Advanced Therapeutics最新文献

Exploiting Spinach-Derived Extracellular Vesicles for Anti-Obesity Therapy Through Lipid Accumulation Inhibition (Adv. Therap. 11/2024) 利用菠菜提取的细胞外囊泡通过抑制脂质积累抗肥胖（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-11-05 DOI: 10.1002/adtp.202470024

Jeong Hyun Lee, Su Jin Kang, Won Jong Rhee

引用次数: 0

Issue Information (Adv. Therap. 19/2024) 发行信息（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-11-05 DOI: 10.1002/adtp.202470025

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Ex Vivo Modeling of the Tumor Microenvironment to Develop Therapeutic Strategies for Gliomas (Adv. Therap. 11/2024) 建立肿瘤微环境的体内外模型以开发胶质瘤的治疗策略（Adv.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-11-05 DOI: 10.1002/adtp.202470026

Philipp Graber, M. Emmy M. Dolman, MoonSun Jung, Maria Kavallaris

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Albumin-Loaded Silica Nanomaterials Functionalized with Organotin(IV) Agents: Theranostic Materials Against Triple-Negative Breast Cancer (Adv. Therap. 10/2024) 用有机锡（IV）制剂功能化的白蛋白负载二氧化硅纳米材料：针对三阴性乳腺癌的治疗材料（Adv.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-10-13 DOI: 10.1002/adtp.202470021

Victoria García-Almodóvar, Karina Ovejero-Paredes, Diana Díaz-García, José M. Méndez-Arriaga, Sanjiv Prashar, Marco Filice, Santiago Gómez-Ruiz

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Urine Liquid Biopsies via Highly Integrated Digital PCR System for Accurate Detection of Bladder Cancer (Adv. Therap. 10/2024) 通过高度集成的数字 PCR 系统进行尿液液体活检以准确检测膀胱癌（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-10-13 DOI: 10.1002/adtp.202470020

Yue Zhang, Ming Xu, Zhihong Wu, Fan Yang, Lu Zhang, Yiquan Liu, Jiahao Lv, Shuyue Xiang, Beiyuan Fan, Zijian Zhao, Yanzhao Li, Yang Yu

引用次数: 0

Issue Information (Adv. Therap. 10/2024) 发行信息（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-10-13 DOI: 10.1002/adtp.202470022

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In Vivo Combined Photoacoustic Imaging and Photothermal Treatment of HPV-Negative Head and Neck Carcinoma with NIR-Responsive Non-Persistent Plasmon Nano-Architectures (Adv. Therap. 10/2024) 利用近红外响应性非持久性等离子体纳米结构对HPV阴性头颈癌进行体内光声成像和光热治疗（Adv.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-10-13 DOI: 10.1002/adtp.202470023

Valentina Frusca, Chiara Cavallini, Agata Zamborlin, Giuliana Drava, Virginia Barone, Lisa Gherardini, Mario Chiariello, Paolo Armanetti, Maria Laura Ermini, Luca Menichetti, Valerio Voliani

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Unlocking the Potential of Chemically Modified Nucleic Acid Therapeutics 释放化学修饰核酸疗法的潜力

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-10-11 DOI: 10.1002/adtp.202400231

Jingjing Gao, Bhingaradiya Nutan, Dorra Gargouri, Nishkal D. Pisal, Vy Do, Muhammad Zubair, Hommam Alanzi, Hiqui Wang, Dongtak Lee, Nitin Joshi, Aman Ullah

{"title":"Unlocking the Potential of Chemically Modified Nucleic Acid Therapeutics","authors":"Jingjing Gao, Bhingaradiya Nutan, Dorra Gargouri, Nishkal D. Pisal, Vy Do, Muhammad Zubair, Hommam Alanzi, Hiqui Wang, Dongtak Lee, Nitin Joshi, Aman Ullah","doi":"10.1002/adtp.202400231","DOIUrl":"https://doi.org/10.1002/adtp.202400231","url":null,"abstract":"Nucleic acid therapeutics have demonstrated tremendous potential for treating diseases by targeting the genetic underpinnings at the transcriptomic level. However, their efficacy hinges on robust strategies to protect nucleic acids from degradation during circulation and to facilitate precise delivery to diseased tissues and cells. Here the critical roles of chemical modification and bioconjugation in advancing nucleic acid therapeutics for improved binding affinity, enhanced stability, and targeted delivery are reviewed. Commencing diverse applications, the significance of different chemical modifications is discussed based on recent literature and clinical products, on oligonucleotides. These modifications encompass backbone, ribose, base alterations and bioconjugation techniques such as N-acetylgalactosamine (GAlNac), aptamers, antibodies, and cell-penetrating peptides (CPPs). Supported by a clinical perspective, diverse applications and ongoing developments are highlighted. Furthermore, the current landscape of nucleic acid therapeutics and their potential in addressing genetic disorders with multiple cellular/organelle targeting is discussed. Here the promising prospect of combining chemical innovation and bioconjugation strategies is underscored to propel the development of more effective nucleic acid therapeutics.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infrared Light Activated Highly Efficient Cell Therapy Using Flower-Shaped Microstructure Device 使用花形微结构装置的红外光激活高效细胞疗法

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-10-11 DOI: 10.1002/adtp.202400046

Ashwini Surendra Shinde, Pallavi Shinde, Moeto Nagai, Srabani Kar, Tuhin Subhra Santra

{"title":"Infrared Light Activated Highly Efficient Cell Therapy Using Flower-Shaped Microstructure Device","authors":"Ashwini Surendra Shinde, Pallavi Shinde, Moeto Nagai, Srabani Kar, Tuhin Subhra Santra","doi":"10.1002/adtp.202400046","DOIUrl":"https://doi.org/10.1002/adtp.202400046","url":null,"abstract":"In this pioneering study, an infrared light-activated highly efficient and uniform, small to large biomolecular delivery into various cell types is developed using a flower-shaped microstructure device (FMD). Featuring a unique structural design, this FMD consists of 8 µm in length, with edges of ≈3 and 20 µm gaps between FMD microstructure. When subjected to IR laser exposure at 1050 nm, the FMD triggers the generation of photothermal cavitation bubbles, exerting jet fluid flow on the cell's plasma membrane surface, and facilitating biomolecule delivery into cells. The platform achieves efficient intracellular delivery spanning various biomolecules — from low-molecular-weight propidium iodide dye to higher molecular weight siRNA, plasmid, and enzymes — across human cervical (SiHa), mouse fibroblast (L929), and neural crest-derived (N2a) cancer cells, ensuring consistently high efficiency without compromising cell viability. 95% delivery efficacy and 96% cell viability are achieved for smaller molecules like PI dye in L929 cells. For larger biomolecules such as enzymes, transfection efficiency reached 82%, and cell viability is nearly 90% in SiHa cells. This is confirmed via confocal microscopy and flow cytometry, the FMD-based delivery system holds broad potential for cellular diagnostics and therapeutics, promising significant advancements in cellular research and biomedical treatments.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Spheroids to Bioprinting: A Literature Review on Biomanufacturing Strategies of 3D In Vitro Osteosarcoma Models 从球到生物打印：三维体外骨肉瘤模型生物制造策略文献综述

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-10-10 DOI: 10.1002/adtp.202400047

Margarida F. Domingues, João C. Silva, Paola Sanjuan-Alberte

{"title":"From Spheroids to Bioprinting: A Literature Review on Biomanufacturing Strategies of 3D In Vitro Osteosarcoma Models","authors":"Margarida F. Domingues, João C. Silva, Paola Sanjuan-Alberte","doi":"10.1002/adtp.202400047","DOIUrl":"https://doi.org/10.1002/adtp.202400047","url":null,"abstract":"Osteosarcoma (OS) is a rare primary malignant bone cancer affecting mainly young individuals. Treatment typically consists of chemotherapy and surgical tumor resection, which has undergone few improvements since the 1970s. This therapeutic approach encounters several limitations attributed to the tumor's inherent chemoresistance, marked heterogeneity and metastatic potential. Therefore, the development of in vitro platforms that closely mimic the OS pathophysiology is crucial to understand tumor progression and discover effective anticancer therapeutics. Contrary to 2D monolayer cultures and animal models, 3D in vitro platforms show promise in replicating the 3D tumor macrostructure, cell-cell and cell-extracellular matrix interactions. This review provides an overview of the biomanufacturing strategies employed in developing 3D in vitro OS models, highlighting their role in replicating different aspects of OS and improving OS anticancer research and drug screening. A variety of 3D in vitro models are explored, including both scaffold-free and scaffold-based models, encompassing cell spheroids, hydrogels, and innovative approaches like electrospun nanofibers, microfluidic devices and bioprinted constructs. By examining the distinctive features of each model type, this review offers insights into their potential transformative impact on the landscape of OS research and therapeutic innovation, addressing the challenges and future directions of 3D in vitro OS modeling.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0