Advanced Therapeutics最新文献_第4页

Correction to “Phage-Derived Oncolytic Viruses with 3C From Seneca Valley Virus for Targeted Therapy of Cervical Cancer” 噬菌体衍生肿瘤溶解病毒与塞内卡山谷病毒 3C 用于宫颈癌靶向治疗 "的更正

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-29 DOI: 10.1002/adtp.202400341

引用次数: 0

Comparison of SGLT1, SGLT2, and Dual Inhibitor Biological Activity in Treating Type 2 Diabetes Mellitus 比较 SGLT1、SGLT2 和双重抑制剂在治疗 2 型糖尿病中的生物活性

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-29 DOI: 10.1002/adtp.202400330

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Probiotics-Loaded Selenium Nanoparticles Effectively Alleviated DSS-Induced Colitis by Scavenging ROS and Remodeling Intestinal Innate Immune and Microbiota 装载益生菌的硒纳米颗粒通过清除 ROS 和重塑肠道先天免疫及微生物群有效缓解了 DSS 诱导的结肠炎

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-28 DOI: 10.1002/adtp.202400275

Yao Yao, Binqing Xue, Duncan James Lessing, Weihua Chu

{"title":"Probiotics-Loaded Selenium Nanoparticles Effectively Alleviated DSS-Induced Colitis by Scavenging ROS and Remodeling Intestinal Innate Immune and Microbiota","authors":"Yao Yao, Binqing Xue, Duncan James Lessing, Weihua Chu","doi":"10.1002/adtp.202400275","DOIUrl":"10.1002/adtp.202400275","url":null,"abstract":"Alterations in the intestinal microenvironment, including increased levels of reactive oxygen species (ROS), abnormalities in intestinal mucosal immune regulation, and dysbiosis of the intestinal microbiota, are crucial to the development of inflammatory bowel disease (IBD). Herein, an oral colon-targeting Se-Probiotic@Alginate bead (BLSe) with ROS-scavenging ability and gut immune-microbiota microenvironment remodeling ability is developed using alginate as the primary outer shell encapsulated with probiotics Bacillus licheniformis (BL) and selenium nanoparticles stabilized by yeast glucan (SeNPs). In vitro studies have shown that SeNPs possess antioxidant activity and BLSe exhibits excellent stability in gastric fluids and are released in intestinal fluids. In vivo studies have also shown that BLSe significantly alleviated dextran sulphate sodium (DSS)-induced colitis in mice by inhibiting colon shortening, enhancing antioxidant activity, reducing pro-inflammatory cytokine secretion, and protecting the intestinal mucosal barrier. 16S ribosomal RNA sequencing shows that BLSe can remodel the composition of the gut microbiota by improving bacterial diversity and restoring the relative abundance of beneficial bacteria in the colon. Overall, this study advances a promising probiotic-based nanomedicine for managing IBD.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Challenges to Solution: The Evolving Landscape of Leprosy Management 从挑战到解决方案：不断演变的麻风病管理格局

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-08-24 DOI: 10.1002/adtp.202400249

Lívia Maria Coelho de Carvalho Moreira, Antônia Carla de Jesus Oliveira, Luíse Lopes Chaves, Mônica Felts de La Rocca Soares, José Lamartine Soares‐Sobrinho

{"title":"From Challenges to Solution: The Evolving Landscape of Leprosy Management","authors":"Lívia Maria Coelho de Carvalho Moreira, Antônia Carla de Jesus Oliveira, Luíse Lopes Chaves, Mônica Felts de La Rocca Soares, José Lamartine Soares‐Sobrinho","doi":"10.1002/adtp.202400249","DOIUrl":"https://doi.org/10.1002/adtp.202400249","url":null,"abstract":"Leprosy, caused by Mycobacterium leprae, despite being a curable disease when treated can induce peripheral neuropathy. However, the medicines used in polychemotherapy promote several side effects. Thus, research for the development of new administration systems is an alternative, but there is a lack of preclinical and clinical studies of the systems, where 90.90% have a level of technological maturity 3 and 9.09% level 4. The main issues are associated with deficiencies in vitro and in vivo cultivation methodologies, lack of financing, as well as the disinterest of the pharmaceutical industry in investing in neglected tropical diseases. In addition, with the emergence of resistant bacteria, there is urgency in the search for vaccines and, therefore, in the expansion of immunomodulation studies to define the molecular targets of the vaccine and future medications. In addition, future treatments for various diseases, including leprosy, will be directly influenced by the evolution of additive manufacturing and 3D printing, seeking personalized, flexible, and reproducible treatment.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"66 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics 植物提取的细胞外囊泡是癌症治疗的潜在新兴工具

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-24 DOI: 10.1002/adtp.202400256

Lin Ding, Chih-Jung Chang, Min-Li Liang, Kang-Mei Dong, Fu-Rong Li

{"title":"Plant-Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics","authors":"Lin Ding, Chih-Jung Chang, Min-Li Liang, Kang-Mei Dong, Fu-Rong Li","doi":"10.1002/adtp.202400256","DOIUrl":"10.1002/adtp.202400256","url":null,"abstract":"Extracellular vesicles (EVs) are membranous structures secreted by cells that play important roles in intercellular communication and material transport. Due to its excellent biocompatibility, lipophilicity, and homing properties, EVs have been used as a new generation of drug delivery systems for the diagnosis and treatment of tumors. Despite the potential clinical benefits of animal-derived extracellular vesicles (AEVs), their large-scale production remains sluggish due to the exorbitant cost of cell culture, challenging quality control measures, and limited production capabilities. This constraint significantly hinders their widespread clinical application. Plant-derived extracellular vesicles (PEVs) share similar functionalities with AEVs, yet they hold several advantages including a wide variety of source materials, cost-effectiveness, ease of preparation, enhanced safety, more stable physicochemical properties, and notable efficacy. These merits position PEVs as promising contenders with broad potential in the biomedical sector. This review will elucidate the advantages of PEVs, delineating their therapeutic mechanisms in cancer treatment, and explore the prospective applications of engineered PEVs as targeted delivery nano-system for drugs, microRNAs, small interfering RNAs, and beyond. The aim is to heighten researchers’ focus on PEVs and expedite the progression from fundamental research to the transformation of groundbreaking discoveries.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy 结核病诊断和治疗中与临床相关的金属纳米粒子

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-08-21 DOI: 10.1002/adtp.202400189

Christianah Aarinola Akinnawo, Admire Dube

引用次数: 0

Plant-Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer 诱导癌症细胞程序性死亡的植物衍生植物化学物质及其纳米制剂

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-20 DOI: 10.1002/adtp.202400197

Haoyu Wang, Xiaoyang Wang, Long Wang, Haifan Wang, Yuxing Zhang

{"title":"Plant-Derived Phytochemicals and Their Nanoformulations for Inducing Programed Cell Death in Cancer","authors":"Haoyu Wang, Xiaoyang Wang, Long Wang, Haifan Wang, Yuxing Zhang","doi":"10.1002/adtp.202400197","DOIUrl":"10.1002/adtp.202400197","url":null,"abstract":"Phytochemicals are a diverse class of compounds found in various plant-based foods and beverages that have displayed the capacity to exert powerful anticancer effects through the induction of programed cell death (PCD) in malignancies. PCD is a sophisticated process that maintains in upholding tissue homeostasis and eliminating injured or neoplastic cells. Phytochemicals have shown the potential to induce PCD in malignant cells through various mechanisms, including modulation of cell signaling pathways, regulation of reactive oxygen species (ROS), and interaction with critical targets in cells such as DNA. Moreover, recent studies have suggested that nanomaterials loaded with phytochemicals may enhance cell death in tumors, which can also stimulate antitumor immunity. In this review, a comprehensive overview of the current understanding of the anticancer effects of phytochemicals and their potential as a promising approach to cancer therapy, is provided. The impacts of phytochemicals such as resveratrol, curcumin, apigenin, quercetin, and some approved plant-derived drugs, such as taxanes on the regulation of some types of PCD, including apoptosis, pyroptosis, anoikis, autophagic cell death, ferroptosis, and necroptosis, are discussed. The underlying mechanisms and the potential of nanomaterials loaded with phytochemicals to enhance PCD in tumors are also explained.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

l-Asparaginase Bio-Betters: Insight Into Current Formulations, Optimization Strategies and Future Bioengineering Frontiers in Anti-Cancer Drug Development l-Asparaginase Bio-Betters：洞察抗癌药物开发中的现有配方、优化策略和未来生物工程前沿

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-19 DOI: 10.1002/adtp.202400156

Sukanya Sonowal, Kalyani Pathak, Dibyajyoti Das, Kabyashree Buragohain, Ankita Gogoi, Nikha Borah, Aparoop Das, Ratul Nath

{"title":"l-Asparaginase Bio-Betters: Insight Into Current Formulations, Optimization Strategies and Future Bioengineering Frontiers in Anti-Cancer Drug Development","authors":"Sukanya Sonowal, Kalyani Pathak, Dibyajyoti Das, Kabyashree Buragohain, Ankita Gogoi, Nikha Borah, Aparoop Das, Ratul Nath","doi":"10.1002/adtp.202400156","DOIUrl":"10.1002/adtp.202400156","url":null,"abstract":"Cancer remains a persistent global health concern, representing a significant challenge in medical science and patient care. In this context, l-asparaginase has emerged as a promising therapeutic agent due to its unique ability to deplete circulating asparagine, thereby selectively targeting cancer cells. However, despite its potential, current formulations of l-asparaginase are not without limitations. Issues such as immunogenicity, short half-life, and variable efficacy present hurdles in its widespread clinical application. To overcome these hurdles, researchers are focusing on developing bio-better versions of l-asparaginase. These bio-betters aim to enhance stability, reduce immunogenicity, and optimize enzyme kinetics, thus improving treatment outcomes. This review critically assesses the current landscape of l-asparaginase bio-betters, offering insights into ongoing formulations and advancements, optimization strategies, and future bio-engineering frontiers. It discusses modifications to enhance therapeutic properties and explores innovative approaches like in-silico enzyme engineering and artificial intelligence, highlighting their potential to improve the therapeutic profile of l-asparaginase. Challenges and debates surrounding the l-asparaginase mechanism are also addressed. By addressing current challenges and outlining future directions, this review aims to contribute to the advancement of anti-cancer therapeutics, particularly in the context of l-asparaginase bio-better research.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cationic Adiposomes as a Delivery System for Neogambogic Acid for the Treatment of Multiple Cancers 阳离子脂肪体作为新甘壁酸的输送系统治疗多种癌症

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-19 DOI: 10.1002/adtp.202400201

Gaoxin Zhang, Zelun Zhi, Bin Pan, Zemin Li, Shuyan Zhang, Zhenzhen Wu, Pengcheng Bu, Zhen Cao, Pingsheng Liu

{"title":"Cationic Adiposomes as a Delivery System for Neogambogic Acid for the Treatment of Multiple Cancers","authors":"Gaoxin Zhang, Zelun Zhi, Bin Pan, Zemin Li, Shuyan Zhang, Zhenzhen Wu, Pengcheng Bu, Zhen Cao, Pingsheng Liu","doi":"10.1002/adtp.202400201","DOIUrl":"10.1002/adtp.202400201","url":null,"abstract":"Neogambogic acid (NGA) is a potent antitumor drug but faces significant obstacles to clinical application, including extremely poor water solubility and systemic toxicity. To overcome these obstacles, a newly developed nanoparticle, adiposome, that consists of a neutral lipid core wrapped with a phospholipid-monolayer membrane, is utilized for the delivery of NGA. In this study, NGA-loaded cationic adiposomes (NGA-C-ADs) are constructed in which NGA is encapsulated within the neutral lipid core and surrounded by phospholipids and a cationic lipid. The concentration of NGA in NGA-C-ADs achieved is as high as 1.0 mg mL−1, which is 2 000-fold higher than in aqueous buffer alone. Moreover, in vitro cell tests revealed that NGA-C-ADs exhibited higher cytotoxicity against various cancer cell lines compared to free NGA. In addition, in vivo anti-tumor animal studies demonstrate that NGA-C-ADs effectively inhibit tumor growth in subcutaneous CT26 tumor-bearing mice and also suppress chemically-induced hepatocellular carcinoma without obvious toxicity to major organs. These findings suggest that NGA-C-ADs hold promise as a potential treatment for multiple cancers.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Doxorubicin-Induced Cardiotoxicity: Insights from Transcriptome Analysis 多柔比星诱发心脏毒性的性别差异：转录组分析的启示

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-18 DOI: 10.1002/adtp.202400036

Qingqing Su, Min Fu, Wanli Xiao, Huan Zhao, Yang Yu, Jianguo Feng, Yulin Liu, Ying Wan, Yajun Yu, Chunxiang Zhang

{"title":"Sex Differences in Doxorubicin-Induced Cardiotoxicity: Insights from Transcriptome Analysis","authors":"Qingqing Su, Min Fu, Wanli Xiao, Huan Zhao, Yang Yu, Jianguo Feng, Yulin Liu, Ying Wan, Yajun Yu, Chunxiang Zhang","doi":"10.1002/adtp.202400036","DOIUrl":"https://doi.org/10.1002/adtp.202400036","url":null,"abstract":"Male patients have a higher risk of cardiotoxicity following doxorubicin (DOX) treatment than female patients. However, how this difference occurs at the transcriptome level remains unclear, and the mechanisms underlying these differences are understudied. This study aimed to describe the transcriptional patterns of males and females after DOX treatment and explore the possible mechanisms of sexual differences in DOX-induced cardiotoxicity. Following DOX treatment, male mice exhibit more severe heart damage than female mice. Transcriptome analysis of mice with and without DOX treatment showed that differentially expressed genes (DEGs) are significantly different between males and females. The majority of DEGs are sex-specific, and more DEGs are identified in males than females. A number of genes, including the oxidation-related genes Gdf15 and Rbm3, exhibited altered expression either in males or females. Some other genes, including the ferroptosis-related gene Cd74, changed their expression levels in both sexes, but at different scales. Biochemical experiments suggested that cardiomyocyte oxidation and ferroptosis may contribute to the sexual dimorphism of DOX-induced cardiotoxicity. In summary, this study shows that, after exposure to DOX, males and females respond differently regarding the expression of hundreds of genes, including Gdf15, Rbm3, and Cd74, possibly explaining the sexual differences in DOX-induced cardiotoxicity.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0