Advanced Therapeutics最新文献_第8页

Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals (Adv. Therap. 7/2024) 冲锋在前：研究电疗法的未来治疗潜力（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-08 DOI: 10.1002/adtp.202470013

Swarnalatha Balasubramanian, David A. Weston, Michael Levin, Devon Charles Cardoso Davidian

引用次数: 0

Issue Information (Adv. Therap. 7/2024) 发行信息（Adv. Therap.）

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-08 DOI: 10.1002/adtp.202470014

引用次数: 0

Breaking Down the Arsenal: Recent Progress in the Nanotherapeutic Strategies for Hepatocellular Carcinoma Treatment 打破武器库：肝细胞癌纳米治疗策略的最新进展

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-06 DOI: 10.1002/adtp.202400126

Sumit Roy, Vancha Harish, Sharfuddin Mohd, Sachin Kumar Singh

{"title":"Breaking Down the Arsenal: Recent Progress in the Nanotherapeutic Strategies for Hepatocellular Carcinoma Treatment","authors":"Sumit Roy, Vancha Harish, Sharfuddin Mohd, Sachin Kumar Singh","doi":"10.1002/adtp.202400126","DOIUrl":"10.1002/adtp.202400126","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a progressed form of advanced liver cancer and is one of the major causes of global cancer burden. The primary causes for high HCC mortality is the delayed diagnosis of the diseaseas early stage HCC is typically asymptomatic and patients frequently overlook the warning signs. Currently, the most efficacious single-drug therapy approved by the food and drug administration (FDA) for HCC is Sorafenib and Nivolumab as a second-line therapy for late stage HCC. Nowadays nanotechnology is used to deliver either a diagnostic tool for biomolecular imaging ortherapeutic agent. Gene therapy based on clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (CRISPR-Cas9) are currently studied to find a potential curative option for HCC. Natural products from plants are being extensively extracted and isolated as they may offer a promising alternative in order to control and treat HCC. They exhibit anti-HCC effects by stimulating the immune system and by hindering various growth pathways involved in cancer development and progression. In this review article, an overview is provided on the current global incidence, ongoing systemic treatment strategies, and recent advances in nanomedicine for the management of HCC and also ongoing efforts to overcome these challenges.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141570745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances of Second-Line Targeted Biopharmaceutical Therapies in Thyroid Associated Ophthalmopathy 甲状腺相关眼病二线靶向生物制药疗法的最新进展

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-05 DOI: 10.1002/adtp.202400137

Shenghua Liu, Jiamin Cao, Shiyao Lu, Feng Zhang, Wei Xiong

{"title":"Recent Advances of Second-Line Targeted Biopharmaceutical Therapies in Thyroid Associated Ophthalmopathy","authors":"Shenghua Liu, Jiamin Cao, Shiyao Lu, Feng Zhang, Wei Xiong","doi":"10.1002/adtp.202400137","DOIUrl":"10.1002/adtp.202400137","url":null,"abstract":"Intravenous glucocorticoids are the clinically preferred treatment for moderate-to-severe thyroid-associated ophthalmopathy. However, the serious adverse effects following intravenous glucocorticoids and the risks posed by the cumulative doses cannot be overlooked. Moreover, it is found to be ineffective in the treatment of many patients with severe thyroid-associated ophthalmopathy. Consequently, the development of superior alternative therapies is imminent. Recent advancements in the identification of multiple autoimmune-related targets have led to the utilization of novel antibodies such as rituximab, teprotumumab, tocilizumab, and batocliumab in clinical settings. They have shown great potential in enhancing the therapeutic effect of thyroid-associated ophthalmopathy, minimizing adverse effects, and shortening treatment duration. Additionally, small molecule targeted drugs, such as single or double aptamers are rapidly developed to target the inflammatory microenvironment. In this review, the advancements in second-line targeted therapeutic options for thyroid-associated ophthalmopathy, providing a clinical rationale for immune mechanism-based treatment of thyroid-associated ophthalmopathy in the era of precision medicine are reported.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploiting Spinach-Derived Extracellular Vesicles for Anti-Obesity Therapy Through Lipid Accumulation Inhibition 利用菠菜提取的细胞外囊泡，通过抑制脂质积累实现抗肥胖疗法

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-05 DOI: 10.1002/adtp.202400150

Jeong Hyun Lee, Su Jin Kang, Won Jong Rhee

{"title":"Exploiting Spinach-Derived Extracellular Vesicles for Anti-Obesity Therapy Through Lipid Accumulation Inhibition","authors":"Jeong Hyun Lee, Su Jin Kang, Won Jong Rhee","doi":"10.1002/adtp.202400150","DOIUrl":"10.1002/adtp.202400150","url":null,"abstract":"Obesity is a global health crisis, necessitating the development of biomaterial-based treatments as alternatives to conventional chemical medications with adverse effects. Extracellular vesicles (EVs), nanosized lipid membrane vesicles containing bioactive components, have emerged as promising biomaterials owing to their biocompatibility, biodistribution, and minimal immune response. Although EVs have been extensively studied for anticancer and anti-inflammatory properties, their potential for obesity therapy remains relatively unexplored. In this study, the therapeutic potential of spinach-derived EVs (Spinex) against obesity is investigated. Spinex is successfully purified from spinach using size exclusion chromatography. Subsequent assessments reveals that Spinex efficiently penetrate preadipocytes without cytotoxicity. Stability assessments reveals that Spinex is stable under various temperatures and serum conditions, suggesting its suitability for storage and clinical use. In vitro studies on 3T3-L1 cells demonstrate the ability of Spinex to suppress lipid accumulation during adipocyte differentiation. In a high-fat diet-induced mouse model, oral Spinex administration significantly reduces adipose tissue weight and body weight gain by downregulating key adipogenic transcription factors. Biodistribution analysis reveals that Spinex accumulated predominantly in the liver, with no apparent toxicity to the major organs. Collectively, the findings highlight Spinex as a promising natural biomaterial for combating obesity and pave the way for further clinical investigations.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 11","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202400150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhalational Delivery of β‐glucan‐chitosan‐poly(lactic co‐glycolic) acid Nanoparticles Enhance Alveolar Macrophage Rifampin Concentrations for the Treatment of Tuberculosis 吸入β-葡聚糖-壳聚糖-聚（乳酸共聚乙醇）酸纳米颗粒可提高肺泡巨噬细胞中利福平的浓度，用于治疗结核病

IF 4.6 4区医学

Advanced Therapeutics Pub Date : 2024-07-05 DOI: 10.1002/adtp.202400057

Hilliard L. Kutscher, Maria Tamblin, Shanta Karki, Lee Chaves, Marissa Baird, Afrin Parvin, Evon Smith, Admire Dube, Zhaoqi Zhang, Saptarshi Chakraborty, Patrick Kenney, Jessica L. Reynolds

{"title":"Inhalational Delivery of β‐glucan‐chitosan‐poly(lactic co‐glycolic) acid Nanoparticles Enhance Alveolar Macrophage Rifampin Concentrations for the Treatment of Tuberculosis","authors":"Hilliard L. Kutscher, Maria Tamblin, Shanta Karki, Lee Chaves, Marissa Baird, Afrin Parvin, Evon Smith, Admire Dube, Zhaoqi Zhang, Saptarshi Chakraborty, Patrick Kenney, Jessica L. Reynolds","doi":"10.1002/adtp.202400057","DOIUrl":"https://doi.org/10.1002/adtp.202400057","url":null,"abstract":"Despite multiple treatments for tuberculosis (TB), there are ≈10 million new cases and 1.5 million deaths annually, warranting the need for new therapeutics. Major clinical treatment issues include the length of treatment which is associated with patient non‐compliance; and poor cellular drug penetration leading to the generation of drug‐resistant strains. This study underscores the potential of β‐glucan‐chitosan (CS) poly(lactic co‐glycolic) acid (PLGA) nanoparticles as a promising immunostimulatory adjunct for TB treatment. To facilitate drug delivery to alveolar macrophage, a CS‐PLGA nanoparticle is developed containing rifampin in the core with β‐glucan as a surface ligand, to stimulate the immune system. Mice are administered a single dose of nanoparticles or free rifampin by oropharyngeal aspiration. Pharmacokinetic investigations reveal sustained release properties of rifampin in vivo, extending over a week. Furthermore, comprehensive analysis indicates stimulation of the innate immune system, as evidenced by cytokine profiling, while concurrently revealing no detrimental effects on the alveolar epithelium, as indicated by histological examination and albumin lung leak assessment. These findings collectively establish a strong foundation for the development of a novel adjuvant immunotherapy approach for TB.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"22 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Multifunctional Purposes of Ultrasound in 3D Models 三维模型中超声波的多功能用途

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-04 DOI: 10.1002/adtp.202400161

Veronica Vighetto, Elia Pascucci, Giorgia Savino, Giada Rosso, Nicolò Maria Percivalle, Marzia Conte, Bianca Dumontel, Alice Balboni, Giulia Mesiano, Alessandro Masoero, Valentina Cauda

{"title":"The Multifunctional Purposes of Ultrasound in 3D Models","authors":"Veronica Vighetto, Elia Pascucci, Giorgia Savino, Giada Rosso, Nicolò Maria Percivalle, Marzia Conte, Bianca Dumontel, Alice Balboni, Giulia Mesiano, Alessandro Masoero, Valentina Cauda","doi":"10.1002/adtp.202400161","DOIUrl":"10.1002/adtp.202400161","url":null,"abstract":"Ultrasound (US), is gaining considerable interest as therapy and diagnostic tool, being safe, deep-tissue penetrating, and enabling variegate interventions. Although some US applications have already reached the clinical practice, innovative interventions combining them to microbubbles, nanoparticles, scaffolds and novel imaging techniques have to face complex clinical translation. Here US technologies are illustrated in 3D cell structures: as in-vitro systems at different levels of complexity, 3D models can fairly recapitulate human tissue complexity, while reducing interventions on animals. First drug delivery is described as mediated by microbubbles or nanoparticles to 3D spheroids, organ-on-chip, microfluidic-embedded 3D-cell structures, and cell-seeded scaffolds, showing the important US role in achieving barriers penetration and highly localized delivery. Then, the assembly of cells in 3D structures thanks to US is highlighted, showing prominent examples of how finely tuning acoustic standing waves can guide the organization and aggregation of cells in 3D. Finally, an outlook of conventional echographic techniques up to the most innovative quantitative US imaging is reviewed, focusing on new imaging options for 3D structures. These intriguing fields of research are discussed related to their actual challenges and opportunities, level of complexity of 3D models, and ability to propose a valid tool toward clinical translation.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Tea Carbon Dots-Based Electrically Active Hydrogel Dressing for Promoting Wound Healing 基于绿茶碳点的电活性水凝胶敷料可促进伤口愈合

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-01 DOI: 10.1002/adtp.202400016

Kang Hu, Zhuo Huang, Qinying Tang, Danyang Chen, Lianxu Chen, Lu Chen, Guohua Jiang, Qianfei Huang, Langjie Chai, Hang Chen, Liang Guo, Bin Li

{"title":"Green Tea Carbon Dots-Based Electrically Active Hydrogel Dressing for Promoting Wound Healing","authors":"Kang Hu, Zhuo Huang, Qinying Tang, Danyang Chen, Lianxu Chen, Lu Chen, Guohua Jiang, Qianfei Huang, Langjie Chai, Hang Chen, Liang Guo, Bin Li","doi":"10.1002/adtp.202400016","DOIUrl":"10.1002/adtp.202400016","url":null,"abstract":"Currently, searching for safer and more effective approaches to promote skin wound healing and tissue regeneration is a significant research focus in the field of public health. Eliminating excessive reactive oxygen species (ROS) and using electrically active dressings to accelerate wound healing has gained significant attention. Herein, green tea-based carbon dots (GCDs) are synthesized from leaves of green tea and proven to possess strong antioxidant, antibacterial, and anti-inflammatory properties. Then, GCDs, polyvinyl alcohol (PVA), and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) are successfully constructed into a multifunctional conductive PVA-PEDOT:PSS/GCDs hydrogel (PPPCD) using a repeated freeze-thaw method for promoting skin wound healing. Highly electrical conductivity is imparted by introducing PEDOT:PSS, while antioxidant and antibacterial properties are conferred by GCDs. In vitro assays demonstrated the excellent biocompatibility of the hydrogel, as well as its ability to scavenge excessive ROS and promote cell migration. Furthermore, the hydrogel not only accelerates wound healing by promoting blood vessel formation and epidermal regeneration but also alleviating excessive inflammation in vivo. Overall, the developed hydrogel dressing demonstrates promising prospects for skin wound healing and offers a new perspective for tissue engineering.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody-Drug Conjugates in Preclinical Models 在临床前模型中通过 ICAM1 抗体-药物共轭物靶向治疗舌鳞状细胞癌

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-01 DOI: 10.1002/adtp.202400018

Letao Ma, Yanzhi Xu, Yuxuan Yang, Teng Yang, Yujie Dai, Takaya Shimura, Chulin Sha, Xinfang Li, Jianmin Fang, Weihui Zheng, Ye Lu, Peng Guo

{"title":"Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody-Drug Conjugates in Preclinical Models","authors":"Letao Ma, Yanzhi Xu, Yuxuan Yang, Teng Yang, Yujie Dai, Takaya Shimura, Chulin Sha, Xinfang Li, Jianmin Fang, Weihui Zheng, Ye Lu, Peng Guo","doi":"10.1002/adtp.202400018","DOIUrl":"10.1002/adtp.202400018","url":null,"abstract":"To date, the treatment options for metastatic and recurrent tongue squamous cell carcinoma (TSCC) remain limited due to the lack of effective drug targets and therapeutics. Here the identification of ICAM1 is reported as a TSCC target candidate for the development of antibody-drug conjugate (ADC), an emerging class of targeted therapeutics. An unbiased and quantitative screening of a panel of 69 TSCC cell surface antigens is first performed that identifies ICAM1 as the most abundant hit. The overexpression level of ICAM1 is validated in 26 TSCC clinical specimens and four cell lines along with genomic information of 127 TSCC patients from the TCGA database. Based on this new target, the anti-TSCC efficacy of ICAM1-targeted ADCs featuring two payloads is evaluated of different mechanisms of action: MMAE and DXd. Both ADCs selectively and potently ablate TSCC tumors in the established SAS cell line and patient-derived xenograft (PDX) models. The findings strongly support ICAM1 as a promising ADC target candidate for TSCC therapy.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-Cysteine Nanostructures for Synergetic Photothermal Therapy and Chemodynamic Therapy of Bacterial Skin Abscesses 铜-半胱氨酸纳米结构用于细菌性皮肤脓肿的协同光热疗法和化学动力疗法

IF 3.7 4区医学

Advanced Therapeutics Pub Date : 2024-07-01 DOI: 10.1002/adtp.202400099

Hadi Bagheri, Shayesteh Bochani, Mohammad Seyedhamzeh, Zahra Shokri, Ali Kalantari-Hesari, Raymond J. Turner, Mahshid Kharaziha, Kimia Esmaeilzadeh, Mehdi Golami, Habib Zeighami, Aziz Maleki

{"title":"Copper-Cysteine Nanostructures for Synergetic Photothermal Therapy and Chemodynamic Therapy of Bacterial Skin Abscesses","authors":"Hadi Bagheri, Shayesteh Bochani, Mohammad Seyedhamzeh, Zahra Shokri, Ali Kalantari-Hesari, Raymond J. Turner, Mahshid Kharaziha, Kimia Esmaeilzadeh, Mehdi Golami, Habib Zeighami, Aziz Maleki","doi":"10.1002/adtp.202400099","DOIUrl":"10.1002/adtp.202400099","url":null,"abstract":"Skin lesions, including skin bacterial abscesses, have become one of the most important health challenges and usually need systemic high-dose antibiotics. Therefore, it is of particular importance to develop novel approaches for treating this ever-growing challenge to human health. To address this challenge, herein a copper nanostructure is developed giving combined photothermal and chemodynamic therapies for focal infection treatment. The Cu-based nanostructures with intrinsic catalytic properties are prepared by D-L or L cysteine (Cys) as ligand and copper ions. It is shown that the multifunctional copper-Cys (Cu-Cys) nanostructures can produce reactive oxygen species (ROS) and they exhibit near infrared (NIR)-enhanced catalytic activities to improve ROS production for highly efficient eradication of bacteria. Moreover, the results proved O2 evolution property of the Cu-Cys nanoparticles (NPs). The nanostructures show shape-dependent antibacterial activity where DL-Cu-Cys NPs show higher bactericidal performance than L-Cu-Cys NPs. In vitro results demonstrate that 2.5 and 1.25 µg mL−1 of DL-Cu-Cys NPs is enough to achieve rapid killing of Escherichia coli (E. coli) or Staphylococcus aureus (S. aureus) respectively under 808 nm light irradiation in 10 min. This work introduces a unique photoactive nanoagent to efficiently treat subcutaneous abscess by combining NIR light-triggered photothermal effect and catalytic generation of ROS without using any antibiotic.","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"7 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0