Fungal Keratitis: Clinical Presentations, Mechanism and Management Strategies

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Min Wang, Manwen Yang, Hang Yin, Zhen Li, Xianwen Wang, Lei Shi
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引用次数: 0

Abstract

Fungal keratitis (FK) is a common cause of blindness in tropical and subtropical regions and is caused mainly by infections caused by filamentous fungi such as the Aspergillus genus. The diagnosis and recovery of FK are complex compared to other ocular diseases. Owing to the anatomy and psychological properties of the cornea, it is difficult for ocular drugs to penetrate the cornea and achieve therapeutic concentrations. In the past 20 years, the clinic has used the traditional medications natamycin, voriconazole, and amphotericin B as first-line treatments. However, the effectiveness of conventional topical antifungal drugs is limited by the cornea's barrier, tear drainage, and challenges in drug penetration and bioavailability. Therefore, novel therapies or drug delivery systems to improve the treatment of FK are urgently needed. In this review, we discuss and summarize the progress of some promising antifungal management methods.

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真菌性角膜炎:临床表现、机制和治疗策略
真菌性角膜炎(FK)是热带和亚热带地区致盲的常见原因,主要由丝状真菌(如曲霉属)引起的感染引起。与其他眼部疾病相比,FK的诊断和康复较为复杂。由于角膜的解剖和心理特性,眼部药物很难穿透角膜并达到治疗浓度。在过去的20年里,诊所一直使用传统药物纳他霉素、伏立康唑、两性霉素B作为一线治疗。然而,常规局部抗真菌药物的有效性受到角膜屏障、泪液引流以及药物渗透和生物利用度方面的挑战的限制。因此,迫切需要新的治疗方法或药物输送系统来改善FK的治疗。本文就几种抗真菌治疗方法的研究进展作一综述。
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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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