Advances in Nutrition最新文献

{"title":"Impact of Iodine Deficiency Trends on the Pathophysiology of Selected Populations","authors":"Nicola De Maio , Fiore Carpenito , Alberto Carpenito , Francesco Turco , Giancarlo Landi , Margot De Marco","doi":"10.1016/j.advnut.2025.100411","DOIUrl":"10.1016/j.advnut.2025.100411","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 5","pages":"Article 100411"},"PeriodicalIF":8.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hook, Line, and Thinker: Seafood Nets Benefits for Neurocognitive Development","authors":"J Thomas Brenna","doi":"10.1016/j.advnut.2025.100415","DOIUrl":"10.1016/j.advnut.2025.100415","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 5","pages":"Article 100415"},"PeriodicalIF":8.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet Item Details: Reporting Checklist for Feeding Studies Measuring the Dietary Metabolome (DID-METAB Checklist)—Explanation and Elaboration Report on the Development of the Checklist by the DID-METAB Delphi Working Group","authors":"Jessica JA Ferguson ,&nbsp;Erin D Clarke ,&nbsp;Jordan Stanford ,&nbsp;María Gómez-Martín ,&nbsp;Tammie Jakstas ,&nbsp;Clare E Collins","doi":"10.1016/j.advnut.2025.100420","DOIUrl":"10.1016/j.advnut.2025.100420","url":null,"abstract":"<div><div>Metabolomics is a postgenomic, systems-based discipline offering valuable applications in nutrition research, including the use of objective biomarkers to characterize dietary intake and metabolic responses more accurately. A scoping review identified the need for reporting guidance on dietary information in the form of a checklist to ensure reproducibility of human feeding studies that are measuring the diet-related metabolome. In this study, we aimed to gain consensus on a core outcome set pertaining to diet-related item details (DIDs) and recommendations for reporting DIDs to inform development of a reporting checklist. The goal of this checklist is to guide researchers on the minimum level of content and detail required for reporting dietary information in human feeding studies measuring the metabolome. A 2-stage online Delphi process encompassing 5 survey rounds with international experts in clinical trial design, feeding study intervention implementation, metabolomics, and/or human biospecimen analyses was conducted. A core outcome set encompassing 29 DIDs and accompanying recommendations was developed across 5 domains: dietary intervention—modeling (8 DIDs), dietary intervention—implementation (3 DIDs), dietary assessment (9 DIDs), adherence and compliance monitoring (4 DIDs), and bias (5 DIDs). The reporting guideline (DID-METAB Checklist) was generated and accepted by the international expert working group in the final survey round. All experts agreed that relevant journals should include the checklist as a suggested reporting tool for relevant studies and/or used alongside existing reporting tools. This report provides examples, explanations and elaboration for each recommendation including examples from published literature and references. The DID-METAB Checklist will be a key tool to advance the standardized reporting for feeding studies assessing the metabolome. Implementation of this tool will enable the ability to better interpret data and ensure global utility of results for furthering the advancement of metabolomics in nutrition research and future precision and personalized nutrition strategies.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 5","pages":"Article 100420"},"PeriodicalIF":8.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seafood During Pregnancy and Lactation and Child Neurocognitive Development: A Systematic Review","authors":"Lauren E O’Connor,&nbsp;Maureen K Spill,&nbsp;Sanjoy Saha,&nbsp;Arin A Balalian,&nbsp;Julie S Davis,&nbsp;Amanda J MacFarlane","doi":"10.1016/j.advnut.2025.100414","DOIUrl":"10.1016/j.advnut.2025.100414","url":null,"abstract":"<div><h3>Background</h3><div>Assessing seafood as a food group, rather than as a source of omega-3 fatty acids or contaminants, may better inform dietary guidance for pregnancy and lactation.</div></div><div><h3>Objectives</h3><div>This study aims to assess relationships between seafood consumption during pregnancy and lactation and neurocognitive development in the child.</div></div><div><h3>Methods</h3><div>Three electronic databases were searched up to September 2024 to update a previous search from 2000 to 2019. Articles were included if seafood intake during pregnancy or lactation and a child outcome was assessed [neurocognitive development including cognitive, social–emotional, behavioral, movement/physical, language/communication, and aggregate scores as well as depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD)]. Articles were screened at title, abstract, and full-text levels independently by 2 analysts. Data were extracted, quality checked, and synthesized narratively considering the direction, magnitude, and statistical significance of results. The risk of bias was assessed using study design-specific tools. Certainty of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluations.</div></div><div><h3>Results</h3><div>Forty articles [1 randomized controlled trial (RCT), 24 prospective cohorts, and 1 retrospective cohort] during pregnancy were identified; none for lactation. Evidence suggested relationships between higher seafood consumption and better social–emotional and behavioral development in children and adolescents aged 0–18 y as well as better aggregate scores of development for those &lt;4 y. The certainty of the evidence was very low to moderate due to the lack of RCTs. Evidence for overall cognitive development was inconsistent but higher seafood may be related to better attention, reasoning and problem-solving, and verbal intelligence. However, evidence was limited in the number of studies and ages assessed. Evidence was inconsistent for movement/physical and language/communication development, and a paucity of studies was found for ADHD and ASD.</div></div><div><h3>Conclusions</h3><div>Seafood consumption within currently recommended amounts during pregnancy may be associated with better social–emotional, behavioral, and aggregate scores of development in the child, as well as potentially some aspects of cognitive development.</div><div>This study was registered at PROSPERO as CRD42023432844.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 5","pages":"Article 100414"},"PeriodicalIF":8.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and Associative Significance of Malnutrition in Sarcopenia: A Systematic Review and Meta-Analysis","authors":"Konstantinos Prokopidis ,&nbsp;Giuseppe Dario Testa ,&nbsp;Christoforos D Giannaki ,&nbsp;Pinelopi Stavrinou ,&nbsp;Eirini Kelaiditi ,&nbsp;Emiel O Hoogendijk ,&nbsp;Nicola Veronese","doi":"10.1016/j.advnut.2025.100428","DOIUrl":"10.1016/j.advnut.2025.100428","url":null,"abstract":"<div><div>Malnutrition is a common phenomenon, particularly in those at an increased risk of muscle mass and function losses. In this systematic review and meta-analysis, we aimed to explore the association of malnutrition with sarcopenia in middle-aged and older adults and the prognostic association of malnutrition and sarcopenia compared with sarcopenia alone on all-cause mortality. PubMed, Scopus, Web of Science, and Cochrane Library were searched from inception until January 2024. A meta-analysis using a random-effect model was employed, utilizing the Mini Nutritional Assessment malnutrition tool as a continuous and categorical variable. The study protocol was registered in the International Prospective Register of Systematic Reviews (CRD42024501521). Malnutrition was significantly associated with a greater risk of sarcopenia [continuous: <em>k</em> = 12, odds ratio (OR): 1.38, 95% confidence interval (CI): 1.18, 1.61, <em>I</em>² = 94.8%, <em>P</em> &lt; 0.01; categorical: <em>k</em> = 37, OR: 2.99, 95% CI: 2.26, 3.96, <em>I</em>² = 78.3%, <em>P</em> &lt; 0.01]. Sarcopenia and malnutrition were associated with a higher risk of mortality compared with sarcopenia alone (<em>k</em> = 5, hazard ratio: 4.04, 95% CI: 1.36, 11.94, <em>I</em>² = 92.8%, <em>P</em> &lt; 0.01). Metaregression showed age, sex, and number of adjustments did not explain heterogeneity among studies. The included studies had a moderate risk of bias. Malnutrition is associated with higher odds of sarcopenia and their combined presence is a better predictor of all-cause mortality compared with sarcopenia alone, further highlighting the importance of applying interventions to counteract these two closely related phenomena.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 5","pages":"Article 100428"},"PeriodicalIF":8.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homocysteine and Multiple Health Outcomes: An Outcome-Wide Umbrella Review of Meta-analyses and Mendelian Randomization Studies","authors":"Futao Zhou ,&nbsp;Yue He ,&nbsp;Xinhua Xie ,&nbsp;Ning Guo ,&nbsp;Wanjiao Chen ,&nbsp;Yushi Zhao","doi":"10.1016/j.advnut.2025.100434","DOIUrl":"10.1016/j.advnut.2025.100434","url":null,"abstract":"<div><div>Elevated levels of homocysteine (Hcy) are associated with various health outcomes. We aimed to systematically assess the credibility and certainty of evidence of associations of Hcy and Hcy-lowering therapies with various health outcomes. We retrieved observational meta-analyses examining the associations between Hcy and health outcomes, interventional meta-analyses investigating health outcomes related to Hcy-lowering treatments, and Mendelian randomization (MR) studies exploring the causal associations of Hcy with health outcomes to perform an umbrella review. A total of 135 observational meta-analyses, 106 MR studies, and 26 interventional meta-analyses were included. Among observational studies, 10 associations of diseases/outcomes were classified as highly suggestive; only 1 outcome (digestive tract cancer) was supported by convincing evidence (class I; odd ratio = 1.27, 95% confidence interval = 1.16, 1.40; <em>P</em> = 6.79 × 10^-7; <em>I</em>² = 0, 95% prediction interval excluding null, &gt;1000 cases; <em>P</em> &gt; 0.1 for tests of both small-study effects and excess significance bias). In MR studies, 5 outcomes associated with Hcy presented robust evidence (<em>P</em> &lt; 0.01, power &gt;80%). Among 25 outcomes explored by both observational meta-analyses and MR studies, 7 had consistent results, indicating that elevated Hcy is causally associated with an increased risk of these outcomes. The 3 types of studies collectively suggested that the association of stroke with Hcy was supported by observational studies, causally by MR studies, and further validated by intervention meta-analyses showing that Hcy-lowering with folic acid significantly reduced risk of stroke. For dementia and colorectal cancer, Hcy was significantly associated in meta-analyses of observational studies and folic acid decreased disease risks in interventional meta-analyses. The current umbrella review indicates that convincing evidence for a definitive role of Hcy exposure solely exists in the context of digestive tract cancer excluding bias; however, Hcy may not be causal for this disease. All the 3 types of studies collectively support that Hcy is a key causal risk factor, and Hcy-lowering (specifically with folic acid) may serve as an effective intervention for stroke.</div><div>This trial was registered at PROSPERO as CRD42024541335.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 6","pages":"Article 100434"},"PeriodicalIF":8.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the Secrets of Human Milk: Isolation and Characterization of Extracellular Vesicles","authors":"Klaudia Tiszbein,&nbsp;Izabela Koss-Mikołajczyk,&nbsp;Dorota Martysiak-Żurowska","doi":"10.1016/j.advnut.2025.100430","DOIUrl":"10.1016/j.advnut.2025.100430","url":null,"abstract":"<div><div>Extracellular vesicles from human milk (HMEVs) are crucial for neonatal development, immune modulation, and protection against pathogens. However, the lack of standardized isolation and characterization protocols poses significant challenges. This review aims to evaluate and compare various methods for the isolation and characterization of HMEVs, highlighting their effectiveness and potential applications. Preliminary purification steps, including the removal of cells, fat globules, and casein micelles, enhance the purity of isolated HMEVs. We categorized isolation methods into density-based, size-based, and affinity-based techniques. Density-based methods include differential and density gradient ultracentrifugation. Size-based methods encompass polymer precipitation, membrane filtration, electrophoretic filtration, size exclusion chromatography, and microfluidics. Affinity-based methods involve immunoisolation using antibodies specific to HMEV surface proteins. Characterization techniques discussed include flow cytometry, dynamic light scattering, nanoparticle tracking analysis, tunable resistive pulse sensing, electron microscopy, atomic force microscopy, confocal microscopy, western blotting, ELISA, and lateral flow immunoassay systems. Differential ultracentrifugation, considered the “gold standard,” provides high purity but is time-consuming. Density gradient ultracentrifugation offers precise separation. Size-based methods like polyethylene glycol precipitation and membrane filtration are simple and fast. Electrophoretic filtration and microfluidics provide precise control of sample flow. Affinity-based methods are highly specific but costly. Advanced characterization techniques provide comprehensive insights into HMEV properties and functions. Standardizing isolation protocols and employing advanced characterization techniques are essential for advancing HMEV research. Future studies should focus on understanding the molecular mechanisms of HMEVs, exploring the impact of maternal health, and developing targeted delivery technologies. These efforts will enhance the therapeutic potential of HMEVs in neonatal care and contribute to personalized nutritional interventions.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 6","pages":"Article 100430"},"PeriodicalIF":8.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein and Free Amino Acid Composition of Preterm Human Milk: A Systematic Review and Meta-analysis","authors":"Derek C Miketinas ,&nbsp;Mindy A Patterson ,&nbsp;Tonya M Bender ,&nbsp;Jennifer N Kinnaman ,&nbsp;Dixie L Carter ,&nbsp;Nathan A Meredith ,&nbsp;Katie E Niemeier ,&nbsp;Ariana DL Bailey","doi":"10.1016/j.advnut.2025.100432","DOIUrl":"10.1016/j.advnut.2025.100432","url":null,"abstract":"<div><div>The composition of total protein and free amino acids (FAA) in preterm human milk (HM) is crucial for optimizing infant growth and development. The objective of this systematic review and meta-analysis is to quantify the amount of true, crude, and unspecified protein and FAA in preterm HM. EBSCO, PubMed, and Scopus databases were searched up to July 2023 measuring total protein and FAA in preterm HM. Two reviewers, working independently, screened all titles and abstracts using Covidence software to identify studies meeting inclusion criteria [preterm &lt;37 wk; Human Development Index &gt;0.8; cross-sectional, case-controlled (<em>n &gt;</em> 1), prospective cohort, and randomized clinical trials; English language]. Random-effects models were used to estimate mean protein and FAA content across studies. Data were aggregated for studies reporting multiple estimates (e.g. across time). Heterogeneity was estimated using <em>I</em>² and publication bias using Kendall tau rank correlation coefficient. Of the 884 articles identified, a total of 66 original studies were included for the meta-analysis comprising an estimated 30,421 preterm HM samples. Preterm colostrum (&lt;4 d) contained the highest mean (95% confidence interval) true protein at 2. 32 (1. 96, 2. 68) g/100 mL, followed by transition preterm HM (5–14 d) mean true protein of 1. 77 (1. 60, 1.93) g/100 mL. Mature (&gt;14 d) preterm HM had the lowest mean true protein content at 1.46 (1.34, 1.59) g/100 mL. Glutamate was the most prevalent FAA reported. This systematic review provides updated estimates of protein and FAA concentrations in preterm HM. There was significant variability in the quality of studies, completeness of the reported results, and analytical methodologies across studies.</div><div>This trial was registered at PROSPERO as CRD42023445191.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 6","pages":"Article 100432"},"PeriodicalIF":8.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Milk Oligosaccharides Modulating Inflammation in Infants, Adults, and Older Individuals—From Concepts to Applications","authors":"Robert Häsler ,&nbsp;Marta Hanna Mikš ,&nbsp;Danica Bajic ,&nbsp;Buket Soyyilmaz ,&nbsp;Igor Bendik ,&nbsp;Vincent J van Buul ,&nbsp;Robert E Steinert ,&nbsp;Ateequr Rehman","doi":"10.1016/j.advnut.2025.100433","DOIUrl":"10.1016/j.advnut.2025.100433","url":null,"abstract":"<div><div>The increasing global prevalence of inflammatory diseases, such as ulcerative colitis and irritable bowel syndrome, represents a challenging task for healthcare systems. Several approaches to disease management target the intestinal microbiome, which plays a key role in health and disease. One promising approach is modulating the microbiome using human milk oligosaccharides (HMOs). Originating from human milk, HMOs are indigestible carbohydrates that act in a host-optimized prebiotic fashion by providing an energy source for health-promoting intestinal bacteria and exhibiting systemic effects. Commercial products supporting infant health and development have been the primary fields of HMO application. Advancements in the large-scale production of HMOs through bioengineering and precision fermentation have led to evaluation of their potential for managing inflammatory diseases. Several in vitro studies and observations on model systems have been clinically validated in infants, resulting in a large body of evidence supporting the safety and efficacy of HMOs in inflammatory disorders. Although novel approaches seek to explore interventions in adults, the primary goal for the future is to provide cost-efficient, safe, and reliable healthcare compounds across all age groups.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 6","pages":"Article 100433"},"PeriodicalIF":8.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Food-As-Medicine Interventions and Their Impact on Future Food Production, Processing, and Supply Chains","authors":"Thijs Defraeye ,&nbsp;Flora Bahrami ,&nbsp;Tobias Kowatsch ,&nbsp;Simon Annaheim ,&nbsp;Marjolijn CE Bragt ,&nbsp;René M Rossi ,&nbsp;Michael Greger","doi":"10.1016/j.advnut.2025.100421","DOIUrl":"10.1016/j.advnut.2025.100421","url":null,"abstract":"<div><div>Food-as-medicine (FAM) is an emerging trend among medical doctors, health insurers, startups, and governmental public-health and nongovernmental organizations. FAM implies using food as a part of an individual’s health plan to prevent or help treat acute and chronic health conditions and diseases. We highlight trends and hurdles in the FAM intervention pyramid. Our viewpoint is to indicate how interventions might change the future demand for specific food groups, their transport in supply chains, and the technologies used to process them. On the basis of national guidelines, dietary interventions can help to prevent and treat many diseases, including cardiovascular disease, cancers, type 2 diabetes, and obesity. FAM R&amp;D and services offer more individualized treatments. This is challenging given the interindividual variability and complexity of the body’s response to food and related factors, such as dietary habits, genetics, lifestyle, and biosphere. Quantifying health improvements is essential to prove the added value of more individualized FAM interventions compared with adopting a general healthy diet. It is unclear which level of individualization of interventions produces the largest health benefits at the lowest costs for the patient, healthcare system, and climate. FAM interventions can support and complement conventional medical treatment. They will require a shift to producing more health-promoting foods, including whole foods, minimally processed foods, and selected processed foods. The food processing industry and supply chains must adapt to these new scenarios. Auxiliary technologies and methods are enablers, including delivery services, wearable technology, health-monitoring apps, and data-driven consumer behavior analysis.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 6","pages":"Article 100421"},"PeriodicalIF":8.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}