Urine Liquid Biopsies via Highly Integrated Digital PCR System for Accurate Detection of Bladder Cancer (Adv. Therap. 10/2024)

Abstract

In article 2400191, Zijian Zhao, Yanzhao Li, Yang Yu, and co-workers develop a highly accurate urine-based diagnostic tool for bladder cancer using an on-chip heating dPCR system. By integrating genetic and epigenetic biomarkers and optimizing the diagnostic model with machine learning, the tool achieved high sensitivity and specificity in detecting bladder cancer and shows potential for differentiating tumor stages.