{"title":"Brain–computer interfaces for neuropsychiatric disorders","authors":"Lucine L. Oganesian, Maryam M. Shanechi","doi":"10.1038/s44222-024-00177-2","DOIUrl":"10.1038/s44222-024-00177-2","url":null,"abstract":"Neuropsychiatric disorders such as major depression are a leading cause of disability worldwide with standard treatments, including psychotherapy or medication, failing many patients. Deep brain stimulation holds great potential as an alternative therapy for treatment-resistant cases; however, improving the efficacy of stimulation therapy for neuropsychiatric disorders is hindered by the complexity as well as inter-individual and intra-individual variability in symptom manifestations, neural representations and response to therapy. These challenges motivate the development of brain–computer interfaces (BCIs) that can decode the symptom state of a patient from brain activity as feedback to personalize the stimulation therapy in closed loop. Here we review progress on developing BCIs for neuropsychiatric care, focusing on neural biomarkers for decoding symptom states, stimulation site selection and closed-loop stimulation strategies. Moreover, we highlight promising data-driven machine learning and system design approaches and provide a roadmap for realizing these BCIs. Finally, we review current limitations, discuss extensions to other treatment modalities and outline the required scientific and technological advances. These advances can enable next-generation BCIs that provide an alternative therapy for treatment-resistant neuropsychiatric disorders. Stimulation therapy for neuropsychiatric disorders is hindered by the complexity and inter-individual and intra-individual variability in symptom manifestations, neural representations and response to therapy. Brain–computer interfaces could model the brain response to stimulation and decode the symptom state of a patient from brain activity as feedback to personalize the stimulation therapy in closed loop.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 8","pages":"653-670"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00177-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141252279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gerwin Schalk, Peter Brunner, Brendan Z. Allison, Surjo R. Soekadar, Cuntai Guan, Tim Denison, Jörn Rickert, Kai J. Miller
{"title":"Translation of neurotechnologies","authors":"Gerwin Schalk, Peter Brunner, Brendan Z. Allison, Surjo R. Soekadar, Cuntai Guan, Tim Denison, Jörn Rickert, Kai J. Miller","doi":"10.1038/s44222-024-00185-2","DOIUrl":"10.1038/s44222-024-00185-2","url":null,"abstract":"Neurotechnologies combine engineering methods and neuroscientific knowledge to design devices that interface the brain with the outside world. Since the early 2000s, inspiring and encouraging neurotechnology examples have been the subject of high-profile scientific articles and made headlines in popular media. However, although neurotechnologies have the potential to improve people’s lives in ways that cannot be achieved by other solutions such as pharmaceuticals, only a few of them have established themselves as clinical solutions. In this Review, we provide a systematic, state-of-the-art assessment of the opportunities and shortcomings of neurotechnology’s engineering and scientific components, and highlight the requirements to overcome translational barriers. Finally, we present a comprehensive framework to aid the clinical and commercial translation of neurotechnologies. Despite inspiring proof-of-concepts that are often widely covered by the media, only a few neurotechnologies have firmly established themselves as clinical solutions. In this Review, we discuss opportunities and shortcomings of this technology, and provide a framework to facilitate clinical and commercial translation.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 8","pages":"637-652"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00185-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141188945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Injectable liquid bioelectronics","authors":"Sadra Bakhshandeh","doi":"10.1038/s44222-024-00201-5","DOIUrl":"10.1038/s44222-024-00201-5","url":null,"abstract":"An article in Nature Materials reports a new ultrasoft and conformal liquid bioelectronic material for injectable and retrievable biosensing.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 6","pages":"452-452"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141171168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biocomputing with organoid intelligence","authors":"Lena Smirnova","doi":"10.1038/s44222-024-00200-6","DOIUrl":"10.1038/s44222-024-00200-6","url":null,"abstract":"Organoid intelligence towards biocomputing may provide insights into the neuroscience of learning and memory, and offer a biohybrid form of information processing. Advances in brain region-specific organoid engineering, sensors and signal-processing tools, integration of artificial intelligence, and miniaturization will pave the way for organoid intelligence to make an impact in biomedicine and beyond.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 8","pages":"633-634"},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141101698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacqueline C. Linnes, Erika Moore, Ana Maria Porras, Elizabeth Wayne, Patrick M. Boyle, Lesley W. Chow, Katharina Maisel, Shelly R. Peyton, Sarah E. Stabenfeldt, Kelly R. Stevens, Jessica O. Winter, Rebecca Kuntz Willits
{"title":"Framework for department-level accountability to diversify engineering","authors":"Jacqueline C. Linnes, Erika Moore, Ana Maria Porras, Elizabeth Wayne, Patrick M. Boyle, Lesley W. Chow, Katharina Maisel, Shelly R. Peyton, Sarah E. Stabenfeldt, Kelly R. Stevens, Jessica O. Winter, Rebecca Kuntz Willits","doi":"10.1038/s44222-024-00183-4","DOIUrl":"10.1038/s44222-024-00183-4","url":null,"abstract":"Diverse teams are more innovative and creative. Nevertheless, science, technology, engineering and mathematics disciplines, including bioengineering, continue to fall short in increasing representation from persons from groups historically excluded because of their ethnicity or race. Many universities have crafted strategic plans to increase diversity; however, university-wide policies often fail to result in notable changes in microcommunities, such as departments and undergraduate or graduate programs. Therefore, departments may benefit from guidelines not only to craft effective diversity, equity and inclusion (DEI) plans, but also to measure progress towards achieving specific DEI goals. In this Perspective, we present a framework for building, assessing and continuously improving strategic plans to improve recruitment and retention and to make departments more inclusive, including the collection of demographic data, the establishment and assessment of DEI plans, specific goal setting and assessment of achievements, with specific examples and guidelines, which will ultimately help departments to become inclusive working environments. University departments may benefit from guidelines not only to craft effective diversity, equity and inclusion plans, but also to measure progress towards achieving specific goals. This Perspective presents a framework for building, assessing and continuously improving strategic plans to improve recruitment and retention and make departments more inclusive.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 6","pages":"521-530"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prosthetic embodiment or what makes a limb part of your body","authors":"","doi":"10.1038/s44222-024-00188-z","DOIUrl":"10.1038/s44222-024-00188-z","url":null,"abstract":"Prosthetic embodiment, or the incorporation of a prosthesis into one’s sensory and functional body schema, may be achieved by engineering bionic limbs that leverage a closed-loop mechanoneural–machine interface. However, the subjective experience of embodiment remains difficult to define and assess.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 5","pages":"363-363"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00188-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Engineering good viruses to improve crop performance","authors":"Fabio Pasin, Mireia Uranga, Raghavan Charudattan, Choon-Tak Kwon","doi":"10.1038/s44222-024-00197-y","DOIUrl":"10.1038/s44222-024-00197-y","url":null,"abstract":"Viruses can be engineered to deliver nucleic acids, peptides and proteins for plant trait reprogramming. Building on market approvals and sales of recombinant virus-based biopharmaceuticals for veterinary and human medicine, similar innovations may be applied to agriculture for transient or heritable biodesign of crops with improved performance and sustainable production.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 7","pages":"532-534"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Teaching artificial intelligence in medicine","authors":"Yosra Magdi Mekki, Susu M. Zughaier","doi":"10.1038/s44222-024-00195-0","DOIUrl":"10.1038/s44222-024-00195-0","url":null,"abstract":"Artificial intelligence (AI) is finding its way into healthcare. Therefore, medical students need to be trained to be ‘bilingual’ in both medical and computational terminology and concepts to allow them to understand, implement and evaluate AI-related research.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 6","pages":"450-451"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Poly(ethylene glycol) immunogenicity in tissue engineering","authors":"Sunjie Ye","doi":"10.1038/s44222-024-00192-3","DOIUrl":"10.1038/s44222-024-00192-3","url":null,"abstract":"An article in Nature Communications reports the implications of anti-PEG immune reactions for PEG-based hydrogel implants and tissue engineering applications.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 5","pages":"373-373"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140833747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shadman Khan, Zeinab Hosseinidoust, Yingfu Li, Carlos D. M. Filipe, Tohid F. Didar
{"title":"Smart food packaging commercialization","authors":"Shadman Khan, Zeinab Hosseinidoust, Yingfu Li, Carlos D. M. Filipe, Tohid F. Didar","doi":"10.1038/s44222-024-00190-5","DOIUrl":"10.1038/s44222-024-00190-5","url":null,"abstract":"Smart food packaging technologies can actualize real-time, in situ food quality monitoring, increasing food safety and decreasing food waste. Here, we detail challenges that hinder the commercialization of such smart packaging systems and identify opportunities to facilitate their translation from prototype to product.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 7","pages":"535-537"},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140833746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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