{"title":"Technology readiness is not clinical translation readiness","authors":"Chwee Teck Lim, Zubin J. Daruwalla","doi":"10.1038/s44222-026-00484-w","DOIUrl":"10.1038/s44222-026-00484-w","url":null,"abstract":"Health technologies are typically judged by their technical maturity rather than their ability to improve patient care. As a result, many innovations achieve technological success but fail to reach routine clinical use. Here, we propose clinical translation readiness levels to assess whether health technologies are truly ready for adoption, implementation and patient benefit.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 10","pages":"939-940"},"PeriodicalIF":42.7,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rehabilitation beyond prosthetics in wartime Ukraine","authors":"Max Ortiz-Catalan","doi":"10.1038/s44222-026-00486-8","DOIUrl":"10.1038/s44222-026-00486-8","url":null,"abstract":"Ukraine is experiencing an unprecedented burden of major limb loss within a health system strained by war. As an expert in prosthetics and neurorehabilitation and full-time volunteer in wartime Ukraine, I share my experience of how recovery extends beyond prosthetic technology alone and depends on appropriate and timely care, continuity of rehabilitation, and trained personnel. Bioengineering influences not only devices but also how care is delivered under constrained conditions.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 10","pages":"941-943"},"PeriodicalIF":42.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Human disease models by design","authors":"","doi":"10.1038/s44222-026-00473-z","DOIUrl":"10.1038/s44222-026-00473-z","url":null,"abstract":"Human cell-based 3D models hold promise for preclinical research as new approach methodologies, but realizing their translational potential will require moving beyond legacy culture systems and towards bioengineering-guided design to improve reproducibility, scalability and relevance.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 8","pages":"695-696"},"PeriodicalIF":42.7,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44222-026-00473-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye He, Joseph Rufo, Kaichun Yang, Ying Chen, Bruce Drinkwater, Hairong Zheng, Luke P. Lee, Tony Jun Huang
{"title":"Acoustofluidics for translational medicine","authors":"Ye He, Joseph Rufo, Kaichun Yang, Ying Chen, Bruce Drinkwater, Hairong Zheng, Luke P. Lee, Tony Jun Huang","doi":"10.1038/s44222-026-00479-7","DOIUrl":"10.1038/s44222-026-00479-7","url":null,"abstract":"Acoustofluidics uses engineered acoustic fields to manipulate cells, vesicles, biofluids and tissues in a contact-free and highly programmable manner across microscale to macroscale biological systems. Originally developed as a physics-driven platform for microscale manipulation, acoustofluidics is increasingly emerging as a clinically relevant technology for diagnostics, therapeutics and physiological monitoring. However, clinical translation remains limited by insufficient component standardization, limited system integration beyond the proof-of-concept stage and the lack of established regulatory pathways. This Review addresses this gap by offering a structured discussion of translational progress in acoustofluidics, organized around five key healthcare and medical workflows: biomarker isolation and manipulation, point-of-care diagnostics, in vivo therapeutic applications, wearable and implantable acoustic systems, and end-to-end translation pathways from laboratory prototypes to clinically deployable products. Acoustofluidics is emerging as a versatile platform for clinical diagnostics and therapy, enabling real-time, label-free sensing, manipulation and control of biological and chemical systems across scales. This Review discusses translational progress across key medical workflows, highlights challenges in standardization and integration, and outlines pathways from proof-of-concept devices to clinically deployable systems.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 10","pages":"1007-1023"},"PeriodicalIF":42.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacqueline C. Linnes, Margaret J. Mutumba Nakalembe
{"title":"Human-centred design","authors":"Jacqueline C. Linnes, Margaret J. Mutumba Nakalembe","doi":"10.1038/s44222-026-00475-x","DOIUrl":"10.1038/s44222-026-00475-x","url":null,"abstract":"Design failures often result not from technical flaws but from a lack of consideration into how, why and by whom a technology will be used. Human-centred design prioritizes collaboration with user communities to develop adoptable technologies, ultimately saving time and resources.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 9","pages":"811-812"},"PeriodicalIF":42.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kourosh Kalantar-Zadeh, Daniella Susic, David A. MacIntyre
{"title":"The unmet need for cervicovaginal biosensors","authors":"Kourosh Kalantar-Zadeh, Daniella Susic, David A. MacIntyre","doi":"10.1038/s44222-026-00482-y","DOIUrl":"10.1038/s44222-026-00482-y","url":null,"abstract":"Despite advances in precision medicine, continuous biomarker monitoring for women’s health is largely unavailable. The cervicovaginal tract is an ideal site for tracking biologically and clinically relevant biomarkers. Multiplexed sensor technologies could enable early diagnosis and improve gynaecological health, but substantial challenges remain.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 9","pages":"808-810"},"PeriodicalIF":42.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electroecology for biohybrid and robotic systems","authors":"Giulia Raffaele, Donato Romano, Fabian Meder","doi":"10.1038/s44222-026-00481-z","DOIUrl":"10.1038/s44222-026-00481-z","url":null,"abstract":"Exogenous electric fields enable sensory perception and information exchange between organisms and their surroundings, influencing vital processes from pollination to microbial metabolism. Integrating electroecological principles into bioengineering could support the development of new energy sources, robots and biohybrid systems that interact with organisms and ecosystems.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 9","pages":"815-817"},"PeriodicalIF":42.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioiontronics","authors":"Yujia Zhang \u0000 (, ), Hagan Bayley","doi":"10.1038/s44222-026-00471-1","DOIUrl":"10.1038/s44222-026-00471-1","url":null,"abstract":"Bioiontronics is an interdisciplinary field emerging from a confluence of breakthroughs in iontronics and bioengineering. Bioiontronics promotes communication with living matter through ions and biological molecules, thereby mediating the detection and modulation of biological activities. This process can function at abiotic–biotic interfaces in an autonomous fashion or in integral, modular components of biomedical devices. The clinical need to use specific biomolecular information, such as ion concentrations and biomarker levels, for personalized diagnostics and treatments has driven the rapid evolution of bioiontronics, through the convergence of fundamental science and application-oriented engineering. However, several challenges remain, including control of ion transport, device miniaturization, biocompatible encapsulation for long-term implantation and tools to decipher and then harness multimodal biological signals. In this Review, we discuss the underlying mechanisms and recent prototypes of bioiontronic devices and describe challenges in the fabrication and application of such systems. Bioiontronics enables communication with living systems through controlled ion and biomolecule transport at abiotic–biotic interfaces. This Review outlines the mechanisms and emerging device prototypes driving the field and discusses key challenges in ion control, miniaturization, biocompatible fabrication, as well as diagnostic and therapeutic applications.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 10","pages":"953-969"},"PeriodicalIF":42.7,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New approach methodologies to reduce reliance on animal toxicity testing","authors":"Natalie Burden","doi":"10.1038/s44222-026-00480-0","DOIUrl":"10.1038/s44222-026-00480-0","url":null,"abstract":"New approach methodologies are transforming safety science towards more human-relevant, mechanistic models. Bioengineers are central to this shift, but their impact depends on delivering systems that are relevant, robust, scalable and bridge the research-to-regulation gap.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 9","pages":"806-807"},"PeriodicalIF":42.7,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioengineering needs systems thinking","authors":"","doi":"10.1038/s44222-026-00469-9","DOIUrl":"10.1038/s44222-026-00469-9","url":null,"abstract":"Bioengineering succeeds or fails as a system, not as a collection of optimized parts. From closed-loop devices to cell therapies, organ chips and synthetic circuits, systems engineering can help convert independently optimized components into robust, validated and usable technologies that work across laboratories, clinics and everyday life.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 7","pages":"581-581"},"PeriodicalIF":42.7,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44222-026-00469-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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