Advanced Therapeutics最新文献_第4页

Issue Information (Adv. Therap. 6/2025) 发行信息（add . therapy . 6/2025）

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-06-18 DOI: 10.1002/adtp.202570014

引用次数: 0

Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis 利用可激活Janus纳米探针进行NIR-II成像和酶样活性监测肝纤维化

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-06-17 DOI: 10.1002/adtp.202500142

Zhouyu Yu, Lijia Zou, Ruiqi Liu, Xiaoyan Zhang, Zhen Cheng, Si Chen, Baisong Chang

{"title":"Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis","authors":"Zhouyu Yu, Lijia Zou, Ruiqi Liu, Xiaoyan Zhang, Zhen Cheng, Si Chen, Baisong Chang","doi":"10.1002/adtp.202500142","DOIUrl":"10.1002/adtp.202500142","url":null,"abstract":"Liver fibrosis presents a significant global health challenge due to its potential progression to cirrhosis, liver failure, or hepatocellular carcinoma, highlighting the necessity for precise imaging of fibrosis progression. Here, a straightforward synthesis method is proposed to design bioresponsive nanoprobes capable of achieving high-resolution bioimaging of liver fibrosis. Janus MnO2-coated Ag/Ag2S nanoparticles modified by polyethylene glycol (denoted as jMAP) can inherit both the activatable properties from Ag/Ag2S and MnO2 components in the pathological microenvironment. Multiple lines of evidence supported that overexpressed levels of reactive oxygen species (ROS) in liver fibrosis efficiently transformed jMAP nanoprobes to Ag2S products, activating bright fluorescence in the second near-infrared window (NIR-II, 1000–1700 nm). In addition, the catalase-like and superoxide dismutase-like activities of jMAP probes reduce hypoxia and oxidative stress with a clearance rate of about 73.3% toward ROS, thereby downregulating hypoxia-inducible factor (HIF-1α) and NADPH oxidase-4 (NOX-4) by 49.5% and 47.9%, respectively. Overall, the developed jMAP probes demonstrate impressive diagnostic accuracy, offering transformative prospects for liver fibrosis diagnosis.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor Cell-Derived Antigens for Cancer Immunotherapy 肿瘤细胞源性抗原用于肿瘤免疫治疗

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-06-05 DOI: 10.1002/adtp.202500113

Lishang Xu, Yanfei Liu, Fei Liu, Qiwen Chen, Mingfeng Li, Nian Liao, Nanjiang Zheng, Xiangyu Fang, Yihao Qiu, Zhenbao Liu

{"title":"Tumor Cell-Derived Antigens for Cancer Immunotherapy","authors":"Lishang Xu, Yanfei Liu, Fei Liu, Qiwen Chen, Mingfeng Li, Nian Liao, Nanjiang Zheng, Xiangyu Fang, Yihao Qiu, Zhenbao Liu","doi":"10.1002/adtp.202500113","DOIUrl":"10.1002/adtp.202500113","url":null,"abstract":"Tumor vaccines have emerged as a transformative strategy in cancer immunotherapy, demonstrating substantial clinical potential. However, the genetic heterogeneity of tumor cells often leads to immune escape, limiting the effectiveness of traditional therapies that rely on a single antigen. Tumor cell-derived antigens offer a significant advantage in this regard, as they represent the unique molecular profile of the tumor, allowing for a broader and more diverse activation of the immune system. This diversity enhances the ability to overcome immune escape mechanisms, increasing the effective tumor eradication and reducing the risk of relapse. This review systematically examines two major sources of antigens: exogenous antigens, including tumor cells, tumor lysates, tumor exosomes, and tumor cell membranes, and endogenous antigens, which arise from immunogenic cell death (ICD) and possess unique advantages in eliciting strong immune activation. This work investigates synergistic therapies aimed at boosting tumor immunogenicity and counteracting the immunosuppressive microenvironment. This work reviews recent advances and challenges in tumor cell-derived antigen strategies for immune activation, emphasizing their potential to overcome limitations and facilitate the clinical translation of tumor vaccines.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modern Strategies in Wound Healing: The Rise of Bacterial Cellulose Dressings 伤口愈合的现代策略：细菌纤维素敷料的兴起

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-06-01 DOI: 10.1002/adtp.202500072

Elif Naz Gürsoy, Kubra Sener, M. Burcu Külahci, K. Barbaros Balabanli, Şule Coşkun Cevher

{"title":"Modern Strategies in Wound Healing: The Rise of Bacterial Cellulose Dressings","authors":"Elif Naz Gürsoy, Kubra Sener, M. Burcu Külahci, K. Barbaros Balabanli, Şule Coşkun Cevher","doi":"10.1002/adtp.202500072","DOIUrl":"10.1002/adtp.202500072","url":null,"abstract":"Advancements in wound care have necessitated the development of innovative dressings that address the limitations of traditional options while enhancing the healing process. Bacterial cellulose (BC) stands out due to its exceptional properties, including high water retention, biocompatibility, mechanical strength, and modification adaptability. This review critically compares BC-based wound dressings with traditional and next-generation alternatives, highlighting their unique advantages and potential as ideal wound coverings. BC's ability to maintain a moist environment, promote tissue regeneration, and minimize secondary injuries during dressing changes positions it as a superior option in wound care. BC's nanoporous structure also supports its functionalization with bioactive agents, antimicrobial compounds, and advanced fabrication techniques such as 3D printing and electrospinning. These modifications allow for tailored solutions that meet specific wound care requirements. Despite high production costs and the absence of intrinsic antimicrobial properties, BC surpasses many traditional dressings by addressing key areas such as moisture retention, biocompatibility, and ease of use. This study emphasizes BC's potential to transform wound care by combining its inherent properties with innovative modifications. BC-based dressings offer promising avenues for developing more effective, tailored, and sustainable wound management strategies by bridging the gap between traditional and next-generation solutions.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202500072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disintegration of the KITENIN/ErbB4 Functional Complex by the Flavonoid Hispidulin Suppresses Colorectal Cancer Progression 类黄酮Hispidulin分解KITENIN/ErbB4功能复合物抑制结直肠癌进展

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-05-29 DOI: 10.1002/adtp.202400227

Mücahit Varlı, Songjin Oh, Eunae Kim, Barış Gökalsın, Nüzhet Cenk Sesal, Kyung Keun Kim, Man Jeong Paik, Hangun Kim

{"title":"Disintegration of the KITENIN/ErbB4 Functional Complex by the Flavonoid Hispidulin Suppresses Colorectal Cancer Progression","authors":"Mücahit Varlı, Songjin Oh, Eunae Kim, Barış Gökalsın, Nüzhet Cenk Sesal, Kyung Keun Kim, Man Jeong Paik, Hangun Kim","doi":"10.1002/adtp.202400227","DOIUrl":"10.1002/adtp.202400227","url":null,"abstract":"KITENIN (KAI1 C-terminal interacting tetraspanin, VANGL1) has oncogenic functions and plays a role in the progression of colorectal cancer by interacting with many proteins, including ErbB4, DVL2, RACK1, and KSRP. The receptor tyrosine kinase ErbB4 forms a complex with KITENIN to activate the downstream AP-1 signaling axis. Therefore, disrupting this oncogenic complex is a promising therapeutic strategy. In this study, the potential therapeutic effects of the flavonoid hispidulin on the KITENIN/ErbB4 oncogenic complex and its signaling are examined. The effects of hispidulin on the KITENIN/ErbB4 oncogenic complex and colorectal cancer progression are evaluated by in vitro and in silico studies, including the investigation of oncometabolite levels. The results show that hispidulin binds to ErbB4 and blocks the interaction between KITENIN and ErbB4, thereby reducing KITENIN-mediated cell motility, AP-1 signaling, transcriptional regulator expression, aerobic glycolysis, and levels of metabolites associated with energy metabolism in colorectal cancer. In addition, hispidulin causes the lysosomal degradation of ErbB4 and KITENIN. Hispidulin has a promising therapeutic effect on signaling mediated by the KITENIN/ErbB4 oncogenic complex.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles and Their Impact on Epigenetic Mechanisms: Insights and Implications 纳米颗粒及其对表观遗传机制的影响：见解和启示

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-05-24 DOI: 10.1002/adtp.202500006

Zakieh Sadat Hoseini, Zahra Rezaee, Atefe Derakhshani, Sai-Yang Zhang, Sahar SH Tehrani, Mohammad Taleb, Hossein Ghanbari

{"title":"Nanoparticles and Their Impact on Epigenetic Mechanisms: Insights and Implications","authors":"Zakieh Sadat Hoseini, Zahra Rezaee, Atefe Derakhshani, Sai-Yang Zhang, Sahar SH Tehrani, Mohammad Taleb, Hossein Ghanbari","doi":"10.1002/adtp.202500006","DOIUrl":"10.1002/adtp.202500006","url":null,"abstract":"Nanoparticles have been investigated for extensive applications across scientific disciplines, including the medical field. Despite extensive research aimed at enhancing the understanding of their intracellular behavior and the potential genomic side effects of nanoparticles, scientists have paid relatively little attention to nanoparticle-induced epigenetic changes. This oversight is surprising given the critical role of epigenetic mechanisms in shaping cellular function and destiny. Epigenetic mechanisms include the procedures that modulate DNA or RNA and influence the production of proteins as well as the extent to which they are produced. Each cell type demonstrates unique epigenetic profiles. Epigenetic changes can disrupt normal cellular functions, potentially leading to devastating outcomes. Investigating how nanoparticles impact these epigenetic mechanisms provides valuable insights into their safe and effective use in medical applications. This review provides a detailed overview of how nanoparticles enter cells and the impact of nanoparticles on epigenetic mechanisms, focusing on current related studies on different types of cells.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Selenium-Based Nanomedicine: Transforming Cancer Therapy Across Diverse Types 硒基纳米医学的进展：改变不同类型的癌症治疗

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-05-24 DOI: 10.1002/adtp.202500042

Prashant Kesharwani, Kratika Halwai, Garima Gupta, Saurav Kumar Jha, Khang Wen Goh, Mohammed A.S. Abourehab

{"title":"Advancements in Selenium-Based Nanomedicine: Transforming Cancer Therapy Across Diverse Types","authors":"Prashant Kesharwani, Kratika Halwai, Garima Gupta, Saurav Kumar Jha, Khang Wen Goh, Mohammed A.S. Abourehab","doi":"10.1002/adtp.202500042","DOIUrl":"10.1002/adtp.202500042","url":null,"abstract":"Selenium (Sel) is an important trace element that plays a role in a variety of biological processes and reactions across species. It is well known for its antiviral, antioxidant, cytokine-modulating, immune-boosting, and anticoagulant characteristics, which have the potential to help manage illnesses like cancer. With the evolution of nanotechnology, customized medicine has made great progress, notably in increasing medication targeting while reducing the toxicity of anticancer treatments. Targeted nano-drug delivery systems are now being used to circumvent multidrug resistance and minimize side effects. By encapsulating medicines, these systems improve their solubility and tumor-targeting efficacy via active and passive transport modes. Sel nanoparticles (NPs) (Sel-NPs) have been identified as a potential anticancer platform because to their regulated size, excellent drug-loading capacity, increased antitumor efficacy, and reduced cytotoxicity. Importantly, no significant health hazards or toxicities have been documented in people or animals after utilizing these biogenic synthetic materials, making them a cost-effective and environmentally friendly solution. This review focuses on current breakthroughs in cancer therapy and preventive research using synthetic and biogenic Sel-NPs alone and in combination with chemo-, radiation-, and immunotherapy, as well as the hurdles faced during their development.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polydopamine-Integrated Nanomedicine through Dual Metabolic Intervention with Enhanced Photothermal Therapy against Triple-Negative Breast Cancer 多多巴胺整合纳米药物通过双代谢干预和增强光热疗法治疗三阴性乳腺癌

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-05-22 DOI: 10.1002/adtp.202400570

Chenlu Xu, Yujuan Gao, Xiaoyu Zhang, Fan Jia, Zian Pan, Mingjun Li, Weifeng Wang, Xianlei Li, Yan Wu

{"title":"Polydopamine-Integrated Nanomedicine through Dual Metabolic Intervention with Enhanced Photothermal Therapy against Triple-Negative Breast Cancer","authors":"Chenlu Xu, Yujuan Gao, Xiaoyu Zhang, Fan Jia, Zian Pan, Mingjun Li, Weifeng Wang, Xianlei Li, Yan Wu","doi":"10.1002/adtp.202400570","DOIUrl":"10.1002/adtp.202400570","url":null,"abstract":"Combining metabolic therapy with photothermal therapy (PTT) shows promise for the treatment of triple-negative breast cancer (TNBC). However, a strategy is still required to effectively overcome the metabolic adaptation of TNBC with thermotolerance during thermotherapy, thereby enhancing therapeutic outcomes. In this study, the polydopamine-integrated nanomedicine is designed, with glucose oxidase (GOx) chemically conjugated to its surface and curcumin (Cur)-loaded calcium phosphate (CaP) shell. The outer CaP layer disintegrates in response to the acidic environment of tumor cells, releasing calcium ions with the calcium efflux inhibitor Cur, which causes mitochondrial functional disruption by inducing mitochondrial calcium overload. Concurrently, GOx consumes intracellular glucose to inhibit glycolysis. The dual intervention of mitochondrial metabolism and glycolysis serves to counteract the metabolic adaptations in TNBC, effectively blocking the pathways of energy supply, which results in a 56.61% reduction of ATP. In addition, inhibition of ATP production by dual metabolic regulation can downregulate the expression of heat shock proteins (HSPs) and sensitized PTT, the HSP70 level and HSP90 level are downregulated by 25.68% and 41.89%, respectively. This study provides new insights into combining metabolic therapy and PTT for the treatment of TNBC.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair 冷等离子体产生局部炎症反应并促进肌肉修复

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-05-20 DOI: 10.1002/adtp.202500097

Carly J. Smith, Amanda R. Watkins, Abigail A. Lucas, Arianna J. Moniodes, Conn Ritchie, Thomas P. Thompson, Thomas P. Schaer, Brendan F. Gilmore, Noreen J. Hickok, Theresa A. Freeman

{"title":"Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair","authors":"Carly J. Smith, Amanda R. Watkins, Abigail A. Lucas, Arianna J. Moniodes, Conn Ritchie, Thomas P. Thompson, Thomas P. Schaer, Brendan F. Gilmore, Noreen J. Hickok, Theresa A. Freeman","doi":"10.1002/adtp.202500097","DOIUrl":"10.1002/adtp.202500097","url":null,"abstract":"The FDA-approved Renuvion cold plasma device is currently used for dermal skin tightening procedures and subdermal tightening after liposuction. Anecdotally, patients report improved tissue healing outcomes following treatment. The most likely explanation for this is plasma-generated reactive species which are inflammatory but also activate cellular signaling pathways, stimulate antioxidant responses, and activate immune cells. In this study, we aimed to determine the immediate and long-term molecular effects of a single plasma treatment on surgically injured muscle and the soft tissue envelope. We used RNA sequencing, histology, and immunohistochemistry to determine changes to the tissue following treatment. Neutrophils and mast cells rapidly mobilize 6 h after treatment in conjunction with an upregulated cellular antioxidant response. Additionally, genes identified by RNAseq indicate upregulated pro-regenerative muscle-tissue-protective gene transcripts and downregulated apoptotic pathway transcripts in the muscle tissue 6 h after treatment. The histology and RNAseq results from 4- and 14-days post plasma treatment indicate that these early inflammatory and antioxidant events drive muscle regeneration to skew toward myogenic differentiation over adipogenesis. Thus, we conclude that a single plasma treatment results in an immediate inflammatory and antioxidant response that enhances long-term muscle fiber repair through reduced adipogenesis.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202500097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Narrative Review on Efficacy of Cell- and Tissue-Based Therapies for Diabetic Foot Ulcer 以细胞和组织为基础的治疗糖尿病足溃疡的疗效综述

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-05-19 DOI: 10.1002/adtp.202400335

Behnaz Niroomand, Ibrahim Mohammadzadeh, Maryam Tabarzad, Elham Mohit

{"title":"A Narrative Review on Efficacy of Cell- and Tissue-Based Therapies for Diabetic Foot Ulcer","authors":"Behnaz Niroomand, Ibrahim Mohammadzadeh, Maryam Tabarzad, Elham Mohit","doi":"10.1002/adtp.202400335","DOIUrl":"10.1002/adtp.202400335","url":null,"abstract":"Diabetic foot ulcers (DFUs) are complex, making conventional treatments challenging in restoring skin tissue. Stem cell therapy (SCT) and skin replacement therapy (SRT) offer promising solutions by addressing prolonged inflammation, impaired cell proliferation, and reduced extracellular support. Here, based on the origin of cells, SCTs are categorized into embryonic, induced pluripotent, fetal, and adult stem cells (ASCs). Mesenchymal stem cells are among the most employed types of ASCs in clinical trials for treating DFUs. Furthermore, their delivery routes, and stem-cell-derived products are also discussed. However, the lack of phase III/V clinical trials limits their clinical use. SRTs are classified by tissue origin (human or animal) and product cellularity. Clinical trials and systematic reviews indicate that placenta-based grafts (e.g., EpiFix), acellular dermal matrices from human cadaver skin (e.g., DermACell and Graftjacket), and bioengineered cell-based products (e.g., Apligraf and Dermagraft) are the most effective and safe for SRT. Both SCT and SRT are evolving fields with ongoing challenges, including injection barriers, cell reprogramming risks, ethical concerns, foreign body reactions, and a lack of long-term follow-up studies.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0