Advanced Therapeutics最新文献_第5页

Canine Breast Carcinomas: Recent Advances in Diagnostic and Treatment Strategies 犬乳腺癌：诊断和治疗策略的最新进展

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-16 DOI: 10.1002/adtp.202400115

Pritish Rath, Chitra Jaiswal, Debajyoti Pal, Samit Kumar Nandi, Biman B. Mandal

{"title":"Canine Breast Carcinomas: Recent Advances in Diagnostic and Treatment Strategies","authors":"Pritish Rath, Chitra Jaiswal, Debajyoti Pal, Samit Kumar Nandi, Biman B. Mandal","doi":"10.1002/adtp.202400115","DOIUrl":"https://doi.org/10.1002/adtp.202400115","url":null,"abstract":"Breast cancer in canines is one of the leading causes of death globally due to client misinterpretation and improper diagnosis and treatment. In past centuries, the diagnosis and treatment of breast carcinoma in dogs followed conventional techniques adopted from human oncology. However, with increasing demand and scientific advancements in the upcoming future, there is an emerging necessity to modernize the diagnostic and treatments in canine breast cancer (CBC) patients. This review explores recent advances in diagnostic techniques and novel therapeutic approaches such as adjuvant-based targeted therapy, nanomaterial therapy, immune-based therapy, adoptive cell therapy, tumor vaccine, oncolytic virotherapy, and the use of noncoding RNAs in CBCs. In addition, the review discusses the healthcare policies aimed at improving diagnostic and therapeutic efficacy and future directions for translation from human oncology into veterinary oncology. By adopting these modern strategies, the quality of care can be significantly enhanced by translating them into practical applications with better outcomes and improved survival rates for canine patients.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation 通过阻断自噬通量和抑制肿瘤增殖，将舍曲林重新用于治疗结直肠癌

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-08-16 DOI: 10.1002/adtp.202400199

Leping He, Xijun Guo, Wanrong Wang, Weifeng Xu, Xiaoli Feng, Yuanfeng Fu, Yuxi Tian, Zongmao He, Sulan Luo, Jiaolin Bao, Ren‐Bo Ding

{"title":"Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation","authors":"Leping He, Xijun Guo, Wanrong Wang, Weifeng Xu, Xiaoli Feng, Yuanfeng Fu, Yuxi Tian, Zongmao He, Sulan Luo, Jiaolin Bao, Ren‐Bo Ding","doi":"10.1002/adtp.202400199","DOIUrl":"https://doi.org/10.1002/adtp.202400199","url":null,"abstract":"Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer‐related death worldwide. More than 30% of CRC patients will experience treatment failure and tumor recurrence after standard‐of‐care treatment. Therefore, it is important to discover new therapeutic regimens for treating CRC. Repurposing existing clinically used drugs into new anticancer agents represents a feasible way and has become increasingly popular. In this study, the aim is to investigate the anticancer effect of sertraline on CRC and to elucidate its underlying mechanism. The data showed that sertraline exhibited a potent anticancer effect against CRC in vitro and in vivo. Sertraline inhibited Akt‐ and STAT3‐mediated cell proliferation but do not affect several programmed cell deaths in CRC, such as apoptosis, pyroptosis, ferroptosis, and mitophagy. Meanwhile, sertraline induced autophagosome accumulation but blocked autophagic flux in CRC cells. Further investigations reveal that sertraline impeded late autophagic flux at the stage of autolysosomal degradation rather than autophagosome‐lysosomal fusion in CRC. Furthermore, it is also demonstrated that sertraline synergistically sensitized chemotherapeutic agents against CRC. Overall, the study reveals the great potential of sertraline as a novel therapeutic candidate for CRC, which is worthy of further development in the future.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"25 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Irreversible Electroporation has More Synergistic Effect with Anti-PD-1 Immunotherapy than Thermal Ablation or Cryoablation, in a Colorectal Cancer Model 在结直肠癌模型中，与热消融或冷冻消融相比，不可逆电穿孔技术与抗-PD-1免疫疗法的协同作用更强

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-14 DOI: 10.1002/adtp.202400068

Minhan Jiang, Qi Shao, Joseph Slaughter, John Bischof

{"title":"Irreversible Electroporation has More Synergistic Effect with Anti-PD-1 Immunotherapy than Thermal Ablation or Cryoablation, in a Colorectal Cancer Model","authors":"Minhan Jiang, Qi Shao, Joseph Slaughter, John Bischof","doi":"10.1002/adtp.202400068","DOIUrl":"https://doi.org/10.1002/adtp.202400068","url":null,"abstract":"Boosting the response rate of immune checkpoint blockade (ICB) therapy to improve treatment efficacy is a primary goal in cancer immunotherapy. One of the promising approaches involves focal tumor ablation to reduce tumor burden and trigger the in situ vaccination. Even though this combination strategy has demonstrated enhanced therapeutic outcomes in both preclinical research and clinical trials, limited research has comparatively investigated diverse ablation techniques. The optimal choice among focal therapy techniques remains largely unknown. In a murine colorectal cancer model (MC-38), the therapeutic efficacy of anti-PD-1 in combination with thermal ablation, cryoablation, and irreversible electroporation (IRE) is evaluated, utilizing well-characterized miniature probes. In this model, ICB monotherapy has limited effect in controlling tumor growth. IRE exhibits the most favorable synergistic effect with anti-PD-1 immunotherapy than thermal ablation or cryoablation, leading to the greatest primary tumor growth delay, longest tumor-free survival, and highest protection against secondary tumor challenge. Furthermore, the co-administration of IRE and anti-PD-1 significantly fosters the infiltration of CD8+ T cells into the tumor coupled with a remarkable stem-like progenitor phenotype. The findings demonstrate that IRE stands as a promising modality that can potentiate the antitumor efficacy when the tumor is poorly responding to ICB monotherapy.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Modified Glucose-Derived, Blood–Brain Barrier-Crossing Nanospheres Dually Targets Macrophage and Cancer Cells for Effective In Situ Anti-Glioma Effect 表面修饰的葡萄糖衍生、可穿越血脑屏障的纳米球可同时靶向巨噬细胞和癌细胞，实现有效的原位抗胶质瘤效果

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-09 DOI: 10.1002/adtp.202400100

Madhan Mohan Chandra Sekhar Jaggarapu, Aasia Ansari, Sudhakar Jinka, Kathyayani Sridharan, Narendra Varma Nimmu, Namita Mahadik, Venu Yakati, Kuncha Madhusudana, Muthusamy Eswaramoorthy, Tapas K. Kundu, Rajkumar Banerjee

{"title":"Surface Modified Glucose-Derived, Blood–Brain Barrier-Crossing Nanospheres Dually Targets Macrophage and Cancer Cells for Effective In Situ Anti-Glioma Effect","authors":"Madhan Mohan Chandra Sekhar Jaggarapu, Aasia Ansari, Sudhakar Jinka, Kathyayani Sridharan, Narendra Varma Nimmu, Namita Mahadik, Venu Yakati, Kuncha Madhusudana, Muthusamy Eswaramoorthy, Tapas K. Kundu, Rajkumar Banerjee","doi":"10.1002/adtp.202400100","DOIUrl":"10.1002/adtp.202400100","url":null,"abstract":"Glucose-derived carbon nanospheres (CSP), uniquely derived by hydrothermal condensation process, inherently cross blood–brain-barrier (BBB) but distribute all over the brain. Albeit its potential to treat glioma as an effective drug delivery system, it is challenging to restrict drug-associated CSP within the glioma region and reduce non-specific side effects. Incidentally, gliomas moderately express sigma receptors (SR). Earlier, a cationic lipid-conjugated neuropsychotic drug, haloperidol (H8) is developed with SR-targetability and anticancer effect but with zero BBB-crossing ability. In this study, the CSP surface is modified with H8 (CH8 nano-conjugate) and dual targeting is achieved within glioma-tumor microenvironment: 1) glioma cells and 2) pro-proliferative M2 tumor-associated macrophages (TAM), as both express SR. CH8-treatment increases the survivability of orthotopic glioma-tumor bearing mice and significantly reduces tumor burden in the glioma-subcutaneous model. Further CH8-surface is modified by combining the brain tumor drug, carmustine (CH8-CRM). CH8-CRM nano-conjugate selectively enhances the survivability of orthotopic glioma-carrying mice and reduces tumor aggressiveness significantly in comparison to other treatment groups. Lysates from CH8-CRM-treated tumor show upregulation of cleaved-caspase 3, p53, but downregulation of pAkt. The combination treatment pronouncedly enhances the anti-glioma effect of H8. Conclusively, CH8-mediated dual-targeting via SR within orthotopic glioma-associated mice exemplifies the repurposing of neuropsychotic drugs for treating glioma.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the AhR Therapeutic Potential for Cystic Fibrosis With an Integrated Mucosal Platform for Drug Screening 利用药物筛选粘膜综合平台释放囊性纤维化的 AhR 治疗潜力

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-07 DOI: 10.1002/adtp.202400141

Lorenzo Sardelli, Enrica Frasca, Valentina Olga Garbero, Cosmin Butnarasu, Alex Affricano, Claudio Medana, Sonja Visentin

{"title":"Unlocking the AhR Therapeutic Potential for Cystic Fibrosis With an Integrated Mucosal Platform for Drug Screening","authors":"Lorenzo Sardelli, Enrica Frasca, Valentina Olga Garbero, Cosmin Butnarasu, Alex Affricano, Claudio Medana, Sonja Visentin","doi":"10.1002/adtp.202400141","DOIUrl":"10.1002/adtp.202400141","url":null,"abstract":"Bacterial-derived molecules are at the basis of bacteria–bacteria and bacteria–host communication. In the context of cystic fibrosis (CF), they are considered possible therapeutic molecules for their natural binding capability on the immunomodulatory cytoplasmic aryl hydrocarbon receptor (AhR). An exponentially growing number of bacteria-derived molecules are identified as AhR activators, highlighting the need for systems to screen possible lead candidates. This challenge is addressed by applying an in vitro tool mimicking the two main barriers that potential AhR-targeting drugs must overcome: the cytoplasmic membrane and the CF pathological mucus. A small dataset of AhR ligands with potential therapeutic applications is selected. The apparent permeability of bacterial-derived molecules across a cellular membrane model is quantified and molecules capable of reaching the cytoplasmic target (AhR) are identified. In a second step, a CF in vitro mucus model is integrated with the phospholipid membrane and the impact of mucus on permeability is assessed. Overall, this study proposes an integrated mucosal platform as a suitable tool in the emerging field of postbiotics as a therapeutic strategy for CF. The mucosal platform can enable the rapid identification of molecules compatible with cytoplasmic targeting of AhR among candidate-drug representatives.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141936781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustained-Release of Antigens and CpG-DNA using Temperature-Responsive Biodegradable Injectable Polymers: Performance on Induction of Immune Responses (Adv. Therap. 8/2024) 使用温度响应型生物可降解注射聚合物持续释放抗原和 CpG-DNA：诱导免疫反应的性能（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-07 DOI: 10.1002/adtp.202470015

Yuta Yoshizaki, Kenta Horii, Nobuo Murase, Akinori Kuzuya, Yuichi Ohya

引用次数: 0

Issue Information (Adv. Therap. 8/2024) 发行信息（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-07 DOI: 10.1002/adtp.202470016

引用次数: 0

Nanostructured Hybrid Polymer-Lipid Drug Delivery Platforms for Rapamycin Repositioning in Anticancer Therapy 雷帕霉素在抗癌治疗中重新定位的纳米结构杂化聚合物-脂质给药平台

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-07 DOI: 10.1002/adtp.202400143

Cinzia Scialabba, Silvia Codenotti, Delia Mandracchia, Marta Cabibbo, Alessandro Fanzani, Emanuela Fabiola Craparo, Gennara Cavallaro

{"title":"Nanostructured Hybrid Polymer-Lipid Drug Delivery Platforms for Rapamycin Repositioning in Anticancer Therapy","authors":"Cinzia Scialabba, Silvia Codenotti, Delia Mandracchia, Marta Cabibbo, Alessandro Fanzani, Emanuela Fabiola Craparo, Gennara Cavallaro","doi":"10.1002/adtp.202400143","DOIUrl":"10.1002/adtp.202400143","url":null,"abstract":"Here, hybrid polymer-lipid nanoparticles are designed as colloidal carriers for Rapamycin, to improve the aqueous drug stability and to support the drug repositioning for cancer treatment, that is, against rhabdomyosarcoma (RMS). With this aim, Rapamycin – loaded hybrid nanoparticles are produced by using as nanoparticle core a graft copolymer obtained from the functionalization of the α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) with Rhodamine B (RhB), Polylactic acid (PLA), the PHEA-g-RhB-g-PLA, and different phospholipids, that is, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) coated, pegylated and Mannose/PEG, for the surface coating. The drug loading of these samples allows for controlled release, and improves drug stability at pH 5.5 and 7.4 compared to the free drug. Chemical-physical characterization confirms the nanostructure size below 200 nm, ideal for systemic administration, and easy re-dispersibility in aqueous media. Moreover, biological characterization to test the potential use as antitumor agent shows induction of cytotoxicity in human rhabdomyosarcoma (RD) and macrophage (RAW) cell lines in a time- and concentration – dependent manner, and stimulated autophagy, comparable to the free drug. The uptake study following the fluorescence of the copolymer reveals that the hybrid nanoparticles are internalized by both tested cell lines, with a significantly higher amounts of internalized particles in the case of surface mannosylated and/or pegylated systems.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141936782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLGA Nanoparticles Coated with Activated Dendritic Cell Membrane Can Prolong Protein Expression and Improve the Efficacy of mRNA 涂有活化树突状细胞膜的 PLGA 纳米颗粒可延长蛋白质表达并提高 mRNA 的疗效

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-06 DOI: 10.1002/adtp.202400180

Minghao Xu, Ao Zhu, Yunzhi Pan, Zainab Suleman, Junping Cheng, Mi Liu

{"title":"PLGA Nanoparticles Coated with Activated Dendritic Cell Membrane Can Prolong Protein Expression and Improve the Efficacy of mRNA","authors":"Minghao Xu, Ao Zhu, Yunzhi Pan, Zainab Suleman, Junping Cheng, Mi Liu","doi":"10.1002/adtp.202400180","DOIUrl":"10.1002/adtp.202400180","url":null,"abstract":"In future, mRNA drugs likely play crucial roles in vaccines and protein replacement therapy etc. Lipid nanoparticles (LNPs) are the only formulation approved for mRNA delivery. However, in cancer vaccine, the mRNA encapsulated in LNP can only encode limited (20–40) tumor antigens. Due to highly heterogeneous of tumor cells and tumor antigens, including more diverse antigens could improve the efficacy of cancer vaccines. Including both strong immunogenic antigens and more diverse antigens could maximize the efficacy of cancer vaccines. Herein, poly (lactic-co-glycolic acid) (PLGA) nanoparticles and activated dendritic cell membrane were designed as mRNA delivery platforms, which possess merits such as prolonged protein expression, lyophilized formulation, and greater efficacy etc. Dendritic cells were activated with particles loading whole tumor antigens which can activate broad range antigen-specific T cells. The sustained release of mRNA in PLGA nanoparticles can significantly prolong protein expression in APCs, and lyophilization improved the stability of mRNA formulation. Compared with LNPs, these nanovaccines significantly improved the therapeutic efficacy of mRNA. In addition, tumor antigen-specific T cells in mice treated with nanovaccines was significantly greater than that treated with LNPs. Overall, a new platform for delivering mRNA was demonstrated, that can prolong protein expression and have better efficacy.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141936783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sonodynamic Treatment Triggers Cancer Cell Killing by Doxorubicin in P-Glycoprotein-Mediated Multidrug Resistant Cancer Models 在P-糖蛋白介导的多药耐药性癌症模型中，声动力治疗可通过多柔比星杀死癌细胞

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-03 DOI: 10.1002/adtp.202400070

Federica Foglietta, Marta Giacone, Gianni Durando, Roberto Canaparo, Loredana Serpe

{"title":"Sonodynamic Treatment Triggers Cancer Cell Killing by Doxorubicin in P-Glycoprotein-Mediated Multidrug Resistant Cancer Models","authors":"Federica Foglietta, Marta Giacone, Gianni Durando, Roberto Canaparo, Loredana Serpe","doi":"10.1002/adtp.202400070","DOIUrl":"10.1002/adtp.202400070","url":null,"abstract":"Doxorubicin is a widely used chemotherapeutic agent that can be hampered in its efficacy by the occurrence of multidrug resistance (MDR), due to the overexpression of the drug efflux transporter P-glycoprotein. As overcoming MDR still remains an unmet clinical need, this work aims at investigating an innovative strategy. Sonodynamic therapy (SDT) selectively kills cancer cells by combining low-intensity ultrasound (US) with a responsive chemical agent (sonosensitiser) that can be activated to produce reactive oxygen species (ROS). Therefore, the efficacy of SDT, using doxorubicin as sonosensitiser, is studied on human MDR ovarian (A2780/MDR) and colon (HT-29/MDR) cancer cells. The ultrasound exposure of MDR cells pre-incubated with non-cytotoxic concentrations of doxorubicin for 1 h has induced a statistically significant decrease of cell proliferation after 72 h. Interestingly, US has selectively triggered the ROS-mediated cytotoxicity of the doxorubicin entrapped into the cancer cell membrane leading to necrotic cancer cell death by lipid peroxidation. Moving from 2D to 3D HT-29/MDR cell cultures, the ability of SDT to reduce the growth of MDR spheroids by inducing significant necrotic cancer cell death is also confirmed. In conclusion, SDT can have a role in treating MDR tumors by eliciting the ROS-mediated cytotoxicity of doxorubicin.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0