Karoline Faust

引用次数: 0

From equitable access to equitable innovation: rethinking bioengineering for global health 从公平获取到公平创新：重新思考促进全球健康的生物工程

Nature reviews bioengineering Pub Date : 2024-04-02 DOI: 10.1038/s44222-024-00182-5

Alice Street, Maïwenn Kersaudy Kerhoas, Zibusiso Ndlovu

引用次数: 0