Advanced Therapeutics最新文献

Issue Information (Adv. Therap. 7/2025) 发行信息（ad . Therap. 7/2025）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-07-10 DOI: 10.1002/adtp.70023

引用次数: 0

Injectable Immune-Engineered Hydrogel Niche Remote from the Immune Suppressed Tumor Microenvironment for Cancer Immunotherapy 远离免疫抑制肿瘤微环境的可注射免疫工程水凝胶小生境用于癌症免疫治疗

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-06-23 DOI: 10.1002/adtp.202500120

Saira Nujoom Muhammad, Zahara T Zakariya, Sherin Shaji, Anjali K Sunilkumar, Amal George, Sreedevi P Radhakrishnan, Shantikumar V Nair, Manzoor Koyakutty

{"title":"Injectable Immune-Engineered Hydrogel Niche Remote from the Immune Suppressed Tumor Microenvironment for Cancer Immunotherapy","authors":"Saira Nujoom Muhammad, Zahara T Zakariya, Sherin Shaji, Anjali K Sunilkumar, Amal George, Sreedevi P Radhakrishnan, Shantikumar V Nair, Manzoor Koyakutty","doi":"10.1002/adtp.202500120","DOIUrl":"https://doi.org/10.1002/adtp.202500120","url":null,"abstract":"Immunocompromise is a hallmark of cancer, affecting both the peripheral immune system and local tumor microenvironment (TME). Current immunotherapies like checkpoint inhibitors, CAR-T cells, and neo-antigen vaccines show limited efficacy due to severe immunosuppression in most patients. Here, an immunologically engineered injectable immunehydrogel (iHG) is reported that can: i) recruit the desired set of immune cells away from the suppressed TME and peripheral organs, ii) activate them within a protective ambit of engineered immune-stimulatory hydrogel niche, and iii) release them to target cancer even in distant locations. Biodegradable and injectable iHG compositions are tested and optimized for their ability to attract and activate dendritic cells (DC), macrophages, monocytes, natural killer (NK) cells, B cells, and T cells via stimulator of interferon genes (STING), TLR, CD86, and Th1-polarized cytokine pathway without requiring exogenously introduced neo-antigens as vaccines. In a mouse melanoma model, optimized iHGs elicit a robust antitumor immune response through innate and adaptive arms. Most importantly, iHGs as a single agent immunomodulator exhibit better tumor control than when combined with anti-PD1 immune checkpoint antibody. These findings highlight the potential of engineering immunologically functional and injectable hydrogel niches as a new type of immunotherapeutics to reprogram immune cells to overcome both local and systemic immunosuppression and combat cancer effectively.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking Biochemical Traits with a Synthetic Lipid Nanoparticles SARS-COV-2 Model (Adv. Therap. 6/2025) 利用合成脂质纳米颗粒模拟SARS-COV-2模型的生化特性（Adv. Therap. 6/2025）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-06-18 DOI: 10.1002/adtp.202570013

Ignasia Handipta Mahardika, Hyun Park, Eunjin Huh, Changyoon Baek, Shin-Gyu Cho, Kwang-Hwan Jung, Junhong Min, Kwanwoo Shin

引用次数: 0

Issue Information (Adv. Therap. 6/2025) 发行信息（add . therapy . 6/2025）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-06-18 DOI: 10.1002/adtp.202570014

引用次数: 0

Modern Strategies in Wound Healing: The Rise of Bacterial Cellulose Dressings 伤口愈合的现代策略：细菌纤维素敷料的兴起

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-06-01 DOI: 10.1002/adtp.202500072

Elif Naz Gürsoy, Kubra Sener, M. Burcu Külahci, K. Barbaros Balabanli, Şule Coşkun Cevher

{"title":"Modern Strategies in Wound Healing: The Rise of Bacterial Cellulose Dressings","authors":"Elif Naz Gürsoy, Kubra Sener, M. Burcu Külahci, K. Barbaros Balabanli, Şule Coşkun Cevher","doi":"10.1002/adtp.202500072","DOIUrl":"https://doi.org/10.1002/adtp.202500072","url":null,"abstract":"Advancements in wound care have necessitated the development of innovative dressings that address the limitations of traditional options while enhancing the healing process. Bacterial cellulose (BC) stands out due to its exceptional properties, including high water retention, biocompatibility, mechanical strength, and modification adaptability. This review critically compares BC-based wound dressings with traditional and next-generation alternatives, highlighting their unique advantages and potential as ideal wound coverings. BC's ability to maintain a moist environment, promote tissue regeneration, and minimize secondary injuries during dressing changes positions it as a superior option in wound care. BC's nanoporous structure also supports its functionalization with bioactive agents, antimicrobial compounds, and advanced fabrication techniques such as 3D printing and electrospinning. These modifications allow for tailored solutions that meet specific wound care requirements. Despite high production costs and the absence of intrinsic antimicrobial properties, BC surpasses many traditional dressings by addressing key areas such as moisture retention, biocompatibility, and ease of use. This study emphasizes BC's potential to transform wound care by combining its inherent properties with innovative modifications. BC-based dressings offer promising avenues for developing more effective, tailored, and sustainable wound management strategies by bridging the gap between traditional and next-generation solutions.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202500072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disintegration of the KITENIN/ErbB4 Functional Complex by the Flavonoid Hispidulin Suppresses Colorectal Cancer Progression 类黄酮Hispidulin分解KITENIN/ErbB4功能复合物抑制结直肠癌进展

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-05-29 DOI: 10.1002/adtp.202400227

Mücahit Varlı, Songjin Oh, Eunae Kim, Barış Gökalsın, Nüzhet Cenk Sesal, Kyung Keun Kim, Man Jeong Paik, Hangun Kim

{"title":"Disintegration of the KITENIN/ErbB4 Functional Complex by the Flavonoid Hispidulin Suppresses Colorectal Cancer Progression","authors":"Mücahit Varlı, Songjin Oh, Eunae Kim, Barış Gökalsın, Nüzhet Cenk Sesal, Kyung Keun Kim, Man Jeong Paik, Hangun Kim","doi":"10.1002/adtp.202400227","DOIUrl":"https://doi.org/10.1002/adtp.202400227","url":null,"abstract":"KITENIN (KAI1 C-terminal interacting tetraspanin, VANGL1) has oncogenic functions and plays a role in the progression of colorectal cancer by interacting with many proteins, including ErbB4, DVL2, RACK1, and KSRP. The receptor tyrosine kinase ErbB4 forms a complex with KITENIN to activate the downstream AP-1 signaling axis. Therefore, disrupting this oncogenic complex is a promising therapeutic strategy. In this study, the potential therapeutic effects of the flavonoid hispidulin on the KITENIN/ErbB4 oncogenic complex and its signaling are examined. The effects of hispidulin on the KITENIN/ErbB4 oncogenic complex and colorectal cancer progression are evaluated by in vitro and in silico studies, including the investigation of oncometabolite levels. The results show that hispidulin binds to ErbB4 and blocks the interaction between KITENIN and ErbB4, thereby reducing KITENIN-mediated cell motility, AP-1 signaling, transcriptional regulator expression, aerobic glycolysis, and levels of metabolites associated with energy metabolism in colorectal cancer. In addition, hispidulin causes the lysosomal degradation of ErbB4 and KITENIN. Hispidulin has a promising therapeutic effect on signaling mediated by the KITENIN/ErbB4 oncogenic complex.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles and Their Impact on Epigenetic Mechanisms: Insights and Implications 纳米颗粒及其对表观遗传机制的影响：见解和启示

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-05-24 DOI: 10.1002/adtp.202500006

Zakieh Sadat Hoseini, Zahra Rezaee, Atefe Derakhshani, Sai-Yang Zhang, Sahar SH Tehrani, Mohammad Taleb, Hossein Ghanbari

{"title":"Nanoparticles and Their Impact on Epigenetic Mechanisms: Insights and Implications","authors":"Zakieh Sadat Hoseini, Zahra Rezaee, Atefe Derakhshani, Sai-Yang Zhang, Sahar SH Tehrani, Mohammad Taleb, Hossein Ghanbari","doi":"10.1002/adtp.202500006","DOIUrl":"https://doi.org/10.1002/adtp.202500006","url":null,"abstract":"Nanoparticles have been investigated for extensive applications across scientific disciplines, including the medical field. Despite extensive research aimed at enhancing the understanding of their intracellular behavior and the potential genomic side effects of nanoparticles, scientists have paid relatively little attention to nanoparticle-induced epigenetic changes. This oversight is surprising given the critical role of epigenetic mechanisms in shaping cellular function and destiny. Epigenetic mechanisms include the procedures that modulate DNA or RNA and influence the production of proteins as well as the extent to which they are produced. Each cell type demonstrates unique epigenetic profiles. Epigenetic changes can disrupt normal cellular functions, potentially leading to devastating outcomes. Investigating how nanoparticles impact these epigenetic mechanisms provides valuable insights into their safe and effective use in medical applications. This review provides a detailed overview of how nanoparticles enter cells and the impact of nanoparticles on epigenetic mechanisms, focusing on current related studies on different types of cells.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Selenium-Based Nanomedicine: Transforming Cancer Therapy Across Diverse Types 硒基纳米医学的进展：改变不同类型的癌症治疗

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-05-24 DOI: 10.1002/adtp.202500042

Prashant Kesharwani, Kratika Halwai, Garima Gupta, Saurav Kumar Jha, Khang Wen Goh, Mohammed A.S. Abourehab

{"title":"Advancements in Selenium-Based Nanomedicine: Transforming Cancer Therapy Across Diverse Types","authors":"Prashant Kesharwani, Kratika Halwai, Garima Gupta, Saurav Kumar Jha, Khang Wen Goh, Mohammed A.S. Abourehab","doi":"10.1002/adtp.202500042","DOIUrl":"https://doi.org/10.1002/adtp.202500042","url":null,"abstract":"Selenium (Sel) is an important trace element that plays a role in a variety of biological processes and reactions across species. It is well known for its antiviral, antioxidant, cytokine-modulating, immune-boosting, and anticoagulant characteristics, which have the potential to help manage illnesses like cancer. With the evolution of nanotechnology, customized medicine has made great progress, notably in increasing medication targeting while reducing the toxicity of anticancer treatments. Targeted nano-drug delivery systems are now being used to circumvent multidrug resistance and minimize side effects. By encapsulating medicines, these systems improve their solubility and tumor-targeting efficacy via active and passive transport modes. Sel nanoparticles (NPs) (Sel-NPs) have been identified as a potential anticancer platform because to their regulated size, excellent drug-loading capacity, increased antitumor efficacy, and reduced cytotoxicity. Importantly, no significant health hazards or toxicities have been documented in people or animals after utilizing these biogenic synthetic materials, making them a cost-effective and environmentally friendly solution. This review focuses on current breakthroughs in cancer therapy and preventive research using synthetic and biogenic Sel-NPs alone and in combination with chemo-, radiation-, and immunotherapy, as well as the hurdles faced during their development.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polydopamine-Integrated Nanomedicine through Dual Metabolic Intervention with Enhanced Photothermal Therapy against Triple-Negative Breast Cancer 多多巴胺整合纳米药物通过双代谢干预和增强光热疗法治疗三阴性乳腺癌

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-05-22 DOI: 10.1002/adtp.202400570

Chenlu Xu, Yujuan Gao, Xiaoyu Zhang, Fan Jia, Zian Pan, Mingjun Li, Weifeng Wang, Xianlei Li, Yan Wu

{"title":"Polydopamine-Integrated Nanomedicine through Dual Metabolic Intervention with Enhanced Photothermal Therapy against Triple-Negative Breast Cancer","authors":"Chenlu Xu, Yujuan Gao, Xiaoyu Zhang, Fan Jia, Zian Pan, Mingjun Li, Weifeng Wang, Xianlei Li, Yan Wu","doi":"10.1002/adtp.202400570","DOIUrl":"https://doi.org/10.1002/adtp.202400570","url":null,"abstract":"Combining metabolic therapy with photothermal therapy (PTT) shows promise for the treatment of triple-negative breast cancer (TNBC). However, a strategy is still required to effectively overcome the metabolic adaptation of TNBC with thermotolerance during thermotherapy, thereby enhancing therapeutic outcomes. In this study, the polydopamine-integrated nanomedicine is designed, with glucose oxidase (GOx) chemically conjugated to its surface and curcumin (Cur)-loaded calcium phosphate (CaP) shell. The outer CaP layer disintegrates in response to the acidic environment of tumor cells, releasing calcium ions with the calcium efflux inhibitor Cur, which causes mitochondrial functional disruption by inducing mitochondrial calcium overload. Concurrently, GOx consumes intracellular glucose to inhibit glycolysis. The dual intervention of mitochondrial metabolism and glycolysis serves to counteract the metabolic adaptations in TNBC, effectively blocking the pathways of energy supply, which results in a 56.61% reduction of ATP. In addition, inhibition of ATP production by dual metabolic regulation can downregulate the expression of heat shock proteins (HSPs) and sensitized PTT, the HSP70 level and HSP90 level are downregulated by 25.68% and 41.89%, respectively. This study provides new insights into combining metabolic therapy and PTT for the treatment of TNBC.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair 冷等离子体产生局部炎症反应并促进肌肉修复

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-05-20 DOI: 10.1002/adtp.202500097

Carly J. Smith, Amanda R. Watkins, Abigail A. Lucas, Arianna J. Moniodes, Conn Ritchie, Thomas P. Thompson, Thomas P. Schaer, Brendan F. Gilmore, Noreen J. Hickok, Theresa A. Freeman

{"title":"Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair","authors":"Carly J. Smith, Amanda R. Watkins, Abigail A. Lucas, Arianna J. Moniodes, Conn Ritchie, Thomas P. Thompson, Thomas P. Schaer, Brendan F. Gilmore, Noreen J. Hickok, Theresa A. Freeman","doi":"10.1002/adtp.202500097","DOIUrl":"https://doi.org/10.1002/adtp.202500097","url":null,"abstract":"The FDA-approved Renuvion cold plasma device is currently used for dermal skin tightening procedures and subdermal tightening after liposuction. Anecdotally, patients report improved tissue healing outcomes following treatment. The most likely explanation for this is plasma-generated reactive species which are inflammatory but also activate cellular signaling pathways, stimulate antioxidant responses, and activate immune cells. In this study, we aimed to determine the immediate and long-term molecular effects of a single plasma treatment on surgically injured muscle and the soft tissue envelope. We used RNA sequencing, histology, and immunohistochemistry to determine changes to the tissue following treatment. Neutrophils and mast cells rapidly mobilize 6 h after treatment in conjunction with an upregulated cellular antioxidant response. Additionally, genes identified by RNAseq indicate upregulated pro-regenerative muscle-tissue-protective gene transcripts and downregulated apoptotic pathway transcripts in the muscle tissue 6 h after treatment. The histology and RNAseq results from 4- and 14-days post plasma treatment indicate that these early inflammatory and antioxidant events drive muscle regeneration to skew toward myogenic differentiation over adipogenesis. Thus, we conclude that a single plasma treatment results in an immediate inflammatory and antioxidant response that enhances long-term muscle fiber repair through reduced adipogenesis.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202500097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0