Self-Assembled Nanocarriers of Synthetic and Natural Plasmalogens for Potential Nanomedicine Development (Adv. Therap. 2/2025)

Abstract

In article 2400093, Angelina Angelova and co-workers use synchrotron small-angle X-ray scattering to reveal the variety of nanoassemblies (cubosomes, hexosomes, or vesicles) that scallop-derived plasmalogen phospholipids can form in mixtures with co-lipids. Plasmalogen-based nanotherapeutics exert anti-apoptotic effects and improve brain-derived neurotrophic factor (BDNF) protein expression required for neuronal cell survival.