Nature reviews bioengineering最新文献_第8页

Electronic hairs for prosthetic control 用于假肢控制的电子毛发

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-27 DOI: 10.1038/s44222-026-00421-x

Caroline Beyer

引用次数: 0

Multi-framework validation of wearable cuffless blood pressure monitors 可穿戴式无袖带血压计的多框架验证

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-27 DOI: 10.1038/s44222-026-00422-w

Kanimozhi Sadasivam, Sharad Sinha, Aanantha KNR, Balaji Chinnasami

引用次数: 0

Overcoming xenotransplantation barriers through gene editing and immunomodulation 通过基因编辑和免疫调节克服异种移植障碍

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-23 DOI: 10.1038/s44222-026-00412-y

Andy Tully, Avneesh K. Singh, Javier Galindo, Bartley P. Griffith, Muhammad M. Mohiuddin

{"title":"Overcoming xenotransplantation barriers through gene editing and immunomodulation","authors":"Andy Tully, Avneesh K. Singh, Javier Galindo, Bartley P. Griffith, Muhammad M. Mohiuddin","doi":"10.1038/s44222-026-00412-y","DOIUrl":"10.1038/s44222-026-00412-y","url":null,"abstract":"Xenotransplantation, the transplantation of organs, tissues or cells across species, offers a potential solution to the shortage of human organs for patients with organ failure. Porcine organs, which share key physiological, anatomical and immunological features with human organs, are currently the primary focus of preclinical and clinical xenotransplantation studies. In this Review, we examine major considerations and barriers in xenotransplantation, including species selection, hyperacute and acute rejection, and xenozoonosis, and discuss strategies to overcome these challenges through gene editing and immunomodulation. We emphasize the need to address antibody-mediated rejection, control complement activation, block co-stimulatory pathways, optimize graft preservation, develop high-fidelity endothelial models, identify additional porcine antigens, and promote immunohomeostasis and tissue repair. Furthermore, robust safety protocols, surveillance systems and mechanisms for ethical transparency are essential. The future success of xenotransplantation will depend on innovative technologies and refined models to resolve these complex challenges. Xenotransplantation aims to address the shortage of human organs by using organs from species other than human; in particular, porcine organs share similarities with human organs in key aspects. This Review highlights major challenges in xenotransplantation, such as immune rejection and disease transmission, and explores solutions, such as gene editing, immunomodulation, and robust safety and ethical frameworks to enable future success.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 5","pages":"402-416"},"PeriodicalIF":37.6,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147968221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De novo design of synthetic microbial genomes 合成微生物基因组的从头设计

IF 42.7

Nature reviews bioengineering Pub Date : 2026-02-23 DOI: 10.1038/s44222-026-00410-0

Charlotte C. Koster, Henrique da Costa Oliveira, Fabian van Beveren, Joep Houkes, Jolien J. E. van Hooff, Thijs J. G. Ettema, John van der Oost, Nico J. Claassens

{"title":"De novo design of synthetic microbial genomes","authors":"Charlotte C. Koster, Henrique da Costa Oliveira, Fabian van Beveren, Joep Houkes, Jolien J. E. van Hooff, Thijs J. G. Ettema, John van der Oost, Nico J. Claassens","doi":"10.1038/s44222-026-00410-0","DOIUrl":"10.1038/s44222-026-00410-0","url":null,"abstract":"Synthetic biology enables the bottom-up synthesis of microbial genomes through the assembly of synthetic DNA fragments. Such de novo genome synthesis could enable the generation of synthetic cells, with applications in fundamental biology, biotechnology and biomedicine. In this Review, we explore the rational design of synthetic microbial genomes, including expression unit optimization, codon usage, transcriptional and translational control, and RNA and protein turnover. We then examine genome-level design considerations, highlighting the roles of chromosome architecture, gene orientation and positioning, and 3D gene arrangement, outlining strategies for the assembly and testing of synthetic genomes. Finally, we propose a path towards a fully realized synthetic cell, emphasizing the importance of method integration, including evolution-based strategies and machine learning. Synthetic biology might enable the bottom-up construction of synthetic genomes, offering a foundation for building synthetic cells. This Review discusses strategies for rational genome design, genome-scale organization, and integration of experimental and computational methods to realize a fully synthetic cell.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 6","pages":"523-540"},"PeriodicalIF":42.7,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responsible innovation in bioengineering 负责任的生物工程创新

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-18 DOI: 10.1038/s44222-026-00415-9

Shweta Agarwala

引用次数: 0

Multi-device collaborative theranostics across tissue depth 跨组织深度的多设备协同治疗

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-18 DOI: 10.1038/s44222-026-00419-5

Haoxiang Wang, Jiaqi Zhu, Philip Wai Yan Chiu, Li Zhang, Kewang Nan

引用次数: 0

Sex as a biological variable in biomedical engineering 性别作为生物医学工程中的生物变量

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-16 DOI: 10.1038/s44222-026-00411-z

引用次数: 0

Engineering long-term stability in soft bioelectronics for clinical translation 工程长期稳定的软生物电子临床翻译

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-12 DOI: 10.1038/s44222-026-00414-w

Yuhang Ye (, ), Yuanwen Jiang (, )

引用次数: 0

The status of extracellular vesicles as drug carriers and therapeutics 细胞外囊泡作为药物载体和治疗手段的地位

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-05 DOI: 10.1038/s44222-026-00405-x

Ameya P. Chaudhari, Omar M. Budayr, Emily E. Bonacquisti, Caden C. Kussatz, Mark S. Bannon, Karissa J. Law, Yusha Liu, Matthew L. Bolton, Patrick M. Glassman, Leaf Huang, Juliane Nguyen

{"title":"The status of extracellular vesicles as drug carriers and therapeutics","authors":"Ameya P. Chaudhari, Omar M. Budayr, Emily E. Bonacquisti, Caden C. Kussatz, Mark S. Bannon, Karissa J. Law, Yusha Liu, Matthew L. Bolton, Patrick M. Glassman, Leaf Huang, Juliane Nguyen","doi":"10.1038/s44222-026-00405-x","DOIUrl":"10.1038/s44222-026-00405-x","url":null,"abstract":"Owing to their natural origin and biocompatibility, extracellular vesicles (EVs) are being recognized as next-generation vehicles for targeted drug delivery. Despite their potential as therapeutic carriers, EVs suffer from heterogeneity, low yields, limited cargo loading efficiency and rapid clearance by the mononuclear phagocyte system. Since the first EV-based clinical trial in 2005, more than 100 clinical trials have investigated the use of EVs as therapeutics and drug carriers. Despite this, no EV-based therapies have received regulatory approval to date. This gap between preclinical research activity and clinical translation underscores persistent scientific challenges and regulatory hurdles that continue to impede the advancement of EV-based therapeutics. In this Review, we examine the research articles published in the field between 2012 and 2024 (38,177 articles), highlighting key developments, persistent challenges and evolving assumptions. We review the current EV landscape and clinical trials, focusing on their organotropism and use as carriers for therapeutics. We compare their advantages and limitations in relation to other nanoparticles, such as lipid nanoparticles and liposomes, and examine how labelling strategies and cell sources influence EV biodistribution. Finally, we outline translational considerations for EV-based therapeutics and propose additional reporting standards, complementing the MISEV 2023 guidelines. Extracellular vesicles (EVs) are emerging as biocompatible carriers for targeted drug delivery, yet challenges in yield, cargo loading and biodistribution persist. In this Review, key trends from over a decade of research are analysed, comparing EVs with lipid-based systems and outlining strategies for improving therapeutic translation and reporting standards.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 4","pages":"301-318"},"PeriodicalIF":37.6,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design principles of lipid nanoparticles for RNA delivery 用于RNA递送的脂质纳米颗粒的设计原则

IF 37.6

Nature reviews bioengineering Pub Date : 2026-02-02 DOI: 10.1038/s44222-026-00401-1

Mariah L. Arral, Kathryn A. Whitehead

{"title":"Design principles of lipid nanoparticles for RNA delivery","authors":"Mariah L. Arral, Kathryn A. Whitehead","doi":"10.1038/s44222-026-00401-1","DOIUrl":"10.1038/s44222-026-00401-1","url":null,"abstract":"Lipid nanoparticles can serve as safe and effective delivery vehicles for RNA therapies by facilitating RNA encapsulation, cell uptake and endosomal escape, enabling precise control of protein expression. Beyond their established role in prophylactic vaccines, formulations of lipid nanoparticles with RNA are being explored in cancer immunotherapy, protein replacement and gene therapy. In this Review, we examine the design landscape of RNA–lipid-nanoparticle formulations, detailing their key components, formation, physicochemical properties and methods of characterization. We discuss how the composition and stoichiometry of the constituents of lipid nanoparticles influence delivery efficiency, tissue targeting and clearance in vivo. Finally, we highlight major therapeutic applications and outline future directions from both engineering and translational perspectives. Lipid nanoparticles can serve as carriers for RNA therapies, enabling efficient encapsulation, cellular uptake and controlled protein expression. This Review explores their design principles, key components, physicochemical properties and therapeutic potential, highlighting how formulation parameters influence delivery performance.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 5","pages":"417-434"},"PeriodicalIF":37.6,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147968226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0