Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation (Adv. Therap. 12/2024)

Abstract

Autophagy facilitates the degradation and recycling of nonfunctional proteins and organelles in autolysosome, which contributes to tumor maintenance. Antidepressant sertraline was found to induce AMPK-mTOR signaling mediated autophagosome accumulation, but block autophagic flux at the stage of autolysosomal degradation, thus suppressing the colorectal cancer survival. The study reports the repurposing of sertraline as an anticancer drug through the mechanism of inhibiting autophagic flux. More details can be found in article 2400199 by Jiaolin Bao, Ren-Bo Ding and co-workers.