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Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation (Adv. Therap. 12/2024) 通过阻断自噬通量和抑制肿瘤增殖，将舍曲林重新用于结直肠癌的治疗（Adv.）
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470028
Leping He, Xijun Guo, Wanrong Wang, Weifeng Xu, Xiaoli Feng, Yuanfeng Fu, Yuxi Tian, Zongmao He, Sulan Luo, Jiaolin Bao, Ren-Bo Ding
{"title":"Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation (Adv. Therap. 12/2024)","authors":"Leping He,&nbsp;Xijun Guo,&nbsp;Wanrong Wang,&nbsp;Weifeng Xu,&nbsp;Xiaoli Feng,&nbsp;Yuanfeng Fu,&nbsp;Yuxi Tian,&nbsp;Zongmao He,&nbsp;Sulan Luo,&nbsp;Jiaolin Bao,&nbsp;Ren-Bo Ding","doi":"10.1002/adtp.202470028","DOIUrl":"https://doi.org/10.1002/adtp.202470028","url":null,"abstract":"<p>Autophagy facilitates the degradation and recycling of nonfunctional proteins and organelles in autolysosome, which contributes to tumor maintenance. Antidepressant sertraline was found to induce AMPK-mTOR signaling mediated autophagosome accumulation, but block autophagic flux at the stage of autolysosomal degradation, thus suppressing the colorectal cancer survival. The study reports the repurposing of sertraline as an anticancer drug through the mechanism of inhibiting autophagic flux. More details can be found in article 2400199 by Jiaolin Bao, Ren-Bo Ding and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information (Adv. Therap. 12/2024) 发行信息（Adv. Therap.）
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470029
{"title":"Issue Information (Adv. Therap. 12/2024)","authors":"","doi":"10.1002/adtp.202470029","DOIUrl":"https://doi.org/10.1002/adtp.202470029","url":null,"abstract":"","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast-Like Synoviocytes by Encapsulation in a Chitosan-Based Hydrogel (Adv. Therap. 12/2024)
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470027
Francesco Bisconti, Beatrice Vilardo, Gaia Corallo, Francesca Scalera, Giuseppe Gigli, Annalisa Chiocchetti, Alessandro Polini, Francesca Gervaso
{"title":"An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast-Like Synoviocytes by Encapsulation in a Chitosan-Based Hydrogel (Adv. Therap. 12/2024)","authors":"Francesco Bisconti,&nbsp;Beatrice Vilardo,&nbsp;Gaia Corallo,&nbsp;Francesca Scalera,&nbsp;Giuseppe Gigli,&nbsp;Annalisa Chiocchetti,&nbsp;Alessandro Polini,&nbsp;Francesca Gervaso","doi":"10.1002/adtp.202470027","DOIUrl":"https://doi.org/10.1002/adtp.202470027","url":null,"abstract":"<p>Rheumatoid arthritis (RA) is a complex autoimmune disorder with poorly understood mechanisms. In the article 2400166, Alessandro Polini, Francesca Gervaso, and co-workers introduce a chitosan-based hydrogel for 3D culture of fibroblast-like synoviocytes, offering new insights into RA. The cover image highlights the hydrogel's cellular structure. Cover designed by: Francesco Bisconti, Jacopo Tarantino, Francesca Gervaso, Alessandro Polini.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Challenges to Solution: The Evolving Landscape of Leprosy Management (Adv. Therap. 12/2024)
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470030
Lívia Maria Coelho de Carvalho Moreira, Antônia Carla de Jesus Oliveira, Luíse Lopes Chaves, Mônica Felts de La Rocca Soares, José Lamartine Soares-Sobrinho
{"title":"From Challenges to Solution: The Evolving Landscape of Leprosy Management (Adv. Therap. 12/2024)","authors":"Lívia Maria Coelho de Carvalho Moreira,&nbsp;Antônia Carla de Jesus Oliveira,&nbsp;Luíse Lopes Chaves,&nbsp;Mônica Felts de La Rocca Soares,&nbsp;José Lamartine Soares-Sobrinho","doi":"10.1002/adtp.202470030","DOIUrl":"https://doi.org/10.1002/adtp.202470030","url":null,"abstract":"<p><i>Mycobacterium leprae</i> infects macrophages and Schwann cells, causing leprosy. Current treatments, though effective, have many side effects. Developing safer therapies, such as drug delivery systems and advances in immunoprophylaxis, can improve efficacy and patient quality of life. More details can be found in article 2400249 by José Lamartine Soares-Sobrinho and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-11-12 DOI: 10.1002/adtp.202400159
Yongli Chen, Yanyan Zhang, Kaimin Zhang, Lihong Gu, Liang Dong, Ken Oakes, Xu Zhang
{"title":"Transdermal Delivery of Superoxide Dismutase Using Polymeric Microneedle Patches to Inhibit Skin Aging","authors":"Yongli Chen,&nbsp;Yanyan Zhang,&nbsp;Kaimin Zhang,&nbsp;Lihong Gu,&nbsp;Liang Dong,&nbsp;Ken Oakes,&nbsp;Xu Zhang","doi":"10.1002/adtp.202400159","DOIUrl":"https://doi.org/10.1002/adtp.202400159","url":null,"abstract":"<p>Skin aging is characterized by a deterioration of skin quality over time resulting from physiological changes and oxidative stress (OS). Superoxide dismutase (SOD) is an effective antioxidant enzyme widely used as a food supplement and cosmetic additive to alleviate OS and retard skin aging. However, conventional SOD delivery routes commonly yield unsatisfactory results due to limited stability, compromised bioavailability, and low absorption efficiency in the gastrointestinal (GI) tract. These issues are addressed by developing SOD-encapsulated polymeric microneedle (PMN) patches for efficient transdermal delivery. The use of a highly stable SOD isolated from a hot spring microbe ensures its reactivity throughout PMN fabrication and application. This SOD vehicle demonstrated excellent effectiveness through inhibiting skin-aging and promoting hair growth as validated by extensive in vivo experiments using D-galactose (D-gal) induced aging-mouse model. SOD-PMNs promoted excellent regeneration of hair follicles, increased melanin synthesis, decreased lipid oxidation, and elevated antioxidative capacity of skin tissue. The success in effective transdermal delivery of SOD promises wide applicability in pharmaceutical and cosmetic industries.</p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in Cancer Research: 3D Models, Single-Cell, and Live-Cell Techniques for Better Insights
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-11-09 DOI: 10.1002/adtp.202400351
Federica Carnevali, Stefania Forciniti, Valentina Onesto, Anna Chiara Siciliano, Helena Iuele, Giuliana Grasso, Anderson Fraga da Cruz, Ilaria Serra, Norma Depalma, Stefano D'Ugo, Prisco Piscitelli, Marcello G. Spampinato, Giuseppe Gigli, Carolina Camargo de Oliveira, Loretta L. del Mercato
{"title":"Advancements in Cancer Research: 3D Models, Single-Cell, and Live-Cell Techniques for Better Insights","authors":"Federica Carnevali,&nbsp;Stefania Forciniti,&nbsp;Valentina Onesto,&nbsp;Anna Chiara Siciliano,&nbsp;Helena Iuele,&nbsp;Giuliana Grasso,&nbsp;Anderson Fraga da Cruz,&nbsp;Ilaria Serra,&nbsp;Norma Depalma,&nbsp;Stefano D'Ugo,&nbsp;Prisco Piscitelli,&nbsp;Marcello G. Spampinato,&nbsp;Giuseppe Gigli,&nbsp;Carolina Camargo de Oliveira,&nbsp;Loretta L. del Mercato","doi":"10.1002/adtp.202400351","DOIUrl":"https://doi.org/10.1002/adtp.202400351","url":null,"abstract":"<p>The present review provides a comprehensive overview of the current state of in vitro cancer studies, focusing on recent advancements and ongoing in cell culture models and analyses techniques. Cancer cells grow in a complex and dynamic environment, interacting with various cellular components, such as stromal cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix (ECM). The ECM provides structural support and unique characteristics essential for tumorigenesis. Accurately modeling this intricate tumor microenvironment and precisely analyzing cell–cell and cell–ECM interactions are crucial for understanding cancer progression and therapeutic responses. Consequently, oncology research is advancing toward a) three-dimensional tumor models, b) single-cell level analyses, and c) live-cell analyses. This review aims to elucidate current knowledge in this field, emphasizing the benefits these innovative approaches offer over traditional two-dimensional models, bulk analyses, and endpoint measurements.</p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-Responsive Lipid Nanoparticles for Targeted Therapy and Controlled Drug Release in Non-Small Cell Lung Cancer
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-11-05 DOI: 10.1002/adtp.202400248
Min Woo Kim, Sol Moon, Yong Il Park, Jungho Kim, Seung Il Kim, Ruda Lee
{"title":"Ultrasound-Responsive Lipid Nanoparticles for Targeted Therapy and Controlled Drug Release in Non-Small Cell Lung Cancer","authors":"Min Woo Kim,&nbsp;Sol Moon,&nbsp;Yong Il Park,&nbsp;Jungho Kim,&nbsp;Seung Il Kim,&nbsp;Ruda Lee","doi":"10.1002/adtp.202400248","DOIUrl":"https://doi.org/10.1002/adtp.202400248","url":null,"abstract":"<p>Multifunctional drug delivery systems offer tremendous potential for improving antitumor efficacy, precise drug targeting, and controlled drug release in treating non-small cell lung cancer (NSCLC). In this study, the study develops a novel tumor-targeting ultrasound-responsive lipid nanoparticle (TUSL) platform capable of responding to external stimulation, enabling precise drug delivery with controlled release at the tumor site while minimizing systemic exposure and side effects. The TUSL platform is designed to carry doxorubicin (DOX) and tetrandrine (TET), specifically for drug-resistant NSCLC. The developed TUSL exhibits a nano sized spherical structure with a hydrodynamic size of 141.8 nm, accommodating anti-cancer drugs with loading capacities of 3.8% and 6.2% for TET and DOX, respectively. TUSL is engineered to target the epidermal growth factor receptor (EGFR) while demonstrating an ultrasound-triggered drug release profile. Through the generation of CO<sub>2</sub> bubbles upon ultrasound stimulation, the TUSL enhances DOX and TET internalization into tumor cells. In tumor-bearing mice, TUSL administration demonstrates a superior tumor accumulation with minimal off-target toxicity. The combined treatment with DOX and TET within TUSL exhibits synergistic effects, effectively inhibiting the growth of drug-resistant NSCLC tumors. These findings highlight the efficacy of the EGFR-targeted TUSL formulation in overcoming drug resistance and enhancing therapeutic outcomes in NSCLC.</p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploiting Spinach-Derived Extracellular Vesicles for Anti-Obesity Therapy Through Lipid Accumulation Inhibition (Adv. Therap. 11/2024) 利用菠菜提取的细胞外囊泡通过抑制脂质积累抗肥胖（Adv. Therap.）
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-11-05 DOI: 10.1002/adtp.202470024
Jeong Hyun Lee, Su Jin Kang, Won Jong Rhee
{"title":"Exploiting Spinach-Derived Extracellular Vesicles for Anti-Obesity Therapy Through Lipid Accumulation Inhibition (Adv. Therap. 11/2024)","authors":"Jeong Hyun Lee,&nbsp;Su Jin Kang,&nbsp;Won Jong Rhee","doi":"10.1002/adtp.202470024","DOIUrl":"https://doi.org/10.1002/adtp.202470024","url":null,"abstract":"<p>The spinach-derived extracellular vesicles (Spinex) isolated from spinach efficiently suppressed lipid accumulation during adipocyte differentiation. The anti-obesity properties of Spinex are also demonstrated in a high-fat diet-induced mouse model. The research highlights Spinex as a promising natural biomaterial for combating obesity. More details can be found in article 2400150 by Won Jong Rhee and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information (Adv. Therap. 19/2024) 发行信息（Adv. Therap.）
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-11-05 DOI: 10.1002/adtp.202470025
{"title":"Issue Information (Adv. Therap. 19/2024)","authors":"","doi":"10.1002/adtp.202470025","DOIUrl":"https://doi.org/10.1002/adtp.202470025","url":null,"abstract":"","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ex Vivo Modeling of the Tumor Microenvironment to Develop Therapeutic Strategies for Gliomas (Adv. Therap. 11/2024) 建立肿瘤微环境的体内外模型以开发胶质瘤的治疗策略（Adv.）
IF 3.7 4区 医学
Advanced Therapeutics Pub Date : 2024-11-05 DOI: 10.1002/adtp.202470026
Philipp Graber, M. Emmy M. Dolman, MoonSun Jung, Maria Kavallaris
{"title":"Ex Vivo Modeling of the Tumor Microenvironment to Develop Therapeutic Strategies for Gliomas (Adv. Therap. 11/2024)","authors":"Philipp Graber,&nbsp;M. Emmy M. Dolman,&nbsp;MoonSun Jung,&nbsp;Maria Kavallaris","doi":"10.1002/adtp.202470026","DOIUrl":"https://doi.org/10.1002/adtp.202470026","url":null,"abstract":"<p>The tumor microenvironment of gliomas is fundamental to developing new therapeutic strategies. In article 2300442, Maria Kavallaris and co-workers explore the tumor environment of gliomas, focusing on the extracellular environment. The authors review 3D culture models as a tool to replicate this environment, providing valuable insights for therapeutic advancements. Cover image created with BioRender.com.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202470026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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