Nature reviews bioengineering最新文献_第9页

Rethinking immunity in bioengineering 重新思考生物工程中的免疫

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-14 DOI: 10.1038/s44222-025-00336-z

引用次数: 0

Using ‘supporting molecules’ (SUMs) to improve mRNA LNP therapies 使用“支持分子”（sum）改善mRNA LNP治疗

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-10 DOI: 10.1038/s44222-025-00339-w

Rachel VanKeulen-Miller, Vincent Fung, Owen S. Fenton

引用次数: 0

The CL1 as a platform technology to leverage biological neural system functions CL1作为利用生物神经系统功能的平台技术

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-07 DOI: 10.1038/s44222-025-00340-3

Brett J. Kagan

引用次数: 0

Mobile medical systems for equitable healthcare 移动医疗系统促进公平医疗

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Nature reviews bioengineering Pub Date : 2025-07-03 DOI: 10.1038/s44222-025-00330-5

Justin Chan, Mayank Goel, Shyamnath Gollakota, Rajalakshmi Nandakumar

{"title":"Mobile medical systems for equitable healthcare","authors":"Justin Chan, Mayank Goel, Shyamnath Gollakota, Rajalakshmi Nandakumar","doi":"10.1038/s44222-025-00330-5","DOIUrl":"10.1038/s44222-025-00330-5","url":null,"abstract":"Major barriers to accessible healthcare include the high cost of medical devices and limited healthcare facilities. Mobile computing technologies, such as smartphones and smart watches, include high-quality hardware, such as microphones, speakers and cameras, which can be leveraged for the design of low-cost mobile medical systems intended to be remotely applied to monitor health and disease. In this Review, we discuss low-cost and accessible hardware — in particular, mobile phones — that can be used in mobile medical systems to aid in medical diagnostics and monitoring. Specifically, we outline acoustic-based systems, vision-based systems and sensor fusion systems that allow different levels of health and disease assessment, relying on the speakers, microphones and sensors of smart mobile devices. We highlight the challenges related to the deployment of mobile medical systems in the clinical continuum, including scaling, generalizability, bias, trust and privacy. Finally, we examine clinical integration and regulatory considerations with regard to mobile medical devices as well as future applications. The features of smart devices such as smartphones and smart watches, including speakers, microphones and other sensors, can be leveraged for the design of mobile medical systems. This Review discusses acoustic-based, vision-based and sensor fusion systems that rely on smart device hardware and software for remote health and disease assessment.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"855-874"},"PeriodicalIF":37.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable production of chemicals by algorithm-assisted (bio)synthesis 通过算法辅助（生物）合成的可持续化学品生产

IF 37.6

Nature reviews bioengineering Pub Date : 2025-06-27 DOI: 10.1038/s44222-025-00312-7

Bartosz A. Grzybowski, Anna Żądło-Dobrowolska, Natalia Onishchenko, Eric S. Larsen

{"title":"Sustainable production of chemicals by algorithm-assisted (bio)synthesis","authors":"Bartosz A. Grzybowski, Anna Żądło-Dobrowolska, Natalia Onishchenko, Eric S. Larsen","doi":"10.1038/s44222-025-00312-7","DOIUrl":"10.1038/s44222-025-00312-7","url":null,"abstract":"Although research on computer-assisted planning of organic chemical syntheses dates back to the 1960s, it has only been in recent years that algorithms became powerful enough to autonomously design complete pathways, both in retrosynthetic and forward directions. Some of these modern programmes can plan chemically correct routes to complex targets and multiple such designs have now been validated by experiment. With chemical correctness secured, the next frontier for machines is to help design syntheses that are green (for example, in terms of conditions applied), sustainable (in terms of resources used) or circular (for example, in terms of waste feedstocks being revalorized). This Perspective argues that several parts of this challenge can benefit from close collaboration between synthetic chemists and bioengineers — for instance, to design better metrics of the environmental impact of syntheses or to develop algorithms with which to delineate the substrate scope of enzymatic transformations. Computers able to plan efficient and greener routes combining chemical and enzymatic steps will have a powerful and lasting impact on the production of fine chemicals. Synthesis-planning algorithms equipped with accurate knowledge of reaction rules can nowadays rival designs of expert organic chemists. This Review discusses how computer-assisted synthesis is used to help design routes that are not only chemically correct but also green, sustainable or circular.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 9","pages":"791-803"},"PeriodicalIF":37.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart closed-loop drug delivery systems 智能闭环给药系统

IF 37.6

Nature reviews bioengineering Pub Date : 2025-06-26 DOI: 10.1038/s44222-025-00328-z

Marco M. Paci, Tamoghna Saha, Omeed Djassemi, Steven Wu, Corrine Ying Xuan Chua, Joseph Wang, Alessandro Grattoni

{"title":"Smart closed-loop drug delivery systems","authors":"Marco M. Paci, Tamoghna Saha, Omeed Djassemi, Steven Wu, Corrine Ying Xuan Chua, Joseph Wang, Alessandro Grattoni","doi":"10.1038/s44222-025-00328-z","DOIUrl":"10.1038/s44222-025-00328-z","url":null,"abstract":"The administration of therapeutics for long-term chronic disease management or treatment faces considerable challenges, such as the need for precise dosage control, timely delivery and adherence to medication regimens. Traditional drug delivery methods often result in suboptimal therapeutic outcomes owing to variable responses, fluctuating drug concentrations and lack of feedback from real-time monitoring. Smart closed-loop systems (CLSs) could address these limitations by integrating real-time biosensing with automated drug delivery, thereby personalizing treatments to individual needs. This Review explores the current landscape of CLSs, highlighting recent advancements in wearable and implantable technologies that facilitate continuous monitoring of biomarkers and offer responsive therapeutic interventions. We discuss the implications of device design and the trade-offs between wearable and implantable systems. In addition, we highlight the potential of artificial intelligence enhancement of CLS control algorithms by enabling systems to learn from and predict responses to achieve more effective and adaptive optimal therapies. Ultimately, this Review charts a path towards next-generation CLSs, emphasizing the integration of synthetic biology and engineered cells into implantable devices. The administration of therapeutics for chronic disease management faces challenges like precise dosage control and timely delivery. This Review explores how smart closed-loop systems can address these issues by integrating real-time biosensing with automated drug delivery, highlighting advancements in wearable and implantable technologies, artificial intelligence-enhanced control algorithms and the integration of synthetic biology for personalized, adaptive therapies.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"816-834"},"PeriodicalIF":37.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome synthesis in plants 植物基因组合成

IF 37.6

Nature reviews bioengineering Pub Date : 2025-06-25 DOI: 10.1038/s44222-025-00326-1

Tianlong Lan (, ), Lian-Ge Chen (, ), Ying Wang (, ), Yuling Jiao (, )

{"title":"Genome synthesis in plants","authors":"Tianlong Lan \u0000 (, ), Lian-Ge Chen \u0000 (, ), Ying Wang \u0000 (, ), Yuling Jiao \u0000 (, )","doi":"10.1038/s44222-025-00326-1","DOIUrl":"10.1038/s44222-025-00326-1","url":null,"abstract":"Owing to advances in genome sequencing and editing, a genome can now be redesigned, synthesized and introduced into cells as desired. The field of synthetic genomics not only aims to provide deeper understanding of how the genome functions but can also be harnessed for a wide range of synthetic biology and bioengineering applications, from rapid evolution and screening for favourable strains to biotechnological and bioproduction tool development. Although genome synthesis has been carried out mainly in simple unicellular organisms, plants and animals are now also being investigated. Compared with animals, plants have unique advantages, such as fewer ethical concerns, simpler experimental operations and easier regeneration from cells to organisms. In this Review, we focus on genome synthesis in plants, discuss the current research landscape and assess possible future directions. Owing to advances in genome sequencing and editing, a genome can now be redesigned, synthesized and introduced into cells as desired. This Review discusses plant genome synthesis, highlighting bottom-up genome design, large-fragment assembly and site-directed targeting.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"875-889"},"PeriodicalIF":37.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired and biointegrated vision for artificial sight convergence 人工视觉收敛的生物启发和生物集成视觉

IF 37.6

Nature reviews bioengineering Pub Date : 2025-06-25 DOI: 10.1038/s44222-025-00324-3

Yifei Yang, Yifei Wang, Chaoyi Zhu, Zhengdao Xie, Zhengsheng Qin, Zhaoqing Wang, Yang Chai

{"title":"Bioinspired and biointegrated vision for artificial sight convergence","authors":"Yifei Yang, Yifei Wang, Chaoyi Zhu, Zhengdao Xie, Zhengsheng Qin, Zhaoqing Wang, Yang Chai","doi":"10.1038/s44222-025-00324-3","DOIUrl":"10.1038/s44222-025-00324-3","url":null,"abstract":"The long-standing effort to achieve artificial sight can be classified into two complementary approaches. The first is the development of bioinspired optics and optoelectronics for machine vision, which takes cues from the different ocular structures and intricate retinal functions found across various species, and aims to enhance the visual capabilities of machines. The second approach focuses on biointegrated vision, which seeks to integrate intraocular prosthetics within the biological vision system to restore or enhance the sight of the visually impaired. As these two approaches evolve, their convergence is becoming more apparent, underlining the growing need for shared knowledge and collaboration. In this Review, we discuss bioinspired and biointegrated vision placing emphasis on visual devices that mimic the structures of the natural eyes and the information-processing capabilities of biological visual systems. Furthermore, we highlight opportunities for reciprocal exchange and collaborative development across these two disciplines. The historically independent evolution of bioinspired and biointegrated vision is increasingly showing a trend of convergence. This Review discusses each technological framework emphasizing visual devices that mimic the structures of the natural eyes and the information-processing capabilities of biological visual systems.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 11","pages":"939-954"},"PeriodicalIF":37.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-friendly insect control in crop production 作物生产中的生态友好型昆虫控制

IF 37.6

Nature reviews bioengineering Pub Date : 2025-06-18 DOI: 10.1038/s44222-025-00332-3

Eva M. Steiner-Rebrova, Kenneth V. Halberg

引用次数: 0

Writing is thinking 写作就是思考

IF 37.6

Nature reviews bioengineering Pub Date : 2025-06-16 DOI: 10.1038/s44222-025-00323-4

引用次数: 0