Advanced Therapeutics最新文献_第10页

Silk Fibroin-Based Nanoparticles Blended Fluoridated Hydrogel with Photodynamic Antibacterial for Infected Wound Healing 基于蚕丝纤维素的纳米粒子混合氟化水凝胶与光动力抗菌剂，用于感染性伤口愈合

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-16 DOI: 10.1002/adtp.202400151

Zehan Liu, Shengjie Liu, Ming Zhang, Lei Zhu, LiBo Zhou, Bonan Hao, Guanqing Zhou, Cheng Wang, Chenhui Zhu, Zhengshang Ruan, Hong Chen, Feng Liu, Yongming Zhang

{"title":"Silk Fibroin-Based Nanoparticles Blended Fluoridated Hydrogel with Photodynamic Antibacterial for Infected Wound Healing","authors":"Zehan Liu, Shengjie Liu, Ming Zhang, Lei Zhu, LiBo Zhou, Bonan Hao, Guanqing Zhou, Cheng Wang, Chenhui Zhu, Zhengshang Ruan, Hong Chen, Feng Liu, Yongming Zhang","doi":"10.1002/adtp.202400151","DOIUrl":"10.1002/adtp.202400151","url":null,"abstract":"Traditional approaches for treating wound infections often involve the use of chitosan or hyaluronic acid as carriers for antibacterial agents. In contrast, an innovative method is devised for wound infection management that synergizes photodynamic therapy (PDT) with novel functional matrix materials. This new strategy offers multiple benefits, such as reduced secondary damage to the wound area, a multifaceted antibacterial mechanism, and enhanced moisturization and biocompatibility. The method employs a novel organic semiconductor nanoparticle (OSN) capable of mediating PDT, which is integrated with silk fibroin (SF), perfluorosulfonic acid (PFSA), and agar. Silk fibroin is demonstrated to effectively induce macrophage aggregation, while PDT can further activate these immune cells. The inclusion of PFSA bestows the hydrogel with moisturizing and porous characteristics. Both in vivo and in vitro antibacterial assays confirm the efficacy of PDT in eliminating bacteria, and mouse wound infection model studies show that the hydrogels significantly enhance wound healing and hair follicle regeneration. This novel hydrogel dressing holds promise as an advanced wound care solution, with substantial potential for promoting hair follicle regeneration and providing effective sterilization.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ex Vivo Modeling of the Tumor Microenvironment to Develop Therapeutic Strategies for Gliomas 建立肿瘤微环境体内外模型以开发胶质瘤治疗策略

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-16 DOI: 10.1002/adtp.202300442

Philipp Graber, M. Emmy M. Dolman, MoonSun Jung, Maria Kavallaris

引用次数: 0

Alginate-Coated Silicone Implants with Antisolvent-Crystallized Paclitaxel to Prevent Breast Cancer Recurrence and Reduce Fibrosis (Adv. Therap. 6/2024) 藻酸盐包裹的硅胶植入体与抗溶剂结晶紫杉醇可预防乳腺癌复发并减少纤维化（Adv. Therap.）

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-06-10 DOI: 10.1002/adtp.202470011

Noehyun Myung, Seoyoung Hwang, Won Ha, Hyun-Wook Kang

引用次数: 0

Issue Information (Adv. Therap. 6/2024) 发行信息（Adv. Therap.）

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-06-10 DOI: 10.1002/adtp.202470012

引用次数: 0

The Implication and Application of Brain Glymphatic System in Multiple Diseases 脑回流系统在多种疾病中的意义和应用

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-08 DOI: 10.1002/adtp.202400088

Yufan Du, Chenxing Yan, Yazhen Wang, Yanyan Xu, Xingli Cun, Huile Gao

{"title":"The Implication and Application of Brain Glymphatic System in Multiple Diseases","authors":"Yufan Du, Chenxing Yan, Yazhen Wang, Yanyan Xu, Xingli Cun, Huile Gao","doi":"10.1002/adtp.202400088","DOIUrl":"10.1002/adtp.202400088","url":null,"abstract":"The glymphatic system within the central nervous system (CNS) facilitates the exchange and elimination of cerebrospinal fluid (CSF) and interstitial fluid (ISF), aiding in the removal of potentially poisonous metabolic wastes to maintain brain stability. Sleep and Aquaporin-4 (AQP-4) expression positively regulate the glymphatic system. When sleep is disturbed and AQP-4 polarization is inhibited, the glymphatic system is impaired, leading to the inability to effectively eliminate soluble wastes from the brain. This disruption can potentially contribute to, or accelerate, the progression of various CNS diseases, such as Alzheimer's disease and Parkinson's disease, as well as non-CNS diseases, like diabetes mellitus and hypertension. Therefore, the normal functioning of the glymphatic system is essential for the recovery from both CNS diseases and non-CNS diseases. In this review, an overview of the constituents and functions of the glymphatic system in the brain, specifically highlighting the glymphatic system lesions in different diseases is provided. Additionally, currently unresolved questions pertaining to this topic are summarized. Ultimately, the cerebral glymphatic system is expected to be a novel and promising target for the diagnosis and treatment of multiple diseases.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorinated Chitosan-Mediated Transepithelial Delivery of Intravesical Dual-Drug Immunotherapeutic for Bladder Cancer Therapy 氟化壳聚糖介导的膀胱癌膀胱内双药免疫疗法的跨上皮传递

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-07 DOI: 10.1002/adtp.202400084

Lida Feng, Guixiao Huang, Qifang Lei, Mingkang Liang, Dashi Deng, Xiaocen Liu, Chenfan Kong, Chenchen Li, Xiyang Tan, Guangzhi Li, Song Wu

{"title":"Fluorinated Chitosan-Mediated Transepithelial Delivery of Intravesical Dual-Drug Immunotherapeutic for Bladder Cancer Therapy","authors":"Lida Feng, Guixiao Huang, Qifang Lei, Mingkang Liang, Dashi Deng, Xiaocen Liu, Chenfan Kong, Chenchen Li, Xiyang Tan, Guangzhi Li, Song Wu","doi":"10.1002/adtp.202400084","DOIUrl":"10.1002/adtp.202400084","url":null,"abstract":"Intravesical instillation-based immunotherapy for bladder-preservation of bladder cancer (BCa) treatment has not been explored. In the current study, two irrigated nano-formulations of immunological adjuvant-fluorinated chitosan (FCS) and therapeutic antibody-FCS are developed for synergistic immunotherapy against BCa. In this system, FCS is employed as a transepithelial carrier to assemble with bovine serum albumin (BSA)-flubendazole (FBZ) complex and anti-PD-1 (αPD-1) respectively, to facilitate efficient transepithelial delivery of intravesical FBZ-BSA and αPD-1 though transiently regulating the distribution of tight junction proteins on bladder epithelium. In addition, the FBZ–BSA complex exhibits tumor microenvironment-responsive charge reversal and BSA carrier-broken effects to drive tumor-targeted dissociation and drug release of FBZ–BSA/FCS. Moreover, FBZ not only promotes apoptosis and inhibits glycolysis in cancer cells but also displays adjuvant properties to activate potent immune responses through IL-12/IFN-γ pathway. Interestingly, combined perfusion of FBZ–BSA/FCS and αPD-1/FCS nano-formulations can significantly activate the tumor immune microenvironment, especially CD8+ T cell infiltration and αPD-1 sensitivity, and finally remarkably inhibit tumor growth in the mouse orthotopic BCa model. Thus, this study presents a novel intravesical delivery platform for ICB antibodies and a smart adjuvant system to achieve potent synergy immunotherapy, which is promising for bladder-preserving treatment against BCa.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic-Driven Hydrogel Spiral PVA/Fe3O4 Micromotors for Targeted Photothermal Therapy 用于靶向光热疗法的磁驱动水凝胶螺旋 PVA/Fe3O4 微电机

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-07 DOI: 10.1002/adtp.202300334

Suyi Liu, Qimin Lu, Ziying Liang, Dailing Du, Bin Chen, Ye Feng, Chao Gao, Tingting Jiang, Yingfeng Tu, Fei Peng

引用次数: 0

Dual Gallium Drug Treatment Against Carbapenem-Resistant Klebsiella Pneumoniae: Efficacy and Potential Mechanism(s) of Action and Resistance 针对耐碳青霉烯类肺炎克雷伯氏菌的双镓药物治疗：疗效和潜在作用机制及耐药性

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-06 DOI: 10.1002/adtp.202400147

Zachary Scott, Seoung-ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy

{"title":"Dual Gallium Drug Treatment Against Carbapenem-Resistant Klebsiella Pneumoniae: Efficacy and Potential Mechanism(s) of Action and Resistance","authors":"Zachary Scott, Seoung-ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy","doi":"10.1002/adtp.202400147","DOIUrl":"10.1002/adtp.202400147","url":null,"abstract":"Klebsiella pneumoniae (KLP) is a Gram-negative pathogen that can be highly antibiotic-resistant. Our group has worked with gallium-based compounds as a means of treating bacterial infections. Here the possible mechanism is investigated for dual therapy comprised of gallium nitrate (Ga(NO3)3) and gallium protoporphyrin (GaPP) on KLP. It is found that in vitro the combination of Ga(NO3)3 and GaPP is synergistic against KLP. The in vivo efficacy is of the dual therapy is additionally tested by treating pulmonary KLP infections in mice. Much greater effectiveness are observed in bacterial clearance and survival of mice receiving the dual therapy than that of singly treated or untreated mice. It is found that in in vitro the dual therapy increased reactive oxygen stress in treated bacteria. Combination therapy impacted KLP catalase, but not superoxide dismutase (SOD) activity. Finally, alterations in KLP genes encoding 6-phosphogluconate phosphatase or cytochrome C assembly protein are found to be associated with increased resistance to combination gallium therapy, raising the MIC to both Ga(NO3)3 and GaPP by 4-fold. These cumulative data lend validation to the potential for the use of Ga(NO3)3 and GaPP combination therapy against KLP and suggest that increased oxidative stress is involved in the mechanism of action.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141377518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Transcriptome Analysis of Radioresistant Cells Revealed Genes and Pathways Predictive Of Tumor Response to Radiotherapy and Chemotherapy in Breast Cancer 耐放射细胞的综合转录组分析揭示了可预测肿瘤对乳腺癌放疗和化疗反应的基因和通路

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-06 DOI: 10.1002/adtp.202300274

Isidro X. Perez-Añorve, Mauricio Flores-Fortis, Carlos C. Patiño-Morales, Elizabeth Ortiz-Gutierrez, Oscar Del Moral-Hernandez, Claudia H. Gonzalez-De la Rosa, Ernesto Soto-Reyes, Raul Bonilla-Moreno, Margarita Chavez Saldaña, Daniel A. Landero-Huerta, Daniel Ortega-Bernal, Nicolas Villegas, Elena Arechaga-Ocampo

{"title":"Integrated Transcriptome Analysis of Radioresistant Cells Revealed Genes and Pathways Predictive Of Tumor Response to Radiotherapy and Chemotherapy in Breast Cancer","authors":"Isidro X. Perez-Añorve, Mauricio Flores-Fortis, Carlos C. Patiño-Morales, Elizabeth Ortiz-Gutierrez, Oscar Del Moral-Hernandez, Claudia H. Gonzalez-De la Rosa, Ernesto Soto-Reyes, Raul Bonilla-Moreno, Margarita Chavez Saldaña, Daniel A. Landero-Huerta, Daniel Ortega-Bernal, Nicolas Villegas, Elena Arechaga-Ocampo","doi":"10.1002/adtp.202300274","DOIUrl":"10.1002/adtp.202300274","url":null,"abstract":"Breast cancer cells exposed to radiotherapy frequently develop radiation resistance through molecular and phenotypic changes. While there is evidences of pathways controlling radioresistance, the evolution of diverse cell phenotypes and transcriptional changes as mediators of radioresistance in breast cancer are restricted. Moreover, the effectiveness of the chemotherapy on radioresistant cells remains uncertain. In this work, an isogenic model of radioresistant breast cancer cells (RR cells) is used to study this phenotype. RR cells show high survival rates after radiation, moreover, RR cells of the triple negative breast cancer (TNBC) subtype show a significantly advanced invasiveness phenotype. Notably, RR cells are significantly sensitive to chemotherapy by inhibit cell survival and promote apoptosis. Transcriptomics and gene co-expression network analysis identify differentially expressed genes (DEGs) and hub genes related to survival and apoptosis pathways in the RR cells of luminal subtype, while in TNBC subtype, cell migration, cell differentiation, and immune pathways are enriched. Hub genes predict the failure of radiotherapy in breast cancer patients, but they are also related to pathological complete response after chemotherapy. Transcriptome changes during acquired radioresistance uncover genes and pathways associated to radio and chemotherapy response. These results demonstrate that radioresistant pathways may converge to develop collateral chemo-sensitivity.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202300274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Combined Photoacoustic Imaging and Photothermal Treatment of HPV-Negative Head and Neck Carcinoma with NIR-Responsive Non-Persistent Plasmon Nano-Architectures 利用近红外响应性非持久性 Plasmon 纳米结构对 HPV 阴性头颈癌进行体内联合光声成像和光热治疗

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-06 DOI: 10.1002/adtp.202400110

Valentina Frusca, Chiara Cavallini, Agata Zamborlin, Giuliana Drava, Virginia Barone, Lisa Gherardini, Mario Chiariello, Paolo Armanetti, Maria Laura Ermini, Luca Menichetti, Valerio Voliani

{"title":"In Vivo Combined Photoacoustic Imaging and Photothermal Treatment of HPV-Negative Head and Neck Carcinoma with NIR-Responsive Non-Persistent Plasmon Nano-Architectures","authors":"Valentina Frusca, Chiara Cavallini, Agata Zamborlin, Giuliana Drava, Virginia Barone, Lisa Gherardini, Mario Chiariello, Paolo Armanetti, Maria Laura Ermini, Luca Menichetti, Valerio Voliani","doi":"10.1002/adtp.202400110","DOIUrl":"10.1002/adtp.202400110","url":null,"abstract":"The combination of photoacoustic imaging (PAI) and photothermal therapy (PTT) is an attractive approach in cancer management due to the non-invasive features combined with real-time imaging and selective tissue damage by non-ionizing radiation. This approach is especially appealing for Head and Neck Squamous Cell Carcinoma (HNSCC) management, where up to 40% of patients require modifications of the treatment regimen. On the other hand, most of the agents developed for PAI/PTT suffer from persistence or re-shaping issues. Here, a unique non-persistent plasmon nano-architecture (tNAs-IRDye) is presented that simultaneously acts as a contrast agent for PAI and as a photothermal transducer for PTT. The tNAs-IRDye are fully characterized and evaluated in vitro and ex vivo, and their performance as theranostic agents is assessed in HPV-negative HNSCC murine models. A significant modulation of tumor growth is obtained in vivo upon intratumoral injection of tNAs-IRDye and subsequent NIR irradiation compared to the solely irradiated control. The outcomes of this study exhibit a noteworthy potential to foster the development of innovative clinical strategies for the management of HPV-negative head and neck carcinoma.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0