Advanced Therapeutics最新文献_第7页

Zeolitic Imidazolate Frameworks Based Anticancer Drug Delivery System Associated with Dual Action of Surface Charge and Lewis Base Ligand (Adv. Therap. 9/2024) 基于沸石咪唑框架的抗癌药物输送系统与表面电荷和路易斯碱配体的双重作用有关（Adv.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-11 DOI: 10.1002/adtp.202470017

Wenjuan Yang, Lingling Tian, Ning Zhao, Lingyan Feng, Bingpu Zhou, Yongheng Zhu, Xinghua Gao, Yuan Zhang

引用次数: 0

Targeting Glioblastoma Tumor Hyaluronan to Enhance Therapeutic Interventions that Regulate Metabolic Cell Properties 以胶质母细胞瘤肿瘤透明质酸为靶点，加强调节细胞代谢特性的治疗干预措施

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-11 DOI: 10.1002/adtp.202400041

Edward R Neves, Achal Anand, Joseph Mueller, Roddel A Remy, Hui Xu, Kim A Selting, Jann N Sarkaria, Brendan AC Harley, Sara Pedron-Haba

{"title":"Targeting Glioblastoma Tumor Hyaluronan to Enhance Therapeutic Interventions that Regulate Metabolic Cell Properties","authors":"Edward R Neves, Achal Anand, Joseph Mueller, Roddel A Remy, Hui Xu, Kim A Selting, Jann N Sarkaria, Brendan AC Harley, Sara Pedron-Haba","doi":"10.1002/adtp.202400041","DOIUrl":"10.1002/adtp.202400041","url":null,"abstract":"Despite extensive advances in cancer research, glioblastoma (GBM) still remains a very locally invasive and thus challenging tumor to treat, with a poor median survival. Tumor cells remodel their microenvironment and utilize extracellular matrix to promote invasion and therapeutic resistance. It is aimed here to determine how GBM cells exploit hyaluronan (HA) to maintain proliferation using ligand-receptor dependent and ligand-receptor independent signaling. Tissue engineering approaches are used to recreate the 3D tumor microenvironment in vitro, then analyze shifts in metabolism, hyaluronan secretion, HA molecular weight distribution, as well as hyaluronan synthetic enzymes (HAS) and hyaluronidases (HYAL) activity in an array of patient-derived xenograft GBM cells. It is revealed that endogenous HA plays a role in mitochondrial respiration and cell proliferation in a tumor subtype-dependent manner. A tumor-specific combination treatment of HYAL and HAS inhibitors is proposed to disrupt the HA stabilizing role in GBM cells. Taken together, these data shed light on the dual metabolic and ligand – dependent signaling roles of hyaluronan in glioblastoma.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information (Adv. Therap. 9/2024) 发行信息（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-11 DOI: 10.1002/adtp.202470018

引用次数: 0

Targeting Cross-Talks of Notch and VEGF to Tweak the EMT and EPT Dynamics in Triple Negative Breast Cancer Cells 以 Notch 和血管内皮生长因子的交叉对话为靶点，调整三阴性乳腺癌细胞的 EMT 和 EPT 动态变化

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-10 DOI: 10.1002/adtp.202400059

Plaboni Sen, Siddhartha Sankar Ghosh

{"title":"Targeting Cross-Talks of Notch and VEGF to Tweak the EMT and EPT Dynamics in Triple Negative Breast Cancer Cells","authors":"Plaboni Sen, Siddhartha Sankar Ghosh","doi":"10.1002/adtp.202400059","DOIUrl":"10.1002/adtp.202400059","url":null,"abstract":"The associations of the Notch pathway with the major oncogenic pathways (especially the receptor tyrosine kinases, RTKs) are primarily responsible for inducing EMT (epithelial to mesenchymal transition), angiogenesis, and chemoresistance. In this study, Axitinib is used in combination with LY411575 (γ-secretase inhibitor) and it is observed that the co-treatment synergistically induced apoptosis (by 37.36% in MDAMB231 and 27.9% in MDAMB468), arrests cells at the G2/M phase, decreases the stemness properties of the triple-negative breast cancer (TNBC) cells. It also diminishes the spheroid forming ability, enhances the expression of epithelial markers, such as E-cadherin (by 2.2 fold in MDAMB231 and 2.51 fold in MDAMB468), and downregulated the expression of mesenchymal markers. Additionally, the protein expression profile of the pro-oncogenic and pro-survival genes also reduces significantly after the administration of co-therapy, which is highlighted by a reduction in the levels of pEGFR, pFAK, pMAPK, NF-κB, etc. Moreover, the expression of pericyte markers (such as PDGFRs, α-SMA, c-kit, and NG2) reduces significantly in both TNBC cells upon co-treatment, thereby hinting toward the inhibition of epithelial-to-pericyte transition (EPT). The current work endows with the effectiveness of the co-therapy on the EMT and EPT dynamics of TNBC upon inhibition of the major crosstalk between the Vascular endothelial growth factor (VEGF)t and Notch pathway.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Inulin‐Coated MCT Microcapsules in Modulating the Gut Microbiome for Effective Treatment of Diet‐Induced Obesity 菊粉包裹的 MCT 微胶囊在调节肠道微生物组以有效治疗饮食诱发肥胖症方面的治疗潜力

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-09-09 DOI: 10.1002/adtp.202400305

Amin Ariaee, Hannah R. Wardill, Anthony Wignall, Aurelia S. Elz, Leah Wright, Clive Prestidge, Paul Joyce

{"title":"Therapeutic Potential of Inulin‐Coated MCT Microcapsules in Modulating the Gut Microbiome for Effective Treatment of Diet‐Induced Obesity","authors":"Amin Ariaee, Hannah R. Wardill, Anthony Wignall, Aurelia S. Elz, Leah Wright, Clive Prestidge, Paul Joyce","doi":"10.1002/adtp.202400305","DOIUrl":"https://doi.org/10.1002/adtp.202400305","url":null,"abstract":"Obesity, a global epidemic, leads to metabolic dysregulation and systemic inflammation. Recently, therapies targeting the gut microbiome have garnered attention for metabolic health regulation. This study evaluates the potential of inulin‐coated medium‐chain triglyceride (InuMCT) microcapsules in rats with diet‐induced obesity (DIO). Inulin prebiotic fibers have been shown to promote the gut microbiome, while the digestion products of medium chain triglycerides (MCTs), free fatty acids, and mono‐/diglycerides, can attenuate pro‐inflammatory outcomes. It is hypothesized that encapsulating MCTs within inulin via spray drying creates a solid dosage form that can exert multifunctional effects in ameliorating inflammation in DIO. Inulin and InuMCT treatments not only reduce DIO weight gain but also improve metabolic markers in high‐fat diet (HFD) fed rats. Specifically, inulin attenuates the reduction of high‐density lipoprotein (HDL) by 55% and lowers glucose levels by 21%. Meanwhile, InuMCT increases HDL by 23% and reduces glucose levels by 15%. Furthermore, inulin decreases serum proinflammatory tumor necrosis factor‐alpha (TNF‐α) by 35%, while InuMCT further reduces TNF‐α to normal diet levels within 21 days. These results highlight InuMCT's superior efficacy, offering a promising strategy for combating obesity and related metabolic diseases.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"23 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of a Plasma-Induced Dendritic Cell Vaccine and its Anti-Tumor Immunity in a Murine Model of Melanoma 血浆诱导树突状细胞疫苗的制备及其在小鼠黑色素瘤模型中的抗肿瘤免疫作用

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-09 DOI: 10.1002/adtp.202400142

Xiangni Wang, Jinren Liu, Xiying Wang, Jiajia Lu, Guimin Xu, Yixin Cui, Zhirou He, Yulin Xu, Xingmin Shi, Guanjun Zhang

{"title":"Preparation of a Plasma-Induced Dendritic Cell Vaccine and its Anti-Tumor Immunity in a Murine Model of Melanoma","authors":"Xiangni Wang, Jinren Liu, Xiying Wang, Jiajia Lu, Guimin Xu, Yixin Cui, Zhirou He, Yulin Xu, Xingmin Shi, Guanjun Zhang","doi":"10.1002/adtp.202400142","DOIUrl":"10.1002/adtp.202400142","url":null,"abstract":"Dendritic cell (DC) vaccines play an important role in anti-tumor immunotherapy. Tumor-associated cells or cytokines in the tumor microenvironment (TME) can inhibit the antigen-presenting function of DC. Immunogenic cell death (ICD) can enhance the uptake and presentation of tumor antigens by DC. This study investigates the maturation mechanism of DC induced by low-temperature plasma (LTP), as well as the therapeutic and protective effects of LTP-induced DC vaccine in a tumor model. DC2.4 that is co-cultured with LTP-treated B16F10 (LTP-B16) or with these supernatants exhibited decreased phagocytic activity, increased production of cytokines (IL-12, IL-6, TNF-α, and IL-1β), and increased expression of cell surface activation markers (CD80, CD86, and MHC II). The expression of CD80+/CD86+ is decreased after pre-treatment with TLR4 and NF-κB (p65) inhibitors, respectively. In vivo, trials indicated that the LTP-induced DC vaccine-induced anti-tumor immunity and, when combined with cisplatin, synergistically reduced tumor growth.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Targeted Drug Delivery for Scar Prevention: Clathrin-Coated Solid Lipid Nanoparticles for Model Drug Encapsulation 增强疤痕预防的靶向给药：用于模型药物封装的 Clathrin 包裹固体脂质纳米粒子

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-09 DOI: 10.1002/adtp.202400185

Farinaz Jonidi Shariatzadeh, Vinith Yathindranath, Yang Liu, Donald W. Miller, Francis Lin, Sarvesh Logsetty, Song Liu

{"title":"Enhanced Targeted Drug Delivery for Scar Prevention: Clathrin-Coated Solid Lipid Nanoparticles for Model Drug Encapsulation","authors":"Farinaz Jonidi Shariatzadeh, Vinith Yathindranath, Yang Liu, Donald W. Miller, Francis Lin, Sarvesh Logsetty, Song Liu","doi":"10.1002/adtp.202400185","DOIUrl":"10.1002/adtp.202400185","url":null,"abstract":"Excessive scar formation is a major complication of wound healing. Premature release of anti-scarring drugs can negatively impact healing. This study aims to develop a targeted delivery system for the controlled release of anti-scarring drugs during the scar formation stage. Solid lipid nanoparticles (SLNs) coated with Clathrin, a cage-like protein, to prevent premature drug release is developed. Insulin-like growth factor (IGF) is conjugated to the SLNs for targeted delivery via its affinity for connective tissue growth factor (CTGF), a protein overexpressed during scar formation. The IGF-Clathrin-SLNs exhibited a size of 300 ± 20 nm and a zeta potential of 9.23 ± 0.4 mV. In vitro studies demonstrated sustained release of the encapsulated drug- kynurenic acid; less than 10% of kynurenic acid is released within three days, while over 50% is released within 10 h upon Clathrin removal using a surfactant at pH 8. Cellular uptake studies confirmed targeting efficacy. Fibroblasts with low CTGF expression displayed low uptake (<10%), whereas MCF7 cells with high CTGF expression showed significantly higher uptake (80%). This work demonstrates a promising targeted delivery platform for the controlled release of anti-scarring drugs during scar formation.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Physically Crosslinked Hyaluronic Acid Hydrogel in the Treatment of Radiation-Induced Skin Injury 物理交联透明质酸水凝胶在治疗辐射引起的皮肤损伤中的应用

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-09 DOI: 10.1002/adtp.202400165

Suyue Gao, Tingyu Zheng, Kai Tian, Zou Jia, Wushuang Xu, Pingfan Wu, Shikun Cao, Ke Li, Lijun Wu

{"title":"Application of Physically Crosslinked Hyaluronic Acid Hydrogel in the Treatment of Radiation-Induced Skin Injury","authors":"Suyue Gao, Tingyu Zheng, Kai Tian, Zou Jia, Wushuang Xu, Pingfan Wu, Shikun Cao, Ke Li, Lijun Wu","doi":"10.1002/adtp.202400165","DOIUrl":"10.1002/adtp.202400165","url":null,"abstract":"Wounds caused by radiation exposure are often hard to heal. The functional hydrogel can be used as a wound treatment material of multiple dimensions according to patients' needs. Hyaluronic acid hydrogel can be used to create a moist environment conducive to wound healing. In this study, new complex hydrogels based on physically crosslinked hyaluronic acid are investigated, which adopt the freeze-thaw technique, loaded with small molecule drugs deferoxamine and retinoic acid, and effectively promote the healing of radiation-induced skin ulcers. The combined application of deferoxamine and retinoic acid can improve skin injury after radiation, promoting angiogenesis, reducing inflammation, and protecting skin appendages. In vitro and in vivo results show enhanced cell viability and biological function, significantly accelerate healing of the irradiated wounds, and improve collagen deposition in the skin of the irradiated rats. Also, the skin appendages, such as hair follicles, are protected to a certain extent, implying functionally repairing the skin. Considering the ease of use of the hydrogel system in clinical applications, complex hydrogels can be considered a suitable candidate for treating radiation-induced skin injury.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal Control of Immune Responses with Nucleic Acid Cocktail Vaccine 核酸鸡尾酒疫苗对免疫反应的时空控制

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-06 DOI: 10.1002/adtp.202400263

Chunxi Wang, Andrew N. Macintyre, Thomas H. Oguin III, Kevin R. McCarthy, M. Anthony Moody, Fan Yuan

{"title":"Spatiotemporal Control of Immune Responses with Nucleic Acid Cocktail Vaccine","authors":"Chunxi Wang, Andrew N. Macintyre, Thomas H. Oguin III, Kevin R. McCarthy, M. Anthony Moody, Fan Yuan","doi":"10.1002/adtp.202400263","DOIUrl":"10.1002/adtp.202400263","url":null,"abstract":"Nucleic acid vaccines play important roles in the prevention and treatment of diseases. However, limited immunogenicity remains a major obstacle for DNA vaccine applications in the clinic. To address the issue, the present study investigates a cocktail approach to DNA vaccination. In this proof-of-the-concept study, the cocktail consists of two DNAs encoding viral hemagglutinin (HA) and granulocyte-macrophage colony stimulatory factor (GM-CSF), respectively. Data from the study demonstrate that recruitment and activation of antigen-presenting cells (APCs) can be substantially improved by spatiotemporal regulation of GM-CSF and HA expressions at the site of vaccination. The types of recruited APCs and their phenotypes are also controllable by adjusting the cocktail compositions. Compared to the mono-ingredient vaccine, the optimized cocktail vaccine is able to enhance the anti-viral humoral and T cell immune responses. No significant systemic inflammation is detected after either prime or boost immunization using the cocktail vaccine. Data in the study suggest that the DNA cocktail is a safe, effective, and controllable platform for improving vaccine efficacy.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon Nanotubes in Cancer Diagnosis and Treatment: Current Trends and Future Perspectives 碳纳米管在癌症诊断和治疗中的应用：当前趋势与未来展望

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-09-05 DOI: 10.1002/adtp.202400283

Sunny Kumar, Aafreen Ansari, Malini Basu, Sayani Ghosh, Sabana Begam, Mrinal K Ghosh

引用次数: 0