Ceramides as Emerging Players in Cardiovascular Disease: Focus on Their Pathogenetic Effects and Regulation by Diet

IF 8 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition Pub Date : 2024-07-01 DOI:10.1016/j.advnut.2024.100252

Riccardo Spaggiari , Sharon Angelini , Alessandra Di Vincenzo , Gerarda Scaglione , Sara Morrone , Veronica Finello , Sofia Fagioli , Fabiola Castaldo , Juana M Sanz , Domenico Sergi , Angelina Passaro

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引用次数: 0

Abstract

Impaired lipid metabolism is a pivotal driver of cardiovascular disease (CVD). In this regard, the accumulation of ceramides within the circulation as well as in metabolically active tissues and atherosclerotic plaques is a direct consequence of derailed lipid metabolism. Ceramides may be at the nexus between impaired lipid metabolism and CVD. Indeed, although on one hand ceramides have been implicated in the pathogenesis of CVD, on the other specific ceramide subspecies have also been proposed as predictors of major adverse cardiovascular events. This review will provide an updated overview of the role of ceramides in the pathogenesis of CVD, as well as their pathogenetic mechanisms of action. Furthermore, the manuscript will cover the importance of ceramides as biomarkers to predict cardiovascular events and the role of diet, both in terms of nutrients and dietary patterns, in modulating ceramide metabolism and homeostasis.

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神经酰胺是心血管疾病中的新兴角色：关注它们的致病作用和饮食调节。

脂质代谢障碍是心血管疾病（CVD）的关键驱动因素。在这方面，神经酰胺在血液循环以及代谢活跃的组织和动脉粥样硬化斑块中的积累是脂质代谢失调的直接后果。神经酰胺可能是脂质代谢受损与心血管疾病之间的联系纽带。事实上，一方面神经酰胺与心血管疾病的发病机制有关，另一方面特定的神经酰胺亚种也被认为是主要不良心血管事件的预测因子。本综述将概述神经酰胺在心血管疾病发病机制中的作用及其致病机制。此外，手稿还将介绍神经酰胺作为生物标志物在预测心血管事件中的重要性，以及饮食（包括营养素和饮食模式）在调节神经酰胺代谢和平衡中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Nutrition 医学-营养学

CiteScore

17.40

自引率

2.20%

发文量

117

审稿时长

56 days

期刊介绍： Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.