Advanced Therapeutics最新文献

Efficacy and Safety of The Albumin-Bound Paclitaxel Combined with Anti-PD-1 Antibody in Pancreatic Ductal Adenocarcinoma (Adv. Therap. 9/2025) 白蛋白结合紫杉醇联合抗pd -1抗体治疗胰管腺癌的疗效和安全性（Adv. Therap. 9/2025）

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-09-18 DOI: 10.1002/adtp.70054

Wenjing Hao, Yunxia Wang, Jun Zhang, Weimin Cai

引用次数: 0

Issue Information (Adv. Therap. 9/2025) 发布信息（第9/2025号公告）

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-09-18 DOI: 10.1002/adtp.70052

引用次数: 0

Issue Information (Adv. Therap. 8/2025) 发布信息（ad . Therap. 8/2025）

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-08-13 DOI: 10.1002/adtp.70039

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Cytokine Engineering Approaches for Regenerative Medicine 再生医学中的细胞因子工程方法

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-08-11 DOI: 10.1002/adtp.202500103

Shiyi Li, Wenhao You, Mikaël M. Martino

{"title":"Cytokine Engineering Approaches for Regenerative Medicine","authors":"Shiyi Li, Wenhao You, Mikaël M. Martino","doi":"10.1002/adtp.202500103","DOIUrl":"10.1002/adtp.202500103","url":null,"abstract":"Cytokines are central in orchestrating immune responses during tissue repair and regeneration, making them attractive candidates for regenerative medicine. However, their pleiotropic effects, short half-life, and poor biodistribution have limited their clinical translation. Advances in protein engineering have enabled the design of modified cytokines with enhanced stability, receptor selectivity, and tissue-targeting capabilities, offering new therapeutic opportunities for modulating immune activity and promoting tissue healing. Many of these engineering approaches have been pioneered in cancer immunotherapy, where cytokines are often designed to sustain inflammation and enhance cytotoxic immune responses. In contrast, regenerative medicine usually requires immune resolution, necessitating a distinct and sometimes opposite application of cytokine engineering strategies. This review explores the latest advancements in cytokine engineering for regenerative applications, focusing on strategies to enhance cytokine stability, modulate receptor affinity, improve targeting, and regulate endogenous cytokine signaling. Numerous approaches, highlighting how targeted immune modulation can enhance tissue healing while minimizing fibrosis and chronic inflammation, are discussed. These advances hold great promise for treating chronic wounds, fibrotic diseases, and tissue injuries with limited regenerative capacity, paving the way for precise, effective, and clinically translatable cytokine therapeutics. By adapting principles from cancer immunotherapy, cytokine-based therapies could transform regenerative medicine.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202500103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of The Albumin-Bound Paclitaxel Combined with Anti-PD-1 Antibody in Pancreatic Ductal Adenocarcinoma 白蛋白结合紫杉醇联合抗pd -1抗体治疗胰管腺癌的疗效和安全性

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-08-08 DOI: 10.1002/adtp.202500075

Wenjing Hao, Yunxia Wang, Jun Zhang, Weimin Cai

{"title":"Efficacy and Safety of The Albumin-Bound Paclitaxel Combined with Anti-PD-1 Antibody in Pancreatic Ductal Adenocarcinoma","authors":"Wenjing Hao, Yunxia Wang, Jun Zhang, Weimin Cai","doi":"10.1002/adtp.202500075","DOIUrl":"10.1002/adtp.202500075","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited response to chemotherapy and immune checkpoint inhibitors (ICIs). This study evaluates the efficacy and safety of combining Albumin-Bound Paclitaxel (nab-PTX) with an anti-PD-1 antibody and aims to identify potential biomarkers to optimize therapeutic outcomes. The murine model of PDAC is established by subcutaneously injecting the murine pancreatic cancer cell line Panc02 into C57BL/6J mice. The mice are treated with either an anti-PD-1 antibody, nab-PTX, or nab-PTX plus anti-PD-1 antibody, with untreated mice serving as the control. Tumor growth, immune cell infiltration, cytokine levels, overall survival, organ damage, and gene expression profiles are analyzed. The combination therapy shows superior efficacy compared to nab-PTX and non-inferior efficacy compared to the anti-PD-1 antibody. Moreover, this strategy significantly reduces the risk of irAEs and hyperprogression caused by the anti-PD-1 antibody. In addition, screening identifies WNT9a as a potential gene associated with improved efficacy and ATF3 with enhanced safety, providing valuable insights for optimizing therapeutic strategies in PDAC.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancement of Photobiomodulation Therapy Using 680 and 850 nm Light-Emitting Diodes for the Differentiation of Human Brain Endothelial Cells 680 nm和850 nm发光二极管光生物调节治疗人脑内皮细胞分化的研究进展

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-08-08 DOI: 10.1002/adtp.202500164

Hossein Chamkouri, Lei Chen

{"title":"Advancement of Photobiomodulation Therapy Using 680 and 850 nm Light-Emitting Diodes for the Differentiation of Human Brain Endothelial Cells","authors":"Hossein Chamkouri, Lei Chen","doi":"10.1002/adtp.202500164","DOIUrl":"10.1002/adtp.202500164","url":null,"abstract":"Photobiomodulation (PBM) has emerged as a promising therapeutic approach for modulating cellular behavior and improving health outcomes, particularly in the context of vascular health. Despite growing interest in PBM, a key gap exists in understanding how specific wavelengths, such as 680 and 850 nm, affect endothelial cell function. While light's general effects on cell viability and mitochondrial function are known, the precise mechanisms underlying PBM's influence on endothelial cells remain unclear, limiting the optimization of PBM protocols for vascular dysfunction. In this study, the effects of PBM on endothelial cells are investigated using the light peaked at 680 and 850 nm with full width at half maximum (FWHM) about 17.5 and 25.1 nm, respectively, assessing cell viability, mitochondrial activity, reactive oxygen species (ROS) production, calcium flux (Ca2+), and transepithelial electrical resistance (TEER). These findings demonstrate that PBM exposure enhances mitochondrial function, reduces oxidative stress, and modulates calcium signaling, all of which contribute to changes in endothelial barrier integrity. These results highlight the potential of PBM as a novel therapeutic strategy for enhancing endothelial cell function and addressing endothelial dysfunction, opening new avenues for future research and clinical applications in vascular health.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FeS2/WS2 Heterostructure: A Promising Candidate for Mild-Temperature Photothermal Therapy with Enhanced Photodynamic Effect and Antibacterial Activity FeS2/WS2异质结构：具有增强光动力效应和抗菌活性的温和光热治疗候选材料

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-25 DOI: 10.1002/adtp.202500119

Abdurrahman Mustafa, Ahmed AlSarori, Hasan Akyıldız, Ismail Cihan Kaya, Gulcihan Guzel Kaya

{"title":"FeS2/WS2 Heterostructure: A Promising Candidate for Mild-Temperature Photothermal Therapy with Enhanced Photodynamic Effect and Antibacterial Activity","authors":"Abdurrahman Mustafa, Ahmed AlSarori, Hasan Akyıldız, Ismail Cihan Kaya, Gulcihan Guzel Kaya","doi":"10.1002/adtp.202500119","DOIUrl":"10.1002/adtp.202500119","url":null,"abstract":"FeS2, a member of metal chalcogenide semiconductors, is a cheap and available material with distinguishable photothermal activity under light irradiation. However, its photodynamic properties have to be improved for practical phototherapy applications. Therefore, in this study, FeS2/WS2 p-n junctions, comprising varying amounts of WS2, are synthesized using the simple hot injection method. Establishment of the heterostructure is verified using X-ray diffraction (XRD), scanning transmission electron microscopy (STEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS) analysis. p-n junction formation is further validated via calculations based on ultraviolet-visible (UV–vis.) spectrophotometer and XPS data. Photothermal and photodynamic properties of the samples are examined considering various aspects. The FeS2/WS2 heterostructure provides a heating response above 50 °C with a high photothermal conversion efficiency of 52.6%. The reactive oxygen species (ROS) formation ability is observed to depend on the material concentration and O2•‾ is determined as the primary reactive oxygen species. The in vitro antibacterial activity of the samples is tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria as a function of material concentration. At all concentrations, the FeS2/WS2 heterostructure exhibits higher activity than that of FeS2 nanoparticles. The efficiency of the sample against S. aureus and E. coli is calculated to be 100% and 99.4% respectively, at a low material concentration of 100 µg mL−1.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding miR-200c: an Important Player in Resistance to Cancer Treatment 了解miR-200c在癌症治疗耐药中的重要作用

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-23 DOI: 10.1002/adtp.202500238

Fatma Sanli, Omer Faruk Karatas

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Evolution of Ocular Organ-On-Chip Systems for Disease Modelling and Drug Testing: Where are We Now? 用于疾病建模和药物测试的眼部器官芯片系统的进化：我们现在在哪里？

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-21 DOI: 10.1002/adtp.202500200

Sara Trujillo

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Gas-Molecule-Mediated Radiosensitization in Cancer Therapy 肿瘤治疗中气体分子介导的放射增敏

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-21 DOI: 10.1002/adtp.202500062

Yu Jin, Zuotao Zhou, Siyuan Luo, Jiahui Sheng, Zhiqiang Shen, Jinming Hu

{"title":"Gas-Molecule-Mediated Radiosensitization in Cancer Therapy","authors":"Yu Jin, Zuotao Zhou, Siyuan Luo, Jiahui Sheng, Zhiqiang Shen, Jinming Hu","doi":"10.1002/adtp.202500062","DOIUrl":"10.1002/adtp.202500062","url":null,"abstract":"Radiotherapy (RT) is one of the widely used cancer treatments, but its efficacy can be limited by the hypoxic tumor microenvironment (TME), which reduces reactive oxygen species (ROS) generation and promotes radioresistance. Recent studies suggest that gas small molecule-mediated sensitization may be a promising strategy for enhancing radiosensitivity. Therapeutic gas small molecules, including nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), ozone (O3), hydrogen (H2), and sulfur dioxide (SO2), have demonstrated potential in regulating the TME. These gas small molecules have been shown to improve tumor oxygenation, promote ROS generation, induce DNA damage, and modulate immune responses, which may contribute to enhanced RT outcomes. This review summarizes the latest progress in gas small molecule-mediated radiosensitization strategies, focusing on the release mechanisms, therapeutic platforms, and potential clinical applications. Additionally, current challenges and future directions in this field are discussed, aiming to provide insights into optimizing the gas small molecule-mediated radiosensitization strategy.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0