Advances in Nutrition最新文献

{"title":"Seafood Toxicant Exposure During Pregnancy, Lactation, and Childhood and Child Outcomes: A Scoping Review","authors":"Rupal Trivedi ,&nbsp;Maureen K Spill ,&nbsp;Sanjoy Saha ,&nbsp;Rachel C Thoerig ,&nbsp;Julie S Davis ,&nbsp;Amanda J MacFarlane","doi":"10.1016/j.advnut.2024.100353","DOIUrl":"10.1016/j.advnut.2024.100353","url":null,"abstract":"<div><div>Determining dietary recommendations for seafood consumed during pregnancy, lactation, and childhood requires consideration of the known nutritional benefits and potential harm due to toxicant exposure as they relate to child outcomes. This study aimed to describe the scope of the evidence associated with seafood-related toxicant exposure and child outcomes and to identify toxicant–outcome pairs that may have sufficient evidence to conduct a systematic review. We included studies examining seafood toxicant exposure during pregnancy, lactation, and childhood, and child outcomes. In total, 81 studies were included: 69 studies on exposure during pregnancy and lactation and 14 on exposure during childhood. The number of studies varied by toxicant and exposure population (maternal; child): mercury (<em>n</em> = 49; 7), methylmercury (<em>n</em> = 13; 3), polychlorinated biphenyls (PCBs; <em>n</em> = 11; 1), selenium (<em>n</em> = 11; 1), lead (<em>n</em> = 9; 3), perfluoroalkyl and polyfluoroalkyl substances (<em>n</em> = 8; 2), dichlorodiphenyltrichloroethane (<em>n</em> = 5; 1), arsenic (<em>n</em> = 4; 4), cadmium (<em>n</em> = 4; 4), zinc (<em>n</em> = 3; 2), polybrominated diphenyl ethers (<em>n</em> = 3; 1), dioxin-like compounds (<em>n</em> = 3; 0), iron (<em>n</em> = 2; 1), and magnesium (<em>n</em> = 1; 1). No studies examined polybrominated biphenyls, polycyclic aromatic hydrocarbons, iodine, aldrin, dieldrin, chlordane, chlorpyrifos, or microplastic exposures. Outcomes also varied by exposure population (maternal;child): neurodevelopment (<em>n</em> = 35; 9), child exposure biomarkers (<em>n</em> = 22; 4), growth (<em>n</em> = 17; 1), other adverse events (<em>n</em> = 4; 0), cardiometabolic (<em>n</em> = 3; 2), chronic disease indicators (<em>n</em> = 2; 0), and immune-related (<em>n</em> = 1; 2). Twelve maternal toxicant–outcome pairs had ≥3 studies, including mercury, methylmercury, lead, PCBs, perfluoroalkyl and polyfluoroalkyl substances, and arsenic as exposures and neurodevelopment, child exposure biomarkers, growth, and cardiometabolic as outcomes. For child exposure, only mercury and neurodevelopment had ≥3 studies. In conclusion, this scoping review shows relevant evidence for 14 of the 22 toxicants. Only 12 maternal and 1 child toxicant–outcome pairs, the majority of which examined maternal (methyl)mercury exposure, had ≥3 studies, our cutoff for consideration for systematic review. This scoping review indicates a paucity of research examining seafood toxicants beyond mercury and exposure during childhood. Systematic reviews are required to evaluate the associations for each toxicant–outcome pairs.</div><div>The protocol was registered at Open Science Framework (<span><span>https://doi.org/10.17605/OSF.IO/FQZTA</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100353"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Polyphenols as Potential Therapeutic Agents in Type 2 Diabetes Management: Advances and Opportunities","authors":"Sisir Kumar Barik ,&nbsp;Srabasti Sengupta ,&nbsp;Rakesh Arya ,&nbsp;Surendra Kumar ,&nbsp;Jong Joo Kim ,&nbsp;Reetika Chaurasia","doi":"10.1016/j.advnut.2024.100346","DOIUrl":"10.1016/j.advnut.2024.100346","url":null,"abstract":"<div><div>Poor dietary intake or unhealthy lifestyle contributes to various health disorders, including postprandial hyperglycemia, leading to type 2 diabetes mellitus (T2DM). Reduction of postprandial glucose concentrations through diet is a key strategy for preventing and managing T2DM. Thus, it is essential to understand how dietary components affect glycemic regulation. Dietary polyphenols (DPs), such as anthocyanins and other phenolics found in various fruits and vegetables, are often recommended for their potential health benefits, although their systemic effectiveness is subject to ongoing debate. Therefore, this review assesses the current and historical evidence of DPs bioactivities, which regulate crucial metabolic markers to lower postprandial hyperglycemia. Significant bioactivities such as modulation of glucose transporters, activation of AMP kinase, and regulation of incretins are discussed, along with prospects for diet-induced therapeutics to prevent the onset of T2DM.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100346"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are We What We Breathe? Rethinking Air as a Nutritional Source","authors":"Jean Debédat","doi":"10.1016/j.advnut.2024.100360","DOIUrl":"10.1016/j.advnut.2024.100360","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100360"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Maternal Polychlorinated Biphenyls (PCBs) Exposure from Seafood Consumption during Pregnancy and Lactation and Child Growth: A Systematic Review and Meta-Analysis","authors":"Arin A Balalian ,&nbsp;Maureen K Spill ,&nbsp;Rachel C Thoerig ,&nbsp;Rupal Trivedi ,&nbsp;Sanjoy Saha ,&nbsp;Margaret J Foster ,&nbsp;Amanda J MacFarlane","doi":"10.1016/j.advnut.2024.100350","DOIUrl":"10.1016/j.advnut.2024.100350","url":null,"abstract":"<div><div>Beyond its nutritional benefits, seafood is a source of toxicant exposure including polychlorinated biphenyls (PCB). The association of PCB exposure from seafood intake during pregnancy and/or lactation (PL) and child growth outcomes is uncertain. This systematic review investigated the evidence and quantified the association between PCB exposure during PL from seafood intake and child growth outcomes. Embase, PubMed, and CENTRAL databases were searched from their inception for peer-reviewed English articles. Records were screened independently by 2 researchers at title and abstract, and then full-text levels. Studies were included if they: <em>1</em>) were conducted in a country with a high Human Development Index, <em>2</em>) measured maternal PCB exposure directly, <em>3</em>) assessed the relationship between PCB and seafood exposures or PCB or seafood associations with a child growth outcome, and <em>4</em>) were randomized or nonrandomized interventions, cohort, or nested case-control studies. Pooled partial correlations (<em>r</em>_<em>p</em>) were calculated using random-effects models for studies with sufficient data and narratively for the remaining studies. Cochrane ROBINS-E and GRADE tools were used to assess risk of bias and certainty of evidence, respectively. Child growth outcomes included birthweight, birth length, head and chest circumference at birth, and small for gestational age (SGA). Seven studies were included. PCB exposure during PL was weakly but significantly associated with lower birthweight [<em>r</em>_<em>p</em> = −0.07; 95% confidence interval (CI): −0.12, −0.02; <em>n</em> = 5], but showed no association with birth length (<em>r</em>_<em>p</em> = −0.04; 95% CI: −0.09, 0.02; <em>n</em> = 4) and head circumference (<em>r</em>_<em>p</em> = −0.03, 95% CI: −0.09, 0.03; <em>n</em> = 3). Studies on SGA and chest circumference yielded inconclusive results. The certainty of the evidence was low or very low because of the risk of bias from confounding, missing data, and exposure misclassification. The evidence suggests minimal to no link between PCB exposure from seafood during PL on child growth outcomes but with low to very low certainty.</div><div>This trial was registered at PROSPERO as CRD42023493302.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100350"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing Two New Prestigious Awards to Advance Nutrition & Obesity Science","authors":"Paul Coates PhD (Chair) ,&nbsp;Arne Astrup MD, DMSc (Senior Vice President) ,&nbsp;Sarah Booth PhD (President)","doi":"10.1016/j.advnut.2025.100369","DOIUrl":"10.1016/j.advnut.2025.100369","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100369"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nine Myths about Enteral Feeding in Critically Ill Adults: An Expert Perspective","authors":"Tara Ramaswamy ,&nbsp;Michael P DeWane ,&nbsp;Hassan S Dashti ,&nbsp;Meghan Lau ,&nbsp;Paul E Wischmeyer ,&nbsp;Alexander Nagrebetsky ,&nbsp;Jamie Sparling","doi":"10.1016/j.advnut.2024.100345","DOIUrl":"10.1016/j.advnut.2024.100345","url":null,"abstract":"<div><div>Malnutrition is a well-studied and significant prognostic risk factor for morbidity and mortality in critically ill perioperative patients. Common nutrition myths in the critically ill may prevent early, consistent, and adequate delivery of enteral nutrition. We outlined 9 common intensive care unit (ICU) nutrition misconceptions and our recommendations to optimize enteral nutrition in critically ill patients based on the review of available literature. Our approach is to treat every patient admitted to the ICU as at risk for malnutrition and to initiate enteral nutrition upon admission in the absence of contraindications. Early enteral nutrition via the gastric route is more beneficial than delaying feeding while awaiting small bowel access and daytime-intermittent nutrition support can safely be initiated over continuous feeding. Gastric residual volumes to assess feeding tolerance should no longer be routinely measured. For perioperative nutrition, we recommend continuing enteral nutrition for most patients with secure airways undergoing anesthesia and resuming nutrition within 24 h of abdominal surgery; even patients with open abdomens can be safely fed in the absence of bowel injury. Critically ill patients who are proned, paralyzed, and on vasopressors can usually continue enteral nutrition. Finally, continuing enteral nutrition before extubation may optimize nutrition without compromising extubation success. In this review, we highlight several common misconceptions regarding ICU nutrition that may prevent achieving nutrition goals and subsequently lead to increased malnutrition, morbidity, and mortality. This knowledge may contribute to increased implementation of early and consistent enteral nutrition strategies to improve outcomes in critically ill adult patients.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100345"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Opportunities to Better Characterize the Effects of Dietary Protein on Health across the Lifespan","authors":"John W Carbone ,&nbsp;Stuart M Phillips ,&nbsp;Connie M Weaver ,&nbsp;Julie M Hughes ,&nbsp;Stefan M Pasiakos","doi":"10.1016/j.advnut.2024.100347","DOIUrl":"10.1016/j.advnut.2024.100347","url":null,"abstract":"<div><div>Remarkable advances have been made over the last 30 y in understanding the role of dietary protein in optimizing muscle health across the lifespan. That is, acute (&lt;24 h) stable isotope-derived measures of muscle protein synthesis have led to established recommendations for protein quantity, quality, source, and timing of protein ingestion to support muscle health at rest, post exercise, and to overcome age-related anabolic resistance in older adults. Although muscle health is undoubtedly important, moving from muscle to other associated or disease-specific outcomes is a critical next step for the field, given the mounting evidence documenting the effects of dietary protein on measures of chronic disease and age-related decline (for example, cardiovascular disease, type 2 diabetes mellitus, obesity, frailty, and osteoporosis). In this narrative review, we posit that future studies evaluating the potential role of dietary protein build off of the existing knowledge base generated from decades of past research and focus their efforts on closing unanswered knowledge gaps pertaining to dietary protein and health across the lifespan. Throughout this review, we highlight potential methodologies and novel outcome measures that researchers may consider as starting points to facilitate the next 30 y of advances in the field of dietary protein and health.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100347"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"With Appreciation","authors":"","doi":"10.1016/j.advnut.2024.100354","DOIUrl":"10.1016/j.advnut.2024.100354","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100354"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Gabrielle Viscardi ,&nbsp;Songhee Back ,&nbsp;Amna Ahmed ,&nbsp;Shuting Yang ,&nbsp;Sonia Blanco Mejia ,&nbsp;Andreea Zurbau ,&nbsp;Tauseef A Khan ,&nbsp;Amanda Selk ,&nbsp;Mark Messina ,&nbsp;Cyril WC Kendall ,&nbsp;David JA Jenkins ,&nbsp;John L Sievenpiper ,&nbsp;Laura Chiavaroli","doi":"10.1016/j.advnut.2024.100327","DOIUrl":"10.1016/j.advnut.2024.100327","url":null,"abstract":"<div><div>Despite recommendations to increase plant food consumption for public and planetary health and the role that soy foods can play in plant-predominant diets, controversies around the effects of soy foods, especially soy isoflavones, are a barrier to their intake. Given their cardioprotective effects and ability to alleviate menopausal symptoms, addressing these concerns is particularly relevant to women. This systematic review and meta-analysis of randomized controlled trials aimed to determine the effect of soy isoflavones on measures of estrogenicity in postmenopausal women. MEDLINE, Embase, and Cochrane Library were searched through August 2024 for randomized trials <span><math><mrow><mo>≥</mo></mrow></math></span>3-mo investigating soy isoflavones compared with non-isoflavone controls in postmenopausal women. Outcomes included endometrial thickness (ET), vaginal maturation index (VMI), follicle-stimulating hormone (FSH), and estradiol. Independent authors extracted data and assessed risk of bias. Grading of Recommendations, Assessment, Development and Evaluation was used to assess certainty of evidence. We included 40 trials (52 trial comparisons, <em>n</em> = 3285) assessing the effect of a median reported dose of 75 mg/d of soy isoflavones in substitution for non-isoflavone controls over a median of 24 wk. Soy isoflavones had no statistically significant effect on any measure of estrogenicity; ET [mean difference, –0.22 mm (95% confidence interval, –0.45, 0.01 mm), <em>P</em>_MD = 0.059], VMI [2.31 (–2.14, 6.75), <em>P</em>_MD = 0.310], FSH [–0.02 IU/L (–2.39, 2.35 IU/L), <em>P</em>_MD = 0.987], and estradiol [1.61 pmol/L (–1.17, 4.38 pmol/L), <em>P</em>_MD = 0.256]. The certainty of evidence was high to moderate for all outcomes. Current evidence suggests that soy isoflavones do not exhibit estrogenic effects compared with non-isoflavone controls on 4 measures of estrogenicity in postmenopausal women. This synthesis supports that soy isoflavones likely act as selective estrogen receptor modulators, differing clinically from the hormone estrogen. Addressing public health concerns may promote soy foods as high-quality plant protein sources with low environmental impact and cost, particularly benefiting postmenopausal women and aligning with sustainable dietary patterns and guidelines.</div><div>This study was registered in PROSPERO as CRD42023439239.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100327"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Reviews on the Association of Low Calorie Sweetener Consumption With Body Weight and Adiposity","authors":"Kelly A Higgins ,&nbsp;Rita Rawal ,&nbsp;Matthew Kramer ,&nbsp;David J Baer ,&nbsp;Aaron Yerke ,&nbsp;David M Klurfeld","doi":"10.1016/j.advnut.2024.100239","DOIUrl":"10.1016/j.advnut.2024.100239","url":null,"abstract":"<div><h3>Background</h3><div>Numerous systematic reviews (SR) and meta-analyses (MA) on low calorie sweeteners (LCS) have been published in recent years, concluding that LCS have beneficial, neutral, or detrimental effects on various health outcomes, depending on the review.</div></div><div><h3>Objectives</h3><div>The objective of this overview of reviews was to determine how the methodologies of SR investigating the association between LCS consumption and body weight (BW) influence their findings and whether MA results can provide a consistent estimated effect.</div></div><div><h3>Methods</h3><div>Systematic searches of PubMed, Scopus, and Cochrane Library were conducted in November 2022 to identify SR of randomized controlled trials (RCT) or non-randomized studies (NRS) investigating the association between LCS consumption and BW. The methods, MA results, and conclusions were extracted from each eligible SR.</div></div><div><h3>Results</h3><div>Of the 985 search results, 20 SR evaluated the association between LCS and BW, drawing from publications of 75 RCT, 42 prospective cohort studies, and 10 cross-sectional studies. There was a considerable lack of overlap of studies included within each SR attributed, in part, to the inclusion of studies based on design; thus, each SR synthesized results from distinctly different studies. Evidence synthesis methods were heterogeneous and often opaque, making it difficult to determine why results from certain studies were excluded or why disparate results were observed between SR.</div></div><div><h3>Conclusions</h3><div>SR investigating the effect of LCS on BW implement different methodologies to answer allegedly the same question, drawing from a different set of heterogeneous studies, ignoring the basic assumptions required for MA, resulting in disparate results and conclusions. Previous MA show the large effects of study design, which results in inconsistent estimates of the effect of LCS on BW between MA of RCT and NRS. Given the availability of long-term RCT, these studies should be the basis of determining causal relationships (or lack thereof) between LCS and BW.</div><div>This trial was registered at PROSPERO as CRD42022351200.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"15 12","pages":"Article 100239"},"PeriodicalIF":8.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}