Seafood Toxicant Exposure During Pregnancy, Lactation, and Childhood and Child Outcomes: A Scoping Review

Abstract

Determining dietary recommendations for seafood consumed during pregnancy, lactation, and childhood requires consideration of the known nutritional benefits and potential harm due to toxicant exposure as they relate to child outcomes. This study aimed to describe the scope of the evidence associated with seafood-related toxicant exposure and child outcomes and to identify toxicant–outcome pairs that may have sufficient evidence to conduct a systematic review. We included studies examining seafood toxicant exposure during pregnancy, lactation, and childhood, and child outcomes. In total, 81 studies were included: 69 studies on exposure during pregnancy and lactation and 14 on exposure during childhood. The number of studies varied by toxicant and exposure population (maternal; child): mercury (n = 49; 7), methylmercury (n = 13; 3), polychlorinated biphenyls (PCBs; n = 11; 1), selenium (n = 11; 1), lead (n = 9; 3), perfluoroalkyl and polyfluoroalkyl substances (n = 8; 2), dichlorodiphenyltrichloroethane (n = 5; 1), arsenic (n = 4; 4), cadmium (n = 4; 4), zinc (n = 3; 2), polybrominated diphenyl ethers (n = 3; 1), dioxin-like compounds (n = 3; 0), iron (n = 2; 1), and magnesium (n = 1; 1). No studies examined polybrominated biphenyls, polycyclic aromatic hydrocarbons, iodine, aldrin, dieldrin, chlordane, chlorpyrifos, or microplastic exposures. Outcomes also varied by exposure population (maternal;child): neurodevelopment (n = 35; 9), child exposure biomarkers (n = 22; 4), growth (n = 17; 1), other adverse events (n = 4; 0), cardiometabolic (n = 3; 2), chronic disease indicators (n = 2; 0), and immune-related (n = 1; 2). Twelve maternal toxicant–outcome pairs had ≥3 studies, including mercury, methylmercury, lead, PCBs, perfluoroalkyl and polyfluoroalkyl substances, and arsenic as exposures and neurodevelopment, child exposure biomarkers, growth, and cardiometabolic as outcomes. For child exposure, only mercury and neurodevelopment had ≥3 studies. In conclusion, this scoping review shows relevant evidence for 14 of the 22 toxicants. Only 12 maternal and 1 child toxicant–outcome pairs, the majority of which examined maternal (methyl)mercury exposure, had ≥3 studies, our cutoff for consideration for systematic review. This scoping review indicates a paucity of research examining seafood toxicants beyond mercury and exposure during childhood. Systematic reviews are required to evaluate the associations for each toxicant–outcome pairs.

The protocol was registered at Open Science Framework (https://doi.org/10.17605/OSF.IO/FQZTA).