Nature reviews bioengineering最新文献_第2页

Biophotonics technologies for skin disease diagnosis and monitoring 皮肤疾病诊断与监测的生物光子学技术

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-28 DOI: 10.1038/s44222-025-00350-1

Renzhe Bi, Malini Olivo, U. S. Dinish

引用次数: 0

Boosting precision and confidence in percutaneous nephrolithotomy 提高经皮肾镜取石术的准确性和信心

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-28 DOI: 10.1038/s44222-025-00351-0

Sadra Bakhshandeh

引用次数: 0

Dendrimer engineering to overcome delivery challenges of nucleic acids 树突分子工程克服了核酸传递的挑战

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-18 DOI: 10.1038/s44222-025-00347-w

Qianqian Ni, Jing Wu, Christina Galanakou, Cheng-Cai Zhang, Donald A. Tomalia, Ling Peng

引用次数: 0

Author Correction: Microbial bioelectronic sensors for environmental monitoring 作者更正：用于环境监测的微生物电子传感器

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-17 DOI: 10.1038/s44222-025-00348-9

Siliang Li, Xinyuan Zuo, Matthew D. Carpenter, Rafael Verduzco, Caroline M. Ajo-Franklin

引用次数: 0

Image-activated cell sorting 图像激活细胞分选

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-17 DOI: 10.1038/s44222-025-00334-1

Tianben Ding, Kelvin C. M. Lee, Kevin K. Tsia, T. Nicolai Siegel, Dino Di Carlo, Keisuke Goda

{"title":"Image-activated cell sorting","authors":"Tianben Ding, Kelvin C. M. Lee, Kevin K. Tsia, T. Nicolai Siegel, Dino Di Carlo, Keisuke Goda","doi":"10.1038/s44222-025-00334-1","DOIUrl":"10.1038/s44222-025-00334-1","url":null,"abstract":"The field of genomic research has undergone a remarkable transformation with the rapid expansion of high-quality genome databases, the discovery of epigenetic factors and the advent of CRISPR–Cas technology. However, a major challenge remains in linking these genetic and epigenetic perturbations to spatially resolved cellular phenotypes at scale. Image-activated cell sorting (IACS) offers a way to address this challenge by enabling real-time image-based sorting of suspended objects (for example, single live cells, cell clusters or cells adhered to carriers) at high rates of over 1,000 events per second. Unlike fluorescence-activated cell sorting (FACS), which relies on one-dimensional fluorescence intensity profiles of cells, IACS leverages multi-dimensional optical imaging to capture the full complexity of cellular characteristics, enabling high-content sorting based on both visual and functional attributes. A distinctive feature of IACS is its ability to integrate artificial intelligence for real-time image analysis, enabling sophisticated and precision decision-making in the sorting process. In this Review, we explore the principles, components and key performance indicators of IACS. We also highlight its unique applications across fields such as microbiology, immunology, cancer biology, food science and sustainability science, while addressing the challenges and future opportunities that lie ahead for IACS. Our goal is for this Review to serve as a comprehensive guide to IACS for beginners and experienced users alike, fostering its adoption and driving discoveries across biology and medicine. Genomic research has been transformed by genome databases, epigenetic discoveries and precise editing, yet linking genetic and epigenetic changes to cellular phenotypes remains challenging. In this Review, we explore the principles, components and applications of image-activated cell sorting (IACS) and discuss how it can address these limitations by enabling high-rate, real-time image-based sorting.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"890-907"},"PeriodicalIF":37.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable ultrasound technology 可穿戴超声技术

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-15 DOI: 10.1038/s44222-025-00329-y

Sai Zhou, Geonho Park, Muyang Lin, Xinyi Yang, Sheng Xu

{"title":"Wearable ultrasound technology","authors":"Sai Zhou, Geonho Park, Muyang Lin, Xinyi Yang, Sheng Xu","doi":"10.1038/s44222-025-00329-y","DOIUrl":"10.1038/s44222-025-00329-y","url":null,"abstract":"Wearable ultrasound technology refers to ultrasound devices designed with compact form factors that do not restrict the mobility or routine functions of the wearer. These devices are intended to provide continuous monitoring of internal tissue structures and offer therapeutic intervention without manual operation. Wearable ultrasound technology has potential applications in the management of chronic diseases, acute conditions during surgeries and emergencies, and post-operative care. This technology can provide clinicians and patients with data and insights, such as patterns of physiological variations over time and critical periods of disease progression, that are hardly attainable using conventional handheld ultrasound devices. In this Review, we discuss recent advances in wearable ultrasound technology, focusing on material selection, mechanical design, the integration of wearable systems, and exemplary medical applications. Additionally, we provide a framework for expanding the adoption of wearable ultrasound technology, particularly in low-resource settings, by exploring barriers in technology transfer. Finally, we identify critical challenges from scientific, engineering and clinical perspectives to advance wearable ultrasound technology to the next stages of development. This Review discusses wearable ultrasound technology, covering device design, integration, clinical applications and translational potential. It highlights key barriers to wide deployment and explores future development directions from scientific, engineering and clinical perspectives.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"835-854"},"PeriodicalIF":37.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking immunity in bioengineering 重新思考生物工程中的免疫

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-14 DOI: 10.1038/s44222-025-00336-z

引用次数: 0

Using ‘supporting molecules’ (SUMs) to improve mRNA LNP therapies 使用“支持分子”（sum）改善mRNA LNP治疗

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-10 DOI: 10.1038/s44222-025-00339-w

Rachel VanKeulen-Miller, Vincent Fung, Owen S. Fenton

引用次数: 0

The CL1 as a platform technology to leverage biological neural system functions CL1作为利用生物神经系统功能的平台技术

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-07 DOI: 10.1038/s44222-025-00340-3

Brett J. Kagan

引用次数: 0

Mobile medical systems for equitable healthcare 移动医疗系统促进公平医疗

IF 37.6

Nature reviews bioengineering Pub Date : 2025-07-03 DOI: 10.1038/s44222-025-00330-5

Justin Chan, Mayank Goel, Shyamnath Gollakota, Rajalakshmi Nandakumar

{"title":"Mobile medical systems for equitable healthcare","authors":"Justin Chan, Mayank Goel, Shyamnath Gollakota, Rajalakshmi Nandakumar","doi":"10.1038/s44222-025-00330-5","DOIUrl":"10.1038/s44222-025-00330-5","url":null,"abstract":"Major barriers to accessible healthcare include the high cost of medical devices and limited healthcare facilities. Mobile computing technologies, such as smartphones and smart watches, include high-quality hardware, such as microphones, speakers and cameras, which can be leveraged for the design of low-cost mobile medical systems intended to be remotely applied to monitor health and disease. In this Review, we discuss low-cost and accessible hardware — in particular, mobile phones — that can be used in mobile medical systems to aid in medical diagnostics and monitoring. Specifically, we outline acoustic-based systems, vision-based systems and sensor fusion systems that allow different levels of health and disease assessment, relying on the speakers, microphones and sensors of smart mobile devices. We highlight the challenges related to the deployment of mobile medical systems in the clinical continuum, including scaling, generalizability, bias, trust and privacy. Finally, we examine clinical integration and regulatory considerations with regard to mobile medical devices as well as future applications. The features of smart devices such as smartphones and smart watches, including speakers, microphones and other sensors, can be leveraged for the design of mobile medical systems. This Review discusses acoustic-based, vision-based and sensor fusion systems that rely on smart device hardware and software for remote health and disease assessment.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 10","pages":"855-874"},"PeriodicalIF":37.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0