Advanced Therapeutics最新文献_第7页

Electro-Responsive Nanotherapeutics for Tumor Therapy by Manipulating Accidental and Regulated Cell Death Pathway 通过操纵意外和调控细胞死亡途径治疗肿瘤的电反应纳米疗法

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-18 DOI: 10.1002/adtp.202400160

Chang Qu, Xinyue Shao, Yuling Li, Ran Jia, Jinping Wang, Hailong An

引用次数: 0

RNA Encapsulation in Metal–Organic Frameworks for Targeting Cancer-Causing Genes 在金属有机框架中封装 RNA 以靶向致癌基因

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-18 DOI: 10.1002/adtp.202400144

Meemansha Mishra, Tapan Dey, Mallya Mishra, Isha Chauhan, Saikat Dutta

{"title":"RNA Encapsulation in Metal–Organic Frameworks for Targeting Cancer-Causing Genes","authors":"Meemansha Mishra, Tapan Dey, Mallya Mishra, Isha Chauhan, Saikat Dutta","doi":"10.1002/adtp.202400144","DOIUrl":"10.1002/adtp.202400144","url":null,"abstract":"A rapid emergence of small interfering ribonucleic acid (siRNA) is witnessed as a powerful tool in gene therapy for suppressing gene expression. Since highly porous metal-organic frameworks (MOFs) are fragile and inefficient with non-specific gene delivery techniques, developing strategies use them to encapsulate unmodified natural siRNA from enzymatic degradation. MOFs with high nucleic acid binding affinity are ideal for encapsulating siRNAs in cancer therapy, bypassing circulation time and non-specificity. To knock down Plk1gene, tumor cell membranes can hide Plk1 siRNA-containing (Zeolitic Imidazolate framework) ZIF-8 nanoparticles. For tumor suppression MOF-promoted lysosome siRNA release, cell membrane coating, and PLK1 silencing are employed. Lysosomes attack cancer by delivering miRNA to targeted cells. Single-stranded miRNA, two-stranded siRNA. Despite their different sources, structures, modes of action, and biological activities, miRNA and siRNA regulate gene expression. SIRNA blocks genes more accurately than miRNA, which regulates larger genes. SiRNA-MOF integration in vitro results in a maximum of 27% consistent gene silencing during endocytic absorption. Cofactor-encapsulated MOF-internalized siRNA kills enzymes. A universal siRNA delivery for a specific genetic sequence with personalized therapeutic potential contrasts with multi-route cancer drugs. SiRNAs cleave long-stranded RNAs coding for specific genes, allowing biocompatible MOFs to encapsulate macromolecules and protect them from injury.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141744626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy Evaluation of Adjuvant Therapeutic Drugs Against Early and Middle Stage Non-Small Cell Lung Cancer Organoids 辅助治疗药物对早期和中期非小细胞肺癌组织细胞的疗效评估

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-18 DOI: 10.1002/adtp.202400163

Lin-Jie Liu, Hong Li, Chun-Yuan Chen, Ting-Ting Li, Biao Deng, Zhu Liang, Jia Liu

{"title":"Efficacy Evaluation of Adjuvant Therapeutic Drugs Against Early and Middle Stage Non-Small Cell Lung Cancer Organoids","authors":"Lin-Jie Liu, Hong Li, Chun-Yuan Chen, Ting-Ting Li, Biao Deng, Zhu Liang, Jia Liu","doi":"10.1002/adtp.202400163","DOIUrl":"10.1002/adtp.202400163","url":null,"abstract":"30–55% post-surgical recurrent rate of early and middle stage non-small cell lung cancer (e/mNSCLC) suggests the need of adjuvant therapy. The e/mNSCLC derived organoids (e/mNSCLCOs)-based efficacy evaluation of the proposed regimens may improve clinical benefits for e/mNSCLC patients. The e/mNSCLCOs are established from 33 IA-IIIB resectable non-small cell lung cancer (NSCLC) patients without systemic antitumor therapy via optimized 3D culture, of which six with epidermal growth factor receptor (EGFR) mutation. Immunohistochemical staining is employed to ascertain the maintenance of biomarker expression patterns of e/mNSCLCOs with that of their parental tumors. The e/mNSCLCOs are treated with six conventional anti-NSCLC chemotherapeutic regimens, respectively. Calcein-AM/PI cell viability/cytotoxicity assay and EdU cell proliferation test reveal that the platinum-based chemotherapeutic or mono-chemotherapeutic regimens are generally ineffective to e/mNSCLCOs because of their high IC50 values. Non-platinum gemcitabine combined with vinorelbine achieve better anti-e/mNSCLCOs outcome in terms of suppressed cell proliferation and 51.6–65.8% of intra-organoid cell death. The 6 e/mNSCLCOs with EGFR mutations are sensitive to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in drug selective patterns. The low efficacy of conventional anti-NSCLC drugs to e/mNSCLCOs suggests the necessity to explore alternative approaches for better adjuvant management of e/mNSCLC patients.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141746321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calixarene-Guest Complexes: The Next Innovation in Delivery of Drugs and Biologics 卡利卡林-客体复合物：药物和生物制剂递送领域的下一次创新

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-17 DOI: 10.1002/adtp.202400207

Sheetal Muley, Hozefa Dhila, Meghana Gote

{"title":"Calixarene-Guest Complexes: The Next Innovation in Delivery of Drugs and Biologics","authors":"Sheetal Muley, Hozefa Dhila, Meghana Gote","doi":"10.1002/adtp.202400207","DOIUrl":"10.1002/adtp.202400207","url":null,"abstract":"Calixarenes are third generation of macrocyclic molecules with excellent biocompatibility currently being researched extensively for their diverse potential as therapeutic candidates and for delivery of drugs and biologics. This review discusses the unique structural features which allow them to selectively bind to a wide variety of guest molecules within their hydrophobic cavity, as well as complex with other molecules on their upper and lower rims to enable their application for encapsulation of drugs for targeted and controlled release, molecular carriers for antigens and nucleic acids, and as biomedical sensors. The calixarenes’ unique host–guest chemistry enables encapsulation of lipophilic drugs in the latter's cavity, while the head groups and side chains on the upper and lower rim can be functionalized readily with various targeting moieties as peptides and biological ligands which specifically recognize and bind to cancer cells via surface receptors. The design of calixarene constructs help incorporation of multiple functionalities into a single platform. This active targeting approach enhances the accumulation of the drug at the tumor site while reducing its distribution in healthy tissues, thereby minimizing side effects. Ongoing research in exploration and optimization of calixarenes for application as targeted drug and gene delivery agents has been discussed.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141746320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designer Solvents for Pharmaceutics: Role of Ionic Liquids/ Deep Eutectic Solvents in Pharmaceutical Formulations 用于制药的设计溶剂：离子液体/深共晶溶剂在药物制剂中的作用

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-14 DOI: 10.1002/adtp.202400090

Diksha Dhiman, Munirah Alhammadi, Hanseung Kim, Reddicherla Umapathi, Yun Suk Huh, Pannuru Venkatesu

引用次数: 0

Novel Delivery Systems for Oral Administration of Enfuvirtide: New Treatment Options for HIV/AIDS 用于口服恩夫韦肽的新型给药系统：艾滋病毒/艾滋病的新治疗方案

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-14 DOI: 10.1002/adtp.202300439

Huiwen Pang, Zhi Qu, Vinod Kumar, Yinuo Wang, Youzhi Wu, Min-Hsuan Lin, David Harrich, Felicity Y. Han

引用次数: 0

Effect of APOE ɛ4 Status on Brain Amyloid-β and Cognitive Function in Amnestic and Nonamnestic Mild Cognitive Impairment: A [18F] Florbetapir PET-CT Study APOE ɛ4状态对失忆症和非失忆症轻度认知障碍患者脑淀粉样蛋白-β和认知功能的影响：18F]氟贝他匹PET-CT研究

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-14 DOI: 10.1002/adtp.202400008

Mengjie Wang, Zhengwei Zhang, Ying Wang, Lin Huang, Qi Huang, Shuhua Ren, Luojun Qian, Ruiqing Ni, Qihao Guo, Yihui Guan, Fang Xie

{"title":"Effect of APOE ɛ4 Status on Brain Amyloid-β and Cognitive Function in Amnestic and Nonamnestic Mild Cognitive Impairment: A [18F] Florbetapir PET-CT Study","authors":"Mengjie Wang, Zhengwei Zhang, Ying Wang, Lin Huang, Qi Huang, Shuhua Ren, Luojun Qian, Ruiqing Ni, Qihao Guo, Yihui Guan, Fang Xie","doi":"10.1002/adtp.202400008","DOIUrl":"10.1002/adtp.202400008","url":null,"abstract":"Mild cognitive impairment (MCI) is recognized as a predementia syndrome caused by multiple etiologies and nonmemory symptoms in MCI have recently gained increasing attention. However, the pattern of Aβ deposition and the effect of APOE (apolipoprotein E, APOE) ε4 on cognitive impairment in amnestic MCI (aMCI) and nonamnestic MCI (naMCI) patients has not been demonstrated. In this work, the amyloid-β (Aβ) load by [18F]florbetapir PET imaging and cognitive performance is compared by comprehensive neuropsychological scales in participants with different MCI types or different APOE ε4 carriage status. According to the Aβ positivity and results of voxel-wise analysis, higher Aβ loads are observed in aMCI patients than naMCI patients, especially aMCI patients with APOE ε4. Additionally, it is observed that memory domain Z scores show a strong negative correlation with global florbetapir SUVR in the aMCI group (r = – 0.352, p < 0.001) but not in the naMCI group (r = –0.016, p = 0.924). Moreover, this correlation is independent of APOE e4 carriage status. This study aims to identify high-risk groups at an early stage of AD(Alzheimer's Disease, AD) through cognitive performance and APOE ε4 carrier status, which can be important for guiding clinical intervention trials.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141650645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Facile Approach to Producing Liposomal J-Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential 生产具有诊断和治疗潜力的吲哚菁绿脂质体 J-聚集体的简便方法

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-12 DOI: 10.1002/adtp.202400042

Noah B Stern, Binita Shrestha, Tyrone Porter

{"title":"A Facile Approach to Producing Liposomal J-Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential","authors":"Noah B Stern, Binita Shrestha, Tyrone Porter","doi":"10.1002/adtp.202400042","DOIUrl":"10.1002/adtp.202400042","url":null,"abstract":"Liposomal J-Aggregates of Indocyanine Green (L-JA) can serve as a biocompatible and biodegradable nanoparticle for photoacoustic imaging (PAI) and photothermal therapy (PTT). When compared to monomeric indocyanine green (IcG), L-JA is characterized by longer circulation, improved photostability, elevated absorption at longer wavelengths, and increased photoacoustic signal generation. However, the documented methods for the production of L-JA vary widely. An approach to efficiently form IcG J-aggregates (IcG-JA) directly in liposomes at elevated temperatures is developed. Aggregating within fully formed liposomes ensures particle uniformity and allows for control of J-aggregate size. L-JA has unique properties compared to IcG. L-JA provides significant contrast enhancement in photoacoustic images for up to 24 h after injection, while IcG and unencapsulated IcG-JA are cleared within an hour. L-JA allows for more accurate photoacoustic-based blood oxygen saturation (sO2) estimation and particle tracking compared to IcG. Furthermore, photothermal heating of L-JA with an 852 nm laser is demonstrated to be more effective at lower laser powers than conventional 808 nm lasers for the first time. The presented technique offers an avenue for formulating a multi-faceted contrast agent for photoacoustic imaging and photothermal therapy that offers significant advantages over other conventional agents.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141609980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Albumin-Loaded Silica Nanomaterials Functionalized with Organotin(IV) Agents: Theranostic Materials Against Triple-Negative Breast Cancer 用有机锡（IV）制剂功能化的白蛋白负载硅纳米材料：抗三阴性乳腺癌的放射治疗材料

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-11 DOI: 10.1002/adtp.202400114

Victoria García-Almodóvar, Karina Ovejero-Paredes, Diana Díaz-García, José M. Méndez-Arriaga, Sanjiv Prashar, Marco Filice, Santiago Gómez-Ruiz

{"title":"Albumin-Loaded Silica Nanomaterials Functionalized with Organotin(IV) Agents: Theranostic Materials Against Triple-Negative Breast Cancer","authors":"Victoria García-Almodóvar, Karina Ovejero-Paredes, Diana Díaz-García, José M. Méndez-Arriaga, Sanjiv Prashar, Marco Filice, Santiago Gómez-Ruiz","doi":"10.1002/adtp.202400114","DOIUrl":"10.1002/adtp.202400114","url":null,"abstract":"The current search for more effective and milder cancer treatments has led to the development of a wide variety of multifunctional nanoplatforms that are designed to both diagnose and treat cancer. In this study, the optimization of the synthesis of theranostic materials based on mesoporous silica nanoparticles (MSNs) functionalized with different cytotoxic (organotin(IV) compounds), imaging (fluorescein and/or indocyanine green), and targeting agents of interest, such as albumin (HA), is achieved by using different strategies. These systems shows good cytotoxic capacity against triple negative breast cancer (TNBC) cells (MDA-MB-231) in MTT (dimethylthiazolyl-diphenyl-tetrazolium bromide) assays and confocal analysis shows that the incorporation of HA as a potential active targeting molecule may enhance the cellular uptake of the nanomaterial, and thus, increasing its therapeutic potential. The analysis of the results and the effect of the imaging, targeting, and cytotoxic fragments should allow a more in-depth study of these materials in other in vitro and/or in vivo models.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141614615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembled HYP Liposome Nanoparticles Promote Diabetic Wound Healing by Regulating the Polarization of M1 Macrophages 自组装 HYP 脂质体纳米颗粒通过调节 M1 型巨噬细胞的极化促进糖尿病伤口愈合

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-10 DOI: 10.1002/adtp.202400011

Bao Hou, Shijie Zhang, Yuanyuan Wen, Anjing Xu, Xuexue Zhu, Weiwei Cai, Yuetao Zhou, Liying Qiu, Haijian Sun

{"title":"Self-Assembled HYP Liposome Nanoparticles Promote Diabetic Wound Healing by Regulating the Polarization of M1 Macrophages","authors":"Bao Hou, Shijie Zhang, Yuanyuan Wen, Anjing Xu, Xuexue Zhu, Weiwei Cai, Yuetao Zhou, Liying Qiu, Haijian Sun","doi":"10.1002/adtp.202400011","DOIUrl":"10.1002/adtp.202400011","url":null,"abstract":"Suppression of the polarization of M1 macrophages is crucial for promoting diabetic wound healing. Hypahorine (HYP), a small molecule alkaloid compound with anti-inflammatory properties, is encapsulated in liposome nanospheres (HYP-INPS) using a one-step ultrasound method and applied to treat open wounds in diabetic rats. Transmission electron microscopy (TEM) revealed that HYP-INPS nanoparticles are spherical and coated with a lipid layer. ZetaPALS analysis demonstrated that HYP-INPS has a potential of -15.67 ± 2.58 mV and a size of 212.87 ± 13.34 nm. In vitro, confocal microscopy revealed the cellular uptake of HYP-INPS in macrophages. Flow cytometry showed that HYP-INPS inhibited the polarization of bone marrow-derived macrophages (BMDMs) to the M1 phenotype. In vivo, HYP-INPS promoted diabetic wound healing by improving the inflammatory microenvironment within wounds. Immunofluorescence revealed that HYP-INPS up-regulated the expression of M2 macrophages and down-regulated the expression of M1 macrophages at the wound site. Transcriptome sequencing showed that HYP-INPS treatment specifically up-regulated ASB10 expression in LPS-induced RAW264.7 cells. Loss-of-function or gain-of-function experiments confirmed the regulatory role of ASB10 in M1 macrophage polarization. Therefore, HYP-INPS targeted ASB10 is concluded to accelerate wound healing in diabetes by inhibiting the polarization of M1 macrophages and improving the inflammatory microenvironment. This newly developed HYP-INPS system holds promise as a potential treatment for diabetic wounds.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141587147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0