Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment-Integrated Organ-On-Chip Models

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi
{"title":"Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment-Integrated Organ-On-Chip Models","authors":"Fabiana Moresi,&nbsp;Francesco Noto,&nbsp;Jyothsna Vasudevan,&nbsp;Xavier Bisteau,&nbsp;Giulia Adriani,&nbsp;Andrea Pavesi","doi":"10.1002/adtp.202500098","DOIUrl":null,"url":null,"abstract":"<p>The intricate tumor microenvironment (TME) poses a significant barrier to effective cancer immunotherapy, requiring innovative strategies to model and address its challenges. Traditional models, such as 2D cultures and animal studies, often fail to capture the TME's dynamic, multicellular, and spatially complex nature, limiting their predictive power for therapeutic outcomes. To overcome these limitations, this review examines innovative microphysiological systems (MPS) that enhance the understanding of tumor-immune interactions and pave the way for more effective immunotherapeutic strategies. First the complex features of the TME and its key players are detailed, elaborating on their dynamic interplay with tumors. Importantly, it is highlighted how these components contribute to treatment resistance, offering crucial insights into therapeutic failures. Then, state-of-the-art 3D in vitro organ-on-chip (OoC) models are presented that faithfully recapitulate the TME, incorporating patient-derived tumors to enhance clinical relevance. These advanced systems not only overcome the limitations of traditional animal models and 2D cultures but also provide a robust platform for assessing and improving immunotherapeutic regimens. By bridging the gap between bench and bedside, MPS promises to accelerate the development of novel, more effective immunotherapies for solid tumors, potentially transforming cancer treatment in the near future.</p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202500098","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adtp.202500098","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

The intricate tumor microenvironment (TME) poses a significant barrier to effective cancer immunotherapy, requiring innovative strategies to model and address its challenges. Traditional models, such as 2D cultures and animal studies, often fail to capture the TME's dynamic, multicellular, and spatially complex nature, limiting their predictive power for therapeutic outcomes. To overcome these limitations, this review examines innovative microphysiological systems (MPS) that enhance the understanding of tumor-immune interactions and pave the way for more effective immunotherapeutic strategies. First the complex features of the TME and its key players are detailed, elaborating on their dynamic interplay with tumors. Importantly, it is highlighted how these components contribute to treatment resistance, offering crucial insights into therapeutic failures. Then, state-of-the-art 3D in vitro organ-on-chip (OoC) models are presented that faithfully recapitulate the TME, incorporating patient-derived tumors to enhance clinical relevance. These advanced systems not only overcome the limitations of traditional animal models and 2D cultures but also provide a robust platform for assessing and improving immunotherapeutic regimens. By bridging the gap between bench and bedside, MPS promises to accelerate the development of novel, more effective immunotherapies for solid tumors, potentially transforming cancer treatment in the near future.

Abstract Image

Abstract Image

Abstract Image

Abstract Image

癌症研究中的微生理系统:通过肿瘤微环境集成器官芯片模型推进免疫治疗
复杂的肿瘤微环境(TME)对有效的癌症免疫治疗构成了重大障碍,需要创新的策略来模拟和解决其挑战。传统的模型,如二维培养和动物研究,往往不能捕捉TME的动态、多细胞和空间复杂性,限制了它们对治疗结果的预测能力。为了克服这些限制,本综述研究了创新的微生理系统(MPS),以增强对肿瘤免疫相互作用的理解,并为更有效的免疫治疗策略铺平道路。首先,详细介绍了TME及其主要参与者的复杂特征,阐述了它们与肿瘤的动态相互作用。重要的是,它强调了这些成分是如何导致治疗耐药性的,为治疗失败提供了重要的见解。然后,提出了最先进的体外器官芯片(OoC) 3D模型,忠实地再现了TME,纳入了患者来源的肿瘤,以增强临床相关性。这些先进的系统不仅克服了传统动物模型和二维培养的局限性,而且还为评估和改进免疫治疗方案提供了一个强大的平台。通过弥合实验和临床之间的差距,MPS有望加速开发新的、更有效的实体瘤免疫疗法,在不久的将来有可能改变癌症治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信