Advanced Therapeutics最新文献_第3页

FeS2/WS2 Heterostructure: A Promising Candidate for Mild-Temperature Photothermal Therapy with Enhanced Photodynamic Effect and Antibacterial Activity FeS2/WS2异质结构：具有增强光动力效应和抗菌活性的温和光热治疗候选材料

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-25 DOI: 10.1002/adtp.202500119

Abdurrahman Mustafa, Ahmed AlSarori, Hasan Akyıldız, Ismail Cihan Kaya, Gulcihan Guzel Kaya

{"title":"FeS2/WS2 Heterostructure: A Promising Candidate for Mild-Temperature Photothermal Therapy with Enhanced Photodynamic Effect and Antibacterial Activity","authors":"Abdurrahman Mustafa, Ahmed AlSarori, Hasan Akyıldız, Ismail Cihan Kaya, Gulcihan Guzel Kaya","doi":"10.1002/adtp.202500119","DOIUrl":"10.1002/adtp.202500119","url":null,"abstract":"FeS2, a member of metal chalcogenide semiconductors, is a cheap and available material with distinguishable photothermal activity under light irradiation. However, its photodynamic properties have to be improved for practical phototherapy applications. Therefore, in this study, FeS2/WS2 p-n junctions, comprising varying amounts of WS2, are synthesized using the simple hot injection method. Establishment of the heterostructure is verified using X-ray diffraction (XRD), scanning transmission electron microscopy (STEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS) analysis. p-n junction formation is further validated via calculations based on ultraviolet-visible (UV–vis.) spectrophotometer and XPS data. Photothermal and photodynamic properties of the samples are examined considering various aspects. The FeS2/WS2 heterostructure provides a heating response above 50 °C with a high photothermal conversion efficiency of 52.6%. The reactive oxygen species (ROS) formation ability is observed to depend on the material concentration and O2•‾ is determined as the primary reactive oxygen species. The in vitro antibacterial activity of the samples is tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria as a function of material concentration. At all concentrations, the FeS2/WS2 heterostructure exhibits higher activity than that of FeS2 nanoparticles. The efficiency of the sample against S. aureus and E. coli is calculated to be 100% and 99.4% respectively, at a low material concentration of 100 µg mL−1.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding miR-200c: an Important Player in Resistance to Cancer Treatment 了解miR-200c在癌症治疗耐药中的重要作用

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-23 DOI: 10.1002/adtp.202500238

Fatma Sanli, Omer Faruk Karatas

引用次数: 0

Evolution of Ocular Organ-On-Chip Systems for Disease Modelling and Drug Testing: Where are We Now? 用于疾病建模和药物测试的眼部器官芯片系统的进化：我们现在在哪里？

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-21 DOI: 10.1002/adtp.202500200

Sara Trujillo

引用次数: 0

Gas-Molecule-Mediated Radiosensitization in Cancer Therapy 肿瘤治疗中气体分子介导的放射增敏

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-21 DOI: 10.1002/adtp.202500062

Yu Jin, Zuotao Zhou, Siyuan Luo, Jiahui Sheng, Zhiqiang Shen, Jinming Hu

{"title":"Gas-Molecule-Mediated Radiosensitization in Cancer Therapy","authors":"Yu Jin, Zuotao Zhou, Siyuan Luo, Jiahui Sheng, Zhiqiang Shen, Jinming Hu","doi":"10.1002/adtp.202500062","DOIUrl":"10.1002/adtp.202500062","url":null,"abstract":"Radiotherapy (RT) is one of the widely used cancer treatments, but its efficacy can be limited by the hypoxic tumor microenvironment (TME), which reduces reactive oxygen species (ROS) generation and promotes radioresistance. Recent studies suggest that gas small molecule-mediated sensitization may be a promising strategy for enhancing radiosensitivity. Therapeutic gas small molecules, including nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), ozone (O3), hydrogen (H2), and sulfur dioxide (SO2), have demonstrated potential in regulating the TME. These gas small molecules have been shown to improve tumor oxygenation, promote ROS generation, induce DNA damage, and modulate immune responses, which may contribute to enhanced RT outcomes. This review summarizes the latest progress in gas small molecule-mediated radiosensitization strategies, focusing on the release mechanisms, therapeutic platforms, and potential clinical applications. Additionally, current challenges and future directions in this field are discussed, aiming to provide insights into optimizing the gas small molecule-mediated radiosensitization strategy.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing Precision Medicine: Unveiling Smart Stimuli-Responsive Nanomedicine 革新精准医学：揭示智能刺激反应纳米医学

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-17 DOI: 10.1002/adtp.202500073

Ayushi Taneja, Himanshu Sekhar Panda, Jiban Jyoti Panda, Thakur Gurjeet Singh, Avneet Kour

{"title":"Revolutionizing Precision Medicine: Unveiling Smart Stimuli-Responsive Nanomedicine","authors":"Ayushi Taneja, Himanshu Sekhar Panda, Jiban Jyoti Panda, Thakur Gurjeet Singh, Avneet Kour","doi":"10.1002/adtp.202500073","DOIUrl":"10.1002/adtp.202500073","url":null,"abstract":"Smart stimuli-responsive nanomaterials have emerged as promising candidates in pharmaceutical delivery due to their ability to react to diverse physical, chemical, and biological stimuli. These systems can be precisely engineered to release therapeutic agents in response to specific internal cues, allowing for controlled and targeted interventions tailored to individual patient conditions. Their nanoscale architecture, ease of surface modification, and multifunctional physicochemical properties further enhance their suitability for biomedical applications. Recent advances underscore their potential in treating complex and chronic diseases such as cancer, neurological disorders, and inflammatory conditions, where conventional therapies often fall short. By integrating these responsive nanotechnologies into precision medicine, it is possible to enhance therapeutic efficacy while minimizing systemic toxicity. Herein, this work highlights the ongoing progress in the development and application of stimuli-responsive nanomedicines. This work also emphasizes the need for extensive clinical validation to determine their long-term safety and effectiveness in human subjects.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal Control of IL-12 Delivery Improves Its Efficacy in Treatment of Solid Tumors 时空控制IL-12的传递提高其治疗实体瘤的疗效

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-16 DOI: 10.1002/adtp.202500077

Jonathan C. Su, Garrett M. Kelly, Joshua J. Milligan, Sonal Deshpande, Rachel L. Strader, Max R. Ney, Nikhil Peterson, Parul Sirohi, Shaily Pal, Lance W. Lindsey, Daniel M. Shapiro, Xinghai Li, Ashutosh Chilkoti

{"title":"Spatiotemporal Control of IL-12 Delivery Improves Its Efficacy in Treatment of Solid Tumors","authors":"Jonathan C. Su, Garrett M. Kelly, Joshua J. Milligan, Sonal Deshpande, Rachel L. Strader, Max R. Ney, Nikhil Peterson, Parul Sirohi, Shaily Pal, Lance W. Lindsey, Daniel M. Shapiro, Xinghai Li, Ashutosh Chilkoti","doi":"10.1002/adtp.202500077","DOIUrl":"10.1002/adtp.202500077","url":null,"abstract":"Despite renewed interest in IL-12 as a cancer immunotherapy due to its ability to stimulate the adaptive immune system, its short half-life and narrow therapeutic window continues to present challenges for effective delivery. Previous studies with IL-12 have investigated the effects of route of delivery or sustained delivery of the cytokine on its efficacy but are unable to simultaneously investigate the effects of both within the same system. This work seeks to address this gap by utilizing an elastin-like polypeptide (ELP) carrier, which can undergo a thermally triggered phase transition to a gel-like depot, to probe the effects of both sustained release and spatial delivery of IL-12. By conjugating IL-12 with an ELP, this work creates an IL-12-ELP fusion that can be injected intratumorally or subcutaneously to form a sustained-release depot. In a B16F10 murine model, intratumoral injection of a depot-forming IL-12-ELP fusion significantly improved survival compared to free IL-12. IL-12-ELP is retained within the tumor approximately fourfold longer than free IL-12, resulting in higher CD8+ T cell recruitment at the tumor and local concentrations of inflammatory cytokines at Day 2. Taken together, this work provides insights into rational cytokine delivery, the importance of tumor localization, and the benefits of sustained release.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine mRNA Delivery and Local Immunomodulation in the Placenta Using Lipid Nanoparticles 细胞因子mRNA在胎盘中的传递和局部免疫调节

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-16 DOI: 10.1002/adtp.202500148

Samuel I. Hofbauer, Luisa A. Fink, Rachel E. Young, Tara Vijayakumar, Katherine M. Nelson, Nia Bellopede, Mohamad-Gabriel Alameh, Drew Weissman, Jason P. Gleghorn, Rachel S. Riley

{"title":"Cytokine mRNA Delivery and Local Immunomodulation in the Placenta Using Lipid Nanoparticles","authors":"Samuel I. Hofbauer, Luisa A. Fink, Rachel E. Young, Tara Vijayakumar, Katherine M. Nelson, Nia Bellopede, Mohamad-Gabriel Alameh, Drew Weissman, Jason P. Gleghorn, Rachel S. Riley","doi":"10.1002/adtp.202500148","DOIUrl":"10.1002/adtp.202500148","url":null,"abstract":"During pregnancy, the maternal immune system adapts to balance tolerance of the semi-allogenic fetus while protecting the fetus from pathogens. Dysregulated immune activity at the maternal–fetal interface contributes to pregnancy complications, such as recurrent pregnancy loss and preeclampsia. Compared to healthy placentas, preeclamptic placentas exhibit increased pro-inflammatory signaling, including a predominance of inflammatory macrophages, leading to impaired tissue remodeling and restricted blood flow. However, the precise mechanisms driving this immune imbalance remain poorly understood, in part due to the lack of tools to probe individual pathways. Here, lipid nanoparticles (LNPs) are used to deliver cytokine-encoded mRNA to placental cells, called trophoblasts, enabling local immunomodulation. LNP-mediated delivery of IL-4 and IL-13 mRNA induced cytokine secretion by trophoblasts, leading to polarization of primary human monocytes toward anti-inflammatory phenotypes. Notably, lowering the mRNA dose increased expression of alternatively-activated macrophage markers, revealing an inverse relationship between dose and polarization status. Intravenous injection of LNPs in pregnant mice achieves placental secretion of IL-4 and IL-13 with minimal changes to pro-inflammatory cytokines in the serum. These findings establish LNPs as tools for local immunomodulation in the placenta, offering a strategy to study and treat immune dysfunction in pregnancy and in other inflammatory conditions.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202500148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquiritin Exerts a Dual Effect on BMSCs Osteogenic Differentiation and Fracture Healing by Activating the ERK/JNK Pathway and Providing Antioxidant Protection 甘草素通过激活ERK/JNK通路和提供抗氧化保护，对骨髓间充质干细胞成骨分化和骨折愈合具有双重作用

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-16 DOI: 10.1002/adtp.202400552

Haijun Mao, Jing Liu, Juan Feng, Yalikun Yusufu, Lei Yang, Qing Jiang, Minghui Sun

{"title":"Liquiritin Exerts a Dual Effect on BMSCs Osteogenic Differentiation and Fracture Healing by Activating the ERK/JNK Pathway and Providing Antioxidant Protection","authors":"Haijun Mao, Jing Liu, Juan Feng, Yalikun Yusufu, Lei Yang, Qing Jiang, Minghui Sun","doi":"10.1002/adtp.202400552","DOIUrl":"10.1002/adtp.202400552","url":null,"abstract":"Liquiritin, a flavonoid from Glycyrrhiza uralensis L., has diverse pharmacological properties, but its impact on fracture healing is unexplored. This study investigates its osteogenic and antioxidative effects on bone marrow mesenchymal stem cells (BMSCs) in vitro and its regenerative effect on rat femoral fractures in vivo. Cytotoxicity is assessed via MTT assay, and osteogenic differentiation via ALP and ARS staining. A rat femoral fracture model validates its therapeutic effects, with micro-CT and histological assessments evaluating healing outcomes. Gene and protein expression in osteogenic and signaling pathways are analyzed through RT-qPCR, western blot, and immunofluorescence. ROS levels are measured using DCFH-DA staining. Results show liquiritin enhances osteogenesis in BMSCs, evidenced by increased ALP activity and calcium deposition. In rats, it facilitates bone regeneration and upregulates phosphorylated ERK and JNK. Additionally, it reduces ROS generation post-oxidative injury, boosting NRF2, HO1, and NQO1 expression.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-Step Freeze Drying Strategy for Scalable Production of Small Extracellular Vesicles Derived From Mesenchymal Stem Cells 间充质干细胞细胞外小泡规模化生产的一步冷冻干燥策略

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-13 DOI: 10.1002/adtp.202500121

Yashvi Sharma, Meenakshi Mendiratta, Suchi Gupta, Sonali Rawat, Pardeep Kumar Vaishnav, Sujata Mohanty

{"title":"One-Step Freeze Drying Strategy for Scalable Production of Small Extracellular Vesicles Derived From Mesenchymal Stem Cells","authors":"Yashvi Sharma, Meenakshi Mendiratta, Suchi Gupta, Sonali Rawat, Pardeep Kumar Vaishnav, Sujata Mohanty","doi":"10.1002/adtp.202500121","DOIUrl":"10.1002/adtp.202500121","url":null,"abstract":"The clinical translation of mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) holds immense promise due to their regenerative and immunomodulatory properties. However, their widespread application is hindered by challenges in storage, stability, and cold chain transport. In this study, it is explored lyophilisation as a strategy to extend the shelf life of MSC-sEV while maintaining their structural integrity and biological functionality. Lyophilised sEV are stored at four different temperatures—room temperature (RT), 4, −20°C, and −80 °C—for durations of 1, 3, and 6 months. This findings reveal that normal refrigeration temperature of 4 °C storage is suitable for maintaining sEV stability for up to 1 month, while −20°C and −80 °C are more effective for longer durations, preserving sEV integrity and functionality for 6 months and beyond. These results underscore the importance of optimizing storage protocols for lyophilised MSC-sEV to ensure their viability for clinical and research applications. This study establishes a foundation for improved storage and cold chain transport of MSC-sEV, paving the way for their integration into scalable and standardized therapeutic platforms.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information (Adv. Therap. 7/2025) 发行信息（ad . Therap. 7/2025）

IF 2.6 4区医学

Advanced Therapeutics Pub Date : 2025-07-10 DOI: 10.1002/adtp.70023

引用次数: 0