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Structure-Governed MXene Quantum Dots for Cancer Theranostics: From Quantum Confinement to Tumor-Selective Catalytic and Photothermal Activation 结构调控的MXene量子点用于癌症治疗：从量子限制到肿瘤选择性催化和光热激活
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-20 DOI: 10.1002/adtp.70145
Ghaleb Oriquat, Aziz Kubaev, Sanjar Usmanaliyev, Thaer Abdul Allh, Faris Anad Muhammad, Rajashree Panigrahi, Neeraj Bainsal, Hadi Noorizadeh
{"title":"Structure-Governed MXene Quantum Dots for Cancer Theranostics: From Quantum Confinement to Tumor-Selective Catalytic and Photothermal Activation","authors":"Ghaleb Oriquat,&nbsp;Aziz Kubaev,&nbsp;Sanjar Usmanaliyev,&nbsp;Thaer Abdul Allh,&nbsp;Faris Anad Muhammad,&nbsp;Rajashree Panigrahi,&nbsp;Neeraj Bainsal,&nbsp;Hadi Noorizadeh","doi":"10.1002/adtp.70145","DOIUrl":"https://doi.org/10.1002/adtp.70145","url":null,"abstract":"<div>\u0000 \u0000 <p>MXene quantum dots (MQDs) have recently emerged as a compelling class of nanomaterials for cancer theranostics, owing to their confined electronic structure, multifunctional activation mechanisms, and favorable in vivo performance. In this review, the structure-governed behavior of MQDs is systematically examined and interpreted, highlighting how their quantum-scale architecture influences therapeutic functionality. The chemical and physical origins of functional diversity in MQDs are discussed, with an emphasis on dimensional miniaturization, electronic confinement, and structure–property relationships beyond biological contexts. Building on this foundation, recent advances in tumor-selective catalytic and photothermal activation of MQDs are analyzed, highlighting Fenton-like redox processes, near-infrared photothermal conversion, and synergistic therapeutic modalities supported by in vivo evidence. Particular attention is given to tumor microenvironment modulation, spatiotemporal control, and imaging-guided activation strategies that distinguish MQDs from conventional nanotherapeutics. Finally, key challenges related to clinical advancement, manufacturing scalability, safety evaluation, and regulatory considerations are evaluated. By integrating fundamental structure-driven insights with therapeutic and clinical perspectives, MQDs are positioned as a versatile and promising platform for next-generation precision cancer theranostics.</p>\u0000 </div>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148039844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-20
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引用次数: 0
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-20
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148116022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-20
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148085416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-17
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148111906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria-Targeted Curcumin Delivery: Therapeutic Strategies for Mitochondrial Dysfunction-Related Disorders 线粒体靶向姜黄素递送：线粒体功能障碍相关疾病的治疗策略
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-17 DOI: 10.1002/adtp.202500578
Mishara M G, Mayank Singh, Abhay S. Chauhan, Lekshmi R Nath, Sabitha M, M.S. Sudheesh
{"title":"Mitochondria-Targeted Curcumin Delivery: Therapeutic Strategies for Mitochondrial Dysfunction-Related Disorders","authors":"Mishara M G,&nbsp;Mayank Singh,&nbsp;Abhay S. Chauhan,&nbsp;Lekshmi R Nath,&nbsp;Sabitha M,&nbsp;M.S. Sudheesh","doi":"10.1002/adtp.202500578","DOIUrl":"https://doi.org/10.1002/adtp.202500578","url":null,"abstract":"<div>\u0000 \u0000 <p>Mitochondria (MT), commonly known as the powerhouse of the cell, performs a wide range of critical cellular functions beyond energy production. Mitochondrial dysfunction has been implicated in the pathophysiology of several diseases, making them an attractive target for therapeutic interventions. Disorders associated with mitochondrial dysfunction include metabolic disorders, cardiovascular and pulmonary diseases, neurological disorders, and cancer. Curcumin (CUR), a polyphenolic compound derived from turmeric (Curcuma longa) rhizomes, is a potent phytomolecule known for its diverse biological activities, including anticancer, anti-inflammatory, antioxidant, antimutagenic, antidiabetic, cardioprotective, pulmonoprotective, neuroprotective, and lipid-modifying effects.</p>\u0000 <p>Targeting CUR to MT is a promising drug-delivery strategy for diseases in which mitochondrial dysfunction plays a critical role in pathogenesis. This article highlights the role of mitochondrial dysfunction in the development of various diseases and discusses the significance of mitochondria-targeted delivery of CUR using various drug-delivery approaches. Furthermore, the article elaborates on the key challenges in mitochondrial biology and the biological barriers associated with MT-targeted drug delivery systems. Translational challenges, clinical hurdles and limitations of MT-targeted curcumin delivery systems are also highlighted.</p>\u0000 </div>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148039895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-17
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148079484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-17
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148079485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Ferroptosis for Cancer Immunotherapy: Molecular Mechanisms, Immune Microenvironment Crosstalk, and Clinical Translation Prospects 针对铁下垂的癌症免疫治疗：分子机制、免疫微环境串扰和临床转化前景
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-10 DOI: 10.1002/adtp.202500529
Jiamin Shi, Guoren Zhou
{"title":"Targeting Ferroptosis for Cancer Immunotherapy: Molecular Mechanisms, Immune Microenvironment Crosstalk, and Clinical Translation Prospects","authors":"Jiamin Shi,&nbsp;Guoren Zhou","doi":"10.1002/adtp.202500529","DOIUrl":"10.1002/adtp.202500529","url":null,"abstract":"<div>\u0000 \u0000 <p>Ferroptosis, a novel form of iron-dependent programmed cell death (PCD), has garnered extensive attention in the cancer research field in recent years. Through its unique iron-dependent regulatory mechanisms and dynamic crosstalk with the cancer immune microenvironment (CIME), ferroptosis has established a new research paradigm for cancer therapy. This review systematically clarifies the molecular mechanisms underlying ferroptosis, thoroughly explores its dual regulatory roles within the CIME, and elaborates on the reciprocal interactions between ferroptosis and immune cell functions. It also comprehensively discusses ferroptosis-based cancer immunotherapy strategies and their clinical translation prospects. By integrating the latest research advances, this work provides a theoretical foundation and practical guidance for the clinical application of ferroptosis in cancer immunotherapy.</p>\u0000 </div>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 2.6 4区 医学
Advanced Therapeutics Pub Date : 2026-04-10
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148105880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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