Nano Convergence最新文献

{"title":"Bionanotechnology at microplastic and nanoplastic interfaces: detection, adsorption and degradation","authors":"Angrui Jiang,&nbsp;Wei Mao,&nbsp;Bowen Dai,&nbsp;Jung Heon Lee,&nbsp;Xue Bai,&nbsp;Juewen Liu","doi":"10.1186/s40580-026-00563-z","DOIUrl":"10.1186/s40580-026-00563-z","url":null,"abstract":"<div><p>Micro-nano plastics (M/NPs) are pervasive environmental pollutants whose small size, persistence, and evolving surface states complicate reliable detection and remediation. As interface-dominated contaminants, their environmental behavior is largely governed by interactions at plastic–bio–nano interfaces. In this article, we review recent advances in three interconnected aspects of M/NPs research: biomolecular recognition, nano-enabled enrichment, and catalytic degradation, with particular emphasis on the central role of interfaces. Biomolecular recognition elements, including antibodies, peptides, aptamers, and molecularly imprinted materials, enable selective identification of plastics through interfacial pattern recognition. Nanomaterials such as magnetic nanoparticles, plasmonic nanostructures, metal–organic frameworks, and carbon-based materials further facilitate selective capture and signal amplification in complex matrices. Emerging degradation strategies, including engineered enzymes, enzyme–nanomaterial hybrids, nanozymes, single-atom nanozymes, and advanced oxidation processes, rely on interface-mediated adsorption, catalytic activation, and polymer transformation. Future research should therefore focus on elucidating plastic–bio–nano interfacial mechanisms and leveraging these insights to integrate molecular recognition, nano-enabled enrichment, and catalytic transformation within multifunctional platforms.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing effect of high-energy proton irradiation on the reliability of HfZrO based high-k dielectrics","authors":"Chan Bin Lee,&nbsp;Useok Choi,&nbsp;Yongsu Lee,&nbsp;Jun-Hyeok Choi,&nbsp;Hyeon-Seok Shin,&nbsp;Uigwan Shin,&nbsp;Byeong Gwan Kim,&nbsp;Jun Yeong Hong,&nbsp;Jae Min Jo,&nbsp;Jeong Min Park,&nbsp;Hyeon Jun Hwang,&nbsp;Chang Goo Kang,&nbsp;Byoung Hun Lee","doi":"10.1186/s40580-026-00562-0","DOIUrl":"10.1186/s40580-026-00562-0","url":null,"abstract":"<div><p>This study investigates the impact of high-energy proton irradiation (33 and 100 MeV) on the radiation response and statistical uniformity of the breakdown field of Hf_xZr_1−xO₂ based metal–insulator–metal capacitors. While macroscopic electrical characteristics—such as polarization hysteresis, dielectric constant, and leakage current—exhibit remarkable radiation stability across various crystalline phases, a distinct improvement is observed in the statistical distribution of the breakdown field (<i>E</i>_<i>BD</i>). Weibull distribution analysis reveals a consistent increase in the shape factor (β) following irradiation, indicating a \"healing effect\" that effectively narrows the variance of dielectric breakdown. This enhancement leads to a normalized yield improvement ranging from 3.0% to 14.8%. Our findings suggest that optimized high-energy proton treatment can effectively mitigate localized defects and suppress early-stage failures. These results provide a strategic pathway for enhancing the reliability and operational lifetime of high-k dielectrics in space-qualified and radiation-hardened electronics.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s40580-026-00562-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering graphene oxide interfaces for electrochemical biosensing of biomolecules, cells, and organoids","authors":"Huijung Kim,&nbsp;Cheol-Hwi Kim,&nbsp;Chang-Dae Kim,&nbsp;Zhengtang Luo,&nbsp;Tae-Hyung Kim","doi":"10.1186/s40580-026-00560-2","DOIUrl":"10.1186/s40580-026-00560-2","url":null,"abstract":"<div><p>Graphene oxide (GO) has established itself as a premier material for electrochemical biosensing due to its exceptional chemical tunability, aqueous processability, and unique sp²-sp³ hybridized structure. This review provides a comprehensive analysis of diverse engineering strategies to functionalize GO, enabling highly sensitive and selective detection of a broad spectrum of biological analytes. We systematically categorize these advancements into five key methodologies: (1) controlled reduction to precisely tune electrical conductivity and surface defects, (2) covalent functionalization for robust bioreceptor immobilization, (3) non-covalent modification to preserve biomolecular conformation, (4) metal nanoparticle hybridization for enhanced electrocatalysis, and (5) integration with polymeric/framework materials to build advanced three-dimensional sensing architectures. By examining applications ranging from small molecule metabolites and proteins to nucleic acids and whole pathogens, we demonstrate how tailored GO interfaces overcome conventional sensing trade-offs. Finally, we highlight the pivotal role of these engineered GO platforms in addressing the challenges of real-time monitoring at complex biological interfaces, including living cells and organoids, and outline the pathway toward clinically deployable diagnostic technologies.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s40580-026-00560-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-irradiated coffee waste: a path to eco-friendly anode materials for lithium-ion batteries","authors":"Si Eun Park,&nbsp;Tongmei Jing,&nbsp;Mee-Ree Kim,&nbsp;Dongwook Yang,&nbsp;Han Ku Nam,&nbsp;Sangbaek Park,&nbsp;Young-Jin Kim","doi":"10.1186/s40580-026-00561-1","DOIUrl":"10.1186/s40580-026-00561-1","url":null,"abstract":"<div><p>Hard carbon is being actively explored as a candidate anode material for next-generation batteries, offering ion storage mechanisms distinct from and potentially advantageous to those of graphite. However, conventional synthesis of hard carbon usually relies on high-temperature pyrolysis and chemical activation, which involve high energy consumption and environmental challenges. Spent coffee grounds (SCGs), generated in large amounts worldwide, represent an abundant biomass resource with high carbon content that is often discarded with limited recycling. In this study, SCGs were directly converted into hard carbon and partially graphitized structures using femtosecond laser direct writing (FsLDW) under solvent-free and non-vacuum conditions. Localized photothermal reactions induced by the ultrashort pulses promoted particle consolidation and structural rearrangement, and by varying the laser parameters, the carbonization pathway could be directed to favor either hard carbon or graphene domains. A copper substrate was deliberately employed to spontaneously generate copper compound nanoparticles, which were subsequently etched to create micro-porous carbon with tunable pore characteristics. This laser-based approach provides a controllable and one-step pathway for transforming SCGs into functional carbon anodes, highlighting the potential to selectively prepare materials suitable for both lithium-ion and sodium-ion batteries by adjusting only the laser conditions. While this study focused on lithium-ion battery applications, the tunable control of carbon structure and porosity offers the possibility of extending this strategy to sodium-ion batteries.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>Femtosecond laser converts spent coffee grounds into laser-induced hard carbon and graphene (LIH–LIG) composites, enabling eco-friendly anode materials for high-performance lithium-ion batteries</p></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s40580-026-00561-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic photothermal and magnetothermal heat generation with Sc-doped iron oxide nanoflakes: a platform for potential bimodal tumor therapy","authors":"Ihtisham Ahmad Butt,&nbsp;Naihan Chen,&nbsp;Wei Zhang","doi":"10.1186/s40580-026-00558-w","DOIUrl":"10.1186/s40580-026-00558-w","url":null,"abstract":"<div><p>Enhancement of specific absorption rate (SAR) of iron oxide (Fe₃O₄) is crucial for ensuring selectivity of hyperthermia tumor therapy, yet both magnetothermal and photothermal approaches endure shortcomings i.e., high dosage and laser power densities, that compromise therapeutic efficacy. This work reports the Scandium (Sc) doped Fe₃O₄ nanoflakes synthesized by sol-gel route with superior heat generation properties enabling bimodal tumor therapy. The novel <span>( {text{Sc}}_{{0.05}} left[ {{text{Fe}}^{{2 + }} {text{Fe}}^{{3 + }} _{{1.95}} } right]{text{O}}_{4} )</span> nanoflakes superstructure exhibits pronounced optical extinction and a high saturation magnetization of 90.33 emu/g, arising from lattice expansion and enhanced magnetic exchange coupling. Photothermal conversion efficiency reached 66.84%, while SAR value under magnetic field (32 kA/m, 100 kHz) peaked at 1311.24 W/g (intrinsic loss power (ILP): 11.34 nHm²/kg). Under 808 nm laser exposure (2 W/cm²), photothermal SAR reached to 3480.84 W/g and with combined bimodal (LASER + AMF) heating the SAR synergically boosted to 11857.53 W/g due to temperature modulated magnetic and optical relaxation supporting each other. The material exhibits excellent biocompatibility and in vitro tumor ablation with A375 cell line using small (1 mg/mL) dosage under minimal magnetic field and laser parameters.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s40580-026-00558-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148323603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D MoS2-conformal 3D-printed platform for dual-phototherapy and bone regeneration","authors":"Jong Hwa Seo,&nbsp;Inho Choi,&nbsp;Hyun Lee,&nbsp;Seojoon Bang,&nbsp;Hyeong Seok Kang,&nbsp;Chan Ho Moon,&nbsp;Ju Yeong Gwon,&nbsp;Nayoung Lee,&nbsp;Geonwoo Kim,&nbsp;Yun-Ha Cho,&nbsp;Sejin Choi,&nbsp;Hyojin Joo,&nbsp;Ji-Hye Kim,&nbsp;Eunsaem Song,&nbsp;Jihoon Kim,&nbsp;Dongjun Kim,&nbsp;Sungsu Kang,&nbsp;Dong Yun Lee,&nbsp;Donghyun Lim,&nbsp;Kisuk Yang,&nbsp;Gi Doo Cha,&nbsp;Soo-Hong Lee,&nbsp;Jungwon Park,&nbsp;Min-Ho Kang,&nbsp;Hyun-Do Jung","doi":"10.1186/s40580-026-00559-9","DOIUrl":"10.1186/s40580-026-00559-9","url":null,"abstract":"<div><p>Osteosarcoma has poor prognosis owing to its aggressive metastasis and high recurrence rates due to residual cancer cells which are common even after surgical resection. In addition, for irregular defects, site-specific design is essential to ensure anatomical conformity. Consequently, a critical demand exists for a theragenerative approach that simultaneously provides structural reconstruction and functional eradication of residual cancer cells. Herein, we present a patient-specific 3D-printed theragenerative polyetheretherketone (PEEK) scaffold integrated with biofunctional 2D molybdenum disulfide (MoS₂) to impart enhanced bioactivity and dual-phototherapy. 2D monolayer MoS₂ synthesized via nanoseed-initiated atmospheric pressure chemical vapor deposition (APCVD) was subsequently integrated onto the 3D-printed PEEK through a polymer-assisted transfer process. The fabricated 2D MoS₂-conformal 3D-printed PEEK scaffold (MoS₂@PEEK) enabled simultaneous photothermal and photodynamic therapy via the intrinsic photoresponsive properties MoS₂. Under dual-wavelength irradiation, this combined phototherapy effectively induced pronounced cancer cell apoptosis and exhibited antibacterial activity through the synergistic effects of localized hyperthermia and reactive oxygen species generation. In contrast, under the same photothermal stimulation, pre-osteoblasts and vascular endothelial cells exhibited enhanced attachment, proliferation, and differentiation. Therefore, this theragenerative system represents a promising patient-specific platform for simultaneous tumor suppression, infection control, and bone regeneration after osteosarcoma resection.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s40580-026-00559-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-throughput discovery of Li3Sc2(PO4)3 as a protective coating for stabilizing mid-Ni NCM interfaces in all-solid-state batteries","authors":"Ji Hoon Kim,&nbsp;Seunghyun Lee,&nbsp;Sang Uck Lee","doi":"10.1186/s40580-026-00555-z","DOIUrl":"10.1186/s40580-026-00555-z","url":null,"abstract":"<div><p>As all-solid-state battery (ASSB) technologies continue to advance, interest has resurfaced in mid-nickel (mid-Ni) LiNi_xCo_yMn_zO₂ (NCM; x = 0.5) cathodes due to their enhanced structural stability, reduced oxygen evolution, and higher capacities at elevated cutoff voltages compared to high-nickel compositions. However, interfacial degradation including parasitic reactions with solid-state electrolytes (SSEs) remains a major challenge. To address this issue, we conducted a high-throughput computational screening of oxide-based coating materials, evaluating their electrochemical stability, interfacial robustness, and Li-ion conductivity using Li–Li network descriptors. From this screening, 8 candidates were selected based on strict criteria. Among them, Li₃Sc₂(PO₄)₃ emerged as a particularly promising coating material, exhibiting strong electrochemical stability under high-voltage conditions (&gt; 4 V) and substantial ionic conductivity (0.2 mS/cm), exceeding that of most oxide-type SSEs, as confirmed by ab initio molecular dynamics simulations. Furthermore, large-scale molecular dynamics simulations using a universal machine-learning interatomic potential demonstrate its ability to suppress surface degradation of mid-Ni NCM and prevent [PS₄]³⁻ decomposition in Li₆PS₅Cl, confirming its potential as a protective coating. These findings highlight the effectiveness of our computational screening strategy for coating-material discovery and underscore the potential of Li₃Sc₂(PO₄)₃ as a robust interfacial layer for stabilizing mid-Ni ASSBs.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s40580-026-00555-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization strategies for crystal orientation in antimony-based chalcogenide thin-film solar cells","authors":"Xuefeng Chen,&nbsp;Xueling Chen,&nbsp;Hangrui Zhang,&nbsp;Yingying Mo,&nbsp;Xiaomin Wang,&nbsp;Xudong Xiao,&nbsp;Jianmin Li","doi":"10.1186/s40580-026-00557-x","DOIUrl":"10.1186/s40580-026-00557-x","url":null,"abstract":"<div><p>Antimony chalcogenides are highly promising thin-film photovoltaic materials. However, their quasi-one-dimensional structure inherently causes severe transport anisotropy. The thermodynamically stable [hk0] horizontal orientation induces van der Waals barriers that hinder carrier transport, whereas the kinetically favorable [hk1] vertical orientation constructs efficient charge pathways and dangling-bond-free “benign grain boundaries”. Focusing on the thermodynamic and kinetic competition mechanisms during film growth, this review systematically summarizes recent optimization strategies for inducing the [hk1] preferred orientation. Four core approaches are highlighted: solvent and precursor engineering, deposition parameter optimization, interface and substrate engineering, and post-treatment reconstruction. Finally, we delineate the “structure-process-performance” relationship and provide perspectives on deep-level defect passivation, heterojunction band engineering, and flexible, large-area applications, aiming to guide the fabrication of high-efficiency antimony-based solar cells approaching their theoretical limit.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div><div><p>Focusing on the thermodynamic and kinetic competition mechanisms during film growth, this review systematically summarizes four core optimization strategies for inducing the [hk1] preferred orientation, aiming to guide the fabrication of high-efficiency antimony-based solar cells.</p></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s40580-026-00557-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148154826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering quantum dot surfaces to preserve protein-DNA interactions for single-molecule visualization","authors":"Youngseo Kim,&nbsp;Hyerim Kim,&nbsp;Munryul Choi,&nbsp;Hyun Suk Kim,&nbsp;Soyeong An,&nbsp;Orlando D. Schärer,&nbsp;Jongnam Park,&nbsp;Ja Yil Lee","doi":"10.1186/s40580-026-00556-y","DOIUrl":"10.1186/s40580-026-00556-y","url":null,"abstract":"<div><p>Quantum dots (QDs) are fluorescent nanoparticles widely used for single-molecule imaging because of their exceptional brightness and photostability. However, the impact of QD surface chemistry on biomolecular interactions has not been systematically investigated. Here, we report that commercial QDs unexpectedly destabilize protein-DNA complexes by inducing protein dissociation from DNA. Using the human nucleotide excision repair protein, xeroderma pigmentosum complementation group A (XPA) as a model system, we demonstrate that antibody-conjugated QDs promote dissociation of XPA from DNA substrates, independently of sizes and surface modification of QDs, antibody types, epitope tags, buffer conditions, or DNA structures. We find that polyethylene glycol (PEG), a common polymer coating on QD surfaces, is the primary factor responsible for this effect. To tackle this problem, we engineered QDs with precisely controlled surface polymer compositions. By systematically changing the ratio of anchoring, hydrophilic, and PEG-based functional groups, we find that reducing PEG density below a critical threshold effectively suppresses protein dissociation while maintaining excellent colloidal stability and brightness. Furthermore, antibodies conjugated via click chemistry between azide groups and DBCO enabled specific labeling of XPA without perturbing the DNA binding activity. Using these optimized QDs, we conducted single-molecule DNA curtain assays to visualize XPA-DNA interactions. QD-labeled XPA exhibits one-dimensional diffusion with frequent pausing on undamaged DNA. DNA curtain assays revealed that XPA preferentially binds DNA bubbles and searches for bubble structures through both one-dimensional diffusion and three-dimensional collision. Quantitative analysis showed that three-dimensional collision is the dominant pathway for bubble recognition. Taken together, our results uncover a previously unrecognized limitation of PEG-coated QDs in single-molecule studies and provide an improved surface-engineering strategy to preserve native protein-DNA interactions. Newly engineered QDs establish robust platforms for accurate single-molecule visualization of biomolecular processes.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s40580-026-00556-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148147995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven text mining of the female reproductive system: enabling multiscale biomedical modeling and personalized medicine","authors":"Gaeun Lee,&nbsp;Jeehyo Jeon,&nbsp;Sharon Jeeho Ham,&nbsp;Sieun Shin,&nbsp;Seo Yeon Kim,&nbsp;Hongsock Kim,&nbsp;Ju Yeon Lee,&nbsp;Heejin Woo,&nbsp;Jongwoo Ahn,&nbsp;Jungseub Lee,&nbsp;Seokyoung Bang,&nbsp;Susik Yoon,&nbsp;Jungho Ahn","doi":"10.1186/s40580-026-00554-0","DOIUrl":"10.1186/s40580-026-00554-0","url":null,"abstract":"<div><p>The female reproductive system, including the endometrium, placenta, ovary, cervix, and fallopian tube, plays a critical role in conception, implantation, and fetal development. Recent advances in bioengineered models such as organoids, organ-on-a-chip platforms, and 3D bioprinting have expanded experimental capabilities, however, the rapid growth of this field has resulted in a large and fragmented body of literature, limiting systematic integration and analysis. Here, we present an artificial intelligence (AI)-driven text mining framework to systematically map research trends in the female reproductive system. A total of 347 peer-reviewed articles were collected and analyzed. Abstracts were embedded using BioBERT to capture contextual biomedical semantics. Subsequently, unsupervised topic modeling was performed using BERTopic with UMAP-based dimensionality reduction and HDBSCAN clustering. This analysis identified 15 fine-grained subtopics, which were further consolidated into six major thematic categories. The results show that current research is mainly focused on endometrial receptivity and implantation, placental barrier function and maternal–fetal interface, and tissue regeneration and biofabrication. In contrast, integrated multi-organ modeling and translational validation remain relatively underexplored. Overall, this AI-driven framework provides a quantitative and scalable approach to organizing complex biomedical literature. The findings offer a structured overview of the field and highlight emerging directions for multiscale modeling and personalized reproductive medicine.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"13 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13222377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}