{"title":"Dynamic printing at the air–liquid interface","authors":"Sadra Bakhshandeh","doi":"10.1038/s44222-024-00271-5","DOIUrl":"10.1038/s44222-024-00271-5","url":null,"abstract":"The authors introduce a new printing technology called dynamic interface printing (DIP), which leverages an acoustically modulated air–liquid interface to rapidly create supportless structures without requiring specialized chemistry or complex optical systems.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 2","pages":"106-106"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00271-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can AI make scientific data more equitable?","authors":"","doi":"10.1038/s44222-024-00263-5","DOIUrl":"10.1038/s44222-024-00263-5","url":null,"abstract":"Biased and unrepresentative scientific data can lead to misleading conclusions and potentially harm patients. Artificial intelligence (AI) might be able to help make data more representative, but only if a standardized approach to assessing the quality of AI-generated data is established.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 12","pages":"981-981"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00263-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhanar Abil, Simone Giaveri, Tobias J. Erb, Lynn J. Rothschild
{"title":"Integrating metabolism and evolution towards the realization of synthetic life","authors":"Zhanar Abil, Simone Giaveri, Tobias J. Erb, Lynn J. Rothschild","doi":"10.1038/s44222-024-00267-1","DOIUrl":"10.1038/s44222-024-00267-1","url":null,"abstract":"Recognition of life as a dynamic, non-equilibrium and evolvable process suggests that the realization of synthetic life could be achieved by the in vitro integration of metabolic and evolutionary processes.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 1","pages":"9-10"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developing sex-accurate cell culture environments","authors":"Alexandra N. Borelli, Kristyn S. Masters","doi":"10.1038/s44222-024-00265-3","DOIUrl":"10.1038/s44222-024-00265-3","url":null,"abstract":"The extracellular matrix remains under-recognized as a sex-dependent entity. Designing culture environments that account for sex as a biological variable requires considering not only cellular sex, but also the usage of sex-specific scaffolds to create a holistically sex-accurate platform.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 1","pages":"2-3"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biohybrid neuromuscular robots","authors":"Caroline Beyer","doi":"10.1038/s44222-024-00266-2","DOIUrl":"10.1038/s44222-024-00266-2","url":null,"abstract":"An article in Science Robotics presents a wireless bioelectronic robot that integrates living motor neurons and cardiomyocytes to power movement.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 12","pages":"990-990"},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mauro Manno, Antonella Bongiovanni, Leonid Margolis, Paolo Bergese, Paolo Arosio
{"title":"The physico-chemical landscape of extracellular vesicles","authors":"Mauro Manno, Antonella Bongiovanni, Leonid Margolis, Paolo Bergese, Paolo Arosio","doi":"10.1038/s44222-024-00255-5","DOIUrl":"10.1038/s44222-024-00255-5","url":null,"abstract":"Extracellular vesicles are defined as nanosized to microsized particles, delimited by a lipid bilayer membrane, that seem to be released by all cell types and that can transport bioactive molecules between cells, tissues, organs and organisms. Therefore, extracellular vesicles are being explored as biomaterials, drug delivery nanocarriers, therapeutics and multiplexed biomarkers. However, the isolation, characterization and large-scale manufacturing of extracellular vesicles remains challenging. In this Review, we delineate the landscape of the physico-chemical properties of extracellular vesicles, originating from their composition and conformational ensemble, and outline how this landscape is defined by the heterogeneity of their size, composition, membrane structure, surface interactions, cargo and co-isolates. We explore the implications of this heterogeneity on the definition of the purity, identity and function of extracellular vesicles. The comparison of this landscape with the landscape of antibody therapeutics and viral vectors can identify lessons to be learned from the bioprocessing of these products, and the distinct challenges associated with the manufacturing and isolation of extracellular vesicles from biofluids, which will require new concepts and technologies. We highlight the importance of a thorough understanding of the physico-chemical properties of extracellular vesicles for their clinical translation. This includes the development of bioprocessing approaches, assignment of product quality attributes, consistency of extracellular vesicle products and manufacturing at scale. Extracellular vesicles are being explored for various biomedical applications, but face challenges with regard to isolation, characterization and manufacturing. This Review delineates the physico-chemical landscape of extracellular vesicles to identify the distinct challenges associated with the manufacturing and isolation of extracellular vesicles from biofluids and suggests opportunities to address them.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 1","pages":"68-82"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to write an excellent Review article","authors":"","doi":"10.1038/s44222-024-00256-4","DOIUrl":"10.1038/s44222-024-00256-4","url":null,"abstract":"Review articles are our bread and butter. Here, we would like to offer some insights on how to craft a comprehensive and authoritative assessment of a field.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"2 11","pages":"907-907"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44222-024-00256-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging-guided precision hyperthermia with magnetic nanoparticles","authors":"Ali Shakeri-Zadeh, Jeff W. M. Bulte","doi":"10.1038/s44222-024-00257-3","DOIUrl":"10.1038/s44222-024-00257-3","url":null,"abstract":"Magnetic nanoparticles, including those formed of superparamagnetic iron oxides (SPIOs), are employed in various magnetic imaging and therapeutic techniques. In vivo imaging techniques based on the detection of magnetic nanoparticles inside the body include magnetic resonance imaging (MRI), magnetic particle imaging (MPI), magneto-motive ultrasonography (MMUS) and magneto-photoacoustic imaging (MPAI). Preclinical data indicate that the conditions required to heat up magnetic nanoparticles, including energy considerations, particle modifications, localization and exposure time, can be dynamically modulated during a single treatment procedure by monitoring imaging data acquired from the same magnetic nanoparticles. This Review explores the potential use of magnetic-nanoparticle-mediated imaging techniques combined with magnetic fluid hyperthermia (MFH) to selectively and precisely heat tumour locations while avoiding damage to surrounding healthy tissue. Imaging-guided MFH could provide individualized treatment plans based on information about the biodistribution of magnetic nanoparticles within the tumour and adjacent organs, as well as the volumetric distribution of the thermal dose. Requirements for the clinical translation of MFH-enabled magnetic imaging techniques are also discussed — the development of magnetic nanoparticle formulations with a favourable biosafety profile, optimal magnetic heating properties and maximal magnetic imaging signals; and the integration of magnetic imaging and heating hardware into a single platform. This Review details the use of multifunctional magnetic nanoparticles in advanced magnetic imaging modalities and therapeutic hyperthermia. The potential of magnetic nanoparticles for imaging-guided precision heating of tumours and the need for integrated magnetic imaging and heating platforms are highlighted.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 3","pages":"245-260"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cryopreservation of in vitro human tissue models","authors":"Yaqi Sheng, Yan Yan Shery Huang","doi":"10.1038/s44222-024-00261-7","DOIUrl":"10.1038/s44222-024-00261-7","url":null,"abstract":"The widespread use and translation of engineered in vitro tissues, such as organoids, organ-on-chip devices and microphysiological models, will require designs that can be preserved by cryopreservation. Here, we outline the factors that affect their cryopreservation, highlighting the challenges that remain to be addressed.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 1","pages":"4-6"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xin Guan (, ), Guohui Ji (, ), Guocheng Du (, ), Jian Chen (, ), Jingwen Zhou (, )
{"title":"Microbial cell factories for cost-effective and high-quality cultured meat","authors":"Xin Guan \u0000 (, ), Guohui Ji \u0000 (, ), Guocheng Du \u0000 (, ), Jian Chen \u0000 (, ), Jingwen Zhou \u0000 (, )","doi":"10.1038/s44222-024-00258-2","DOIUrl":"10.1038/s44222-024-00258-2","url":null,"abstract":"Commercializing cultured meat requires cost reduction and quality improvement. Microbial cell factories can produce cost-effective and high-quality raw materials for cultured meat production.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 1","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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