Advanced Therapeutics最新文献

Controlled Drug Release Systems for Cerebrovascular Diseases (Adv. Therap. 1/2025)

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-01-13 DOI: 10.1002/adtp.202570001

Celia Martín-Morales, Sofia Caspani, Manuel Desco, Célia Tavares de Sousa, María Victoria Gómez-Gaviro

引用次数: 0

Hybrid Nanoparticles Dual-Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo (Adv. Therap. 1/2025)

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-01-13 DOI: 10.1002/adtp.202570003

Gabriela C. Carvalho, Maria Nolasco Viseu Domingues, Gabriel Davi Marena, Ermei Mäkilä, Jiachen Li, Gésinda Geertsema-Doornbusch, Cleverton Roberto de Andrade, Marc C. A. Stuart, Mohammad-Ali Shahbazi, Ione Corrêa, Brandon W. Peterson, Jarno Salonen, Helena F. Florindo, Taís Maria Bauab, Marlus Chorilli, Hélder A. Santos

引用次数: 0

Issue Information (Adv. Therap. 1/2025)

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-01-13 DOI: 10.1002/adtp.202570002

引用次数: 0

Does Encapsulation of π-Conjugated Polymer Nanoparticles within Biodegradable PEG–PLGA Matrices Mitigate Photoinduced Free Radical Production and Phototoxicity?

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-23 DOI: 10.1002/adtp.202400190

Paola Modicano, Marie-Luise Trutschel, Thüong Phan-Xuan, Bruno F. E. Matarèse, Laura Urbano, Mark Green, Karsten Mäder, Lea Ann Dailey

{"title":"Does Encapsulation of π-Conjugated Polymer Nanoparticles within Biodegradable PEG–PLGA Matrices Mitigate Photoinduced Free Radical Production and Phototoxicity?","authors":"Paola Modicano, Marie-Luise Trutschel, Thüong Phan-Xuan, Bruno F. E. Matarèse, Laura Urbano, Mark Green, Karsten Mäder, Lea Ann Dailey","doi":"10.1002/adtp.202400190","DOIUrl":"https://doi.org/10.1002/adtp.202400190","url":null,"abstract":"Lipophilic π-conjugated polymers (CPs) encapsulated within self-assembling diblock copolymer poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG–PLGA) nanoparticles, are interesting candidates for photodynamic and photothermal therapies. Upon irradiation, CPs generate reactive oxygen species (ROS), which may either cause local phototoxicity or could be exploited for photodynamic therapy. The propensity of the PEG–PLGA matrix to scavenge ROS has never been investigated. Here the ability of two PEG–PLGA structures (PEG2 kDa–PLGA4.5 kDa vs PEG5 kDa–PLGA55 kDa) to mitigate the release of ROS generated by four different CPs (PFO, F8BT, CN-PPV, and PCPDTBT) following irradiation (5 J cm−2) at 385, 455, and 656 nm is studied. The molar content of the PEG–PLGA matrix, rather than the molecular weight or composition, appeared to be the most influential factor, i.e., lower molar concentrations of the matrix polymer are associated with significant increases in phototoxicity. Multivariate analysis reveals that the combination of CP photophysical properties and nanoparticle matrix properties are important for understanding CP nanoparticle-induced phototoxicity.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Acellular Platform to Drive Urinary Bladder Tissue Regeneration 驱动膀胱组织再生的脱细胞平台。

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-20 DOI: 10.1002/adtp.202400158

Mitali Kini, Matthew I. Bury, Arun K. Sharma

{"title":"An Acellular Platform to Drive Urinary Bladder Tissue Regeneration","authors":"Mitali Kini, Matthew I. Bury, Arun K. Sharma","doi":"10.1002/adtp.202400158","DOIUrl":"10.1002/adtp.202400158","url":null,"abstract":"Impaired bladder compliance secondary to congenital or acquired bladder dysfunction can lead to irreversible kidney damage. This is managed with surgical augmentation utilizing intestinal tissue, which can cause stone formation, infections, and malignant transformation. Co-seeded bone marrow mesenchymal stem cell (MSC)/CD34+ hematopoietic stem cell (HSPC) scaffolds (PRS) have been successful in regenerating bladder tissue. However, the acquisition of viable cells is challenging in the clinical setting. Here, the regenerative capacity of human MSC/CD34+ co-cultured total condition media (TCM) is compared to media alone in immune-competent rats augmented with PRS following partial cystectomy. Augmented bladders are instilled with media (control, n = 4) or TCM (n = 5) twice a week for 4 weeks. Regenerated tissue is analyzed for smooth muscle, urothelium, vascular, and peripheral nerve regrowth. Urodynamic (UDS) measures are performed pre- and 4 weeks post-augmentation. The results demonstrate that TCM-instilled grafts have greater muscle content, larger average urothelial widths, higher percent vascularization, and more robust neural infiltration post-augmentation. UDS demonstrates greater percent bladder recovery in the TCM group, indicating functional improvement in bladder storage capacity. This study is the first to propose the use of cell-free TCM as an alternative to traditional cell-seeded scaffolds to promote bladder tissue regeneration.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation (Adv. Therap. 12/2024) 通过阻断自噬通量和抑制肿瘤增殖，将舍曲林重新用于结直肠癌的治疗（Adv.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470028

Leping He, Xijun Guo, Wanrong Wang, Weifeng Xu, Xiaoli Feng, Yuanfeng Fu, Yuxi Tian, Zongmao He, Sulan Luo, Jiaolin Bao, Ren-Bo Ding

引用次数: 0

Issue Information (Adv. Therap. 12/2024) 发行信息（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470029

引用次数: 0

An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast-Like Synoviocytes by Encapsulation in a Chitosan-Based Hydrogel (Adv. Therap. 12/2024) 辅助关节炎研究：壳聚糖水凝胶包封人类成纤维细胞样滑膜细胞的3D细胞培养（Adv. Therap. 12/2024）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470027

Francesco Bisconti, Beatrice Vilardo, Gaia Corallo, Francesca Scalera, Giuseppe Gigli, Annalisa Chiocchetti, Alessandro Polini, Francesca Gervaso

引用次数: 0

From Challenges to Solution: The Evolving Landscape of Leprosy Management (Adv. Therap. 12/2024) 从挑战到解决方案：麻风病管理的演变景观（Adv. Therap. 12/2024）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470030

Lívia Maria Coelho de Carvalho Moreira, Antônia Carla de Jesus Oliveira, Luíse Lopes Chaves, Mônica Felts de La Rocca Soares, José Lamartine Soares-Sobrinho

引用次数: 0

Stable Biotherapeutic Penetration Screening in Critically Small Colorectal Metastatic Cancer Biopsies Allows for Oncolytic Virus-Delivered Chemotherapeutic Response Assessment through 3D Bioprinted Organoid Expansion

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-04 DOI: 10.1002/adtp.202400221

Colin McGuckin, Nico Forraz, Clément Milet, Mathieu Lacroix, Yordan Sbirkov, Victoria Sarafian, Caroline Ebel, Anita Spindler, Véronique Koerper, Eric Quéméneur, Jean-Marc Balloul, Philippe Erbs

{"title":"Stable Biotherapeutic Penetration Screening in Critically Small Colorectal Metastatic Cancer Biopsies Allows for Oncolytic Virus-Delivered Chemotherapeutic Response Assessment through 3D Bioprinted Organoid Expansion","authors":"Colin McGuckin, Nico Forraz, Clément Milet, Mathieu Lacroix, Yordan Sbirkov, Victoria Sarafian, Caroline Ebel, Anita Spindler, Véronique Koerper, Eric Quéméneur, Jean-Marc Balloul, Philippe Erbs","doi":"10.1002/adtp.202400221","DOIUrl":"https://doi.org/10.1002/adtp.202400221","url":null,"abstract":"Oncolytic viral-delivered chemotherapeutics have exciting potential for metastatic cancer therapies, including colorectal cancer, but require advanced screening systems for better patient prediction. We optimized primary metastatic colorectal tumor processing and 3D (3-dimensional) bioprinted tumors to prove efficacy as long-term screening systems. Normally, this time period would use animals, but we show it is possible to gain useful data in vitro before preclinical stages, to reduce animal modeling and give better clinical trial predictions. Liver tumors were collected from 12 colorectal cancer patients, evaluated for expansion, 3D bioprinted, and tested for ability to create long-term organoid models with screening of oncolytic viral-loaded FCU1 enzyme conversion of 5-fluorocytosine (5-FC) into the highly toxic 5-fluorouracil (5-FU). Donated tumor size was the limiting factor. 75% of patients could be used for screening of viral delivery. Response between patients was overall positive, with good secondary tumor development, outer active cellular content and inner necrotic core. Oncolytic challenge shows good screening potential and cellular targeting, demonstrating an added bystander effect, optimizing the low-dose. Stable long-term metastatic organoid models were made, lasting many months, with potential for retesting rather than one-off analysis. Oncolytic virus-delivered chemotherapy is promising and warrants further investigation for metastatic colorectal cancers.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0