Advanced Therapeutics最新文献_第6页

Dimethyl Fumarate Ameliorates the Endometriosis Through Anti-Inflammatory and Anti-Proliferation Mechanisms In Vitro and In Vivo 富马酸二甲酯通过体外和体内抗炎和抗增殖机制改善子宫内膜异位症

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-03 DOI: 10.1002/adtp.202400237

Miji Kim, Wonhyoung Park, Hee Seung Kim, Soo Jin Park, Whasun Lim, Gwonhwa Song, Sunwoo Park

{"title":"Dimethyl Fumarate Ameliorates the Endometriosis Through Anti-Inflammatory and Anti-Proliferation Mechanisms In Vitro and In Vivo","authors":"Miji Kim, Wonhyoung Park, Hee Seung Kim, Soo Jin Park, Whasun Lim, Gwonhwa Song, Sunwoo Park","doi":"10.1002/adtp.202400237","DOIUrl":"10.1002/adtp.202400237","url":null,"abstract":"Dimethyl fumarate is a widely known therapeutic agent with anti-inflammatory properties for psoriasis and multiple sclerosis. Despite the current attempts to use dimethyl fumarate for treating various inflammatory diseases, its effects on endometriosis have not been previously reported. Endometriosis is a genital disease that causes various health problems in women, and treatment methods targeting the inflammatory environment are being attempted. Therefore, it is hypothesized that dimethyl fumarate has therapeutic effects on endometriosis through its anti-inflammatory effects. Dimethyl fumarate exerted remarkable effects on cellular mechanisms, including reactive oxygen species production, activation of mitogen‑activated protein kinase signals, loss of mitochondrial function, and disruption of calcium ion homeostasis in the immortalized human ovarian endometrial stromal cells. In an endometriosis mouse model, dimethyl fumarate downregulated cell cycle-related genes and induced inhibitory effects on endometriosis lesion growth. In particular, the immune cell population and expression of inflammatory cytokines such as IL-1β, IL-6, and IL-10 are regulated by dimethyl fumarate. These results support its potential as a therapeutic agent to control the excessive inflammatory environment in patients with endometriosis. This study identifies for the first time that dimethyl fumarate, which is already in clinical use, can be used to treat endometriosis.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KS-133/KS-487 Nanoparticles Exhibit Potent Antitumor Effects through Synergistic LRP1 Targeting and VIPR2 Inhibition: Therapeutic Nanoarchitectonics for Solid Tumors KS-133/KS-487纳米颗粒通过LRP1靶向和VIPR2抑制的协同作用发挥强效抗肿瘤作用：治疗实体瘤的纳米架构

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-08-02 DOI: 10.1002/adtp.202400278

Kotaro Sakamoto, Taisei Nishiyama, Eijiro Miyako

{"title":"KS-133/KS-487 Nanoparticles Exhibit Potent Antitumor Effects through Synergistic LRP1 Targeting and VIPR2 Inhibition: Therapeutic Nanoarchitectonics for Solid Tumors","authors":"Kotaro Sakamoto, Taisei Nishiyama, Eijiro Miyako","doi":"10.1002/adtp.202400278","DOIUrl":"10.1002/adtp.202400278","url":null,"abstract":"VIPR2 is associated with psychiatric disorders, breast cancer metastasis, and cancer immunostimulation. The VIPR2 antagonist KS-133 changes the polarity of macrophages to the M1 type, and nanoparticles (NPs) releasing KS-133 exhibit antitumor effects against mouse colon cancer cells (CT26) in vivo. To enhance the antitumor effect of KS-133 NPs, KS-133 NPs are combined with the peptide KS-487 targeting LRP1, which is expressed on CT26 cells. Subcutaneous injection of NPs containing indocyanine green (ICG) fluorescent dye and presenting KS-487 in CT26 subcutaneous tumor-bearing mice resulted in significant accumulation of ICG in the CT26 tumor compared to administration of NPs without KS-487. NPs containing KS-133 and presenting KS-487 (KS-133/KS-487 NPs) exhibited dose-dependent antitumor effects in CT26 subcutaneous tumor-bearing mice; the antitumor effects are more potent than the effects of KS-133 NPs without KS-487. In addition, CD8-positive T cells and macrophages significantly infiltrated into CT26 tumors after injection of KS-133/KS-487 NPs. Thus, KS-133/KS-487 NPs efficiently deliver KS-133 to CT26 tumors via LRP1-targeting and activate immune system cells such as CD8 positive T cells and macrophages via KS-133 inhibition of VIPR2 signaling, resulting in antitumor effects. These results demonstrate the potential of KS-133/KS-487 NPs as a therapeutic candidate for treating solid tumors.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141882533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel 关节炎研究的辅助工具：用壳聚糖水凝胶包裹人纤维母细胞样滑膜细胞的三维细胞培养法

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-08-02 DOI: 10.1002/adtp.202400166

Francesco Bisconti, Beatrice Vilardo, Gaia Corallo, Francesca Scalera, Giuseppe Gigli, Annalisa Chiocchetti, Alessandro Polini, Francesca Gervaso

{"title":"An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel","authors":"Francesco Bisconti, Beatrice Vilardo, Gaia Corallo, Francesca Scalera, Giuseppe Gigli, Annalisa Chiocchetti, Alessandro Polini, Francesca Gervaso","doi":"10.1002/adtp.202400166","DOIUrl":"https://doi.org/10.1002/adtp.202400166","url":null,"abstract":"Osteoarthritis (OA) and Rheumatoid arthritis (RA) are the most common arthritis in which the synovium is involved, but the cellular and molecular basis of these pathologies still need better elucidation. Fibroblast‐like synoviocytes (FLS), one of the cellular elements of the synovium, play a key role in RA, an autoimmune disease characterized by joint inflammation and systemic symptoms that afflicts 1% of worldwide population. Despite articular damage starts from synovium and then proceeds involving cartilage till bone erosion, several 3D in vitro models are reported for cartilage and bone while only a few studies focused on the synovial component. Here, a hydrogel formulation suitable for 3D culturing human fibroblast‐like synoviocytes and evaluated its suitability with non‐RA and RA patients derived‐cells is developed. Among different formulations, a chitosan (Cs)‐based hydrogel, constituted by 70% of Cs and 30% of Matrigel, showed the best results in terms of stability as well as cell growth and morphology: non‐RA and RA FLS are able to grow within the hydrogel forming a complex 3D network. Thanks to the low cost, and high market availability of chitosan, this system represents a good alternative to the use of sole Matrigel for encapsulating human synoviocytes.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ring Finger Protein 217 Inhibits Ovarian Cancer Progression by Down-Regulating HAX1 Expression 环指蛋白 217 通过下调 HAX1 表达抑制卵巢癌进展

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-31 DOI: 10.1002/adtp.202400123

Lili Zhou, Junbo Liu, Min Zhou, Lan Xu

{"title":"Ring Finger Protein 217 Inhibits Ovarian Cancer Progression by Down-Regulating HAX1 Expression","authors":"Lili Zhou, Junbo Liu, Min Zhou, Lan Xu","doi":"10.1002/adtp.202400123","DOIUrl":"10.1002/adtp.202400123","url":null,"abstract":"Ring finger protein 217 (RNF217) has been found to interact with the antiapoptotic protein HS-1-associated protein X-1 (HAX-1) in myeloid leukemia cells. However, the understanding of RNF217 in ovarian cancer progression remains limited. The relative expression of RNF217 is screened in ovarian cancer using the GEPIA database and calculated its correlation with MKI67, CCNB1, and CDK4. OVCAR-3 and SK-OV-3 cells are transfected with RNF217-overexpression plasmids. Cell-counting kit-8 assay is utilized to assess proliferation. Immunoprecipitation is performed to reveal the interaction between RNF217 and HAX-1, and a cycloheximide chase assay is performed to analyze HAX-1 degradation. The GEPIA database indicated down-regulated expression of RNF217 in ovarian cancer, negatively correlated with MKI67 (R = -0.26, P = 1.8e-09), CCNB1 (R = -0.37, P = 3.2e-18), and CDK4 expression (R = -0.24, P = 3.4e-08). RNF217 overexpression down-regulated the relative expression of MKI67, CCNB1, and CDK4 in OVCAR-3 and SK-OV-3 cells, resulting in diminished proliferation. In vivo studies using OVCAR-3 and SK-OV-3 cell line-derived xenograft models also showed that RNF217 overexpression reduced ovarian cancer volume and weight. Furthermore, RNF217 overexpression in SK-OV-3 cells inhibited the protein expression of HAX1 by reducing its stability. In conclusion, RNF217 inhibits ovarian cancer progression by down-regulating HS-1-associated protein X-1 expression.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141866459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants 揭示常见抗抑郁药物难以捉摸的结构和机制

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-31 DOI: 10.1002/adtp.202400117

Jieye Lin, Guanhong Bu, Johan Unge, Tamir Gonen

引用次数: 0

The Near-Infrared Light Emitted by LiScO2:Cr3+ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome 用于诱导 Sjogren's 综合征腺体分泌的 LiScO2:Cr3+ 磷光发射的近红外线

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-30 DOI: 10.1002/adtp.202400125

Lei Chen, Qi Liu, Pingping Li, Shuanghong Wei, Yanguang Guo, Ping Chen, Haiyong Ni, Shizhong Wei, Xingxing Huo

{"title":"The Near-Infrared Light Emitted by LiScO2:Cr3+ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome","authors":"Lei Chen, Qi Liu, Pingping Li, Shuanghong Wei, Yanguang Guo, Ping Chen, Haiyong Ni, Shizhong Wei, Xingxing Huo","doi":"10.1002/adtp.202400125","DOIUrl":"10.1002/adtp.202400125","url":null,"abstract":"Photobiomodulation is promisingly used as a noninvasive new weapon against Sjogren's syndrome, which is a disorder of immune system with two main symptoms of dry eyes and a dry mouth. This work reports a new NIR LED device made from LiScO2:Cr3+ phosphor for the application. The absorbance, internal, and external quantum efficiency of the optimal Li(Sc0.98Cr0.02)O2 phosphor reach 40.9%, 34.5%, and 14.1%, respectively; and the output power and energy conversion efficiency of the LED device packaged using the phosphor driven under 20 mA are 4.23 mW, respectively. The emission spectrum of the LED device can well cover the action spectrum of oxidized CuA in cytochrome c oxidase molecules. Both the pathological changes of mice submandibular gland and the expression of human submandibular gland epithelial cells (HSG) in AQP5, M3R andEGR1 confirm that the NIR light has great potential application for treating Sjogren's syndrome. Moreover, study with mice approved that the therapy using the NIR light is more efficient than the conventional medicine treatment using hydroxychloroquine sulfate.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141866460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic Nanoparticle-Mediated Multimodal Cancer Therapy: Hyperthermia, Controlled Drug Release, and Antibody-Based Precision 磁性纳米粒子介导的多模式癌症疗法：热疗、可控药物释放和基于抗体的精准治疗

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-29 DOI: 10.1002/adtp.202400168

S. S. Pawar, O. Selyshchev, L. Rasabathina, O. Hellwig, V. V. Kedage, D.R.T. Zahn, V. Stephan, B. Kersting, G. Salvan, A. D. Chougale, P.B. Patil

{"title":"Magnetic Nanoparticle-Mediated Multimodal Cancer Therapy: Hyperthermia, Controlled Drug Release, and Antibody-Based Precision","authors":"S. S. Pawar, O. Selyshchev, L. Rasabathina, O. Hellwig, V. V. Kedage, D.R.T. Zahn, V. Stephan, B. Kersting, G. Salvan, A. D. Chougale, P.B. Patil","doi":"10.1002/adtp.202400168","DOIUrl":"10.1002/adtp.202400168","url":null,"abstract":"Research in cancer therapies is rapidly advancing and demands the exploration of innovative approaches to further improve the efficacy of treatment. Here a multimodal approach for cancer therapy is reported which combines bioactive targeting, magnetic hyperthermia, and controlled drug release. For this, a nanoformulation MNP-Chi-Dox-Ab, is bioengineered by conjugating CA 15-3 antibodies to doxorubicin-loaded functionalized magnetic nanoparticles (MNPs). Solvothermally synthesized MNPs of uniform spherical shape and size are functionalized with thermo-pH-responsive chitosan. The nanoformulation showed higher drug release of ≈65% at pH 5 and 42 °C temperature compared to the release at physiological pH and temperature. Furthermore, in an alternating magnetic field drug release is enhanced to 74%. Cytotoxicity studies in MCF-7 breast cancer cells confirm the active targeting potential of the nanoformulation. For the nanoformulation without bioactive molecule (anti-CA 15-3) only 18% cancer cell death is noted whereas with the conjugation of anti-CA 15-3, 43% cell death is recorded. Flow cytometry studies revealed an increased apoptotic population at hyperthermic temperature (42 °C) compared to the physiological temperature. These results suggest that MNP-Chi-Dox-Ab nanoformulation represents a promising multimodal platform for synergistic breast cancer therapy by combining active targeting, controlled drug release, and hyperthermia.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141866462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial N-Terminal Signal Sequences as Novel Antimicrobial and Annticancer Peptides 作为新型抗菌肽和抗癌肽的线粒体 N 端信号序列

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-24 DOI: 10.1002/adtp.202400102

Sang-Heon Jo, Kyu-Shik Lee, Min-Gu Lee, Eun-Young Yun, Kyuho Jeong, Tae Won Goo

{"title":"Mitochondrial N-Terminal Signal Sequences as Novel Antimicrobial and Annticancer Peptides","authors":"Sang-Heon Jo, Kyu-Shik Lee, Min-Gu Lee, Eun-Young Yun, Kyuho Jeong, Tae Won Goo","doi":"10.1002/adtp.202400102","DOIUrl":"10.1002/adtp.202400102","url":null,"abstract":"N-terminal mitochondrial targeting sequences (MTS) are signal peptides to drive the localization and import of mitochondrial protein and exhibit an amphipathic α-helix structure similar to that of almost all antimicrobial peptides (AMPs). Here, 2,939 mitochondrial proteins are excavated from various organisms, and 574 MTS are selected with an MTS possibility score exceeding 0.5, as determined via MitoFates (http://mitf.cbrc.jp/MitoFates/cgi-bin/top.cgi). 26 MTS composed of less than 20 amino acids is synthesized and analyzed their antimicrobial activities. The results showed that approximately 50% of MTS exhibited antimicrobial activity. Among them, human mitochondrial transcription termination factor 2 (hMTERF2-ts) is identified as an AMP candidate with strong antimicrobial activity against gram-positive and gram-negative bacteria, antibiotics-resistant (AR) bacteria, and fungi. Furthermore, it shows anticancer activities against various cancer cells, such as MDA-MB-231, HT-29, HepG2, and Panc-1 cells, with high stability against proteases, heat, pH, and salt, and low cytotoxicity toward normal cells, HaCaT and RAW 264.7. In addition, hMTERF2-ts effectively prevented the growth of Panc-1-implanted tumors without weight loss in BALB/c nude mice. In conclusion, this study suggests that MTSs of protozoa are powerful and novel AMP candidates with low cytotoxicity against normal cells.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141770225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Boron Nitride-Hyaluronic Acid Hybrid Hydrogels to Facilitate Joint Motion: Mechanical and Tribological Characterization 促进关节活动的可注射氮化硼-透明质酸混合水凝胶：机械和摩擦学特性分析

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-22 DOI: 10.1002/adtp.202400196

Yapıncak Goncu, Gokçe Mehmet Ay, Aykut Kucukbas, Fatih Kar, Cansu Ozbayer, Ezgi Kar, Hakan Senturk

{"title":"Injectable Boron Nitride-Hyaluronic Acid Hybrid Hydrogels to Facilitate Joint Motion: Mechanical and Tribological Characterization","authors":"Yapıncak Goncu, Gokçe Mehmet Ay, Aykut Kucukbas, Fatih Kar, Cansu Ozbayer, Ezgi Kar, Hakan Senturk","doi":"10.1002/adtp.202400196","DOIUrl":"10.1002/adtp.202400196","url":null,"abstract":"Hexagonal boron nitride (hBN) is used as an additive in engineering applications such as polymers, ceramics, and coatings because of its anti-wear and lubrication performance. It has a high potential as a biomaterial, but it has not been evaluated to facilitate joint motion with its lubricating properties until now. In this study, the hypothesis that boron nitride nanoparticles (BNPs) and nanosheets (BNNSs) can facilitate movement in the joint region is evaluated for the first time. Hyaluronic acid-based hybrid hydrogels are designed to transport BN particles to the target area and pin-on-disc tests on cartilage pins paired with glass disks are conducted to determine the validity of the proposed hypothesis. The injectability, mechanical properties, and friction coefficients of hydrogels with the addition of increasing proportions of different hBN morphologies are monitored. As a result, hyaluronic acid has been found to be a suitable carrier for the injectability of boron nitride in biomedical applications. The amount and morphology of boron nitride are observed as two important parameters. A significant decrease in the friction coefficient (18.9%) is observed in the BNNS-doped hybrid hydrogel compared to the virgin hydrogel. hBN can be considered as a new therapeutic agent with the potential to facilitate joint mobility.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141744625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-22 DOI: 10.1002/adtp.202400192

Priyanka Upadhyay, Ridhima Goel, Deepak Gulwani, Vijaya Sarangthem, Thoudam Debraj Singh

{"title":"Estrogen-Related Receptor Gamma (ERRγ) as Biomarker and Novel Target for Therapeutic Intervention on Cancer: A Review","authors":"Priyanka Upadhyay, Ridhima Goel, Deepak Gulwani, Vijaya Sarangthem, Thoudam Debraj Singh","doi":"10.1002/adtp.202400192","DOIUrl":"10.1002/adtp.202400192","url":null,"abstract":"Estrogen-related receptors (ERRs), genes similar to estrogen receptors, are identified as hormone-responsive systems associated with the ERR subfamily. These hormone-responsive systems facilitate oncometabolic programs to nourish cancer cell growth, a central node at the interface of cellular energy metabolism and cancer. Several independent studies have implicated ERR isoforms like ERRα, ERRβ, and ERRγ in the pathways of cancer development and progression. The construction of tissue-specific ERR transgenic or knockout mice and the application of synthetic ligands have precisely indicated the critical and diverse role of ERRγ than other isoforms. ERRγ, plays a critical and diverse role, enabling switching metabolism to oncometabolism in favor of cancer cells, making it a “hot target” in cancer therapy. ERRγ expression is correlated with the clinical status of diverse cancer types and various cancer tissue treatments. The dual feature of ERRγ raises interest in understanding its biogenesis and function in different tissues. This review aims to describe the structural organization of ERRs, their central occupancy at the interface of cancer and metabolism, and their biogenesis and expression profile across different cancers. It concludes that ERRγ has potential as a clinical marker in cancer prognosis and a novel non-conventional therapeutic target.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141754016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0