Mimicking Biochemical Traits with a Synthetic Lipid Nanoparticles SARS-COV-2 Model (Adv. Therap. 6/2025)

IF 3.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Advanced Therapeutics Pub Date : 2025-06-18 DOI:10.1002/adtp.202570013

Ignasia Handipta Mahardika, Hyun Park, Eunjin Huh, Changyoon Baek, Shin-Gyu Cho, Kwang-Hwan Jung, Junhong Min, Kwanwoo Shin

引用次数: 0

Abstract

In article 2400401, Junhong Min, Kwanwoo Shin, and co-workers present a synthetic lipid nanoparticle (LNP) virus model that mimics SARS-CoV-2 by encapsulating mRNA and nucleocapsid (N) protein, with spike (S) protein on its surface. This model replicates the virus's key biochemical traits, offering a safe, scalable platform for evaluating diagnostic tools through RT-qPCR and commercial rapid antigen kits.

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利用合成脂质纳米颗粒模拟SARS-COV-2模型的生化特性（Adv. Therap. 6/2025）

在文章2400401中，Junhong Min， Kwanwoo Shin等人提出了一种合成脂质纳米颗粒（LNP）病毒模型，该模型通过包裹mRNA和核衣壳(N)蛋白，并在其表面包裹刺突(S)蛋白来模拟SARS-CoV-2。该模型复制了病毒的关键生化特征，为通过RT-qPCR和商用快速抗原试剂盒评估诊断工具提供了一个安全、可扩展的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.10

自引率

2.20%

发文量

130