Advanced Therapeutics最新文献_第10页

Inhalational Delivery of β‐glucan‐chitosan‐poly(lactic co‐glycolic) acid Nanoparticles Enhance Alveolar Macrophage Rifampin Concentrations for the Treatment of Tuberculosis 吸入β-葡聚糖-壳聚糖-聚（乳酸共聚乙醇）酸纳米颗粒可提高肺泡巨噬细胞中利福平的浓度，用于治疗结核病

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-07-05 DOI: 10.1002/adtp.202400057

Hilliard L. Kutscher, Maria Tamblin, Shanta Karki, Lee Chaves, Marissa Baird, Afrin Parvin, Evon Smith, Admire Dube, Zhaoqi Zhang, Saptarshi Chakraborty, Patrick Kenney, Jessica L. Reynolds

{"title":"Inhalational Delivery of β‐glucan‐chitosan‐poly(lactic co‐glycolic) acid Nanoparticles Enhance Alveolar Macrophage Rifampin Concentrations for the Treatment of Tuberculosis","authors":"Hilliard L. Kutscher, Maria Tamblin, Shanta Karki, Lee Chaves, Marissa Baird, Afrin Parvin, Evon Smith, Admire Dube, Zhaoqi Zhang, Saptarshi Chakraborty, Patrick Kenney, Jessica L. Reynolds","doi":"10.1002/adtp.202400057","DOIUrl":"https://doi.org/10.1002/adtp.202400057","url":null,"abstract":"Despite multiple treatments for tuberculosis (TB), there are ≈10 million new cases and 1.5 million deaths annually, warranting the need for new therapeutics. Major clinical treatment issues include the length of treatment which is associated with patient non‐compliance; and poor cellular drug penetration leading to the generation of drug‐resistant strains. This study underscores the potential of β‐glucan‐chitosan (CS) poly(lactic co‐glycolic) acid (PLGA) nanoparticles as a promising immunostimulatory adjunct for TB treatment. To facilitate drug delivery to alveolar macrophage, a CS‐PLGA nanoparticle is developed containing rifampin in the core with β‐glucan as a surface ligand, to stimulate the immune system. Mice are administered a single dose of nanoparticles or free rifampin by oropharyngeal aspiration. Pharmacokinetic investigations reveal sustained release properties of rifampin in vivo, extending over a week. Furthermore, comprehensive analysis indicates stimulation of the innate immune system, as evidenced by cytokine profiling, while concurrently revealing no detrimental effects on the alveolar epithelium, as indicated by histological examination and albumin lung leak assessment. These findings collectively establish a strong foundation for the development of a novel adjuvant immunotherapy approach for TB.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"22 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Multifunctional Purposes of Ultrasound in 3D Models 三维模型中超声波的多功能用途

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-04 DOI: 10.1002/adtp.202400161

Veronica Vighetto, Elia Pascucci, Giorgia Savino, Giada Rosso, Nicolò Maria Percivalle, Marzia Conte, Bianca Dumontel, Alice Balboni, Giulia Mesiano, Alessandro Masoero, Valentina Cauda

{"title":"The Multifunctional Purposes of Ultrasound in 3D Models","authors":"Veronica Vighetto, Elia Pascucci, Giorgia Savino, Giada Rosso, Nicolò Maria Percivalle, Marzia Conte, Bianca Dumontel, Alice Balboni, Giulia Mesiano, Alessandro Masoero, Valentina Cauda","doi":"10.1002/adtp.202400161","DOIUrl":"10.1002/adtp.202400161","url":null,"abstract":"Ultrasound (US), is gaining considerable interest as therapy and diagnostic tool, being safe, deep-tissue penetrating, and enabling variegate interventions. Although some US applications have already reached the clinical practice, innovative interventions combining them to microbubbles, nanoparticles, scaffolds and novel imaging techniques have to face complex clinical translation. Here US technologies are illustrated in 3D cell structures: as in-vitro systems at different levels of complexity, 3D models can fairly recapitulate human tissue complexity, while reducing interventions on animals. First drug delivery is described as mediated by microbubbles or nanoparticles to 3D spheroids, organ-on-chip, microfluidic-embedded 3D-cell structures, and cell-seeded scaffolds, showing the important US role in achieving barriers penetration and highly localized delivery. Then, the assembly of cells in 3D structures thanks to US is highlighted, showing prominent examples of how finely tuning acoustic standing waves can guide the organization and aggregation of cells in 3D. Finally, an outlook of conventional echographic techniques up to the most innovative quantitative US imaging is reviewed, focusing on new imaging options for 3D structures. These intriguing fields of research are discussed related to their actual challenges and opportunities, level of complexity of 3D models, and ability to propose a valid tool toward clinical translation.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Tea Carbon Dots-Based Electrically Active Hydrogel Dressing for Promoting Wound Healing 基于绿茶碳点的电活性水凝胶敷料可促进伤口愈合

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-01 DOI: 10.1002/adtp.202400016

Kang Hu, Zhuo Huang, Qinying Tang, Danyang Chen, Lianxu Chen, Lu Chen, Guohua Jiang, Qianfei Huang, Langjie Chai, Hang Chen, Liang Guo, Bin Li

{"title":"Green Tea Carbon Dots-Based Electrically Active Hydrogel Dressing for Promoting Wound Healing","authors":"Kang Hu, Zhuo Huang, Qinying Tang, Danyang Chen, Lianxu Chen, Lu Chen, Guohua Jiang, Qianfei Huang, Langjie Chai, Hang Chen, Liang Guo, Bin Li","doi":"10.1002/adtp.202400016","DOIUrl":"10.1002/adtp.202400016","url":null,"abstract":"Currently, searching for safer and more effective approaches to promote skin wound healing and tissue regeneration is a significant research focus in the field of public health. Eliminating excessive reactive oxygen species (ROS) and using electrically active dressings to accelerate wound healing has gained significant attention. Herein, green tea-based carbon dots (GCDs) are synthesized from leaves of green tea and proven to possess strong antioxidant, antibacterial, and anti-inflammatory properties. Then, GCDs, polyvinyl alcohol (PVA), and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) are successfully constructed into a multifunctional conductive PVA-PEDOT:PSS/GCDs hydrogel (PPPCD) using a repeated freeze-thaw method for promoting skin wound healing. Highly electrical conductivity is imparted by introducing PEDOT:PSS, while antioxidant and antibacterial properties are conferred by GCDs. In vitro assays demonstrated the excellent biocompatibility of the hydrogel, as well as its ability to scavenge excessive ROS and promote cell migration. Furthermore, the hydrogel not only accelerates wound healing by promoting blood vessel formation and epidermal regeneration but also alleviating excessive inflammation in vivo. Overall, the developed hydrogel dressing demonstrates promising prospects for skin wound healing and offers a new perspective for tissue engineering.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody-Drug Conjugates in Preclinical Models 在临床前模型中通过 ICAM1 抗体-药物共轭物靶向治疗舌鳞状细胞癌

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-01 DOI: 10.1002/adtp.202400018

Letao Ma, Yanzhi Xu, Yuxuan Yang, Teng Yang, Yujie Dai, Takaya Shimura, Chulin Sha, Xinfang Li, Jianmin Fang, Weihui Zheng, Ye Lu, Peng Guo

{"title":"Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody-Drug Conjugates in Preclinical Models","authors":"Letao Ma, Yanzhi Xu, Yuxuan Yang, Teng Yang, Yujie Dai, Takaya Shimura, Chulin Sha, Xinfang Li, Jianmin Fang, Weihui Zheng, Ye Lu, Peng Guo","doi":"10.1002/adtp.202400018","DOIUrl":"10.1002/adtp.202400018","url":null,"abstract":"To date, the treatment options for metastatic and recurrent tongue squamous cell carcinoma (TSCC) remain limited due to the lack of effective drug targets and therapeutics. Here the identification of ICAM1 is reported as a TSCC target candidate for the development of antibody-drug conjugate (ADC), an emerging class of targeted therapeutics. An unbiased and quantitative screening of a panel of 69 TSCC cell surface antigens is first performed that identifies ICAM1 as the most abundant hit. The overexpression level of ICAM1 is validated in 26 TSCC clinical specimens and four cell lines along with genomic information of 127 TSCC patients from the TCGA database. Based on this new target, the anti-TSCC efficacy of ICAM1-targeted ADCs featuring two payloads is evaluated of different mechanisms of action: MMAE and DXd. Both ADCs selectively and potently ablate TSCC tumors in the established SAS cell line and patient-derived xenograft (PDX) models. The findings strongly support ICAM1 as a promising ADC target candidate for TSCC therapy.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-Cysteine Nanostructures for Synergetic Photothermal Therapy and Chemodynamic Therapy of Bacterial Skin Abscesses 铜-半胱氨酸纳米结构用于细菌性皮肤脓肿的协同光热疗法和化学动力疗法

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-01 DOI: 10.1002/adtp.202400099

Hadi Bagheri, Shayesteh Bochani, Mohammad Seyedhamzeh, Zahra Shokri, Ali Kalantari-Hesari, Raymond J. Turner, Mahshid Kharaziha, Kimia Esmaeilzadeh, Mehdi Golami, Habib Zeighami, Aziz Maleki

{"title":"Copper-Cysteine Nanostructures for Synergetic Photothermal Therapy and Chemodynamic Therapy of Bacterial Skin Abscesses","authors":"Hadi Bagheri, Shayesteh Bochani, Mohammad Seyedhamzeh, Zahra Shokri, Ali Kalantari-Hesari, Raymond J. Turner, Mahshid Kharaziha, Kimia Esmaeilzadeh, Mehdi Golami, Habib Zeighami, Aziz Maleki","doi":"10.1002/adtp.202400099","DOIUrl":"10.1002/adtp.202400099","url":null,"abstract":"Skin lesions, including skin bacterial abscesses, have become one of the most important health challenges and usually need systemic high-dose antibiotics. Therefore, it is of particular importance to develop novel approaches for treating this ever-growing challenge to human health. To address this challenge, herein a copper nanostructure is developed giving combined photothermal and chemodynamic therapies for focal infection treatment. The Cu-based nanostructures with intrinsic catalytic properties are prepared by D-L or L cysteine (Cys) as ligand and copper ions. It is shown that the multifunctional copper-Cys (Cu-Cys) nanostructures can produce reactive oxygen species (ROS) and they exhibit near infrared (NIR)-enhanced catalytic activities to improve ROS production for highly efficient eradication of bacteria. Moreover, the results proved O2 evolution property of the Cu-Cys nanoparticles (NPs). The nanostructures show shape-dependent antibacterial activity where DL-Cu-Cys NPs show higher bactericidal performance than L-Cu-Cys NPs. In vitro results demonstrate that 2.5 and 1.25 µg mL−1 of DL-Cu-Cys NPs is enough to achieve rapid killing of Escherichia coli (E. coli) or Staphylococcus aureus (S. aureus) respectively under 808 nm light irradiation in 10 min. This work introduces a unique photoactive nanoagent to efficiently treat subcutaneous abscess by combining NIR light-triggered photothermal effect and catalytic generation of ROS without using any antibiotic.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled Delivery of Paclitaxel via Stable Synthetic Protein Nanoparticles 通过稳定的合成蛋白纳米颗粒控制紫杉醇的输送

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-27 DOI: 10.1002/adtp.202400208

Ava Mauser, Isabel Waibel, Kaushik Banerjee, Anzar A. Mujeeb, Jingyao Gan, Sophia Lee, William Brown, Nigel Lang, Jason Gregory, Jeffery Raymond, Matthias Franzeb, Anna Schwendeman, Maria G. Castro, Joerg Lahann

{"title":"Controlled Delivery of Paclitaxel via Stable Synthetic Protein Nanoparticles","authors":"Ava Mauser, Isabel Waibel, Kaushik Banerjee, Anzar A. Mujeeb, Jingyao Gan, Sophia Lee, William Brown, Nigel Lang, Jason Gregory, Jeffery Raymond, Matthias Franzeb, Anna Schwendeman, Maria G. Castro, Joerg Lahann","doi":"10.1002/adtp.202400208","DOIUrl":"10.1002/adtp.202400208","url":null,"abstract":"Despite decades of intense research, glioma remains a disease for which no adequate clinical treatment exists. Given the ongoing therapeutic failures of conventional treatment approaches, nanomedicine may offer alternative options because it can increase the bioavailability of drugs and alter their pharmacokinetics. Here, a new type of synthetic protein nanoparticles (SPNPs) is reported that allow for effective loading and controlled release of the potent cancer drug, paclitaxel (PTX) – a drug that so far has been unsuccessful in glioma treatment due to hydrophobicity, low solubility, and associated delivery challenges. SPNPs are prepared by electrohydrodynamic (EHD) jetting of dilute solutions of PTX-loaded albumin made by high-pressure homogenization. After EHD jetting, PTX SPNPs possess a dry diameter of 165 ± 44 nm, hydrated diameter of 297 ± 102 nm, and a zeta potential of −19 ± 8 mV in water. For the SPNP formulation with a total PTX loading of 9.4%, the loading efficiency is 94%, and controlled release of PTX is observed over two weeks (6% burst release). PTX SPNPs are more potent (68% lethality) than free PTX (45% lethality using 0.2% dimethyl sulfoxide). PTX SPNPs in combination with IR show a significant survival benefit in glioma-bearing mouse models, avoid adverse liver toxicity, and maintain a normal brain architecture. Immunohistochemistry reveals a dramatic tumor size reduction including 40% long-term survivors without discernible signs of tumor. Using flexibly engineered SPNPs, this work outlines an efficient strategy for the delivery of hydrophobic drugs that are otherwise notoriously hard to deliver.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Precision Immunotherapy of Colorectal Cancer through Chemo-Photothermal Nanoparticles via Endoplasmic Reticulum Stress Mediated Apoptotic Pathways 通过内质网应激介导的凋亡途径，化疗-光热纳米粒子增强结直肠癌的精准免疫疗法

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-27 DOI: 10.1002/adtp.202400045

Shanshan Wang, Zhiqiang Bi, Tianming Lu, Ruoning Qian, Jie Yu, Qiang Zhang, Hao Yang, Wenli Lu, Yuanyuan Guo, Xiaoqing Xin, Yong Bian, Ruogu Qi

{"title":"Enhanced Precision Immunotherapy of Colorectal Cancer through Chemo-Photothermal Nanoparticles via Endoplasmic Reticulum Stress Mediated Apoptotic Pathways","authors":"Shanshan Wang, Zhiqiang Bi, Tianming Lu, Ruoning Qian, Jie Yu, Qiang Zhang, Hao Yang, Wenli Lu, Yuanyuan Guo, Xiaoqing Xin, Yong Bian, Ruogu Qi","doi":"10.1002/adtp.202400045","DOIUrl":"10.1002/adtp.202400045","url":null,"abstract":"Colorectal cancer (CRC) stands out as one of the most prevalent gastrointestinal cancers. Current treatment strategies for CRC are significantly hindered by systemic toxicity and suboptimal therapeutic efficacy. This study aims to overcome these limitations by developing a robust tumor-targeting chemo-photothermal strategy, combining Bortezomib (BTZ) as a proteasome inhibitor, IR780 iodide as a near-infrared dye, and Photothermal Therapy (PTT) agent, with hyaluronic acid (HA) serving as the shell for tumor targeting, denoted as HA/PB@IR780. The investigations reveal the impressive tumor-targeting affinity of HA/PB@IR780, leading to a synergistic chemo-photothermal therapeutic effect both in vitro and in vivo. Additionally, this material demonstrates the capability for drug release triggered by low pH conditions. Moreover, HA/PB@IR780 induced the generation of reactive oxygen species (ROS), triggered cells apoptosis via the PERK-CHOP-Bcl-2 pathway, and induced Immunogenic Cell Death (ICD) in CT26 cells. Importantly, HA/PB@IR780 selectively targets tumor sites, mitigating systemic toxic side effects and significantly extending the survival of CT26 tumor-bearing mice. In conclusion, this designed tumor-targeting nanocarrier represents a promising and potentially effective platform for the precise treatment of CRC.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LTBP2 Knockdown Ameliorates Cardiac Fibrosis and Apoptosis via Attenuating NF-κB Signaling Pathway and Oxidative Stress in Mice with Cardiac Hypertrophy 敲除 LTBP2 可通过减轻 NF-κB 信号通路和氧化应激改善心肌肥厚小鼠的心肌纤维化和细胞凋亡

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-26 DOI: 10.1002/adtp.202300451

Yifeng Wang, Dongxu Hua, Kun Zhao, Qiyang Xie, Xiaoguang Wu, Min Gao, Wanling Huang, Wen Huang, Peng Li, Yanhui Sheng

{"title":"LTBP2 Knockdown Ameliorates Cardiac Fibrosis and Apoptosis via Attenuating NF-κB Signaling Pathway and Oxidative Stress in Mice with Cardiac Hypertrophy","authors":"Yifeng Wang, Dongxu Hua, Kun Zhao, Qiyang Xie, Xiaoguang Wu, Min Gao, Wanling Huang, Wen Huang, Peng Li, Yanhui Sheng","doi":"10.1002/adtp.202300451","DOIUrl":"10.1002/adtp.202300451","url":null,"abstract":"At present, there is no therapeutic approach available to reverse the progression of pathological fibrosis and ventricle chamber stiffening. This study is designed to explore the effects of latent transforming growth factor-beta-binding protein 2 (LTBP2) on cardiac fibrosis in hypertrophic cardiomyopathy and the underlying mechanisms. The key differential gene LTBP2 is identified by mRNA sequencing. Ang II-induced cells and mice are treated with LTBP2 si-RNA or knockdown adenovirus, respectively, and the indicators of cardiac function, oxidative stress, cardiac fibrosis, apoptosis, and remodeling are examined. The underlying mechanism is elucidated in vitro by oxidative stress and an agonist of nuclear factor-kappa B (NF-κB). LTBP2 is upregulated in the cardiac tissue of mice with Ang II-mediated HF. The knockdown of LTBP2 enhanced cardiac function, attenuated cardiac fibrosis, apoptosis, hypertrophy, and oxidative stress injury, and suppressed NF-κB expression. These results are validated in vitro. The effects of LTBP2 gene silencing are reversed by either NF-κB or oxidative stress agonists in vitro. Taken together, these findings suggest that LTBP2 knockdown alleviates HF by inhibiting cardiac fibrosis, apoptosis, and hypertrophy via attenuating NF-κB signaling pathway and oxidative stress. Thus, targeting LTBP2 may be a novel approach to the treatment of HF.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Doxofylline: Advancing and Empowering Equitable Asthma and COPD Management Beyond Tradition 多索茶碱：超越传统，促进并增强哮喘和慢性阻塞性肺病的公平管理

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-06-26 DOI: 10.1002/adtp.202400103

Mario Cazzola, Clive P. Page, Luigino Calzetta, Paola Rogliani, Maria Gabriella Matera

引用次数: 0

Latest Progress on Tuberculosis and HIV Co‐Infection: A Closer Look at People of Different Ages 结核病和艾滋病病毒双重感染的最新进展：不同年龄段人群的近距离观察

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-06-26 DOI: 10.1002/adtp.202400033

Anna Yusuf Aliyu, Oluwatoyin A. Adeleke

引用次数: 0