神经免疫重组:中枢神经系统疾病治疗的纳米平台创新

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng-Yuan Wang, Roey Elnathan, Yaping Chen
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引用次数: 0

摘要

中枢神经系统(CNS)疾病是一个重大的全球健康挑战,目前影响全球六分之一的人。尽管对其分子和细胞机制进行了广泛的研究,但由于中枢神经系统疾病固有的复杂性和血脑屏障(BBB)的保护性限制,有效的治疗仍然难以捉摸。传统的单一疗法往往不能产生令人满意的结果。近年来,纳米材料已成为有前景的治疗平台,提供增强的药代动力学,改善的生物分布,降低全身毒性。更重要的是,多功能纳米材料可以被设计成主动靶向脑实质和病变部位,共同提供多种治疗,并协同调节神经免疫反应。它们对不同病理环境的可调性和适应性使它们非常适合于解决中枢神经系统疾病的多因素性质。这篇综述讨论了导致常见脑部疾病治疗耐药的机制,并强调了工程纳米材料在解决多方面疾病微环境方面的潜力。我们还确定了针对中枢神经系统疾病治疗的多功能纳米平台的合理设计的当前挑战和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Central nervous system (CNS) diseases pose a significant global health challenge, currently affecting one in six individuals worldwide. Despite extensive research into their molecular and cellular mechanisms, effective treatment remains elusive due to the inherent complexity of CNS disorders and the protective constraints of the blood-brain barrier (BBB).Conventional monotherapies often fail to produce satisfactory outcomes. In recent years, nanomaterials have emerged as promising therapeutic platforms—offering enhanced pharmacokinetics, improved biodistribution, and reduced systemic toxicity. More importantly, multifunctional nanomaterials can be engineered to actively target the brain parenchyma and lesion sites, co-deliver multiple therapeutics, and modulate neuroimmune responses synergistically. Their tunability and adaptability to diverse pathological contexts make them well-suited to address the multifactorial nature of CNS diseases. This review discusses the mechanisms contributing to therapeutic resistance in common brain disorders and highlights the potential of engineered nanomaterials that can address the multifaceted disease microenvironment. We also identify current challenges and prospects for the rational design of multifunctional nanoplatforms tailored to CNS disease treatment.

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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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