母亲从海鲜消费中接触铅与神经发育之间的关系：一项系统综述。

IF 8 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition Pub Date : 2025-01-21 DOI:10.1016/j.advnut.2025.100380

Arin A Balalian , Maureen K Spill , Rachel C Thoerig , Rupal Trivedi , Sanjoy Saha , Margaret J Foster , Amanda J MacFarlane

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引用次数: 0

摘要

背景：除了必需的营养物质，孕妇在怀孕或哺乳期食用海鲜也是潜在的毒素来源，包括铅（Pb）。在PL期间暴露于海鲜中的铅与儿童神经发育之间的关系尚不确定。目的：本系统综述评估了PL期间海鲜中铅暴露与儿童神经发育的关系。方法：检索Embase、PubMed、CENTRAL和PsycINFO的英文同行评议文章。两名独立审稿人在标题、摘要和全文层面进行筛选。比较不同海产品和铅暴露水平的实验和观察性研究符合以下条件：1)暴露人群是来自人类发展指数高或非常高的国家的健康孕妇或哺乳期个体；2)评估≤18岁儿童的神经发育情况；3)测定母亲海鲜摄取量和Pb暴露量，分析二者之间的关系和/或与儿童神经发育的关系。使用Cochrane ROBINS-E和GRADE工具评估偏倚风险和证据确定性。结果：四篇纳入的文章来自亚洲的三项前瞻性队列研究，研究了12-60个月儿童的认知、运动发育和行为。只有一项研究报告了在PL期间海鲜摄入量和铅浓度之间的分析，显示出微弱的、不显著的关联。据报道，铅浓度与儿童认知发展或行为问题无关，但与儿童运动发展有微弱的负相关。证据的确定性非常低，因为很少纳入有一定或高偏倚风险的研究。一项前瞻性队列研究表明，较高的海鲜摄入量有利于积极的发育结果，尽管意义各不相同。结论：总的来说，没有证据表明PL期间海鲜摄入的铅暴露与儿童神经发育之间存在直接联系。其他几个限制导致总体证据的确定性非常低。系统评价或荟萃分析的注册和注册号：该系统评价方案在PROSPERO注册（CRD42023494884）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Association between Maternal Lead Exposure from Seafood Consumption and Neurodevelopment: A Systematic Review

Despite the essential nutrients, maternal seafood consumption during pregnancy or lactation (PL) is also a potential source of toxins, including lead (Pb). The association between exposure to Pb from seafood during PL on children’s neurodevelopment is uncertain. This systematic review assessed the association of exposure to Pb from seafood during PL on children’s neurodevelopment. Embase, PubMed, CENTRAL, and PsycINFO were searched for English-language peer-reviewed articles. Two independent reviewers screened at title, abstract, and full-text levels. Experimental and observational studies comparing different levels of exposure to seafood and Pb were eligible if: 1) the exposed population included healthy pregnant or lactating individuals from high or very high human development index countries; 2) assessed neurodevelopment in children ≤18 y old; and 3) measured maternal seafood intake, Pb exposure and analyzed their relationship with each other and/or their association with child neurodevelopment. The Cochrane risk of bias in nonrandomized studies - of exposure (ROBINS-E) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tools were used to assess the risk of bias and certainty of evidence. Four included articles from 3 prospective cohort studies in Asia examined cognition, motor development, and behavior in children 12–60 mo. Only 1 study reported an analysis between seafood intake and Pb concentrations during PL, which showed a weak, nonsignificant association. Pb concentrations were not associated with child cognitive development or behavioral problems, but a weak, negative association with child motor development was reported. The certainty of the evidence was very low due to the few included studies with some or a high risk of bias. Higher seafood intake in this evidence favored positive developmental outcomes from 1 prospective cohort study, though significance varied. Overall, evidence was not available to address a direct association between Pb exposure from seafood intake during PL and child neurodevelopment. Several other limitations resulted in a very low certainty of overall evidence.

This systematic review was registered at PROSPERO as CRD42023494884.

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来源期刊

Advances in Nutrition 医学-营养学

CiteScore

17.40

自引率

2.20%

发文量

117

审稿时长

56 days

期刊介绍： Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.