Using ‘supporting molecules’ (SUMs) to improve mRNA LNP therapies

IF 37.6
Rachel VanKeulen-Miller, Vincent Fung, Owen S. Fenton
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Abstract

Lipid nanoparticles deliver mRNA without considering the amount and type of ‘supporting molecules’ (SUMs) available in the cell to process them. Here we discuss how co-delivering SUMs with mRNA payloads can provide a simple yet effective strategy for amplifying their performance toward the creation of safer and more-effective therapeutics.

Abstract Image

使用“支持分子”(sum)改善mRNA LNP治疗
脂质纳米颗粒传递mRNA而不考虑细胞中可用的“支持分子”(sum)的数量和类型来处理它们。在这里,我们讨论了与mRNA有效载荷共同递送sum如何提供一种简单而有效的策略,以扩大其性能,从而创造更安全、更有效的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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