Nano Convergence最新文献

{"title":"Recent progress in realizing novel one-dimensional polymorphs via nanotube encapsulation","authors":"Yangjin Lee,&nbsp;Uje Choi,&nbsp;Kwanpyo Kim,&nbsp;Alex Zettl","doi":"10.1186/s40580-024-00460-3","DOIUrl":"10.1186/s40580-024-00460-3","url":null,"abstract":"<div><p>Encapsulation of various materials inside nanotubes has emerged as an effective method in nanotechnology that facilitates the formation of novel one-dimensional (1D) structures and enhances their functionality. Because of the effects of geometrical confinement and electronic interactions with host nanotubes, encapsulated materials often exhibit low-dimensional polymorphic structures that differ from their bulk forms. These polymorphs exhibit unique properties, including altered electrical, optical, and magnetic behaviors, making them promising candidates for applications in electronics, energy storage, spintronics, and quantum devices. This review explores recent advancements in the encapsulation of a wide range of materials such as organic molecules, elemental substances, metal halides, metal chalcogenides, and other complex compounds. In particular, we focus on novel polymorphs formed through the geometrical confinement effect within the nanotubes. The atomic structure, other key properties, and potential applications of these encapsulated materials are discussed, highlighting the impact of nanotube encapsulation on their functionalities.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00460-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial charge transfer on hierarchical synergistic shell wall of MXene/MoS2 on CdS nanospheres: heterostructure integrity for visible light responsive photocatalytic H2 evolution","authors":"Kugalur Shanmugam Ranjith,&nbsp;Ali Mohammadi,&nbsp;Ganji Seeta Rama Raju,&nbsp;Yun Suk Huh,&nbsp;Young-Kyu Han","doi":"10.1186/s40580-024-00454-1","DOIUrl":"10.1186/s40580-024-00454-1","url":null,"abstract":"<div><p>Energy scarcity and environmental pollution have prompted research in hydrogen generation from solar to develop clean energy through highly efficient, effective, and long-lasting photocatalytic systems. Designing a catalyst with robust stability and an effective carrier separation rate was achieved through heterostructure assembly, but certain functionalities must be explored. In this paper we designed a ternary heterostructure assembly of CdS nanospheres wrapped with hierarchical shell walls of layered MXene-tagged MoS₂ nanoflakes, forming intimate interfaces through an in-situ growth process. An in-layered shell wall of MXene with surface-wrapped MoS₂ nanoflakes as a core–shell assembly improved the photo-corrosion resistance and accelerated the production of photocatalytic H₂ (38.5 mmol g⁻¹ h⁻¹), which is 10.7, 3.1, and 1.9 times faster than that of CdS, CdS–MXe, and CdS–MoS₂ nanostructures, respectively. The apparent quantum efficiency of the CdS–MXe_2.4/MoS₂ heterostructure was calculated to be 34.6% at λ = 420 nm. X-ray and ultraviolet photoelectron spectroscopies validated the electronic states, energy band alignment, and work function of the heterostructures, whilst time-resolved photoluminescence measured the carrier lifespan to evaluate the effective charge migration in the CdS-MXe/MoS₂ heterostructure. The dual surface wrapping of MXe/MoS₂ over CdS nanospheres confirmed the structural durability that remained intact throughout the photocatalytic reaction, promoting approximately 93.1% of its catalytic property even after five repeatable cycles. This study examined how the MXene heterostructure template improves the catalytic efficiency and opens a new way to design MXene-based durable heterostructure catalysts for solar-energy conversion.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00454-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topological surface states of semimetal TaSb2","authors":"Ji-Eun Lee,&nbsp;Yu Liu,&nbsp;Jinwoong Hwang,&nbsp;Choongyu Hwang,&nbsp;Cedomir Petrovic,&nbsp;Se Young Park,&nbsp;Hyejin Ryu,&nbsp;Sung-Kwan Mo","doi":"10.1186/s40580-024-00457-y","DOIUrl":"10.1186/s40580-024-00457-y","url":null,"abstract":"<div><p>Topological surface states, protected by the global symmetry of the materials, are the keys to understanding various novel electrical, magnetic, and optical properties. TaSb₂ is a newly discovered topological material with unique transport phenomena, including negative magnetoresistance and resistivity plateau, whose microscopic understanding is yet to be reached. In this study, we investigate the electronic band structure of TaSb₂ using angle-resolved photoemission spectroscopy and density functional theory. Our analyses reveal distinct bulk and surface states in TaSb₂, providing direct evidence of its topological nature. Notably, surface states predominate the electronic contribution near the Fermi level, while bulk bands are mostly located at higher binding energies. Our study underlines the importance of systematic investigations into the electronic structures of topological materials, offering insights into their fundamental properties and potential applications in future technologies.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00457-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectroelectrochemical insights into the intrinsic nature of lead halide perovskites","authors":"Seonhong Min,&nbsp;Minwook Jeon,&nbsp;Junsang Cho,&nbsp;Jin Ho Bang,&nbsp;Prashant V. Kamat","doi":"10.1186/s40580-024-00459-w","DOIUrl":"10.1186/s40580-024-00459-w","url":null,"abstract":"<div><p>Lead halide perovskites have emerged as a new class of semiconductor materials with exceptional optoelectronic properties, sparking significant research interest in photovoltaics and light-emitting diodes. However, achieving long-term operational stability remains a critical hurdle. The soft, ionic nature of the halide perovskite lattice renders them vulnerable to various instabilities. These instabilities can be triggered by factors such as photoexcitation, electrical bias, and the surrounding electrolyte/solvent or atmosphere under operating conditions. Spectroelectrochemistry offers a powerful approach to bridge the gap between electrochemistry and photochemistry (or spectroscopy), by providing a comprehensive understanding of the band structure and excited-state dynamics of halide perovskites. This review summarizes recent advances that highlight the fundamental principles, the electronic band structure of halide perovskite materials, and the photoelectrochemical phenomena observed upon photo- and electro-chemical charge injections. Further, we discuss halide instability, encompassing halide oxidation, vacancy formation, ion migration, degradation, and sequential expulsion under electrical bias. Spectroelectrochemical studies that provide a deeper understanding of interfacial processes and halide mobility can pave the way for the design of more robust perovskites, accelerating future research and development efforts.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00459-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142753961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manganese oxide nanomaterials: bridging synthesis and therapeutic innovations for cancer treatment","authors":"Sandip Gangadhar Balwe,&nbsp;Dohyeon Moon,&nbsp;Minki Hong,&nbsp;Joon Myong Song","doi":"10.1186/s40580-024-00456-z","DOIUrl":"10.1186/s40580-024-00456-z","url":null,"abstract":"<div><p>The advent of precision medicine in oncology emphasizes the urgent need for innovative therapeutic strategies that effectively integrate diagnosis and treatment while minimizing invasiveness. Manganese oxide nanomaterials (MONs) have emerged as a promising class of nanocarriers in biomedicine, particularly for targeted drug delivery and the therapeutic management of tumors. These nanomaterials are characterized by exceptional responsiveness to the tumor microenvironment (TME), high catalytic efficiency, favorable biodegradability, and advanced capabilities in magnetic resonance imaging. These attributes significantly enhance drug delivery, facilitate real-time bioimaging, and enable early tumor detection, thereby improving the precision and effectiveness of cancer therapies. This review highlights the significant advancements in the synthesis and therapeutic applications of MONs, beginning with a comprehensive overview of key synthetic methods, including thermal decomposition, potassium permanganate reduction, exfoliation, adsorption–oxidation, and hydro/solvothermal techniques. We delve into the preparation of MONs and H–MnO₂-based nanomaterials, emphasizing their chemical properties, surface modifications, and toxicity profiles, which are critical for their clinical application. Moreover, we discuss the notable applications of H–MnO₂-based nanomaterials in pH-responsive drug release, overcoming multidrug resistance (MDR), immunotherapy, and the development of nanovaccines for synergistic cancer treatments. By addressing the current challenges in the clinical translation of MONs, we propose future research directions for overcoming these obstacles. By underscoring the potential of MONs to transform cancer treatment paradigms, this review aims to inspire further investigations into their multifunctional applications in oncology, thus ultimately contributing to more effective and personalized therapeutic strategies.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00456-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of nanobiosensors into organ-on-chip systems for monitoring viral infections","authors":"Jiande Zhang,&nbsp;Min-Hyeok Kim,&nbsp;Seulgi Lee,&nbsp;Sungsu Park","doi":"10.1186/s40580-024-00455-0","DOIUrl":"10.1186/s40580-024-00455-0","url":null,"abstract":"<div><p>The integration of nanobiosensors into organ-on-chip (OoC) models offers a promising advancement in the study of viral infections and therapeutic development. Conventional research methods for studying viral infection, such as two-dimensional cell cultures and animal models, face challenges in replicating the complex and dynamic nature of human tissues. In contrast, OoC systems provide more accurate, physiologically relevant models for investigating viral infections, disease mechanisms, and host responses. Nanobiosensors, with their miniaturized designs and enhanced sensitivity, enable real-time, continuous, in situ monitoring of key biomarkers, such as cytokines and proteins within these systems. This review highlights the need for integrating nanobiosensors into OoC systems to advance virological research and improve therapeutic outcomes. Although there is extensive literature on biosensors for viral infection detection and OoC models for replicating infections, real integration of biosensors into OoCs for continuous monitoring remains unachieved. We discuss the advantages of nanobiosensor integration for real-time tracking of critical biomarkers within OoC models, key biosensor technologies, and current OoC systems relevant to viral infection studies. Additionally, we address the main technical challenges and propose solutions for successful integration. This review aims to guide the development of biosensor-integrated OoCs, paving the way for precise diagnostics and personalized treatments in virological research.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00455-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D amorphous solids for sub-nanometer scale devices","authors":"Hyeonseo Jang,&nbsp;Hyeonju Kim,&nbsp;Gayoon Kim,&nbsp;Suyeon Cho,&nbsp;Heejun Yang","doi":"10.1186/s40580-024-00453-2","DOIUrl":"10.1186/s40580-024-00453-2","url":null,"abstract":"<div><p>Amorphous solids are a type of condensed matter characterized by the absence of long-range order in their lattice structure. However, they still exhibit short- or medium-range order, which contributes to their versatile local and global electronic and chemical properties. Recently, 2D amorphous solids have gained attention for their exceptional mechanical and electronic features, which are unattainable in conventional crystalline materials. This review highlights the physical properties of ultrathin 2D amorphous solids, which are formed through covalent bonding and feature polyhedron structures with shared edges and corners. Two notable examples of 2D amorphous solids include honeycomb-structured nanosheets with mixed hybrid orbitals and layered materials with reduced coordination numbers of the elements. We provide an in-depth discussion of (1) the phase transition between crystalline and amorphous phases in 2D solids, (2) advanced synthetic methods for producing high-quality amorphous films with precise thickness control, and (3) the potential applications of sub-nanometer scale 2D amorphous solids. Lastly, we explore their potential to revolutionize the design of highly versatile electronic devices at sub-nanometer scales.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00453-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in materials and technologies for digital light processing 3D printing","authors":"Jisoo Nam,&nbsp;Miso Kim","doi":"10.1186/s40580-024-00452-3","DOIUrl":"10.1186/s40580-024-00452-3","url":null,"abstract":"<div><p>Digital light processing (DLP) is a projection-based vat photopolymerization 3D printing technique that attracts increasing attention due to its high resolution and accuracy. The projection-based layer-by-layer deposition in DLP uses precise light control to cure photopolymer resin quickly, providing a smooth surface finish due to the uniform layer curing process. Additionally, the extensive material selection in DLP 3D printing, notably including existing photopolymerizable materials, presents a significant advantage compared with other 3D printing techniques with limited material choices. Studies in DLP can be categorized into two main domains: material-level and system-level innovation. Regarding material-level innovations, the development of photocurable resins with tailored rheological, photocuring, mechanical, and functional properties is crucial for expanding the application prospects of DLP technology. In this review, we comprehensively review the state-of-the-art advancements in DLP 3D printing, focusing on material innovations centered on functional materials, particularly various smart materials for 4D printing, in addition to piezoelectric ceramics and their composites with their applications in DLP. Additionally, we discuss the development of recyclable DLP resins to promote sustainable manufacturing practices. The state-of-the-art system-level innovations are also delineated, including recent progress in multi-materials DLP, grayscale DLP, AI-assisted DLP, and other related developments. We also highlight the current challenges and propose potential directions for future development. Exciting areas such as the creation of photocurable materials with stimuli-responsive functionality, ceramic DLP, recyclable DLP, and AI-enhanced DLP are still in their nascent stages. By exploring concepts like AI-assisted DLP recycling technology, the integration of these aspects can unlock significant opportunities for applications driven by DLP technology. Through this review, we aim to stimulate further interest and encourage active collaborations in advancing DLP resin materials and systems, fostering innovations in this dynamic field.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00452-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple and Cost-Effective Generation of 3D Cell Sheets and Spheroids Using Curvature-Controlled Paraffin Wax Substrates","authors":"Huijung Kim,&nbsp;Kyeong-Mo Koo,&nbsp;Chang-Dae Kim,&nbsp;Min Ji Byun,&nbsp;Chun Gwon Park,&nbsp;Hyungbin Son,&nbsp;Hyung-Ryong Kim,&nbsp;Tae-Hyung Kim","doi":"10.1186/s40580-024-00451-4","DOIUrl":"10.1186/s40580-024-00451-4","url":null,"abstract":"<div><p>The challenges associated with animal testing in pharmaceutical development have driven the search for alternative in vitro models that mimic human tissues more accurately. In this study, we present a simple and cost-effective method for generating 3D cell sheets and spheroids using curvature-controlled paraffin wax films, which are easily accessible laboratory materials that eliminate the need for extracellular matrix (ECM) components or thermo-responsive polymers. By adjusting the curvature of the paraffin wax film, we successfully generated human periodontal ligament fibroblast (HPdLF) cell sheets and bone marrow-derived mesenchymal stem cell (hBMSC) spheroids. Key parameters, such as cell density, substrate curvature, and incubation time, were identified as critical factors for optimizing the formation of these 3D structures. In addition, the use of quantum dots (QDs) for cell tracking enabled long-term visualization and distinction between different cell types within complex tissue-like structures. We further demonstrated that wrapping the hBMSC spheroids with HPdLF cell sheets partially replicated the connective tissue structure of the periodontal ligament surrounding the tooth root. This highlights the potential of this platform for the construction of more sophisticated tissue-mimicking assemblies. In conclusion, curvature-controlled paraffin wax films provide a versatile and practical approach for 3D cell cultures. This simplifies the generation of both cell sheets and spheroids, offering a promising tool for tissue engineering and regenerative medicine applications, where precise cell-to-cell interactions are essential.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional extracellular vesicles and edaravone-loaded scaffolds for kidney tissue regeneration by activating GDNF/RET pathway","authors":"Seung Yeon Lee,&nbsp;Jeong Min Park,&nbsp;Won-Kyu Rhim,&nbsp;Eun Hye Lee,&nbsp;Sang-Hyuk Lee,&nbsp;Jun Yong Kim,&nbsp;Seung-Gyu Cha,&nbsp;Sun Hong Lee,&nbsp;Boram Kim,&nbsp;Dong-Youn Hwang,&nbsp;Seungsoo Rho,&nbsp;Tae-Keun Ahn,&nbsp;Bum Soo Kim,&nbsp;Dong Keun Han","doi":"10.1186/s40580-024-00450-5","DOIUrl":"10.1186/s40580-024-00450-5","url":null,"abstract":"<div><p>With the severity of chronic kidney disease worldwide, strategies to recover renal function via tissue regeneration provide alternatives to kidney replacement therapy. To exclude side effects from direct cell transplantation, extracellular vesicles (EVs) are great substitutes representing paracrine cell signaling. To build three-dimensional structures for implantation into the 5/6 nephrectomy model by incorporating bioactive materials, including multifunctional EVs (mEVs), porous PMEZE/mEV scaffolds were developed in combination with edaravone (EDV; E) and mEV based on PMEZ scaffolds with PLGA (P), MH-RA (M), ECM (E), ZnO-ALA (Z). The oxygen free radical scavenger EDV was incorporated to induce tubular regeneration. mEVs were engineered to serve regenerative activities with a combination of two EVs from SDF-1α overexpressed tonsil-derived mesenchymal stem cells (sEVs) and intermediate mesoderm (IM) cells during differentiation into kidney progenitor cells (dEVs). mEVs displayed beneficial effects on regeneration by facilitating migration and inducing differentiation of surrounding stem cells, and EDV improved kidney function by regulating the GDNF/RET pathway and their downstream genes. The promotion of MSC recruitment was confirmed with sEV particles number dependently, and the regulation of the GDNF/RET pathway by the effect of EDV and its enhanced effect by mEVs were elucidated using in vitro analysis. The regeneration of tubules was additionally demonstrated through the increased expression of aquaporin-1 (AQP-1) and cadherin-16 (CDH16) for proximal tubules, and calbindin and PAX2 for distal tubules in the renal defect model. With these, structural regeneration and functional recovery were achieved with kidney regeneration in the 5/6 nephrectomy mice model.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00450-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}