Nano Convergence最新文献

{"title":"Highly sensitive multiplexed colorimetric lateral flow immunoassay by plasmon-controlled metal–silica isoform nanocomposites: PINs","authors":"Minsup Shin,&nbsp;Wooyeon Kim,&nbsp;Kwanghee Yoo,&nbsp;Hye-Seong Cho,&nbsp;Sohyeon Jang,&nbsp;Han-Joo Bae,&nbsp;Jaehyun An,&nbsp;Jong-chan Lee,&nbsp;Hyejin Chang,&nbsp;Dong-Eun Kim,&nbsp;Jaehi Kim,&nbsp;Luke P. Lee,&nbsp;Bong-Hyun Jun","doi":"10.1186/s40580-024-00449-y","DOIUrl":"10.1186/s40580-024-00449-y","url":null,"abstract":"<div><p>Lateral flow assay (LFA) systems use metal nanoparticles for rapid and convenient target detection and are extensively studied for the diagnostics of various diseases. Gold nanoparticles (AuNPs) are often used as probes in LFAs, displaying a single red color. However, there is a high demand for colorimetric LFAs to detect multiple biomarkers, requiring the use of multicolored NPs. Here, we present a highly sensitive multiplexed colorimetric lateral flow immunoassay by multicolored Plasmon-controlled metal–silica Isoform Nanocomposites (PINs). We utilized the localized surface plasmon resonance effect to create multi-colored PINs by precisely adjusting the distance between the NPs on the surface of PINs through the controlled addition of reduced gold and silver precursors. Through simulations, we also confirmed that the distance between nanoparticles on the surface of PINs significantly affects the color and colorimetric signal intensity of the PINs. We achieved multicolored PINs that exhibit stronger colorimetric signals, offering a new solution for LFA detection with high sensitivity and a 33 times reduced limit of detection (LOD) while maintaining consistent size deviations within 5%. We expect that our PINs-based colorimetric LFA will facilitate the sensitive and simultaneous detection of multiple biomarkers in point-of-care testing. </p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing injectable dermal matrix hydrogel combined with silver nanoparticles for methicillin-resistant Staphylococcus aureus infected wounds healing","authors":"Sunfang Chen,&nbsp;Jun Yao,&nbsp;Shicheng Huo,&nbsp;Chennan Xu,&nbsp;Ruting Yang,&nbsp;Danhua Tao,&nbsp;Bin Fang,&nbsp;Gaoxiang Ma,&nbsp;Zaihua Zhu,&nbsp;Ye Zhang,&nbsp;JingJing Guo","doi":"10.1186/s40580-024-00447-0","DOIUrl":"10.1186/s40580-024-00447-0","url":null,"abstract":"<div><p>Hydrogel-based delivery systems have now emerged as a pivotal platform for addressing chronic tissue defects, leveraging their innate capacity to suppress pathogenic infections and facilitate expedited tissue regeneration. In this work, an injectable hydrogel dressing, termed AgNPs-dermal matrix hydrogel (Ag@ADMH), has been designed to expedite the healing process of wounds afflicted with methicillin-resistant Staphylococcus aureus (MRSA), featuring sustained antibacterial efficacy. The synthesis of the hydrogel dressing entailed a self-assembly process of collagen fibers within an acellular dermal matrix to construct a three-dimensional scaffold, encapsulated with plant polyphenol-functionalized silver nanoparticles (AgNPs). The Ag@ADMH demonstrated exceptional biocompatibility, and enables a sustained release of AgNPs, ensuring prolonged antimicrobial activity. Moreover, the in vitro RT-qPCR analysis revealed that compared with ADMH, Ag@ADMH diminish the expression of iNOS while augmenting CD206 expression, thereby mitigating the inflammatory response and fostering wound healing. Especially, the Ag@ADMH facilitated a reduction in M1 macrophage polarization, as evidenced by a significant decrement in the M1 polarization trend and an enhanced M2/M1 ratio in dermal matrix hydrogels laden with AgNPs, corroborated by confocal microscopy and flow cytometry analyses of macrophage phenotypes. The in vivo assessments indicated that Ag@ADMH minimized fibrous capsule formation. In a full-thickness skin defect model of MRSA infection, the formulation significantly attenuated the inflammatory response by reducing MPO and CD68 expression levels, concurrently promoting collagen synthesis and CD34 expression, pivotal for vasculogenesis, thereby accelerating the resolution of MRSA-infected wounds. These attributes underscore the injectable extracellular matrix hydrogel as a formidable strategy for the remediation and regeneration of infected wounds.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00447-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of size-dependent uptake, transport and cytotoxicity of polystyrene microplastic in a blood-brain barrier (BBB) model","authors":"Yeongseon Cho,&nbsp;Eun U Seo,&nbsp;Kyeong Seob Hwang,&nbsp;Hyelim Kim,&nbsp;Jonghoon Choi,&nbsp;Hong Nam Kim","doi":"10.1186/s40580-024-00448-z","DOIUrl":"10.1186/s40580-024-00448-z","url":null,"abstract":"<div><p>Microplastics, particularly those in the micrometer scale, have been shown to enter the human body through ingestion, inhalation, and dermal contact. Recent research indicates that microplastics can potentially impact the central nervous system (CNS) by crossing the blood-brain barrier (BBB). However, the exact mechanisms of their transport, uptake, and subsequent toxicity at BBB remain unclear. In this study, we evaluated the size-dependent uptake and cytotoxicity of polystyrene microparticles using an engineered BBB model. Our findings demonstrate that 0.2 μm polystyrene microparticles exhibit significantly higher uptake and transendothelial transport compared to 1.0 μm polystyrene microparticles, leading to increased permeability and cellular damage. After 24 h of exposure, permeability increased by 15.6-fold for the 0.2 μm particles and 2-fold for the 1.0 μm particles compared to the control. After 72 h of exposure, permeability further increased by 27.3-fold for the 0.2 μm particles and a 4.5-fold for the 1.0 μm particles compared to the control. Notably, microplastics administration following TNF-α treatment resulted in enhanced absorption and greater BBB damage compared to non-stimulated conditions. Additionally, the size-dependent toxicity observed differently between 2D cultured cells and 3D BBB models, highlighting the importance of testing models in evaluating environmental toxicity.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00448-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142438716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zero-crosstalk silicon photonic refractive index sensor with subwavelength gratings","authors":"Syed Z. Ahmed,&nbsp;Mehedi Hasan,&nbsp;Kyungtae Kim,&nbsp;Sangsik Kim","doi":"10.1186/s40580-024-00446-1","DOIUrl":"10.1186/s40580-024-00446-1","url":null,"abstract":"<div><p>Silicon photonic index sensors have received significant attention for label-free bio and gas-sensing applications, offering cost-effective and scalable solutions. Here, we introduce an ultra-compact silicon photonic refractive index sensor that leverages zero-crosstalk singularity responses enabled by subwavelength gratings. The subwavelength gratings are precisely engineered to achieve an anisotropic perturbation-led zero-crosstalk, resulting in a single transmission dip singularity in the spectrum that is independent of device length. The sensor is optimized for the transverse magnetic mode operation, where the subwavelength gratings are arranged perpendicular to the propagation direction to support a leaky-like mode and maximize the evanescent field interaction with the analyte space. Experimental results demonstrate a high wavelength sensitivity of − 410 nm/RIU and an intensity sensitivity of 395 dB/RIU, with a compact device footprint of approximately 82.8 μm². Distinct from other resonant and interferometric sensors, our approach provides an FSR-free single-dip spectral response on a small device footprint, overcoming common challenges faced by traditional sensors, such as signal/phase ambiguity, sensitivity fading, limited detection range, and the necessity for large device footprints. This makes our sensor ideal for simplified intensity interrogation. The proposed sensor holds promise for a range of on-chip refractive index sensing applications, from gas to biochemical detection, representing a significant step towards efficient and miniaturized photonic sensing solutions.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00446-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142329428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous low-frequency vibration isolation and energy harvesting via attachable metamaterials","authors":"Jaeyub Hyun,&nbsp;Jaesoon Jung,&nbsp;Jeongwon Park,&nbsp;Wonjae Choi,&nbsp;Miso Kim","doi":"10.1186/s40580-024-00445-2","DOIUrl":"10.1186/s40580-024-00445-2","url":null,"abstract":"<div><p>In this study, we achieved energy localization and amplification of flexural vibrations by utilizing the defect mode of plate-attachable locally resonant metamaterials, thereby realizing compact and low-frequency vibration energy suppression and energy harvesting with enhanced output performance. We designed a cantilever-based metamaterial unit cell to induce local resonance inside a periodic supercell structure and form a bandgap within the targeted low-frequency range of 300–450 Hz. Subsequently, a defect area was created by removing some unit cells to break the periodicity inside the metamaterial, which led to the isolation and localization of the vibration energy. This localized vibration energy was simultaneously converted into electrical energy by a piezoelectric energy harvester coupled with a metamaterial inside the defect area. Consequently, a substantially enhanced energy harvesting output power was achieved at 360 Hz, which was 43-times higher than that of a bare plate without metamaterials. The proposed local resonant metamaterial offers a useful and multifunctional platform with the capability of vibration energy isolation and harvesting, while exhibiting easy handling via attachable designs that can be tailored in the low-frequency regime.</p></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00445-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142324407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: PFP@PLGA/Cu12Sb4S13‑mediated PTT ablates hepatocellular carcinoma by inhibiting the RAS/MAPK/MT‑CO1 signaling pathway","authors":"Tianxiu Dong,&nbsp;Jian Jiang,&nbsp;Hao Zhang,&nbsp;Hongyuan Liu,&nbsp;Xiaomeng Zou,&nbsp;Jiamei Niu,&nbsp;Yingxuan Mao,&nbsp;Mingwei Zhu,&nbsp;Xi Chen,&nbsp;Zizhuo Li,&nbsp;Yaodong Chen,&nbsp;Chunying Shi,&nbsp;Xiuhua Yang","doi":"10.1186/s40580-024-00444-3","DOIUrl":"10.1186/s40580-024-00444-3","url":null,"abstract":"","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00444-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perovskite nanocomposites: synthesis, properties, and applications from renewable energy to optoelectronics","authors":"Yunseok Choi,&nbsp;Sangmoon Han,&nbsp;Bo-In Park,&nbsp;Zhihao Xu,&nbsp;Qingge Huang,&nbsp;Sanggeun Bae,&nbsp;Justin S. Kim,&nbsp;Sun Ok Kim,&nbsp;Yuan Meng,&nbsp;Seung‐Il Kim,&nbsp;Ji‐Yun Moon,&nbsp;Ilpyo Roh,&nbsp;Ji-Won Park,&nbsp;Sang‑Hoon Bae","doi":"10.1186/s40580-024-00440-7","DOIUrl":"10.1186/s40580-024-00440-7","url":null,"abstract":"<div><p>The oxide and halide perovskite materials with a ABX₃ structure exhibit a number of excellent properties, including a high dielectric constant, electrochemical properties, a wide band gap, and a large absorption coefficient. These properties have led to a range of applications, including renewable energy and optoelectronics, where high-performance catalysts are needed. However, it is difficult for a single structure of perovskite alone to simultaneously fulfill the diverse needs of multiple applications, such as high performance and good stability at the same time. Consequently, perovskite nanocomposites have been developed to address the current limitations and enhance their functionality by combining perovskite with two or more materials to create complementary materials. This review paper categorizes perovskite nanocomposites according to their structural composition and outlines their synthesis methodologies, as well as their applications in various fields. These include fuel cells, electrochemical water splitting, CO₂ mitigation, supercapacitors, and optoelectronic devices. Additionally, the review presents a summary of their research status, practical challenges, and future prospects in the fields of renewable energy and electronics.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00440-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Emergence of two distinct phase transitions in monolayer CoSe2 on graphene","authors":"Tae Gyu Rhee,&nbsp;Nguyen Huu Lam,&nbsp;Yeong Gwang Kim,&nbsp;Minseon Gu,&nbsp;Jinwoong Hwang,&nbsp;Aaron Bostwick,&nbsp;Sung-Kwan Mo,&nbsp;Seung-Hyun Chun,&nbsp;Jungdae Kim,&nbsp;Young Jun Chang,&nbsp;Byoung Ki Choi","doi":"10.1186/s40580-024-00438-1","DOIUrl":"10.1186/s40580-024-00438-1","url":null,"abstract":"","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00438-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excimer-ultraviolet-lamp-assisted selective etching of single-layer graphene and its application in edge-contact devices","authors":"Minjeong Shin,&nbsp;Jin Hong Kim,&nbsp;Jin-Yong Ko,&nbsp;Mohd Musaib Haidari,&nbsp;Dong Jin Jang,&nbsp;Kihyun Lee,&nbsp;Kwanpyo Kim,&nbsp;Hakseong Kim,&nbsp;Bae Ho Park,&nbsp;Jin Sik Choi","doi":"10.1186/s40580-024-00442-5","DOIUrl":"10.1186/s40580-024-00442-5","url":null,"abstract":"<div><p>Since the discovery of graphene and its remarkable properties, researchers have actively explored advanced graphene-patterning technologies. While the etching process is pivotal in shaping graphene channels, existing etching techniques have limitations such as low speed, high cost, residue contamination, and rough edges. Therefore, the development of facile and efficient etching methods is necessary. This study entailed the development of a novel technique for patterning graphene through dry etching, utilizing selective photochemical reactions precisely targeted at single-layer graphene (SLG) surfaces. This process is facilitated by an excimer ultraviolet lamp emitting light at a wavelength of 172 nm. The effectiveness of this technique in selectively removing SLG over large areas, leaving the few-layer graphene intact and clean, was confirmed by various spectroscopic analyses. Furthermore, we explored the application of this technique to device fabrication, revealing its potential to enhance the electrical properties of SLG-based devices. One-dimensional (1D) edge contacts fabricated using this method not only exhibited enhanced electrical transport characteristics compared to two-dimensional contact devices but also demonstrated enhanced efficiency in fabricating conventional 1D-contacted devices. This study addresses the demand for advanced technologies suitable for next-generation graphene devices, providing a promising and versatile graphene-patterning approach with broad applicability and high efficiency.</p></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00442-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142034868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing SERS as a quantitative technique: challenges, considerations, and correlative approaches to aid validation","authors":"Sian Sloan-Dennison,&nbsp;Gregory Q. Wallace,&nbsp;Waleed A. Hassanain,&nbsp;Stacey Laing,&nbsp;Karen Faulds,&nbsp;Duncan Graham","doi":"10.1186/s40580-024-00443-4","DOIUrl":"10.1186/s40580-024-00443-4","url":null,"abstract":"<div><p>Surface-enhanced Raman scattering (SERS) remains a significant area of research since it’s discovery 50 years ago. The surface-based technique has been used in a wide variety of fields, most prominently in chemical detection, cellular imaging and medical diagnostics, offering high sensitivity and specificity when probing and quantifying a chosen analyte or monitoring nanoparticle uptake and accumulation. However, despite its promise, SERS is mostly confined to academic laboratories and is not recognised as a gold standard analytical technique. This is due to the variations that are observed in SERS measurements, mainly caused by poorly characterised SERS substrates, lack of universal calibration methods and uncorrelated results. To convince the wider scientific community that SERS should be a routinely used analytical technique, the field is now focusing on methods that will increase the reproducibility of the SERS signals and how to validate the results with more well-established techniques. This review explores the difficulties experienced by SERS users, the methods adopted to reduce variation and suggestions of best practices and strategies that should be adopted if one is to achieve absolute quantification.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":712,"journal":{"name":"Nano Convergence","volume":"11 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://nanoconvergencejournal.springeropen.com/counter/pdf/10.1186/s40580-024-00443-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}