Advanced Therapeutics最新文献_第7页

Synthetic Bilirubin-Based Nanomedicine Alleviates Atopic Dermatitis by Reducing Oxidative Stress and Modulating Immune Responses 基于合成胆红素的纳米药物通过降低氧化应激和调节免疫反应缓解特应性皮炎

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-01-10 DOI: 10.1002/adtp.202400403

Dohyeon Kim, Hyeongseop Keum, Ryeowon Kim, Jieun Choi, Monica Celine Prayogo, Hyunjin Kim, Duckhyang Shin, Sharif MD Abuzar, Seunghyun Jo, Pilhan Kim, Chang Ook Park, Sangyong Jon

{"title":"Synthetic Bilirubin-Based Nanomedicine Alleviates Atopic Dermatitis by Reducing Oxidative Stress and Modulating Immune Responses","authors":"Dohyeon Kim, Hyeongseop Keum, Ryeowon Kim, Jieun Choi, Monica Celine Prayogo, Hyunjin Kim, Duckhyang Shin, Sharif MD Abuzar, Seunghyun Jo, Pilhan Kim, Chang Ook Park, Sangyong Jon","doi":"10.1002/adtp.202400403","DOIUrl":"https://doi.org/10.1002/adtp.202400403","url":null,"abstract":"Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a growing prevalence worldwide. Topical corticosteroids and non-steroidal calcineurin inhibitors (CNIs) are used as first-line therapies for AD, but various side effects limit their long-term use. Here, the first synthetic bilirubin(IIIα)-derived nanoparticle is reported, designated BRNP(IIIα), and shows that it exhibits robust antioxidative and immunomodulatory effects and effectively reduces the clinical symptoms of AD upon topical treatment. BRNP(IIIα) in 1% high molecular weight hyaluronic acid (BRNP(IIIα)/HA) readily infiltrates into the dermis layer, notably downregulates disease-associated reactive oxygen species (ROS) and inflammatory chemokines and cytokines, and suppresses the recruitment of leukocytes and mast cells to AD-induced lesions. BRNP(IIIα)/HA also significantly reduces the tissue-resident memory T cell population, suggesting that it may inhibit recurrence. Furthermore, BRNP(IIIα)/HA does not induce any adverse effect related to skin irritation/sensitization or eye irritation in human tissue. Collectively, the findings suggest that BRNP(IIIα)/HA may be useful as an alternative to corticosteroids or CNIs for the safe, effective, and long-term topical treatment of AD.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 2","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy 细胞外基质在癌症中的作用：对肿瘤进展和治疗的见解

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2025-01-06 DOI: 10.1002/adtp.202400370

Nimeet Desai, Deepak Sahel, Bhakti Kubal, Humzah Postwala, Yesha Shah, Vivek P Chavda, Clara Fernandes, Dharmendra K. Khatri, Lalitkumar K. Vora

{"title":"Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy","authors":"Nimeet Desai, Deepak Sahel, Bhakti Kubal, Humzah Postwala, Yesha Shah, Vivek P Chavda, Clara Fernandes, Dharmendra K. Khatri, Lalitkumar K. Vora","doi":"10.1002/adtp.202400370","DOIUrl":"https://doi.org/10.1002/adtp.202400370","url":null,"abstract":"The extracellular matrix (ECM) serves not only as a structural scaffold but also as an active regulator of cancer progression, profoundly influencing tumor behaviour and the tumor microenvironment (TME). This review focuses into the pivotal role of ECM alterations in facilitating tumor metastasis and explores therapeutic strategies aimed at counteracting these changes. We analyse targeted interventions against collagen, including approaches to inhibit its biosynthesis and disrupt associated signalling pathways critical for tumor architecture and cell migration. Additionally, therapies addressing hyaluronan are reviewed, highlighting methods to suppress its synthesis and enzymatic strategies to degrade it, thereby mitigating its tumor-promoting effects. The discussion extends to innovative approaches for modulating ECM stiffness, focusing on the roles of cancer-associated fibroblasts and lysyl oxidases, which are key contributors to ECM remodelling and mechanical signalling. By strategically modifying these ECM components, these interventions aim to enhance the efficacy of existing cancer treatments, tackle resistance mechanisms, and achieve more durable therapeutic outcomes. Insights from recent studies and clinical trials highlight the promise of these strategies in overcoming treatment resistance and improving patient outcomes. Advancing our understanding of ECM biology leads to the development of innovative and more effective cancer therapies.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 2","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Encapsulation of π-Conjugated Polymer Nanoparticles within Biodegradable PEG–PLGA Matrices Mitigate Photoinduced Free Radical Production and Phototoxicity? 在可生物降解的PEG-PLGA基质中封装π共轭聚合物纳米颗粒是否能减轻光诱导自由基的产生和光毒性？

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-23 DOI: 10.1002/adtp.202400190

Paola Modicano, Marie-Luise Trutschel, Thüong Phan-Xuan, Bruno F. E. Matarèse, Laura Urbano, Mark Green, Karsten Mäder, Lea Ann Dailey

{"title":"Does Encapsulation of π-Conjugated Polymer Nanoparticles within Biodegradable PEG–PLGA Matrices Mitigate Photoinduced Free Radical Production and Phototoxicity?","authors":"Paola Modicano, Marie-Luise Trutschel, Thüong Phan-Xuan, Bruno F. E. Matarèse, Laura Urbano, Mark Green, Karsten Mäder, Lea Ann Dailey","doi":"10.1002/adtp.202400190","DOIUrl":"https://doi.org/10.1002/adtp.202400190","url":null,"abstract":"Lipophilic π-conjugated polymers (CPs) encapsulated within self-assembling diblock copolymer poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG–PLGA) nanoparticles, are interesting candidates for photodynamic and photothermal therapies. Upon irradiation, CPs generate reactive oxygen species (ROS), which may either cause local phototoxicity or could be exploited for photodynamic therapy. The propensity of the PEG–PLGA matrix to scavenge ROS has never been investigated. Here the ability of two PEG–PLGA structures (PEG2 kDa–PLGA4.5 kDa vs PEG5 kDa–PLGA55 kDa) to mitigate the release of ROS generated by four different CPs (PFO, F8BT, CN-PPV, and PCPDTBT) following irradiation (5 J cm−2) at 385, 455, and 656 nm is studied. The molar content of the PEG–PLGA matrix, rather than the molecular weight or composition, appeared to be the most influential factor, i.e., lower molar concentrations of the matrix polymer are associated with significant increases in phototoxicity. Multivariate analysis reveals that the combination of CP photophysical properties and nanoparticle matrix properties are important for understanding CP nanoparticle-induced phototoxicity.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting ACAT1 for Precision Chemo-Immunoprevention in Lung Cancer 靶向ACAT1的肺癌精准化疗免疫预防

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-23 DOI: 10.1002/adtp.202400430

Mofei Huang, Jing Pan, Shizuko Sei, Yian Wang, Ming You

{"title":"Targeting ACAT1 for Precision Chemo-Immunoprevention in Lung Cancer","authors":"Mofei Huang, Jing Pan, Shizuko Sei, Yian Wang, Ming You","doi":"10.1002/adtp.202400430","DOIUrl":"https://doi.org/10.1002/adtp.202400430","url":null,"abstract":"Lung cancer (LC) is a leading cause of cancer-related deathworldwide, and altered cholesterol metabolism is a hallmark of cancer cells. Acyl-CoA:cholesterol acyltransferase 1(ACAT1), or Sterol O-acyltransferase 1 (SOAT1), isa key cholesterol esterification enzyme. Its overexpression promotes tumorprogression by accumulating cholesterol esters. Inhibition of ACAT1 also potentiatesCD8+ T cells medicated anti-tumor immunity by increasing plasma membranecholesterol level. This study, as the first of its kind, shows the ACAT1/SOAT1 overexpressioncorrelates with poor prognosis in early-stage lung adenocarcinoma (LUAD) patients.Long-term treatment with ACAT1 inhibitor avasimibe suppresses tumorigenesis inboth Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growthfactor receptor (EGFR) mutation-induced LC mouse models without overttoxicity. ACAT1 inhibition reduces tumor cell proliferation, migration, andinvasion and causes G0/G1 cell cycle arrest, while boosting CD8+ T cells'effector function and memory phenotype. Single-cell RNA sequencing reveals thatACAT1 inhibition downregulates cholesterol biosynthesis and central carbon andnitrogen metabolism pathways in tumor cells, while upregulating genes relatedto oxidative phosphorylation and fatty acid oxidation in CD8+ T cells. Finally, avasimibe improves the efficacy of a human EGFR vaccine in preventing LCprogression. These novel findings suggest potential strategies for cancer preventionand therapy.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 2","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Acellular Platform to Drive Urinary Bladder Tissue Regeneration 驱动膀胱组织再生的脱细胞平台。

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-20 DOI: 10.1002/adtp.202400158

Mitali Kini, Matthew I. Bury, Arun K. Sharma

{"title":"An Acellular Platform to Drive Urinary Bladder Tissue Regeneration","authors":"Mitali Kini, Matthew I. Bury, Arun K. Sharma","doi":"10.1002/adtp.202400158","DOIUrl":"10.1002/adtp.202400158","url":null,"abstract":"Impaired bladder compliance secondary to congenital or acquired bladder dysfunction can lead to irreversible kidney damage. This is managed with surgical augmentation utilizing intestinal tissue, which can cause stone formation, infections, and malignant transformation. Co-seeded bone marrow mesenchymal stem cell (MSC)/CD34+ hematopoietic stem cell (HSPC) scaffolds (PRS) have been successful in regenerating bladder tissue. However, the acquisition of viable cells is challenging in the clinical setting. Here, the regenerative capacity of human MSC/CD34+ co-cultured total condition media (TCM) is compared to media alone in immune-competent rats augmented with PRS following partial cystectomy. Augmented bladders are instilled with media (control, n = 4) or TCM (n = 5) twice a week for 4 weeks. Regenerated tissue is analyzed for smooth muscle, urothelium, vascular, and peripheral nerve regrowth. Urodynamic (UDS) measures are performed pre- and 4 weeks post-augmentation. The results demonstrate that TCM-instilled grafts have greater muscle content, larger average urothelial widths, higher percent vascularization, and more robust neural infiltration post-augmentation. UDS demonstrates greater percent bladder recovery in the TCM group, indicating functional improvement in bladder storage capacity. This study is the first to propose the use of cell-free TCM as an alternative to traditional cell-seeded scaffolds to promote bladder tissue regeneration.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation (Adv. Therap. 12/2024) 通过阻断自噬通量和抑制肿瘤增殖，将舍曲林重新用于结直肠癌的治疗（Adv.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470028

Leping He, Xijun Guo, Wanrong Wang, Weifeng Xu, Xiaoli Feng, Yuanfeng Fu, Yuxi Tian, Zongmao He, Sulan Luo, Jiaolin Bao, Ren-Bo Ding

引用次数: 0

Issue Information (Adv. Therap. 12/2024) 发行信息（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470029

引用次数: 0

An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast-Like Synoviocytes by Encapsulation in a Chitosan-Based Hydrogel (Adv. Therap. 12/2024) 辅助关节炎研究：壳聚糖水凝胶包封人类成纤维细胞样滑膜细胞的3D细胞培养（Adv. Therap. 12/2024）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470027

Francesco Bisconti, Beatrice Vilardo, Gaia Corallo, Francesca Scalera, Giuseppe Gigli, Annalisa Chiocchetti, Alessandro Polini, Francesca Gervaso

引用次数: 0

From Challenges to Solution: The Evolving Landscape of Leprosy Management (Adv. Therap. 12/2024) 从挑战到解决方案：麻风病管理的演变景观（Adv. Therap. 12/2024）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-09 DOI: 10.1002/adtp.202470030

Lívia Maria Coelho de Carvalho Moreira, Antônia Carla de Jesus Oliveira, Luíse Lopes Chaves, Mônica Felts de La Rocca Soares, José Lamartine Soares-Sobrinho

引用次数: 0

Stable Biotherapeutic Penetration Screening in Critically Small Colorectal Metastatic Cancer Biopsies Allows for Oncolytic Virus-Delivered Chemotherapeutic Response Assessment through 3D Bioprinted Organoid Expansion 稳定的生物治疗穿透筛选在临界小结直肠癌转移活检允许溶瘤病毒传递化疗反应评估通过3D生物打印类器官扩张

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-12-04 DOI: 10.1002/adtp.202400221

Colin McGuckin, Nico Forraz, Clément Milet, Mathieu Lacroix, Yordan Sbirkov, Victoria Sarafian, Caroline Ebel, Anita Spindler, Véronique Koerper, Eric Quéméneur, Jean-Marc Balloul, Philippe Erbs

{"title":"Stable Biotherapeutic Penetration Screening in Critically Small Colorectal Metastatic Cancer Biopsies Allows for Oncolytic Virus-Delivered Chemotherapeutic Response Assessment through 3D Bioprinted Organoid Expansion","authors":"Colin McGuckin, Nico Forraz, Clément Milet, Mathieu Lacroix, Yordan Sbirkov, Victoria Sarafian, Caroline Ebel, Anita Spindler, Véronique Koerper, Eric Quéméneur, Jean-Marc Balloul, Philippe Erbs","doi":"10.1002/adtp.202400221","DOIUrl":"https://doi.org/10.1002/adtp.202400221","url":null,"abstract":"Oncolytic viral-delivered chemotherapeutics have exciting potential for metastatic cancer therapies, including colorectal cancer, but require advanced screening systems for better patient prediction. We optimized primary metastatic colorectal tumor processing and 3D (3-dimensional) bioprinted tumors to prove efficacy as long-term screening systems. Normally, this time period would use animals, but we show it is possible to gain useful data in vitro before preclinical stages, to reduce animal modeling and give better clinical trial predictions. Liver tumors were collected from 12 colorectal cancer patients, evaluated for expansion, 3D bioprinted, and tested for ability to create long-term organoid models with screening of oncolytic viral-loaded FCU1 enzyme conversion of 5-fluorocytosine (5-FC) into the highly toxic 5-fluorouracil (5-FU). Donated tumor size was the limiting factor. 75% of patients could be used for screening of viral delivery. Response between patients was overall positive, with good secondary tumor development, outer active cellular content and inner necrotic core. Oncolytic challenge shows good screening potential and cellular targeting, demonstrating an added bystander effect, optimizing the low-dose. Stable long-term metastatic organoid models were made, lasting many months, with potential for retesting rather than one-off analysis. Oncolytic virus-delivered chemotherapy is promising and warrants further investigation for metastatic colorectal cancers.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0